Research output per year
Research output per year
- 1 - 50 out of 62 results
Search results
-
2025
WNK1 mediates M-CSF-induced macropinocytosis to enforce macrophage lineage fidelity
Trzeciak, A. J., Liu, Z.-L., Gatie, M., Krebs, A. S., Saitz Rojas, W., O'Neal, A. J., Baako, A., Wang, Z., Nelson, J., Miranda, I. C., Uddin, J., Lipshutz, A., Xie, J., Huang, C.-L., Saavedra, P. H. V., Hadjantonakis, A.-K., Overholtzer, M., Glickman, M. S., Subramanya, A. R. & Vierbuchen, T. & 4 others, , 28 May 2025, In: Nature Communications. 16, 19 p., 4945 .Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Age-related impairment of intestinal inflammation resolution through an eicosanoid-immune-microbiota axis
Goepp, M., Milburn, J., Zhang, B., Dong, Y., Tyrrell, V., Zheng, X., Marshall, J., Bolsega, S., Basic, M., Glendinning, L., Ho, G.-T., Satsangi, J., Breyer, R. M., Narumiya, S., McSorley, H. J., Schwarze, J., Anderson, C., Dockrell, D. H., Rossi, A. G. & Bleich, A. & 6 others, , 14 May 2025, (E-pub ahead of print) In: Cell Host & Microbe. 33, 5, p. 671-687.e6Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Drosophila complement-like Mcr acts as a wound-induced inflammatory chemoattractant
Zechini, L., Todd, H., Sanchez, T., Tudor, D., Campbell, J., Antonian, E., Jenkins, S. J., Lucas, C. D., Davidson, A. J., van den Elsen, J., Schumacher, L. J., Scopelliti, A. & Wood, W., 18 Mar 2025, In: Current Biology. 35, 7, p. 1656-1664.e4Research output: Contribution to journal › Literature review › peer-review
Open AccessFile -
2024
Broad-spectrum antibiotics disrupt homeostatic efferocytosis
Saavedra, P. H., Trzeciak, A. J., Lipshutz, A., Daman, A. W., O'Neal, A. J., Liu, Z.-L., Wang, Z., Romero-Pichardo, J. E., Saitz Rojas, W., Zago, G., Brink, M. R. M. V. D., Josefowicz, S. Z., Lucas, C. D., Anderson, C., Rudensky, A. Y. & Perry, J. S. A., Sept 2024, In: Nature Metabolism. 6, 9, p. 1682-1694Research output: Contribution to journal › Article › peer-review
Open AccessFile -
ARAP3 protects from excessive formylated peptide-induced microvascular leakage by acting on endothelial cells and neutrophils
Chu, J. Y., McCormick, B., Sundaram, K., Hardisty, G., Karmakar, U., Pumpe, C., Krull, E., Lucas, C. D., Amado-Azevedo, J., Hordijk, P. L., Caporali, A., Mellor, H., Baillie, J. K., Rossi, A. G. & Vermeren, S., 11 May 2024, In: Journal of Pathology. 263, 3, p. 347-359Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2023
Phagocytosis in the retina promotes local insulin production in the eye
Etchegaray, J. I., Kelley, S., Penberthy, K. K., Karvelyte, L., Nagasaka, Y., Gasperino, S., Paul, S., Seshadri, V., Raymond, M. H., Marco, A. R., Pinney, J., Stremska, M. E., Barron, B., Lucas, C. D., Wase, N., Fan, Y., Unanue, E., Kundu, B., Burstyn-Cohen, T. & Perry, J. S. A. & 2 others, , 2 Feb 2023, (E-pub ahead of print) In: Nature Metabolism.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2022
Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments
Wang, Y.-T., Trzeciak, A., Saitz Rojas, W., Saavedra, P., Chen, Y.-T., Chirayil, R., Etchegaray, J. I., Lucas, C. D., Puleston, D., Keshari, K. R. & Perry, J. S. A., 29 Dec 2022, (E-pub ahead of print) In: Cell Metabolism.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Macrophages trigger cardiomyocyte proliferation by increasing epicardial vegfaa expression during larval zebrafish heart regeneration
Bruton, F., Kaveh, A., Ross Stewart, K., Matrone, G., Oremek, M., Solomonidis, E., Tucker, C., Mullins, J., Lucas, C. D., Brittan, M., Taylor, J. M., Rossi, A. G. & Denvir, M. A., 9 Jun 2022, In: Developmental Cell. 57, 12, p. 1512-1528Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Inhibition of cyclin-dependent kinase 9 downregulates cytokine production without detrimentally affecting human monocyte-derived macrophage viability
McHugh, B., Stephen, J., Robb, C., Fox, S., Kipari, T., Cartwright, J., Haslett, C., Duffin, R., Lucas, C. D. & Rossi, A. G., 26 May 2022, In: Frontiers in Cell and Developmental Biology. 10, 905315.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Pannexin 1 drives efficient epithelial repair after tissue injury
Lucas, C. D., Medina, C. B., Bruton, F., Dorward, D., Raymond, M. H., Tufan, T., Etchegaray, J. I., Barron, B., Oremek, M., Arandjelovic, S., Farber, E., Onngut-Gumuscu, S., Ke, E., Whyte, M. K. B., Rossi, A. G. & Ravichandran, K. S., 13 May 2022, In: Science Immunology. 7, 71, eabm4032 .Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Pulmonary macrophages and SARS-Cov2 infection
Bain, C. C., Rossi, A. G. & Lucas, C. D., 20 Apr 2022, International Review of Cell and Molecular Biology. Mariani, S. A., Cassetta, L. & Galluzzi, L. (eds.). Oxford, UK: Academic Press, Vol. 367. 1 p. (International Review of Cell and Molecular Biology).Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review
Open AccessFile -
Live cell tracking of macrophage efferocytosis during Drosophila embryo development in vivo
Raymond, M. H., Davidson, A. J., Shen, Y., Tudor, D. R., Lucas, C. D., Morioka, S., Perry, J. S. A., Krapivkina, J., Perrais, D., Schumacher, L. J., Campbell, R. E., Wood, W. & Ravichandran, K. S., 11 Mar 2022, In: Science. 375, 6585, p. 1182-1187Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2021
Tissue proteomic analysis identifies mechanisms and stages of immunopathology in fatal COVID-19
Russell, C. D., Valanciute, A., Gachanja, N., Stephen, J., Penrice-Randal, R., Armstrong, S. D., Clohisey, S., Wang, B., Al Qsous, W., Wallace, W., Oniscu, G., Stevens, J., Harrison, D. J., Dhaliwal, K., Hiscox, J. A., Baillie, J. K., Akram, A. R., David, D. & Lucas, C. D., 28 Oct 2021, (E-pub ahead of print) In: American Journal of Respiratory Cell and Molecular Biology.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Intestinal Protein Characterisation of SARS-CoV-2 Entry Molecules ACE2 and TMPRSS2 in Inflammatory Bowel Disease (IBD) and Fatal COVID-19 Infection
McAllister, M. J., Kirkwood, K., Chuah, S. C., Thompson, E. J., Cartwright, J. A., Russell, C. D., Dorward, D. A., Lucas, C. D. & Ho, G.-T., 25 Oct 2021, (E-pub ahead of print) In: Inflammation. 45, 2, p. 567-572 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Post-mortem dissection of COVID-19: a pathogenic role for macrophages?
Velu, P. P., Lucas, C. D. & Conway Morris, A., 1 Sept 2021, (E-pub ahead of print) In: Intensive Care Medicine.Research output: Contribution to journal › Editorial › peer-review
Open AccessFile -
In vivo thrombosis imaging in patients recovering from COVID-19 and pulmonary embolism
Bing, R., Andrews, J., Williams, M. C., van Beek, E. J. R., Lucatelli, C., Macnaught, G., Clark, T., Koglin, N., Stephens, A. W., Macaskill, M., Tavares, A. A. S., Dhaliwal, K., Dorward, D. A., Lucas, C. D., Dweck, M. R. & Newby, D. E., 10 Aug 2021, In: American Journal of Respiratory and Critical Care Medicine.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Pannexin 1 channels facilitate communication between T cells to restrict the severity of airway inflammation
Medina, C. B., Chiu, Y.-H., Stremska, M. E., Lucas, C. D., Poon, I., Tung, K. S., Elliott, M. R., Desai, B., Bayliss, D. A., Lorenz, U. M. & Ravichandran, K. S., 19 Jul 2021, In: Immunity.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Mechanisms and Stages of Covid-19 Immunopathology Revealed by Tissue-Specific Proteomes
Russell, C. D., Valanciute, A., Gachanja, N. N., Stephen, J., Penrice-Randal, R., Armstrong, S. D., Clohisey, S., Wang, B., Al Qsous, W., Wallace, W. A., Oniscu, G. C., Stevens, J., Harrison, D. J., Dhaliwal, K., Hiscox, J. A., Baillie, J. K., Akram, A. R., Dorward, D. A. & Lucas, C. D., 27 May 2021, Social Science Research Network (SSRN).Research output: Working paper › Preprint
-
Epithelial Cells and Inflammation in Pulmonary Wound Repair
Croasdell Lucchini, A., Gachanja, N. N., Rossi, A. G., Dorward, D. A. & Lucas, C. D., 5 Feb 2021, In: Cells. 10, 2, p. 339Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Assays of Eosinophil Apoptosis and Phagocytic Uptake
Gachanja, N. N., Dorward, D. A., Rossi, A. G. & Lucas, C. D., 24 Jan 2021, Eosinophils: Methods and Protocols. Walsh, G. M. (ed.). Second ed. Humana, New York, NY, Vol. 2241. p. 113-132 Chapter 10. (Methods in Molecular Biology; vol. 2241).Research output: Chapter in Book/Report/Conference proceeding › Chapter
Open AccessFile -
Tissue-specific Immunopathology in fatal Covid-19
ICECAP consortium, 15 Jan 2021, In: American Journal of Respiratory and Critical Care Medicine. 203, 2, p. 192-201Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2020
Histological Evidence of Pulmonary Microthrombosis and Vasculitis in Life-Threatening Respiratory Virus Diseases
Dolby, H. W., Potey, P., Wilder-Smith, A. B., Clohisey, S., Millar, J. E., Baillie, J. K., Dorward, D. A., Lucas, C. D. & Russell, C. D., 28 Dec 2020, In: Open forum infectious diseases. 8, 2, p. ofaa640Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Src kinase inhibition with dasatinib impairs neutrophil function and clearance of Escherichia coli infection in a murine model of acute lung injury
MacFarlane, J. G., Dorward, D. A., Ruchaud-Sparagano, M.-H., Scott, J., Lucas, C. D., Rossi, A. G. & Simpson, A. J., 30 Oct 2020, In: Journal of inflammation.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Mcl-1 protects eosinophils from apoptosis and exacerbates allergic airway inflammation
Felton, J. M., Dorward, D. A., Cartwright, J., Potey, P. M. D., Robb, C. T., Gui, J., Craig, R. W., Schwarze, J., Haslett, C., Duffin, R., Dransfield, I., Lucas, C. D. & Rossi, A. G., 1 Jul 2020, In: Thorax. 75, 7, p. 600-605Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2019
Interpreting an apoptotic corpse as anti-inflammatory involves a chloride sensing pathway
Perry, J. S. A., Morioka, S., Medina, C. B., Etchegaray, J. I., Barron, B., Raymond, M. H., Lucas, C. D., Onengut-Gumuscu, S., Delpire, E. & Ravichandran, K. S., Dec 2019, In: Nature Cell Biology. 21, 12, p. 1532–1543 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Inflammation Resolution and the Induction of Granulocyte Apoptosis by Cyclin-Dependent Kinase Inhibitor Drugs
Cartwright, J. A., Lucas, C. D. & Rossi, A. G., 19 Feb 2019, In: Frontiers in pharmacology. 10Research output: Contribution to journal › Article › peer-review
Open AccessFile -
A noncanonical role for the engulfment gene ELMO1 in neutrophils that promotes inflammatory arthritis
Arandjelovic, S., Perry, J. S. A., Lucas, C., Penberthy, K. K., Kim, T.-H., Zhou, M., Rosen, D. A., Chuang, T.-Y., Bettina , A. M., Shankman, L. S., Cohen, A. H., Gaultier, C., Conrads, T. P., Kim, M., Elliott, M. R. & Ravichandran, K. S., 14 Jan 2019, (E-pub ahead of print) In: Nature Immunology.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2018
Neutrophils in the initiation and resolution of acute pulmonary inflammation: understanding biological function and therapeutic potential
Potey, P. M. D., Rossi, A. G., Lucas, C. D. & Dorward, D. A., 20 Dec 2018, (E-pub ahead of print) In: The Journal of Pathology.Research output: Contribution to journal › Review article › peer-review
Open AccessFile -
Mer-mediated eosinophil efferocytosis regulates resolution of allergic airway inflammation
Felton, J., Lucas, C. D., Dorward, D. A., Duffin, R., Kipari, T., Vermeren, S., Robb, C., Macleod, K., Serrels, B., Schwarze, J., Haslett, C., Dransfield, I. & Rossi, A. G., 8 Feb 2018, (E-pub ahead of print) In: Journal of Allergy and Clinical Immunology.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Delayed neutrophil apoptosis enhances NET formation in cystic fibrosis
Gray, R. D., Hardisty, G., Regan, K. H., Smith, M., Robb, C. T., Duffin, R., Mackellar, A., Felton, J. M., Paemka, L., McCullagh, B. N., Lucas, C. D., David, D., McKone, E. F., Cooke, G., Donnelly, S. C., Singh, P. K., Stoltz, D. A., Haslett, C., McCray, P. B. & Whyte, M. K. B. & 2 others, , Feb 2018, In: Thorax. 73, 2, p. 134-144 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2017
Novel role for endogenous mitochondrial formylated peptide-driven formyl peptide receptor 1 signalling in Acute Respiratory Distress Syndrome
Dorward, D. A., Lucas, C. D., Doherty, M. K., Chapman, G. B., Scholefield, E., Conway-Morris, A., Felton, J. M., Kipari, T., Humphries, D. C., Robb, C. T., Simpson, A. J., Whitfield, P. D., Haslett, C., Dhaliwal, K. & Rossi, A. G., Oct 2017, In: Thorax. 72, 10, p. 928-936 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Non-small cell lung carcinoma (not otherwise specified) rates are not solely influenced by pathologists’ decisions on the use of immunohistochemistry.
Chapman, G., Dorward, D., Lucas, C. & Wallace, W., Feb 2017, In: Histopathology. 70, 3Research output: Contribution to journal › Article › peer-review
Open AccessFile -
The cyclin-dependent kinase inhibitor AT7519 accelerates neutrophil apoptosis in sepsis-related acute respiratory distress syndrome
Dorward, D. A., Felton, J. M., Robb, C. T., Craven, T., Kipari, T., Walsh, T. S., Haslett, C., Kefala, K., Rossi, A. G. & Lucas, C. D., Feb 2017, In: Thorax. 72, 2, p. 182-185 4 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Increasing use of CTPA for the investigation of suspected pulmonary embolism
Sharma, S. & Lucas, C. D., 20 Jan 2017, In: Postgraduate medicine. p. 1-5 5 p.Research output: Contribution to journal › Article › peer-review
-
2016
Genetic and pharmacological inhibition of CDK9 drives neutrophil apoptosis to resolve inflammation in zebrafish in vivo
Hoodless, L. J., Lucas, C. D., Duffin, R., Denvir, M. A., Haslett, C., Tucker, C. S. & Rossi, A. G., 11 Nov 2016, (E-pub ahead of print) In: Scientific Reports. 36980 .Research output: Contribution to journal › Article › peer-review
Open AccessFile -
11β-Hydroxysteroid Dehydrogenase type 1 is expressed in neutrophils and restrains an inflammatory response in male mice
Coutinho, A. E., Kipari, T. M. J., Zhang, Z., Esteves, C. L., Lucas, C. D., Gilmour, J. S., Webster, S. P., Walker, B. R., Hughes, J., Savill, J. S., Seckl, J. R., Rossi, A. G. & Chapman, K. E., 4 May 2016, (E-pub ahead of print) In: Endocrinology. 157, 7, p. 2928-2936 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2015
The Role of Formylated Peptides and Formyl Peptide Receptor 1 in Governing Neutrophil Function during Acute Inflammation
Dorward, D., Lucas, C. D., Chapman, G., Haslett, C., Dhaliwal, K. & Rossi, A. G., 16 Mar 2015, In: The American Journal of Pathology. 185, 5, p. 1172–1184Research output: Contribution to journal › Literature review › peer-review
-
Wogonin Induces Eosinophil Apoptosis and Attenuates Allergic Airway Inflammation
Lucas, C. D., Dorward, D. A., Sharma, S., Rennie, J., Felton, J. M., Alessandri, A. L., Duffin, R., Schwarze, J., Haslett, C. & Rossi, A. G., 15 Mar 2015, In: American Journal of Respiratory and Critical Care Medicine. 191, 6, p. 626-636 11 p.Research output: Contribution to journal › Article › peer-review
-
2014
P20 DELINEATING THE CONTRIBUTION OF FORMYLATED PEPTIDES AND FORMYL PEPTIDE RECEPTOR 1 TO THE PATHOGENESIS OF ACUTE LUNG INJURY
Dorward, D. A., Lucas, C. D., Doherty, M. K., Chapman, G. B., Scholefield, E., Conway-Morris, A., Kipari, T., Robb, C. T., Felton, J. M., Whitfield, P. D., Haslett, C., Dhaliwal, K. & Rossi, A. G., Dec 2014, In: Thorax. 69, p. A86-A86 1 p.Research output: Contribution to journal › Meeting abstract › peer-review
-
Downregulation of Mcl-1 has anti-inflammatory pro-resolution effects and enhances bacterial clearance from the lung
Lucas, C. D., Dorward, D. A., Tait, M. A., Fox, S., Marwick, J. A., Allen, K. C., Robb, C. T., Hirani, N., Haslett, C., Duffin, R. & Rossi, A. G., Jul 2014, In: Mucosal Immunology. 7, 4, p. 857-868 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Systemic lupus erythematosus complicating simple silicosis
Lucas, C. D., Amft, N. & Reid, P. T., Jul 2014, In: Occupational Medicine. 64, 5, p. 387-90 4 p.Research output: Contribution to journal › Article › peer-review
-
Apoptotic cell clearance: basic biology and therapeutic potential
Poon, I. K. H., Lucas, C. D., Rossi, A. G. & Ravichandran, K. S., Mar 2014, In: Nature Reviews Immunology. 14, 3, p. 166-180 15 p.Research output: Contribution to journal › Literature review › peer-review
Open AccessFile -
Swimming Against the Tide: Drugs Drive Neutrophil Reverse Migration
Lucas, C. D., Hoodless, L. J. & Rossi, A. G., 26 Feb 2014, In: Science Translational Medicine. 6, 225, 3 p., ARTN 225fs9.Research output: Contribution to journal › Article
-
Assessment of neutrophil apoptosis
Dorward, D. A., Rossi, A. G., Dransfield, I. & Lucas, C. D., 2014, Neutrophil Methods and Protocols. Quin, M. & Deleo, F. (eds.). 2nd ed. Totowa: Humana Press, Vol. 1124. p. 159-80 22 p. (Methods in Molecular Biology; vol. 1124).Research output: Chapter in Book/Report/Conference proceeding › Chapter
-
Eosinophils in the lung - modulating apoptosis and efferocytosis in airway inflammation
Felton, J. M., Lucas, C. D., Rossi, A. G. & Dransfield, I., 2014, In: Frontiers in Immunology. 5, 11 p., 302.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2013
Resolution of allergic inflammation
Dorward, D., Lucas, C., Allen, K. C. & Rossi, A., 30 Oct 2013, Middleton’s Allergy: Principles and Practice. Adkinson, N., Bochner, B., Burks, A., Busse, W., Holgate, S., Lemanske, R. & O'Hehir, R. (eds.). 8 ed. MosbyResearch output: Chapter in Book/Report/Conference proceeding › Chapter
-
Oxygen levels determine the ability of glucocorticoids to influence neutrophil survival in inflammatory environments
Marwick, J. A., Dorward, D. A., Lucas, C. D., Jones, K. O., Sheldrake, T. A., Fox, S., Ward, C., Murray, J., Brittan, M., Hirani, N., Duffin, R., Dransfield, I., Haslett, C. & Rossi, A. G., 20 Aug 2013, In: Journal of Leukocyte Biology. 94, 6, p. 1285-1292Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Resolution of inflammation: Mechanisms and opportunity for drug development
Alessandri, A. L., Sousa, L. P., Lucas, C. D., Rossi, A. G., Pinho, V. & Teixeira, M. M., Aug 2013, In: Pharmacology and Therapeutics. 139, 2, p. 189-212 24 p.Research output: Contribution to journal › Literature review › peer-review
-
Technical advance: autofluorescence-based sorting: rapid and nonperturbing isolation of ultrapure neutrophils to determine cytokine production
Dorward, D. A., Lucas, C. D., Alessandri, A. L., Marwick, J. A., Rossi, F., Dransfield, I., Haslett, C., Dhaliwal, K. & Rossi, A. G., Jul 2013, In: Journal of Leukocyte Biology. 94, 1, p. 193-202 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Novel R-roscovitine NO-donor hybrid compounds as potential pro-resolution of inflammation agents
Montanaro, G., Bertinaria, M., Rolando, B., Fruttero, R., Lucas, C., Dorward, D. A., Rossi, A. G., Megson, I. L. & Gasco, A., 1 Apr 2013, In: Bioorganic and Medicinal Chemistry. 21, 7, p. 2107-2116 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile