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Personal profile


Professor Smith is Chair of Psychiatry and Head of the Division of Psychiatry within the Centre for Clinical Brain Sciences. He also works as an Honorary Consualtant Psychiatrist in NHS Lothian and is Convenor for Undergraduate Psychiatry witin Edinburgh Medical School.

He trained in medicine at the University of Edinburgh (BSc, 1994 and MB ChB, 1996) and completed a clinical research training fellowship in Edinburgh (MD, 2006) alongside an International Masters in Affective Neuroscience in Maastricht (MSc, 2006). After clinical training Prfoessor Smith held a postdoctoral fellowship from the National Institute of Health Research (NIHR) at Cardiff University (2006-2012). He moved to the University of Glasgow as Reader in Psychiatry in 2012 and was promoted to a personal chair in 2014. He joined the University of Edinburgh in April 2021.

Professor Smith's work has been recognised by a number of awards and fellowships, including the American Psychiatric Institute ‘Young Minds in Psychiatry’ International Award for Bipolar Disorder (2007), the Association of European Psychiatrists Research Prize (2007), an NIHR Postdoctoral Fellowship (2008-2011), an Independent Investigator Award from the Brain and Behaviour Research Foundation (2014), the British Medical Journal Innovation Team Award (2014), and a Lister Institute Prize Fellowship (2016).


BSc, MB ChB, MSc, MD, FRCPsych.




Current Research Interests

Professor Smith's research interests are in four main areas:

  • The genetic epidemiology of mood disorders (particularly bipolar disorder)
  • Data science and mental health informatics research
  • Understanding comorbidity between mental and physical health disorders
  • Sleep and circadian health as they relate to mood disorders

His group has been at the forefront of mental health research using data from the UK Biobank cohort and he is part of several global research collaborations, including the Psychiatric Genomics Consortium, the Consortium for Lithium Genomics and the Chronobiology Task Force of the International Society for Bipolar Disorder. 



  • RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
  • QH426 Genetics
  • R Medicine (General)
  • RA0421 Public health. Hygiene. Preventive Medicine


Dive into the research topics where Daniel Smith is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years

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  • Severe and common mental disorders and risk of emergency hospital admissions for ambulatory care sensitive conditions among the UK Biobank cohort

    Niedzwiedz, C. L., Aragón, M. J., Breedvelt, J. J. F., Smith, D. J., Prady, S. L. & Jacobs, R., 7 Nov 2023, In: BJPsych Open. 9, 6

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • Comprehensive Assessment of Sleep Duration, Insomnia and Brain Structure within the UK Biobank Cohort

    Stolicyn, A., Lyall, L. M., Lyall, D. M., Høier, N., Adams, M. J., Shen, X., Cole, J. H., McIntosh, A. M., Whalley, H. C. & Smith, D. J., 27 Oct 2023, (E-pub ahead of print) In: Sleep.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • Pilot study of a ketogenic diet in bipolar disorder

    Needham, N., Campbell, I., Grossi, H., Kamenska, I., Rigby, B., Simpson, S. A., McIntosh, E., Bahuguna, P., Meadowcroft, B., Creasy, F., Mitchell-Grigorjeva, M., Norrie, J., Thompson, G., Gibbs, M., McLellan, A., Fisher, C., Moses, T., Burgess, K. E. V., Brown, R., Thrippleton, M. J., & 2 othersCampbell, H. & Smith, D., 10 Oct 2023, In: BJPsych Open. 9, 6, 8 p., e176.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors

    Docherty, A. R., Mullins, N., Ashley-Koch, A. E., Qin, X., Coleman, J. R. I., Shabalin, A., Kang, J., Murnyak, B., Wendt, F., Adams, M. J., Campos, A. I., Diblasi, E., Fullerton, J. M., Kranzler, H. R., Bakian, A. V., Monson, E. T., Rentería, M. E., Walss-Bass, C., Andreassen, O. A., Behera, C., & 236 othersBulik, C. M., Edenberg, H. J., Kessler, R. C., Mann, J. J., Nurnberger, J. I., Pistis, G., Streit, F., Ursano, R. J., Polimanti, R., Dennis, M., Garrett, M., Hair, L., Harvey, P., Hauser, E. R., Hauser, M. A., Huffman, J., Jacobson, D., Madduri, R., Mcmahon, B., Oslin, D. W., Trafton, J., Awasthi, S., Berrettini, W. H., Bohus, M., Chang, X., Chen, H-C., Chen, W. J., Christensen, E. D., Crow, S., Duriez, P., Edwards, A. C., Fernández-Aranda, F., Galfalvy, H., Gandal, M., Gorwood, P., Guo, Y., Hafferty, J. D., Hakonarson, H., Halmi, K. A., Hishimoto, A., Jain, S., Jamain, S., Jiménez-Murcia, S., Johnson, C., Kaplan, A. S., Kaye, W. H., Keel, P. K., Kennedy, J. L., Kim, M., Klump, K. L., Levey, D. F., Li, D., Liao, S-C., Lieb, K., Lilenfeld, L., Marshall, C. R., Mitchell, J. E., Okazaki, S., Otsuka, I., Pinto, D., Powers, A., Ramoz, N., Ripke, S., Roepke, S., Rozanov, V., Scherer, S. W., Schmahl, C., Sokolowski, M., Starnawska, A., Strober, M., Su, M-H., Thornton, L. M., Treasure, J., Ware, E. B., Watson, H. J., Witt, S. H., Woodside, D. B., Yilmaz, Z., Zillich, L., Adolfsson, R., Agartz, I., Alda, M., Alfredsson, L., Appadurai, V., Artigas, M. S., Van der auwera, S., Azevedo, M. H., Bass, N., Bau, C. H. D., Baune, B. T., Bellivier, F., Berger, K., Biernacka, J. M., Bigdeli, T. B., Binder, E. B., Boehnke, M., Boks, M. P., Braff, D. L., Bryant, R., Budde, M., Byrne, E. M., Cahn, W., Castelao, E., Cervilla, J. A., Chaumette, B., Corvin, A., Craddock, N., Djurovic, S., Foo, J. C., Forstner, A. J., Frye, M., Gatt, J. M., Giegling, I., Grabe, H. J., Green, M. J., Grevet, E. H., Grigoroiu-Serbanescu, M., Gutierrez, B., Guzman-Parra, J., Hamshere, M. L., Hartmann, A. M., Hauser, J., Heilmann-Heimbach, S., Hoffmann, P., Ising, M., Jones, I., Jones, L. A., Jonsson, L., Kahn, R. S., Kelsoe, J. R., Kendler, K. S., Kloiber, S., Koenen, K. C., Kogevinas, M., Krebs, M-O., Leboyer, M., Landén, M., Lee, P. H., Levinson, D. F., Liao, C., Lissowska, J., Mayoral, F., Mcelroy, S. L., Mcgrath, P., Mcguffin, P., Mcquillin, A., Mehta, D., Melle, I., Mitchell, P. B., Molina, E., Morken, G., Nievergelt, C., Nöthen, M. M., O’donovan, M. C., Ophoff, R. A., Owen, M. J., Pato, C., Pato, M. T., Penninx, B. W. J. H., Potash, J. B., Power, R. A., Preisig, M., Quested, D., Ramos-Quiroga, J. A., Reif, A., Ribasés, M., Richarte, V., Rietschel, M., Rivera, M., Roberts, A., Roberts, G., Rouleau, G. A., Rovaris, D. L., Sanders, A. R., Schofield, P. R., Schulze, T. G., Scott, L. J., Serretti, A., Shi, J., Sirignano, L., Sklar, P., Smeland, O. B., Smoller, J. W., Sonuga-Barke, E. J. S., Trzaskowski, M., Tsuang, M. T., Turecki, G., Vilar-Ribó, L., Vincent, J. B., Völzke, H., Walters, J. T. R., Weickert, C. S., Weickert, T. W., Weissman, M. M., Williams, L. M., Wray, N. R., Zai, C. C., Agerbo, E., Børglum, A. D., Breen, G., Demontis, D., Gelernter, J., Glatt, S. J., Erlangsen, A., Hougaard, D. M., Hwu, H-G., Kuo, P-H., Lewis, C. M., Li, Q. S., Liu, C-M., Martin, N. G., Mcintosh, A. M., Medland, S. E., Mors, O., Nordentoft, M., Olsen, C. M., Porteous, D., Smith, D. J., Stahl, E. A., Stein, M. B., Wasserman, D., Werge, T., Whiteman, D. C., Willour, V., VA Million Veteran Program, MVP Suicide Exemplar Workgroup, Suicide Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Eating Disorder Working Group of the Psychiatric Genomics Consortium, German Borderline Genomics Consortium, Coon, H., Beckham, J. C., Kimbrel, N. A. & Ruderfer, D. M., 1 Oct 2023, In: The American Journal of Psychiatry. 180, 10, p. 723-738

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • Bipolar disorder: Diagnosis, treatment and future directions

    Lane, N. M. & Smith, D. J., 30 Aug 2023, In: Journal of the Royal College of Physicians of Edinburgh. 53, 3, p. 192-196

    Research output: Contribution to journalArticlepeer-review

    Open Access