Christopher Weir

PROF

Personal chair of Medical Statistics and Clinical Trials, Deanery of Molecular, Genetic and Population Health Sciences
Usher Institute
Edinburgh Clinical Trials Unit

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Personal profile

Biography

Experienced health services researcher and clinical trials methodologist, co-leading the statistical work of the Edinburgh Clinical Trials Unit. Role involves collaboration with clinical investigators to deliver high impact clinical trials and health research studies, alongside development of novel statistical clinical trials methodology to support current and future research.

Current Research Interests

Design and analysis of cluster-randomised trials, including stepped-wedge designs
Statistical methods for the evaluation of potential surrogate outcomes in clinical trials
Adaptive design clinical trials

Education/Academic qualification

Public Health and Health Services Research, Master of Science, University of Aberdeen

1 Oct 1996 → 31 Aug 1997

Award Date: 1 Dec 1997

Statistics, Doctor of Philosophy (PhD), University of Glasgow

1 Oct 1993 → 30 Sep 1996

Award Date: 1 Jul 1997

Statistics, Bachelor of Science, University of Glasgow

1 Oct 1989 → 31 May 1993

Award Date: 1 Jul 1993

External positions

Member, Efficacy and Mechanisms Evaluation Committee, NIHR

Jun 2018 → Jun 2022

Member, Commission on Human Medicines, MHRA

Dec 2014 → …

Member, Health Services and Delivery Research Board, National Institute for Health Research

Nov 2013 → May 2018

Associate Editor, Clinical Trials, Society for Clinical Trials

Jul 2013 → …

Clinical Trials, Biologics and Vaccines Expert Advisory Group , MHRA

Jan 2011 → Dec 2020

Neurology, Pain and Psychiatry Expert Advisory Group , MHRA

Jan 2011 → …

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113 Article
6 Meeting abstract
4 Poster
4 Editorial
More

Principles of dose finding studies in cancer: a comparison of trial designs
Jaki, T., Clive, S. & Weir, C. J., May 2013, In: Cancer chemotherapy and pharmacology. 71, 5, p. 1107-14 8 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
Amiloride, fluoxetine or riluzole to reduce brain volume loss in secondary progressive multiple sclerosis: the MS-SMART four-arm RCT
De Angelis, F., Connick, P., Parker, R. A., Plantone, D., Doshi, A., John, N., Stutters, J., Macmanus, D., Prados, F., Marshall, I., Solanky, B., Samson, R. S., Barkhof, F., Ourselin, S., Braisher, M., Ross, M., Cranswick, G., Pavitt, S. H., Gnanapavan, S., Giovannoni, G. & 8 others, Wheeler-kingshott, C. A. G., Hawkins, C., Sharrack, B., Bastow, R., Weir, C. J., Stallard, N., Chandran, S. & Chataway, J., 1 May 2020, In: Efficacy and Mechanism Evaluation. 7, 3, p. 1-72
Research output: Contribution to journal › Article › peer-review

Open Access
File
A smartphone-based test for the assessment of attention deficits in delirium: A case-control diagnostic test accuracy study in older hospitalised patients
Tieges, Z., Stott, D. J., Shaw, R., Tang, E., Rutter, L-M., Nouzova, E., Duncan, N., Clarke, C., Weir, C. J., Assi, V., Ensor, H., Barnett, J. H., Evans, J., Green, S., Hendry, K., Thomson, M., McKeever, J., Middleton, D. G., Parks, S., Walsh, T. & 4 others, Weir, A. J., Wilson, E., Quasim, T. & MacLullich, A. M. J., 24 Jan 2020, In: PLoS ONE. 15, 1, e0227471.
Research output: Contribution to journal › Article › peer-review

Open Access
File
Efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis (MS-SMART): a phase 2b, multiarm, double-blind, randomised placebo-controlled trial
Chataway, J., De Angelis, F., Connick, P., Parker, R. A., Plantone, D., Doshi, A., John, N., Stutters, J., Macmanus, D., Prados Carrasco, F., Barkhof, F., Ourselin, S., Braisher, M., Ross, M., Cranswick, G., Pavitt, S. H., Giovannoni, G., Gandini Wheeler-kingshott, C. A., Hawkins, C., Sharrack, B. & 5 others, Bastow, R., Weir, C. J., Stallard, N., Chandran, S. & MS -SMART Investigators, 1 Mar 2020, In: The Lancet Neurology. 19, 3, p. 214-225
Research output: Contribution to journal › Article › peer-review

Open Access
File
Evaluating improvement interventions using routine data to support a learning health system: research design, data access, analysis and reporting
Weir, C., Heazell, A. E. P., Whyte, S. & Norman, J., 25 Feb 2020, In: BMJ Quality & Safety. p. bmjqs-2019-010068
Research output: Contribution to journal › Article › peer-review

Open Access
File

1 Oral presentation

Development of a Flow Diagram Template for Stepped Wedge Cluster Randomised Trials
Catriona Keerie (Speaker), Christopher Weir (Reviewer), Marian Brady (Reviewer) & Heather Gray (Reviewer)
19 Mar 2018 → 20 Mar 2018
Activity: Academic talk or presentation types › Oral presentation

5 Active
19 Finished

Macrophage Therapy for Acute Liver failure (DPFS)
Weir, C.
MRC
1/12/20 → 30/11/25
Project: Research
Development and evaluation of a complex ePrescribing-based antimicrobial stewardship (ePAMS+) intervention for hospitals
Sheikh, A., Cresswell, K. & Weir, C.
Other
1/02/19 → 1/02/24
Project: Research
Development and evaluation of a complex ePrescribing-based antimicrobial stewardship (ePAMS+) intervention for hospitals
Weir, C.
Other
1/02/19 → 1/02/24
Project: Research
Alpha 2 Agonists for Sedation to produce Better Outcomes from Critical Illness (A2B TRIAL): A Parallel Group Randomised Controlled Trial Comparing Clonidine, Dexmedetomidine and Current Usual Care
Norrie, J., Parker, R. & Weir, C.
Other
1/04/18 → 31/12/21
Project: Research
Randomised trial of Teriparatide followed by Zoledronic acid versus placebo to prevent fractures in adults with Osteogenesis Imperfecta
Weir, C.
Other
1/11/16 → 30/04/23
Project: Research

Data supporting Rubio et al on exacerbations of COPD
Rubio, N. (Creator), Parker, R. (Creator), Drost, E. (Creator), Pinnock, H. (Creator), Weir, C. (Creator), Mantoani, L. (Creator), MacNee, W. (Creator), McKinstry, B. (Creator), Rabinovich, R. A. (Creator) & McCloughan, L. (Creator), Edinburgh DataShare, 20 Mar 2017
DOI: 10.7488/ds/1981
Dataset