Christopher Lucas

Search results

• 2021

  Epithelial Cells and Inflammation in Pulmonary Wound Repair

  Croasdell Lucchini, A., Gachanja, N. N., Rossi, A. G., Dorward, D. A. & Lucas, C. D., 5 Feb 2021, In: Cells. 10, 2, p. 339

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Pneumonia
  • Epithelial Cells
  • Homeostasis
  • Wounds and Injuries
  • Lung

• Tissue-specific Immunopathology in fatal Covid-19

  ICECAP consortium, 15 Jan 2021, In: American Journal of Respiratory and Critical Care Medicine. 203, 2, p. 192-201

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • SARS Virus
  • Inflammation
  • Lung
  • Macrophages
  • Monocytes
• 2020

  Histological Evidence of Pulmonary Microthrombosis and Vasculitis in Life-Threatening Respiratory Virus Diseases

  Dolby, H. W., Potey, P., Wilder-Smith, A. B., Clohisey, S., Millar, J. E., Baillie, J. K., Dorward, D. A., Lucas, C. D. & Russell, C. D., 28 Dec 2020, In: Open forum infectious diseases. 8, 2, p. ofaa640

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Severe Acute Respiratory Syndrome
  • Vasculitis
  • Human Influenza
  • Virus Diseases
  • Coronavirus Infections

• Mcl-1 protects eosinophils from apoptosis and exacerbates allergic airway inflammation

  Felton, J. M., Dorward, D. A., Cartwright, J. A., Potey, P. M. D., Robb, C. T., Gui, J., Craig, R. W., Schwarze, J., Haslett, C., Duffin, R., Dransfield, I., Lucas, C. D. & Rossi, A. G., 1 Jul 2020, In: Thorax. 75, 7, p. 600-605

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Eosinophils
  • Apoptosis
  • Inflammation
  • CDC2 Protein Kinase
  • Apoptosis Regulatory Proteins

• Src kinase inhibition with dasatinib impairs neutrophil function and clearance of Escherichia coli infection in a murine model of acute lung injury

  MacFarlane, J. G., Dorward, D. A., Ruchaud-Sparagano, M-H., Scott, J., Lucas, C. D., Rossi, A. G. & Simpson, A. J., 30 Oct 2020, In: Journal of inflammation.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Dasatinib
  • Escherichia coli Infections
  • Escherichia coli
  • src-Family Kinases
  • Acute Lung Injury
• 2019

  A noncanonical role for the engulfment gene ELMO1 in neutrophils that promotes inflammatory arthritis

  Arandjelovic, S., Perry, J. S. A., Lucas, C., Penberthy, K. K., Kim, T-H., Zhou, M., Rosen, D. A., Chuang, T-Y., Bettina, A. M., Shankman, L. S., Cohen, A. H., Gaultier, C., Conrads, T. P., Kim, M., Elliott, M. R. & Ravichandran, K. S., 14 Jan 2019, (E-pub ahead of print) In: Nature Immunology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Arthritis
  • Neutrophils
  • Joints
  • Genes
  • Neutrophil Infiltration

• Inflammation Resolution and the Induction of Granulocyte Apoptosis by Cyclin-Dependent Kinase Inhibitor Drugs

  Cartwright, J. A., Lucas, C. D. & Rossi, A. G., 19 Feb 2019, In: Frontiers in pharmacology. 10

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cyclin-Dependent Kinases
  • Granulocytes
  • Apoptosis
  • Inflammation
  • Pharmaceutical Preparations

• Interpreting an apoptotic corpse as anti-inflammatory involves a chloride sensing pathway

  Perry, J. S. A., Morioka, S., Medina, C. B., Etchegaray, J. I., Barron, B., Raymond, M. H., Lucas, C. D., Onengut-Gumuscu, S., Delpire, E. & Ravichandran, K. S., Dec 2019, In: Nature Cell Biology. 21, 12, p. 1532–1543 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chlorides
  • Phagocytes
  • Cadaver
  • Anti-Inflammatory Agents
  • Solute Carrier Proteins
• 2018

  Delayed neutrophil apoptosis enhances NET formation in cystic fibrosis

  Gray, R. D., Hardisty, G., Regan, K. H., Smith, M., Robb, C. T., Duffin, R., Mackellar, A., Felton, J. M., Paemka, L., McCullagh, B. N., Lucas, C. D., David, D., McKone, E. F., Cooke, G., Donnelly, S. C., Singh, P. K., Stoltz, D. A., Haslett, C., McCray, P. B., Whyte, M. K. B. & 2 others, Rossi, A. G. & Davidson, D. J., Feb 2018, In: Thorax. 73, 2, p. 134-144 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Extracellular Traps
  • Cystic Fibrosis
  • Neutrophils
  • Apoptosis
  • ivacaftor

• Mer-mediated eosinophil efferocytosis regulates resolution of allergic airway inflammation

  Felton, J., Lucas, C. D., Dorward, D. A., Duffin, R., Kipari, T., Vermeren, S., Robb, C., Macleod, K., Serrels, B., Schwarze, J., Haslett, C., Dransfield, I. & Rossi, A. G., 8 Feb 2018, (E-pub ahead of print) In: Journal of Allergy and Clinical Immunology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Eosinophils
  • Inflammation
  • Phagocytosis
  • Phagocytes
  • Dexamethasone
• 2017

  Increasing use of CTPA for the investigation of suspected pulmonary embolism

  Sharma, S. & Lucas, C. D., 20 Jan 2017, In: Postgraduate medicine. p. 1-5 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Pulmonary Embolism
  • Angiography
  • Tomography
  • Lung
  • Embolism

• Non-small cell lung carcinoma (not otherwise specified) rates are not solely influenced by pathologists’ decisions on the use of immunohistochemistry.

  Chapman, G. B., Dorward, D., Lucas, C. & Wallace, W., Feb 2017, In: Histopathology. 70, 3

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Pathologists
  • Non-Small Cell Lung Carcinoma
  • Immunohistochemistry
  • Thyroid Nuclear Factor 1
  • Negative Results

• Novel role for endogenous mitochondrial formylated peptide-driven formyl peptide receptor 1 signalling in Acute Respiratory Distress Syndrome

  Dorward, D. A., Lucas, C. D., Doherty, M., Chapman, G. B., Scholefield, E., Conway Morris, A., Felton, J. M., Kipari, T., Humphries, D. C., Robb, C. T., Simpson, A. J., Whitfield, P. D., Haslett, C., Dhaliwal, K. & Rossi, A. G., Oct 2017, In: Thorax. 72, 10, p. 928-936 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Formyl Peptide Receptor
  • Adult Respiratory Distress Syndrome
  • Peptides
  • Lung Injury
  • Pneumonia

• The cyclin-dependent kinase inhibitor AT7519 accelerates neutrophil apoptosis in sepsis-related acute respiratory distress syndrome

  Dorward, D. A., Felton, J. M., Robb, C. T., Craven, T., Kipari, T., Walsh, T. S., Haslett, C., Kefala, K., Rossi, A. G. & Lucas, C. D., Feb 2017, In: Thorax. 72, 2, p. 182-185 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • 4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide
  • Cyclin-Dependent Kinases
  • Adult Respiratory Distress Syndrome
  • Sepsis
  • Neutrophils
• 2016

  11β-Hydroxysteroid Dehydrogenase type 1 is expressed in neutrophils and restrains an inflammatory response in male mice

  Coutinho, A. E., Kipari, T. M. J., Zhang, Z., Esteves, C. L., Lucas, C. D., Gilmour, J. S., Webster, S. P., Walker, B. R., Hughes, J., Savill, J. S., Seckl, J. R., Rossi, A. G. & Chapman, K. E., 4 May 2016, (E-pub ahead of print) In: Endocrinology. 157, 7, p. 2928-2936 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 11-beta-Hydroxysteroid Dehydrogenases
  • Neutrophils
  • Thioglycolates
  • Inflammation
  • Peritoneum

• Genetic and pharmacological inhibition of CDK9 drives neutrophil apoptosis to resolve inflammation in zebrafish in vivo

  Hoodless, L. J., Lucas, C. D., Duffin, R., Denvir, M. A., Haslett, C., Tucker, C. S. & Rossi, A. G., 11 Nov 2016, (E-pub ahead of print) In: Scientific Reports. 36980 .

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Zebrafish
  • Neutrophils
  • Pharmacology
  • Apoptosis
  • Inflammation
• 2015

  Wogonin Induces Eosinophil Apoptosis and Attenuates Allergic Airway Inflammation

  Lucas, C. D., Dorward, D. A., Sharma, S., Rennie, J., Felton, J. M., Alessandri, A. L., Duffin, R., Schwarze, J., Haslett, C. & Rossi, A. G., 15 Mar 2015, In: American Journal of Respiratory and Critical Care Medicine. 191, 6, p. 626-636 11 p.

  Research output: Contribution to journal › Article › peer-review

  • wogonin
  • Eosinophils
  • Apoptosis
  • Inflammation
  • Caspases
• 2014

  Downregulation of Mcl-1 has anti-inflammatory pro-resolution effects and enhances bacterial clearance from the lung

  Lucas, C. D., Dorward, D. A., Tait, M. A., Fox, S., Marwick, J. A., Allen, K. C., Robb, C. T., Hirani, N., Haslett, C., Duffin, R. & Rossi, A. G., Jul 2014, In: Mucosal Immunology. 7, 4, p. 857-868 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Myeloid Leukemia
  • Myeloid Cells
  • Anti-Inflammatory Agents
  • Down-Regulation
  • Neutrophils

• Eosinophils in the lung - modulating apoptosis and efferocytosis in airway inflammation

  Felton, J. M., Lucas, C. D., Rossi, A. G. & Dransfield, I., 2014, In: Frontiers in Immunology. 5, 11 p., 302.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Eosinophils
  • Apoptosis
  • Inflammation
  • Lung
  • Asthma

• Swimming Against the Tide: Drugs Drive Neutrophil Reverse Migration

  Lucas, C. D., Hoodless, L. J. & Rossi, A. G., 26 Feb 2014, In: Science Translational Medicine. 6, 225, 3 p., ARTN 225fs9.

  Research output: Contribution to journal › Article

• Systemic lupus erythematosus complicating simple silicosis

  Lucas, C. D., Amft, N. & Reid, P. T., Jul 2014, In: Occupational Medicine. 64, 5, p. 387-90 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Silicosis
  • Systemic Lupus Erythematosus
  • Silicon Dioxide
  • Autoimmunity
  • Occupational Diseases
• 2013

  Activation of conventional protein kinase C (PKC) is critical in the generation of human neutrophil extracellular traps

  Gray, R. D., Lucas, C., Mackellar, A., Li, F., Hiersemenzel, K., Haslett, C., Davidson, D. J. & Rossi, A. G., 21 Mar 2013, In: Journal of inflammation. 10, 1, 8 p., 12.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Extracellular Traps
  • Protein Kinase C
  • Chemical activation
  • ruboxistaurin
  • NADPH Oxidases

• Flavones induce neutrophil apoptosis by down-regulation of Mcl-1 via a proteasomal-dependent pathway

  Lucas, C., Allen, K. C., Dorward, D. A., Hoodless, L. J., Melrose, L. A., Marwick, J. A., Tucker, C. S., Haslett, C., Duffin, R. & Rossi, A. G., Mar 2013, In: The FASEB Journal. 27, 3, p. 1084-1094 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Flavones
  • Neutrophils
  • Down-Regulation
  • Apoptosis
  • wogonin

• Novel R-roscovitine NO-donor hybrid compounds as potential pro-resolution of inflammation agents

  Montanaro, G., Bertinaria, M., Rolando, B., Fruttero, R., Lucas, C., Dorward, D. A., Rossi, A. G., Megson, I. L. & Gasco, A., 1 Apr 2013, In: Bioorganic and Medicinal Chemistry. 21, 7, p. 2107-2116 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Oxygen levels determine the ability of glucocorticoids to influence neutrophil survival in inflammatory environments

  Marwick, J. A., Dorward, D. A., Lucas, C. D., Jones, K. O., Sheldrake, T. A., Fox, S., Ward, C., Murray, J., Brittan, M., Hirani, N., Duffin, R., Dransfield, I., Haslett, C. & Rossi, A. G., 20 Aug 2013, In: Journal of Leukocyte Biology. 94, 6, p. 1285-1292

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Glucocorticoids
  • Neutrophils
  • Oxygen
  • Aptitude
  • Granulocyte-Macrophage Colony-Stimulating Factor

• Technical advance: autofluorescence-based sorting: rapid and nonperturbing isolation of ultrapure neutrophils to determine cytokine production

  Dorward, D. A., Lucas, C. D., Alessandri, A. L., Marwick, J. A., Rossi, F., Dransfield, I., Haslett, C., Dhaliwal, K. & Rossi, A. G., Jul 2013, In: Journal of Leukocyte Biology. 94, 1, p. 193-202 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Neutrophils
  • Cytokines
  • Neutrophil Activation
  • Chemotaxis
  • Percoll
• 2012

  Cyclin-dependent kinases 7 and 9 specifically regulate neutrophil transcription and their inhibition drives apoptosis to promote resolution of inflammation

  Leitch, A. E., Lucas, C., Marwick, J. A., Duffin, R., Haslett, C. & Rossi, A. G., Dec 2012, In: Cell Death and Differentiation. 19, 12, p. 1950-1961 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cyclin-Dependent Kinase 9
  • Neutrophils
  • Dichlororibofuranosylbenzimidazole
  • Apoptosis
  • Inflammation
• 2011

  Induction of Eosinophil Apoptosis by the Cyclin-Dependent Kinase Inhibitor AT7519 Promotes the Resolution of Eosinophil-Dominant Allergic Inflammation

  Alessandri, A. L., Duffin, R., Leitch, A. E., Lucas, C., Sheldrake, T. A., Dorward, D. A., Hirani, N., Pinho, V., de Sousa, L. P., Teixeira, M. M., Lyons, J. F., Haslett, C. & Rossi, A. G., 30 Sep 2011, In: PLoS ONE. 6, 9, p. - 10 p., e25683.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2006

  Rapid onset of haemodynamic effects after angiotensin converting enzyme-inhibitor overdose: implications for initial patient triage

  Lucas, C., Christie, G. A. & Waring, W. S., 2006, In: Emergency Medicine Journal. 23, 11, p. 854-7 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Triage
  • Angiotensin-Converting Enzyme Inhibitors
  • Hypotension
  • Hemodynamics

• Redefining the ACE-inhibitor dose-response relationship: substantial blood pressure lowering after massive doses

  Christie, G. A., Lucas, C., Bateman, D. N. & Waring, W. S., 2006, In: European journal of clinical pharmacology. 62, 12, p. 989-93 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Angiotensin-Converting Enzyme Inhibitors
  • Blood Pressure
  • Hemodynamics
  • Clinical Trials
• 2005

  Expression of V1A and GRP receptors leads to cellular transformation and increased sensitivity to substance-P analogue-induced growth inhibition

  Mackinnon, A. C., Tufail-hanif, U., Lucas, C., Jodrell, D., Haslett, C. & Sethi, T., 14 Feb 2005, In: British Journal of Cancer. 92, 3, p. 522-31 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Bombesin Receptors
  • Substance P
  • Small Cell Lung Carcinoma
  • Neuropeptides
  • Pulmonary Surfactant-Associated Protein D