Research output per year
Research output per year
Personal profile
Biography
Experienced health services researcher and clinical trials methodologist, co-leading the statistical work of the Edinburgh Clinical Trials Unit. Role involves collaboration with clinical investigators to deliver high impact clinical trials and health research studies, alongside development of novel statistical clinical trials methodology to support current and future research.
Current Research Interests
- Design and analysis of cluster-randomised trials, including stepped-wedge designs
- Statistical methods for the evaluation of potential surrogate outcomes in clinical trials
- Adaptive design clinical trials
Education/Academic qualification
Public Health and Health Services Research, Master of Science, Use of sequential treatment allocation methods and patient-specific outcome measures in a trial of glycaemic control in acute stroke, Robert Gordon University
1 Oct 1996 → 31 Aug 1997
Award Date: 1 Dec 1997
Statistics, Doctor of Philosophy (PhD), Informed clinical management of acute stroke: use of established statistical methods and development of an expert system, University of Glasgow
1 Oct 1993 → 30 Sept 1996
Award Date: 1 Jul 1997
Statistics, Bachelor of Science, University of Glasgow
1 Oct 1989 → 31 May 1993
Award Date: 1 Jul 1993
External positions
Member, Efficacy and Mechanisms Evaluation Committee, NIHR
Jun 2018 → Jun 2022
Member, Commission on Human Medicines, MHRA
Dec 2014 → …
Member, Health Services and Delivery Research Board, National Institute for Health Research
Nov 2013 → May 2018
Associate Editor, Clinical Trials, Society for Clinical Trials
Jul 2013 → …
Clinical Trials, Biologics and Vaccines Expert Advisory Group , MHRA
Jan 2011 → Dec 2020
Neurology, Pain and Psychiatry Expert Advisory Group , MHRA
Jan 2011 → …
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Principles of dose finding studies in cancer: a comparison of trial designs
Jaki, T., Clive, S. & Weir, C. J., May 2013, In: Cancer chemotherapy and pharmacology. 71, 5, p. 1107-14 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Reporting of surrogate endpoints in randomised controlled trial protocols: The SPIRIT-Surrogate extension checklist with explanation and elaboration
Manyara, A. M., Davies, P., Stewart, D., Weir, C. J., Young, A. E., Blazeby, J. M., Butcher, N. J., Bujkiewicz, S., Chan, A-W., Dawoud, D., Offringa, M., Ouwens, M., Hróbjartssson, A., Amstutz, A., Bertolaccini, L., Bruno, V. D., Devane, D., Faria, C. DCM., Gilbert, P. B., Harris, R., & 16 others, 9 Jul 2024, In: British Medical Journal (BMJ). 386, 19 p., e078525.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Reporting of surrogate endpoints in randomised controlled trial reports: the CONSORT-Surrogate extension checklist with explanation and elaboration
Manyara, A. M., Davies, P., Stewart, D., Weir, C. J., Young, A. E., Blazeby, J. M., Butcher, N. J., Bujkiewicz, S., Chan, A-W., Dawoud, D., Offringa, M., Ouwens, M., Hróbjartssson, A., Amstutz, A., Bertolaccini, L., Bruno, V. D., Devane, D., Faria, C. DCM., Gilbert, P. B., Harris, R., & 16 others, 9 Jul 2024, In: British Medical Journal (BMJ). 386, 18 p., e078524.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
A survey on UK researchers’ views regarding their experiences with the de-identification, anonymisation, release methods and re-identification risk estimation for clinical trials datasets
Rodriguez, A., Lewis, S. C., Eldridge, S., Jackson, T. & Weir, C. J., 19 Jun 2024, (E-pub ahead of print) In: Clinical Trials. 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Measuring the impact of maternal critical care admission on short- and longer-term maternal and birth outcomes
Masterson, J., Adamestam, I., Beatty, M., Boardman, J. P., Chislett, L., Johnston, P., Joss, J., Lawrence, H., Litchfield, K., Plummer, N., Rhode, S., Walsh, T. S., Wise, A., Wood, R., Weir, C. J. & Lone, N. I., 7 Jun 2024, In: Intensive Care Medicine. 50, p. 890-900 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile
Activities
- 1 Oral presentation
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Development of a Flow Diagram Template for Stepped Wedge Cluster Randomised Trials
Catriona Keerie (Speaker), Christopher Weir (Reviewer), Marian Brady (Reviewer) & Heather Gray (Reviewer)
19 Mar 2018 → 20 Mar 2018Activity: Academic talk or presentation types › Oral presentation
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PuRe: Pulmonary rehabilitation delivered in low resource settings (LMICs) for people with chronic respiratory disease: a 3-arm assessor-blind implementation
Pinnock, H., Stoddart, A., Weir, C., Rabinovich, R., McQuillan, R. & Jackson, T.
1/03/24 → 31/08/27
Project: Research
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Repurposing flumazenil for pre-hospital intramuscular treatment of coma due to recreational drug overdose
1/02/24 → 31/07/28
Project: Research
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MND-SMART renewal 2023-2028 (MND Scotland)
Carragher, N., Hardingham, G., Pal, S. & Weir, C.
Motor Neurone Disease Scotland
1/11/23 → 31/10/28
Project: Research
Datasets
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Data supporting Rubio et al on exacerbations of COPD
Rubio, N. (Creator), Parker, R. (Creator), Drost, E. (Creator), Pinnock, H. (Creator), Weir, C. (Creator), Mantoani, L. (Creator), MacNee, W. (Creator), McKinstry, B. (Creator), Rabinovich, R. A. (Creator) & McCloughan, L. (Creator), Edinburgh DataShare, 20 Mar 2017
DOI: 10.7488/ds/1981
Dataset