Research output per year
Research output per year
Personal profile
Education/Academic qualification
Neuroscience, Doctor of Philosophy (PhD), Modelling Alzheimer's Disease in Organotypic Slices, University of Cambridge
Oct 2013 → Oct 2016
Award Date: 14 Dec 2016
Natural Sciences, Bachelor of Arts, Natural Sciences- Part II Neuroscience-1st Class, University of Cambridge
Oct 2010 → Jun 2013
Award Date: 20 Jun 2013
External positions
Postdoctoral Researcher, University of Cambridge
Oct 2016 → Aug 2019
Fingerprint
Dive into the research topics where Claire Durrant is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Astrocyte Proximity Protects Synapses From Human Amyloid-Beta Induced Degeneration in a Mouse Ex Vivo Model of Early Alzheimer's Disease
Gobbo, F., King, D., Tulloch, J., Gobbo, D., Bonthron, C., Meftah, S., Stoddart-Campbelton, C., Tamura, A., Rose, J., Smith, C., Durrant, C. & Spires-Jones, T. L., 1 Apr 2026, In: European Journal of Neuroscience. 63, 7, e70480.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Astrocyte proximity protects synapses from human amyloid-beta induced degeneration in a mouse ex vivo model of early Alzheimer’s disease
Gobbo, F., King, D., Tulloch, J., Gobbo, D., Bonthron, C., Meftah, S., Stoddart-Campbelton, C., Tamura, A., Rose, J., Smith, C., Durrant, C. & Spires-Jones, T., Apr 2026, In: European Journal of Neuroscience. 63, 7, 21 p., e70480.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
GABAB Receptor signaling in CA1 Pyramidal Cells is not Regulated by Aging in the APP/PS1 Mouse Model of Amyloid Pathology
Meftah, S., Wilson, M. A., Elliott, J., McLay, L., Dobrovolskis, V., Rosencrans, S., Taylor, L. W., Mugnaini, C., Mostallino, R., Durrant, C. S. & Booker, S. A., 6 Feb 2026, In: eNeuro. 13, 2Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Confirmation of p-tau Ser356’s association with Alzheimer’s disease pathology and lowering in response to WZ4003 treatment in brain slice cultures. Reply to: “Phospho-tau Ser356 is mostly confined to pre-NFT neurons in Alzheimer’s pathology”
Taylor, L. W., Simzer, E. M., Young, L. F. P., Holt, K., Spires-Jones, T. L. & Durrant, C. S., 11 Dec 2025, In: Acta Neuropathologica. 150, 63Research output: Contribution to journal › Letter › peer-review
Open AccessFile -
Divergent actions of physiological and pathological amyloid-β on synapses in live human brain slice cultures
McGeachan, R. I., Meftah, S., Taylor, L. W., Catterson, J. H., Negro, D., Bonthron, C., Holt, K., Tulloch, J., Rose, J. L., Gobbo, F., Chang, Y. Y., Elliott, J., McLay, L., King, D., Liaquat, I., Spires-Jones, T. L., Booker, S. A., Brennan, P. M. & Durrant, C. S., Dec 2025, In: Nature Communications. 16, 1, p. 1-22 22 p., 3753.Research output: Contribution to journal › Article › peer-review
Open AccessFile
Prizes
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1st place team at Dementia Research Meets Motorsport Innovation Accelerator
Durrant, C. (Recipient), 6 Jul 2021
Prize: Prize (including medals and awards)
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Race Against Dementia Fellowship
Durrant, C. (Recipient), 1 Sept 2019
Prize: Fellowships awarded competitively
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SULSA ECR Prize 2020 (Understanding & Treating Disease)
Durrant, C. (Recipient), 16 Sept 2020
Prize: Prize (including medals and awards)
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Edinburgh Human Brain Cluster: Enhancing Investigation of Live Human Brain Slice Models with Deep Patient Phenotyping
Brennan, P. (Principal Investigator), Baillie, K. (Co-investigator), Booker, S. (Co-investigator), Durrant, C. (Co-investigator), Smith, C. (Co-investigator) & Spires-Jones, T. (Co-investigator)
14/11/25 → 13/11/29
Project: Research
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Identifying adeno-associated viruses to successfully and specifically target human glia
Diaz-Castro, B. (Principal Investigator), Durrant, C. (Co-investigator), Hasel, P. (Co-investigator), T Selvaraj, B. (Co-investigator) & Williams, A. (Co-investigator)
UK Dementia Research Institute Ltd
6/01/25 → 5/10/26
Project: Research
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Understanding and preventing synaptic spread of tau
Spires-Jones, T. (Principal Investigator), Diaz-Castro, B. (Co-investigator) & Durrant, C. (Co-investigator)
1/03/24 → 31/08/27
Project: Research
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Mechanisms of tau pathology progression in primary tauopathy
Durrant, C. (Principal Investigator) & Spires-Jones, T. (Co-investigator)
1/07/22 → 30/09/26
Project: Research
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Elucidate the synaptic basis of cognitive resilience to Alzheimer’s disease in humans
Opazo, P. (Principal Investigator), Bowles, K. (Co-investigator), Dando, O. (Co-investigator) & Durrant, C. (Co-investigator)
1/04/26 → 12/07/26
Project: Research
Datasets
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Data from paper: Evidence for trans-synaptic propagation of oligomeric tau in human Progressive Supranuclear Palsy
Chang, Y. Y. (Creator), Spires-Jones, M. (Creator), Gilmore, M. (Creator), Holt, K. (Creator), Meftah, S. (Creator), Ravingerova, N. (Creator), Scutariu, C. (Creator), Taylor, L. (Creator), Hindley-Pollock, N. (Creator), Geary, B. (Creator), Spires-Jones, T. (Creator), Durrant, C. (Creator), Mcgeachan, R. (Creator), Keavey, L. (Creator) & Simzer, E. (Creator), Edinburgh DataShare, 7 Apr 2025
DOI: 10.7488/ds/7908
Dataset
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Divergent actions of physiological and pathological amyloid-β on synapses in live human brain slice cultures
Tulloch, J. (Creator), Rose, J. (Creator), Gobbo, F. (Creator), Chang, Y. Y. (Creator), McLay, L. (Creator), King, D. (Creator), Liaquat, I. (Creator), Spires-Jones, T. (Creator), Booker, S. (Creator), Brennan, P. (Creator), Durrant, C. (Creator), Elliott, J. (Creator), Mcgeachan, R. (Creator), Meftah, S. (Creator), Taylor, L. (Creator), Catterson, J. (Creator), Negro, D. (Creator), Bonthron, C. (Creator) & Holt, K. (Creator), Edinburgh DataShare, 7 Apr 2025
DOI: 10.7488/ds/7890
Dataset
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p-tau Ser356 is associated with Alzheimer’s disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003
Durrant, C. (Creator), Taylor, L. (Creator) & Spires-Jones, T. (Creator), Edinburgh DataShare, 8 Feb 2024
DOI: 10.7488/ds/7680, https://doi.org/10.1007/s00401-023-02667-w
Dataset
Press/Media
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I've donated part of my brain to help find a cure for dementia
1/06/26
1 Media contribution
Press/Media: Research
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Royal patron attends the Eric Liddell Dinner for Dementia
23/01/26
1 Media contribution
Press/Media: Research
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How bringing up daughters could help protect you from dementia
3/01/26
1 Media contribution
Press/Media: Research
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I'm watching brain surgery to see if Alzheimer's can ever be cured
26/12/25
1 Media contribution
Press/Media: Research
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World First! British scientists use live brain tissue to accelerate dementia therapy research
2/05/25
1 Media contribution
Press/Media: Research