Christopher Lucas

2025

WNK1 mediates M-CSF-induced macropinocytosis to enforce macrophage lineage fidelity

Trzeciak, A. J., Liu, Z.-L., Gatie, M., Krebs, A. S., Saitz Rojas, W., O'Neal, A. J., Baako, A., Wang, Z., Nelson, J., Miranda, I. C., Uddin, J., Lipshutz, A., Xie, J., Huang, C.-L., Saavedra, P. H. V., Hadjantonakis, A.-K., Overholtzer, M., Glickman, M. S., Subramanya, A. R. & Vierbuchen, T. & 4 others, Etchegaray, J. I., Lucas, C. D., Parkhurst, C. N. & Perry, J. S. A., 28 May 2025, In: Nature Communications. 16, 19 p., 4945 .

Research output: Contribution to journal › Article › peer-review

Open Access

File

Age-related impairment of intestinal inflammation resolution through an eicosanoid-immune-microbiota axis

Goepp, M., Milburn, J., Zhang, B., Dong, Y., Tyrrell, V., Zheng, X., Marshall, J., Bolsega, S., Basic, M., Glendinning, L., Ho, G.-T., Satsangi, J., Breyer, R. M., Narumiya, S., McSorley, H. J., Schwarze, J., Anderson, C., Dockrell, D. H., Rossi, A. G. & Bleich, A. & 6 others, Lucas, C. D., O'Donnell, V. B., Mole, D. J., Arends, M. J., Zhou, Y. & Yao, C., 14 May 2025, (E-pub ahead of print) In: Cell Host & Microbe. 33, 5, p. 671-687.e6

Research output: Contribution to journal › Article › peer-review

Open Access

File

2024

Broad-spectrum antibiotics disrupt homeostatic efferocytosis

Saavedra, P. H., Trzeciak, A. J., Lipshutz, A., Daman, A. W., O'Neal, A. J., Liu, Z.-L., Wang, Z., Romero-Pichardo, J. E., Saitz Rojas, W., Zago, G., Brink, M. R. M. V. D., Josefowicz, S. Z., Lucas, C. D., Anderson, C., Rudensky, A. Y. & Perry, J. S. A., Sept 2024, In: Nature Metabolism. 6, 9, p. 1682-1694

Research output: Contribution to journal › Article › peer-review

Open Access

File

ARAP3 protects from excessive formylated peptide-induced microvascular leakage by acting on endothelial cells and neutrophils

Chu, J. Y., McCormick, B., Sundaram, K., Hardisty, G., Karmakar, U., Pumpe, C., Krull, E., Lucas, C. D., Amado-Azevedo, J., Hordijk, P. L., Caporali, A., Mellor, H., Baillie, J. K., Rossi, A. G. & Vermeren, S., 11 May 2024, In: Journal of Pathology. 263, 3, p. 347-359

Research output: Contribution to journal › Article › peer-review

Open Access

File

2023

Phagocytosis in the retina promotes local insulin production in the eye

Etchegaray, J. I., Kelley, S., Penberthy, K. K., Karvelyte, L., Nagasaka, Y., Gasperino, S., Paul, S., Seshadri, V., Raymond, M. H., Marco, A. R., Pinney, J., Stremska, M. E., Barron, B., Lucas, C. D., Wase, N., Fan, Y., Unanue, E., Kundu, B., Burstyn-Cohen, T. & Perry, J. S. A. & 2 others, Jayakrishna, A. & Ravichandran, K. S., 2 Feb 2023, (E-pub ahead of print) In: Nature Metabolism.

Research output: Contribution to journal › Article › peer-review

Open Access

File

2022

Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments

Wang, Y.-T., Trzeciak, A., Saitz Rojas, W., Saavedra, P., Chen, Y.-T., Chirayil, R., Etchegaray, J. I., Lucas, C. D., Puleston, D., Keshari, K. R. & Perry, J. S. A., 29 Dec 2022, (E-pub ahead of print) In: Cell Metabolism.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Macrophages trigger cardiomyocyte proliferation by increasing epicardial vegfaa expression during larval zebrafish heart regeneration

Bruton, F., Kaveh, A., Ross Stewart, K., Matrone, G., Oremek, M., Solomonidis, E., Tucker, C., Mullins, J., Lucas, C. D., Brittan, M., Taylor, J. M., Rossi, A. G. & Denvir, M. A., 9 Jun 2022, In: Developmental Cell. 57, 12, p. 1512-1528

Research output: Contribution to journal › Article › peer-review

Open Access

File

Inhibition of cyclin-dependent kinase 9 downregulates cytokine production without detrimentally affecting human monocyte-derived macrophage viability

McHugh, B., Stephen, J., Robb, C., Fox, S., Kipari, T., Cartwright, J., Haslett, C., Duffin, R., Lucas, C. D. & Rossi, A. G., 26 May 2022, In: Frontiers in Cell and Developmental Biology. 10, 905315.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Pannexin 1 drives efficient epithelial repair after tissue injury

Lucas, C. D., Medina, C. B., Bruton, F., Dorward, D., Raymond, M. H., Tufan, T., Etchegaray, J. I., Barron, B., Oremek, M., Arandjelovic, S., Farber, E., Onngut-Gumuscu, S., Ke, E., Whyte, M. K. B., Rossi, A. G. & Ravichandran, K. S., 13 May 2022, In: Science Immunology. 7, 71, eabm4032 .

Research output: Contribution to journal › Article › peer-review

Open Access

File

Live cell tracking of macrophage efferocytosis during Drosophila embryo development in vivo

Raymond, M. H., Davidson, A. J., Shen, Y., Tudor, D. R., Lucas, C. D., Morioka, S., Perry, J. S. A., Krapivkina, J., Perrais, D., Schumacher, L. J., Campbell, R. E., Wood, W. & Ravichandran, K. S., 11 Mar 2022, In: Science. 375, 6585, p. 1182-1187

Research output: Contribution to journal › Article › peer-review

Open Access

File

2021

Tissue proteomic analysis identifies mechanisms and stages of immunopathology in fatal COVID-19

Russell, C. D., Valanciute, A., Gachanja, N., Stephen, J., Penrice-Randal, R., Armstrong, S. D., Clohisey, S., Wang, B., Al Qsous, W., Wallace, W., Oniscu, G., Stevens, J., Harrison, D. J., Dhaliwal, K., Hiscox, J. A., Baillie, J. K., Akram, A. R., David, D. & Lucas, C. D., 28 Oct 2021, (E-pub ahead of print) In: American Journal of Respiratory Cell and Molecular Biology.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Intestinal Protein Characterisation of SARS-CoV-2 Entry Molecules ACE2 and TMPRSS2 in Inflammatory Bowel Disease (IBD) and Fatal COVID-19 Infection

McAllister, M. J., Kirkwood, K., Chuah, S. C., Thompson, E. J., Cartwright, J. A., Russell, C. D., Dorward, D. A., Lucas, C. D. & Ho, G.-T., 25 Oct 2021, (E-pub ahead of print) In: Inflammation. 45, 2, p. 567-572 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

In vivo thrombosis imaging in patients recovering from COVID-19 and pulmonary embolism

Bing, R., Andrews, J., Williams, M. C., van Beek, E. J. R., Lucatelli, C., Macnaught, G., Clark, T., Koglin, N., Stephens, A. W., Macaskill, M., Tavares, A. A. S., Dhaliwal, K., Dorward, D. A., Lucas, C. D., Dweck, M. R. & Newby, D. E., 10 Aug 2021, In: American Journal of Respiratory and Critical Care Medicine.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Pannexin 1 channels facilitate communication between T cells to restrict the severity of airway inflammation

Medina, C. B., Chiu, Y.-H., Stremska, M. E., Lucas, C. D., Poon, I., Tung, K. S., Elliott, M. R., Desai, B., Bayliss, D. A., Lorenz, U. M. & Ravichandran, K. S., 19 Jul 2021, In: Immunity.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Epithelial Cells and Inflammation in Pulmonary Wound Repair

Croasdell Lucchini, A., Gachanja, N. N., Rossi, A. G., Dorward, D. A. & Lucas, C. D., 5 Feb 2021, In: Cells. 10, 2, p. 339

Research output: Contribution to journal › Article › peer-review

Open Access

File

Tissue-specific Immunopathology in fatal Covid-19

ICECAP consortium, 15 Jan 2021, In: American Journal of Respiratory and Critical Care Medicine. 203, 2, p. 192-201

Research output: Contribution to journal › Article › peer-review

Open Access

File

2020

Histological Evidence of Pulmonary Microthrombosis and Vasculitis in Life-Threatening Respiratory Virus Diseases

Dolby, H. W., Potey, P., Wilder-Smith, A. B., Clohisey, S., Millar, J. E., Baillie, J. K., Dorward, D. A., Lucas, C. D. & Russell, C. D., 28 Dec 2020, In: Open forum infectious diseases. 8, 2, p. ofaa640

Research output: Contribution to journal › Article › peer-review

Open Access

File

Src kinase inhibition with dasatinib impairs neutrophil function and clearance of Escherichia coli infection in a murine model of acute lung injury

MacFarlane, J. G., Dorward, D. A., Ruchaud-Sparagano, M.-H., Scott, J., Lucas, C. D., Rossi, A. G. & Simpson, A. J., 30 Oct 2020, In: Journal of inflammation.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Mcl-1 protects eosinophils from apoptosis and exacerbates allergic airway inflammation

Felton, J. M., Dorward, D. A., Cartwright, J., Potey, P. M. D., Robb, C. T., Gui, J., Craig, R. W., Schwarze, J., Haslett, C., Duffin, R., Dransfield, I., Lucas, C. D. & Rossi, A. G., 1 Jul 2020, In: Thorax. 75, 7, p. 600-605

Research output: Contribution to journal › Article › peer-review

Open Access

File

2019

Interpreting an apoptotic corpse as anti-inflammatory involves a chloride sensing pathway

Perry, J. S. A., Morioka, S., Medina, C. B., Etchegaray, J. I., Barron, B., Raymond, M. H., Lucas, C. D., Onengut-Gumuscu, S., Delpire, E. & Ravichandran, K. S., Dec 2019, In: Nature Cell Biology. 21, 12, p. 1532–1543 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Inflammation Resolution and the Induction of Granulocyte Apoptosis by Cyclin-Dependent Kinase Inhibitor Drugs

Cartwright, J. A., Lucas, C. D. & Rossi, A. G., 19 Feb 2019, In: Frontiers in pharmacology. 10

Research output: Contribution to journal › Article › peer-review

Open Access

File

A noncanonical role for the engulfment gene ELMO1 in neutrophils that promotes inflammatory arthritis

Arandjelovic, S., Perry, J. S. A., Lucas, C., Penberthy, K. K., Kim, T.-H., Zhou, M., Rosen, D. A., Chuang, T.-Y., Bettina , A. M., Shankman, L. S., Cohen, A. H., Gaultier, C., Conrads, T. P., Kim, M., Elliott, M. R. & Ravichandran, K. S., 14 Jan 2019, (E-pub ahead of print) In: Nature Immunology.

Research output: Contribution to journal › Article › peer-review

Open Access

File

2018

Mer-mediated eosinophil efferocytosis regulates resolution of allergic airway inflammation

Felton, J., Lucas, C. D., Dorward, D. A., Duffin, R., Kipari, T., Vermeren, S., Robb, C., Macleod, K., Serrels, B., Schwarze, J., Haslett, C., Dransfield, I. & Rossi, A. G., 8 Feb 2018, (E-pub ahead of print) In: Journal of Allergy and Clinical Immunology.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Delayed neutrophil apoptosis enhances NET formation in cystic fibrosis

Gray, R. D., Hardisty, G., Regan, K. H., Smith, M., Robb, C. T., Duffin, R., Mackellar, A., Felton, J. M., Paemka, L., McCullagh, B. N., Lucas, C. D., David, D., McKone, E. F., Cooke, G., Donnelly, S. C., Singh, P. K., Stoltz, D. A., Haslett, C., McCray, P. B. & Whyte, M. K. B. & 2 others, Rossi, A. G. & Davidson, D. J., Feb 2018, In: Thorax. 73, 2, p. 134-144 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

2017

Novel role for endogenous mitochondrial formylated peptide-driven formyl peptide receptor 1 signalling in Acute Respiratory Distress Syndrome

Dorward, D. A., Lucas, C. D., Doherty, M. K., Chapman, G. B., Scholefield, E., Conway-Morris, A., Felton, J. M., Kipari, T., Humphries, D. C., Robb, C. T., Simpson, A. J., Whitfield, P. D., Haslett, C., Dhaliwal, K. & Rossi, A. G., Oct 2017, In: Thorax. 72, 10, p. 928-936 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Non-small cell lung carcinoma (not otherwise specified) rates are not solely influenced by pathologists’ decisions on the use of immunohistochemistry.

Chapman, G., Dorward, D., Lucas, C. & Wallace, W., Feb 2017, In: Histopathology. 70, 3

Research output: Contribution to journal › Article › peer-review

Open Access

File

The cyclin-dependent kinase inhibitor AT7519 accelerates neutrophil apoptosis in sepsis-related acute respiratory distress syndrome

Dorward, D. A., Felton, J. M., Robb, C. T., Craven, T., Kipari, T., Walsh, T. S., Haslett, C., Kefala, K., Rossi, A. G. & Lucas, C. D., Feb 2017, In: Thorax. 72, 2, p. 182-185 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Increasing use of CTPA for the investigation of suspected pulmonary embolism

Sharma, S. & Lucas, C. D., 20 Jan 2017, In: Postgraduate medicine. p. 1-5 5 p.

Research output: Contribution to journal › Article › peer-review

2016

Genetic and pharmacological inhibition of CDK9 drives neutrophil apoptosis to resolve inflammation in zebrafish in vivo

Hoodless, L. J., Lucas, C. D., Duffin, R., Denvir, M. A., Haslett, C., Tucker, C. S. & Rossi, A. G., 11 Nov 2016, (E-pub ahead of print) In: Scientific Reports. 36980 .

Research output: Contribution to journal › Article › peer-review

Open Access

File

11β-Hydroxysteroid Dehydrogenase type 1 is expressed in neutrophils and restrains an inflammatory response in male mice

Coutinho, A. E., Kipari, T. M. J., Zhang, Z., Esteves, C. L., Lucas, C. D., Gilmour, J. S., Webster, S. P., Walker, B. R., Hughes, J., Savill, J. S., Seckl, J. R., Rossi, A. G. & Chapman, K. E., 4 May 2016, (E-pub ahead of print) In: Endocrinology. 157, 7, p. 2928-2936 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

2015

Wogonin Induces Eosinophil Apoptosis and Attenuates Allergic Airway Inflammation

Lucas, C. D., Dorward, D. A., Sharma, S., Rennie, J., Felton, J. M., Alessandri, A. L., Duffin, R., Schwarze, J., Haslett, C. & Rossi, A. G., 15 Mar 2015, In: American Journal of Respiratory and Critical Care Medicine. 191, 6, p. 626-636 11 p.

Research output: Contribution to journal › Article › peer-review

2014

Downregulation of Mcl-1 has anti-inflammatory pro-resolution effects and enhances bacterial clearance from the lung

Lucas, C. D., Dorward, D. A., Tait, M. A., Fox, S., Marwick, J. A., Allen, K. C., Robb, C. T., Hirani, N., Haslett, C., Duffin, R. & Rossi, A. G., Jul 2014, In: Mucosal Immunology. 7, 4, p. 857-868 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Open Access

File

2013

Oxygen levels determine the ability of glucocorticoids to influence neutrophil survival in inflammatory environments

Marwick, J. A., Dorward, D. A., Lucas, C. D., Jones, K. O., Sheldrake, T. A., Fox, S., Ward, C., Murray, J., Brittan, M., Hirani, N., Duffin, R., Dransfield, I., Haslett, C. & Rossi, A. G., 20 Aug 2013, In: Journal of Leukocyte Biology. 94, 6, p. 1285-1292

Research output: Contribution to journal › Article › peer-review

Open Access

File

Technical advance: autofluorescence-based sorting: rapid and nonperturbing isolation of ultrapure neutrophils to determine cytokine production

Dorward, D. A., Lucas, C. D., Alessandri, A. L., Marwick, J. A., Rossi, F., Dransfield, I., Haslett, C., Dhaliwal, K. & Rossi, A. G., Jul 2013, In: Journal of Leukocyte Biology. 94, 1, p. 193-202 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Novel R-roscovitine NO-donor hybrid compounds as potential pro-resolution of inflammation agents

Montanaro, G., Bertinaria, M., Rolando, B., Fruttero, R., Lucas, C., Dorward, D. A., Rossi, A. G., Megson, I. L. & Gasco, A., 1 Apr 2013, In: Bioorganic and Medicinal Chemistry. 21, 7, p. 2107-2116 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Activation of conventional protein kinase C (PKC) is critical in the generation of human neutrophil extracellular traps

Gray, R. D., Lucas, C., Mackellar, A., Li, F., Hiersemenzel, K., Haslett, C., Davidson, D. J. & Rossi, A. G., 21 Mar 2013, In: Journal of inflammation. 10, 1, 8 p., 12.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Flavones induce neutrophil apoptosis by down-regulation of Mcl-1 via a proteasomal-dependent pathway

Lucas, C., Allen, K. C., Dorward, D. A., Hoodless, L. J., Melrose, L. A., Marwick, J. A., Tucker, C. S., Haslett, C., Duffin, R. & Rossi, A. G., Mar 2013, In: The FASEB Journal. 27, 3, p. 1084-1094 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

2012

Cyclin-dependent kinases 7 and 9 specifically regulate neutrophil transcription and their inhibition drives apoptosis to promote resolution of inflammation

Leitch, A. E., Lucas, C., Marwick, J. A., Duffin, R., Haslett, C. & Rossi, A. G., Dec 2012, In: Cell Death & Differentiation (CDD). 19, 12, p. 1950-1961 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

2011

Induction of Eosinophil Apoptosis by the Cyclin-Dependent Kinase Inhibitor AT7519 Promotes the Resolution of Eosinophil-Dominant Allergic Inflammation

Alessandri, A. L., Duffin, R., Leitch, A. E., Lucas, C., Sheldrake, T. A., Dorward, D. A., Hirani, N., Pinho, V., de Sousa, L. P., Teixeira, M. M., Lyons, J. F., Haslett, C. & Rossi, A. G., 30 Sept 2011, In: PLoS ONE. 6, 9, p. - 10 p., e25683.

Research output: Contribution to journal › Article › peer-review

Open Access

File

2006

Rapid onset of haemodynamic effects after angiotensin converting enzyme-inhibitor overdose: implications for initial patient triage

Lucas, C., Christie, G. A. & Waring, W. S., 2006, In: Emergency Medicine Journal. 23, 11, p. 854-7 4 p.

Research output: Contribution to journal › Article › peer-review

Redefining the ACE-inhibitor dose-response relationship: substantial blood pressure lowering after massive doses

Christie, G. A., Lucas, C., Bateman, D. N. & Waring, W. S., 2006, In: European journal of clinical pharmacology. 62, 12, p. 989-93 5 p.

Research output: Contribution to journal › Article › peer-review

2005

Expression of V1A and GRP receptors leads to cellular transformation and increased sensitivity to substance-P analogue-induced growth inhibition

Mackinnon, A. C., Tufail-hanif, U., Lucas, C., Jodrell, D., Haslett, C. & Sethi, T., 14 Feb 2005, In: British Journal of Cancer. 92, 3, p. 522-31 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Christopher Lucas

Research output

Search results