Christopher Weir

2018

Dealing with missing standard deviation and mean values in meta-analysis of continuous outcomes: a systematic review

Weir, C. J., Butcher, I., Assi, V., Lewis, S. C., Murray, G. D., Langhorne, P. & Brady, M. C., 7 Mar 2018, In: BMC Medical Research Methodology. 18, 1, p. 25

Research output: Contribution to journal › Article › peer-review

Open Access

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Adaptive designs in clinical trials: why use them, and how to run and report them

Pallmann, P., Bedding, A. W., Choodari-Oskooei, B., Dimairo, M., Flight, L., Hampson, L. V., Holmes, J., Mander, A., Odondi, L., Sydes, M. R., Villar, S. S., Wason, J., Weir, C., Wheeler, G. M., Yap, C. & Jaki, T., 28 Feb 2018, In: BMC Medicine.

Research output: Contribution to journal › Article › peer-review

Open Access

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Protocol for validation of the 4AT, a rapid screening tool for delirium: a multicentre prospective diagnostic test accuracy study

Shenkin, S., Godfrey, M., Siddiqi, N., Goodacre, S. W., Young, J., Anand, A., Gray, A., Smith, J. W. S., Ryan, T., Hanley, J., MacRaild, A., Steven, J., Black, P., Boyd, J., Weir, C. & Maclullich, A., 10 Feb 2018, (E-pub ahead of print) In: BMJ Open.

Research output: Contribution to journal › Article › peer-review

Open Access

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The provision of seven-day multidisciplinary staffing in Scottish acute medical units: a cross-sectional study

Reid, L. E. M., Lone, N. I., Morrison, Z. J., Weir, C. J. & Jones, M. C., 2 Feb 2018, (E-pub ahead of print) In: QJM: An International Journal of Medicine.

Research output: Contribution to journal › Article › peer-review

Open Access

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Functional Strength Training and Movement Performance Therapy for upper limb recovery early post-stroke – efficacy, neural correlates, predictive markers and cost-effectiveness: FAST-INdiCATE trial

Hunter, S. M., Johansen-Berg, H., Ward, N., Kennedy, N. C., Chandler, E., Weir, C. J., Rothwell, J., Wing, A. M., Grey, M. J., Barton, G., Leavey, N. M., Havis, C., Lemon, R. N., Burridge, J., Dymond, A. & Pomeroy, V. M., 25 Jan 2018, In: Frontiers in Neurology. 8, 733, 733.

Research output: Contribution to journal › Article › peer-review

Open Access

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2017

Promoting Recruitment using Information Management Efficiently (PRIME): a stepped wedge cluster randomised trial of a complex recruitment intervention embedded within the RESTART or Stop Antithrombotics Randomised Trial (RESTART)

Maxwell, A. E., Parker, R., Drever, J., Rudd, A., Dennis, M., Weir, C. & Salman, R., 28 Dec 2017, (E-pub ahead of print) In: Trials.

Research output: Contribution to journal › Article › peer-review

Open Access

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Development of a Bayesian response-adaptive trial design for the Dexamethasone for Excessive Menstruation study

Holm Hansen, C., Warner, P., Parker, R. A., Walker, B. R., Critchley, H. O. D. & Weir, C. J., 1 Dec 2017, In: Statistical Methods in Medical Research. 26, 6, p. 2681-2699 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Embracing model-based designs for dose-finding trials

Love, S. B., Brown, S., Weir, C., Harbron, C., Yap, C., Gaschler-Markefski, B., Matcham, J. & Cornelius, V., 5 Nov 2017.

Research output: Contribution to conference › Poster › peer-review

Comparison of non-traditional biomarkers, and combinations of biomarkers, for vascular risk prediction in people with type 2 diabetes: The Edinburgh Type 2 Diabetes Study

Price, A. H., Weir, C. J., Welsh, P., McLachlan, S., Strachan, M. W. J., Sattar, N. & Price, J., Sept 2017, In: Atherosclerosis. 264

Research output: Contribution to journal › Article › peer-review

Open Access

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Journeying through the development of an adaptive designs reporting guidance: findings from Delphi process

Dimairo, M., Todd, S., Julious, S., Jaki, T., Weir, C., Wason, J., Hind, D., Mander, A., Koenig, F., Altman, D., Nicholl, J., Hamasaki, T., Proschan, M., Scott, J., Walton, M., Ando, Y., Biggs, K., Pallmann, P. & Coates, E., 29 Aug 2017.

Research output: Contribution to conference › Abstract › peer-review

How is it best to deliver care in acute medical units? A systematic review

Reid, L. E. M., Crookshanks, A., Jones, M., Morrison, Z., Lone, N. & Weir, C., 4 Aug 2017, (E-pub ahead of print) In: QJM: An International Journal of Medicine.

Research output: Contribution to journal › Article › peer-review

Open Access

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Can promoting awareness of fetal movements and focussing interventions reduce fetal mortality? - A stepped wedge cluster randomised trial (AFFIRM)

Heazell, A. E. P., Weir, C., Stock, S. J. E., Calderwood, C. J., Burley, S. C., Froen, J. F., Geary, M., Hunter, A., McAuliffe, F. M., Murdoch, E., Rodriguez, A., Ross-Davie, M., Scott, J., Whyte, S. & Norman, J. E., Aug 2017, In: BMJ Open. 7, 8, e014813.

Research output: Contribution to journal › Article › peer-review

Open Access

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Evaluation of practical methods for estimating means for meta-analysis of continuous, non-normally-distributed outcomes

Assi, V., Langhorne, P., Lewis, S., Brady, M. C., Murray, G. & Weir, C., 12 Jul 2017.

Research output: Contribution to conference › Poster › peer-review

Guidances for statistics in regulatory affairs in Wikipedia: Initiative of the ISCB Statistics in Regulatory Affairs Subcommittee (SiRA SC)

ISCB SiRA SC, 12 Jul 2017.

Research output: Contribution to conference › Poster › peer-review

Embracing model-based designs for dose-finding trials

Love, S. B., Brown, S., Weir, C., Harbron, C., Yap, C., Gaschler-markefski, B., Matcham, J., Caffrey, L., Mckevitt, C., Clive, S., Craddock, C., Spicer, J. & Cornelius, V., 29 Jun 2017, (E-pub ahead of print) In: British Journal of Cancer.

Research output: Contribution to journal › Article › peer-review

Open Access

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Journeying through the development of an adaptive designs reporting guidance: preliminary findings

Weir, C., Dimairo, M., Todd, S., Julious, S., Jaki, T., Wason, J., Mander, A., Hind, D., Koenig, F., Altman, D., Nicholl, J., Hamasaki, T., Proschan, M., Scott, J., Walton, M., Ando, Y., Biggs, K., Pallmann, P. & Coates, E., 22 Jun 2017.

Research output: Contribution to conference › Abstract › peer-review

Rigorous Reporting of Stepped Wedge Cluster Randomised Controlled Trials: Development of a Flow Diagram Template

Gray, H., Weir, C., Keerie, C., Mc.Queen, J., Bain, B. & Brady, M., 24 May 2017.

Research output: Contribution to conference › Paper › peer-review

Open Access

Models for estimating and projecting global, regional and national prevalence and disease burden of asthma: protocol for a systematic review

Bhuia, M. R., Nwaru, B., Weir, C. & Sheikh, A., 1 May 2017, In: BMJ Open. 7, e015441, e015441.

Research output: Contribution to journal › Article › peer-review

Open Access

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Home monitoring of breathing rate in people with Chronic Obstructive Pulmonary Disease: observational study of feasibility, acceptability and change after exacerbation

Rubio, N., Parker, R. A., Drost, E., Pinnock, H., Weir, C. J., Hanley, J., Mantoani, L., MacNee, B., McKinstry, B. & Rabinovich, R., 20 Apr 2017, In: International Journal of Chronic Obstructive Pulmonary Disease. 2017:12

Research output: Contribution to journal › Article › peer-review

Open Access

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Promoting Recruitment using Information Management Efficiently (PRIME): statistical analysis plan for a stepped wedge cluster randomised trial within the REstart or STop Antithrombotics Randomised Trial (RESTART)

Parker, R., Weir, C., Maxwell, A. & Al-Shahi Salman, R., 1 Mar 2017, In: Trials.

Research output: Contribution to journal › Article › peer-review

Open Access

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Promoting Recruitment using Information Management Efficiently (PRIME): study protocol for a stepped wedge cluster randomised controlled trial within the REstart or STop Antithrombotics Randomised Trial (RESTART)

Maxwell, A., Dennis, M., Rudd, A., Weir, C., Parker, R. & Salman, R., 1 Mar 2017, In: Trials.

Research output: Contribution to journal › Article › peer-review

Open Access

File

A pilot randomised controlled trial investigating a Mediterranean diet intervention in pregnant women for the primary prevention of allergic diseases in infants

Sewell, D. A., Hammersley, V. S., Robertson, A., Devereux, G., Stoddart, A., Weir, C. J., Worth, A. & Sheikh, A., 16 Feb 2017, In: Journal of Human Nutrition and Dietetics. 30, 5

Research output: Contribution to journal › Article › peer-review

Open Access

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2016

Two categorical endpoints

Ensor, H. & Weir, C., 16 Dec 2016, Applied surrogate endpoint evaluation methods with SAS and R. Alonso, A. (ed.). Boca Raton: Chapman and Hall/CRC, p. 146-154 12 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Application of mixed effects limits of agreement in the presence of multiple sources of variability: exemplar from the comparison of several devices to measure respiratory rate in COPD patients

Parker, R., Weir, C., Rubio, N., Rabinovich, R., Pinnock, H., Hanley, J., McCloughan, C., Drost, E., Mantoani, L., MacNee, W. & McKinstry, B., 14 Dec 2016, In: PLoS ONE. 11(12), e0168321

Research output: Contribution to journal › Article › peer-review

Open Access

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Staff education, regular sedation and analgesia quality feedback, and a sedation monitoring technology for improving sedation and analgesia quality for critically ill, mechanically ventilated patients: a cluster randomised trial

Development and Evaluation of Strategies to Improve Sedation Practice in Intensive Care (DESIST) study investigators, Walsh, T. S., Kydonaki, K., Antonelli, J., Stephen, J., Lee, R. J., Everingham, K., Hanley, J., Phillips, E. C., Uutela, K., Peltola, P., Cole, S., Quasim, T., Ruddy, J., McDougall, M., Davidson, A., Rutherford, J., Richards, J. & Weir, C. J., 1 Oct 2016, In: The Lancet Respiratory Medicine. 4, 10, p. 807-817

Research output: Contribution to journal › Article › peer-review

Open Access

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Statistics in Regulatory Affairs in www.wikipedia.org: Initiative of the ISCB Statistics in Regulatory Affairs Subcommittee (SiRA SC)

Torres, J. V., Weir, C., Close, N., Schumacher, M., Friede, T., Siegel, J., Gerlinger, C., Bender, R., Nakas, C., Seldrup, J. & Chadha-Boreham, H., 22 Aug 2016.

Research output: Contribution to conference › Poster › peer-review

Early PREdiction of Severe Sepsis (ExPRES-Sepsis) study: protocol for an observational derivation study to discover potential leucocyte cell surface biomarkers

ExPRES Sepsis Investigators, Datta, D., Conway Morris, A., Antonelli, J., Warner, N., Brown, K. A., Wright, J., Simpson, A. J., Rennie, J., Hulme, G., Lewis, S. M., Mare, T. A., Cookson, S., Weir, C. J., Dimmick, I., Keenan, J., Rossi, A. G., Shankar-Hari, M. & Walsh, T. S., 1 Aug 2016, In: BMJ Open. 6, 8, p. e011335

Research output: Contribution to journal › Article › peer-review

Open Access

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Predictive value of cell-surface markers in infections in critically ill patients: protocol for an observational study (ImmuNe FailurE in Critical Therapy (INFECT) Study)

Conway Morris, A., Datta, D., Shankar-Hari, M., Weir, C. J., Rennie, J., Antonelli, J., Rossi, A. G., Warner, N., Keenan, J., Wang, A., Brown, K. A., Lewis, S., Mare, T., Simpson, A. J., Hulme, G., Dimmick, I. & Walsh, T. S., 18 Jul 2016, In: BMJ Open. 6, 7, p. e011326

Research output: Contribution to journal › Article › peer-review

Open Access

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The HiSTORIC trial: a hybrid before-and-after and stepped wedge design

Parker, R., Mills, N., Shah, A., Strachan, F., Keerie, C. & Weir, C., 18 Jul 2016, Trials. Suppl 1 ed. BioMed Central, Vol. 17. p. 1 1 p. DOI 10.1186/s13063-016-1436-8

Research output: Chapter in Book/Report/Conference proceeding › Other chapter contribution

The effectiveness and variation of acute medical units: a systematic review.

Reid, L., Dinesen, L., Jones, M., Morrison, Z., Weir, C. & Lone, N., 16 Jun 2016, (E-pub ahead of print) In: International Journal for Quality in Health Care.

Research output: Contribution to journal › Article › peer-review

Open Access

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Phase 2 Randomised Controlled Trial and Feasibility Study of Future Care Planning in Patients with Advanced Heart Disease

Denvir, M. A., Cudmore, S., Highet, G., Robertson, S., Donald, L., Stephen, J., Haga, K., Hogg, K., Weir, C. J., Murray, S. A. & Boyd, K., 19 Apr 2016, In: Scientific Reports. 6, 24619.

Research output: Contribution to journal › Article › peer-review

Open Access

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Rationale, design and methodology of a trial evaluating three strategies designed to improve sedation quality in intensive care units (DESIST study)

Development and Evaluation of Strategies to Improve Sedation practice in inTensive care (DESIST) study investigators, Walsh, T. S., Kydonaki, K., Antonelli, J., Stephen, J., Lee, R. J., Everingham, K., Hanley, J., Uutelo, K., Peltola, P. & Weir, C. J., 4 Mar 2016, In: BMJ Open. 6, 3, p. e010148

Research output: Contribution to journal › Article › peer-review

Open Access

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Development of Process Control Methodology for Tracking the Quality and Safety of Pain, Agitation, and Sedation Management in Critical Care Units

Development and Evaluation of Strategies to Improve Sedation practice in inTensive care Study Investigators, Walsh, T. S., Kydonaki, K., Lee, R. J., Everingham, K., Antonelli, J., Harkness, R. T., Cole, S., Quasim, T., Ruddy, J., McDougall, M., Davidson, A., Rutherford, J., Richards, J. & Weir, C. J., 1 Mar 2016, In: Critical Care Medicine. 44, 3, p. 564-574 11 p.

Research output: Contribution to journal › Article › peer-review

Association of neuropathic limb pain in multiple sclerosis with cognition , behaviour, and measures of brain structure: a case-control MRI neuroimaging study

Foley, P., Pernet, C., Valdes Hernandez, M., Roberts, N., Kong, Y., Sellar, R., Colvin, L., Weir, C., Bak, T., Chandran, S., Tracey, I. & Fallon, M., 25 Feb 2016, In: The Lancet. 387, S45, p. 45 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

Patient characteristics associated with risk of first hospital admission and readmission for acute exacerbation of chronic obstructive pulmonary disease (COPD) following primary care COPD diagnosis: a cohort study using linked electronic patient records

Hunter, L. C., Lee, R., Butcher, I., Weir, C., Fischbacher, C., McAllister, D., Wild, S., Hewitt, N. & Hardie, R. M., 22 Jan 2016, In: BMJ Open. 6

Research output: Contribution to journal › Article › peer-review

Open Access

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2015

Socioeconomic status, comorbidity, and mortality in patients with type 2 diabetes mellitus in Scotland 2004-2011: a cohort study

Walker, J., Halbesma, N., Lone, N., McAllister, D., Weir, C. J. & Wild, S. H., 17 Dec 2015, In: Journal of Epidemiology & Community Health.

Research output: Contribution to journal › Article › peer-review

Open Access

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Challenges in the design and analysis of a factorial-design cluster randomised trial

Stephen, J., Lee, R., Kydonaki, K., Antonelli, J., Walsh, T. S. & Weir, C. J., 16 Nov 2015, In: Trials. 16, Suppl 2, p. P149

Research output: Contribution to journal › Meeting abstract › peer-review

Cancer treatment-related neuropathic pain: Proof of concept study with menthol-a TRPM8 agonist

Fallon, M. T., Storey, D. J., Krishan, A., Weir, C. J., Mitchell, R., Fleetwood-Walker, S. M., Scott, A. C. & Colvin, L. A., 30 Sept 2015, In: Supportive Care in Cancer. 23, 9, p. 2769–2777 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Statistical approaches for evaluating surrogate outcomes in clinical trials: a systematic review

Ensor, H., Lee, R. J., Sudlow, C. & Weir, C. J., 21 Sept 2015, In: Journal of biopharmaceutical statistics.

Research output: Contribution to journal › Literature review › peer-review

Clinical and cost effectiveness of enhanced oral healthcare in stroke care settings (SOCLE II): a pilot, stepped wedge, cluster randomized, controlled trial protocol

Brady, M. C., Stott, D., Weir, C. J., Chalmers, C., Sweeney, P., Donaldson, C., Barr, J., Barr, M., Pollock, A., McGowan, S., Bowers, N. & Langhorne, P., 16 Jun 2015, In: International Journal of Stroke. 10, 6, p. 979-84 6 p.

Research output: Contribution to journal › Article › peer-review

Prescription of emergency antiepileptic medication after a first childhood seizure: analysis of routine administrative data

Chin, R. F., Ajetunmobi, O., Weir, C. J. & Wood, R., Jun 2015, In: Epileptic Disorders. p. 172-6

Research output: Contribution to journal › Article › peer-review

Adaptive clinical trials and their potential to improve drug-development efficiency

Weir, C. J., 29 Apr 2015, In: Clinical drug investigation. 5, 4, p. 359-361 3 p.

Research output: Contribution to journal › Article

Low-dose dexamethasone as a treatment for women with heavy menstrual bleeding: protocol for response-adaptive randomised placebo-controlled dose-finding parallel group trial (DexFEM)

Warner, P., Weir, C. J., Hansen, C. H., Douglas, A., Madhra, M., Hillier, S. G., Saunders, P. T. K., Iredale, J. P., Semple, S., Walker, B. R. & Critchley, H. O. D., 14 Jan 2015, In: BMJ Open. 5, 1, e006837.

Research output: Contribution to journal › Article › peer-review

Open Access

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2014

N-terminal pro-brain natriuretic peptide and risk of cardiovascular events in older patients with type 2 diabetes: the Edinburgh Type 2 Diabetes Study

Price, A. H., Welsh, P., Weir, C. J., Feinkohl, I., Robertson, C. M., Morling, J. R., McLachlan, S., Strachan, M. W. J., Sattar, N. & Price, J. F., Dec 2014, In: Diabetologia. 57, 12, p. 2505-2512 8 p.

Research output: Contribution to journal › Article › peer-review

M146 Validation Of Five Non-invasive Respiratory Rate Monitors In Patients With Copd In A Laboratory Setting

Rubio, N., McKinstry, B., Parker, R., Pinnock, H., Weir, C., Hanley, J., Yerramasu, C., Cruz-Mantoani, L., MacNee, W. & Rabinovich, R. A., 10 Nov 2014, In: Thorax. 69, Supplement 2, p. A216-A216 1 p.

Research output: Contribution to journal › Article › peer-review

Mortality late after mild traumatic brain injury: A prospective population study

McMillan, T., Wainman-Lefley, J. & Weir, C., May 2014, In: Brain Injury. 28, 5-6, p. 775-775 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

Mortality and morbidity 15 years after hospital admission with mild head injury: a prospective case-controlled population study

McMillan, T. M., Weir, C. J. & Wainman-Lefley, J., 12 Mar 2014, In: Journal of Neurology, Neurosurgery & Psychiatry. p. 1214-1220

Research output: Contribution to journal › Article › peer-review

Future Care Planning for patients approaching end-of-life with advanced heart disease: an interview study with patients, carers and healthcare professionals exploring the content, rationale and design of a randomised clinical trial

Denvir, M. A., Highet, G., Robertson, S., Cudmore, S., Reid, J., Ness, A., Hogg, K., Weir, C., Murray, S. & Boyd, K., 2014, In: BMJ Open. 4, 7, p. e005021

Research output: Contribution to journal › Article › peer-review

Open Access

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