David Breen

Search results

• 2024

  Specialist physiotherapy for functional motor disorder in England and Scotland (Physio4FMD): a pragmatic, multicentre, phase 3 randomised controlled trial

  Nielsen, G., Stone, J., Lee, T. C., Goldstein, L. H., Marston, L., Hunter, R. M., Carson, A., Holt, K., Marsden, J., Le novere, M., Nazareth, I., Noble, H., Reuber, M., Strudwick, A-M., Santana suarez, B., Edwards, M. J., Breen, D., Hoeritzauer, I. & Physio4FMD study group, 17 May 2024, (E-pub ahead of print) In: The Lancet Neurology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2023

  White matter hyperintensities and smaller cortical thickness are associated with neuropsychiatric symptoms in neurodegenerative and cerebrovascular diseases

  ONDRI Investigators, Ozzoude, M., Varriano, B., Beaton, D., Ramirez, J., Adamo, S., Holmes, M. F., Scott, C. J. M., Gao, F., Sunderland, K. M., McLaughlin, P., Goubran, M., Kwan, D., Roberts, A., Bartha, R., Symons, S., Tan, B., Swartz, R. H., Abrahao, A., Saposnik, G., & 32 othersMasellis, M., Lang, A. E., Marras, C., Zinman, L., Shoesmith, C., Borrie, M., Fischer, C. E., Frank, A., Freedman, M., Montero-Odasso, M., Kumar, S., Pasternak, S., Strother, S. C., Pollock, B. G., Rajji, T. K., Seitz, D., Tang-Wai, D. F., Turnbull, J., Dowlatshahi, D., Hassan, A., Casaubon, L., Mandzia, J., Sahlas, D., Breen, D. P., Grimes, D., Jog, M., Steeves, T. D. L., Arnott, S. R., Black, S. E., Finger, E., Rabin, J. & Tartaglia, M. C., 20 Jun 2023, In: Alzheimer's research & therapy. 15, 1, p. 114

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cerebrovascular Disease 100%
  • White Matter 100%
  • Neurodegenerative Disorder 100%
  • Frontotemporal Dementia 50%
  • Parkinson's Disease 33%

• Rare neurovascular genetic and imaging markers across neurodegenerative diseases

  ONDRI Investigators, Dilliott, A. A., Berberian, S. A., Sunderland, K. M., Binns, M. A., Zimmer, J., Ozzoude, M., Scott, C. J. M., Gao, F., Lang, A. E., Breen, D. P., Tartaglia, M. C., Tan, B., Swartz, R. H., Rogaeva, E., Borrie, M., Finger, E., Fischer, C. E., Frank, A., Freedman, M., & 24 othersKumar, S., Pasternak, S., Pollock, B. G., Rajji, T. K., Tang-Wai, D. F., Abrahao, A., Turnbull, J., Zinman, L., Casaubon, L., Dowlatshahi, D., Hassan, A., Mandzia, J., Sahlas, D., Saposnik, G., Grimes, D., Marras, C., Steeves, T., Masellis, M., Farhan, S. M. K., Bartha, R., Symons, S., Hegele, R. A., Black, S. E. & Ramirez, J., 5 Jun 2023, (E-pub ahead of print) In: Alzheimer's & Dementia: The Journal of the Alzheimer's Association.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Degenerative Disease 100%
  • Genetics 100%
  • Neurodegenerative Disorder 100%
  • Inpatient 33%
  • Small Vessel Disease 33%

• White matter hyperintensity burden predicts cognitive but not motor decline in Parkinson's disease. Results from the ONDRI

  ONDRI Investigators, Carvalho de Abreu, D. C., Pieruccini-Faria, F., Sarquis-Adamson, Y., Black, A., Fraser, J., Van Ooteghem, K., Cornish, B., Grimes, D., Jog, M., Masellis, M., Steeves, T., Nanayakkara, N., Ramirez, J., Scott, C., Holmes, M., Ozzoude, M., Berezuk, C., Symons, S., Mohammad Hassan Haddad, S., & 25 othersArnott, S. R., Binns, M., Strother, S., Beaton, D., Sunderland, K., Theyers, A., Tan, B., Zamyadi, M., Levine, B., Orange, J. B., Roberts, A. C., Lou, W., Sujanthan, S., Breen, D. P., Marras, C., Kwan, D., Adamo, S., Peltsch, A., Troyer, A. K., Black, S. E., McLaughlin, P. M., Lang, A. E., McIlroy, W., Bartha, R. & Montero-Odasso, M., 24 Jan 2023, (E-pub ahead of print) In: European Journal of Neurology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • White Matter 100%
  • Neurodegenerative Disorder 100%
  • Parkinson's Disease 100%
  • Brain 40%
  • Cognition 30%

• Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function

  ONDRI Investigators, Kapustin, D., Zarei, S., Wang, W., Binns, M. A., McLaughlin, P. M., Abrahao, A., Black, S. E., Borrie, M., Breen, D., Casaubon, L., Dowlatshahi, D., Finger, E., Fischer, C. E., Frank, A., Freedman, M., Grimes, D., Hassan, A., Jog, M., Kwan, D., & 26 othersLang, A., Levine, B., Mandzia, J., Marras, C., Masellis, M., Orange, J. B., Pasternak, S., Peltsch, A., Pollock, B. G., Rajji, T. K., Roberts, A., Sahlas, D., Saposnik, G., Seitz, D., Shoesmith, C., Southwell, A., Steeves, T. D. L., Sunderland, K., Swartz, R. H., Tan, B., Tang-Wai, D. F., Tartaglia, M. C., Troyer, A., Turnbull, J., Zinman, L. & Kumar, S., 13 Jan 2023, (E-pub ahead of print) In: The Canadian Journal of Psychiatry (CJP). p. 7067437221147443

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Symptom 100%
  • Diseases 100%
  • Neurodegenerative Disorder 100%
  • Frontotemporal Dementia 50%
  • Parkinson Disease 16%
• 2022

  Small and Large Magnetic Resonance Imaging-Visible Perivascular Spaces in the Basal Ganglia of Parkinson's Disease Patients

  Ramirez, J., Berberian, S. A., Breen, D. P., Gao, F., Ozzoude, M., Adamo, S., Scott, C. J. M., Berezuk, C., Yhap, V., Mestre, T. A., Marras, C., Tartaglia, M. C., Grimes, D., Jog, M., Kwan, D., Tan, B., Binns, M. A., Arnott, S. R., Bartha, R., Symons, S., & 3 othersMasellis, M., Black, S. E. & Lang, A. E., 15 Jun 2022, In: Movement Disorders. 37, 6, p. 1304-1309

  Research output: Contribution to journal › Article › peer-review

  • Parkinson's Disease 100%
  • Basal Ganglia 100%
  • Magnetic Resonance Imaging 100%
  • Patient 100%
  • Perivascular Space 100%

• Investigating the contribution of white matter hyperintensities and cortical thickness to empathy in neurodegenerative and cerebrovascular diseases

  ONDRI Investigators, Jun 2022, In: GeroScience. 44, p. 1575-1598

  Research output: Contribution to journal › Article › peer-review

  • Cerebrovascular Disease 100%
  • White Matter 100%
  • Neurodegenerative Disorder 100%
  • Brain 28%
  • Frontotemporal Dementia 28%

• Caregiving concerns and clinical characteristics across neurodegenerative and cerebrovascular disorders in the Ontario neurodegenerative disease research initiative

  Beaton, D., McLaughlin, P. M., Orange, J. B., Munoz, D. P., Mandzia, J., Abrahao, A., Binns, M. A., Black, S. E., Borrie, M., Dowlatshahi, D., Freedman, M., Fischer, C. E., Finger, E. C., Frank, A., Grimes, D., Hassan, A., Kumar, S., Lang, A. E., Levine, B., Marras, C., & 20 othersMasellis, M., Pollock, B. G., Rajji, T. K., Ramirez, J., Sahlas, D. J., Saposnik, G., Scott, C. J. M., Seitz, D. P., Strother, S. C., Sunderland, K. M., Tan, B., Tang-Wai, D. F., Troyer, A. K., Turnbull, J., Zinman, L., Swartz, R. H., Tartaglia, M. C., Breen, D. P., Kwan, D. & Roberts, A. C., 27 May 2022, In: International Journal of Geriatric Psychiatry. 37, 6

  Research output: Contribution to journal › Article › peer-review

  • Caregiving 100%
  • Neurodegenerative Disorder 100%
  • Degenerative Disease 100%
  • Cerebrovascular Disease 100%
  • Research 100%
• 2021

  The Cerebrospinal Fluid Profile of Cholesterol Metabolites in Parkinson’s Disease and Their Association With Disease State and Clinical Features

  Griffiths, W. J., Abdel-khalik, J., Moore, S. F., Wijeyekoon, R. S., Crick, P. J., Yutuc, E., Farrell, K., Breen, D. P., Williams-gray, C. H., Theofilopoulos, S., Arenas, E., Trupp, M., Barker, R. A. & Wang, Y., 30 Aug 2021, (E-pub ahead of print) In: Frontiers in Aging Neuroscience. 13

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Early constipation predicts faster dementia onset in Parkinson’s disease

  Camacho, M., Macleod, A. D., Maple-grødem, J., Evans, J. R., Breen, D. P., Cummins, G., Wijeyekoon, R. S., Greenland, J. C., Alves, G., Tysnes, O. B., Lawson, R. A., Barker, R. A. & Williams-gray, C. H., 26 May 2021, In: npj Parkinson's Disease. 7, 1

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Which Neuropsychological Tests? Predicting Cognitive Decline and Dementia in Parkinson’s Disease in the ICICLE-PD Cohort

  Lawson, R. A., Williams-gray, C. H., Camacho, M., Duncan, G. W., Khoo, T. K., Breen, D. P., Barker, R. A., Rochester, L., Burn, D. J. & Yarnall, A. J., 19 May 2021, In: Journal of Parkinson's disease. p. 1-12

  Research output: Contribution to journal › Article › peer-review
• 2020

  Differences in the Presentation and Progression of Parkinson's Disease by Sex

  Iwaki, H., Blauwendraat, C., Leonard, H. L., Makarious, M. B., Kim, J. J., Liu, G., Maple‐grødem, J., Corvol, J., Pihlstrøm, L., Nimwegen, M., Smolensky, L., Amondikar, N., Hutten, S. J., Frasier, M., Nguyen, K. H., Rick, J., Eberly, S., Faghri, F., Auinger, P., Scott, K. M., & 28 othersWijeyekoon, R., Van Deerlin, V. M., Hernandez, D. G., Gibbs, R. J., Day‐williams, A. G., Brice, A., Alves, G., Noyce, A. J., Tysnes, O., Evans, J. R., Breen, D. P., Estrada, K., Wegel, C. E., Danjou, F., Simon, D. K., Andreassen, O. A., Ravina, B., Toft, M., Heutink, P., Bloem, B. R., Weintraub, D., Barker, R. A., Williams‐gray, C. H., Warrenburg, B. P., Van Hilten, J. J., Scherzer, C. R., Singleton, A. B. & Nalls, M. A., 1 Oct 2020, In: Movement Disorders.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Twinkle-associated familial parkinsonism with Lewy pathology: Cause or predisposition?

  Breen, D. P., Munoz, D. G. & Lang, A. E., 26 Aug 2020, (E-pub ahead of print) In: Neurology. p. 10.1212/WNL.0000000000010674

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• REM sleep behaviour disorder in patients without synucleinopathy

  Keir, L. H. M. & Breen, D. P., 13 Aug 2020, In: Journal of Neurology, Neurosurgery & Psychiatry. p. jnnp-2020-323475

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• In Vivo Distribution of α-Synuclein In Multiple Tissues and Biofluids in Parkinson’s Disease

  Systemic Synuclein Sampling Study, Chahine, L. M., Beach, T. G., Brumm, M. C., Adler, C. H., Coffey, C. S., Mosovsky, S., Caspell-Garcia, C., Serrano, G. E., Munoz, D. G., White III, C. L., Crary, J. F., Jennings, D., Taylor, P., Foroud, T., Arnedo, V., Kopil, C. M., Riley, L., Dave, K. D. & Mollenhauer, B., 3 Aug 2020, In: Neurology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Peripheral innate immune and bacterial signals relate to clinical heterogeneity in Parkinson's disease

  Wijeyekoon, R. S., Kronenberg-Versteeg, D., Scott, K. M., Hayat, S., Kuan, W-L., Evans, J. R., Breen, D. P., Cummins, G., Jones, J. L., Clatworthy, M. R., Andres Floto, R., Barker, R. A. & Williams-Gray, C. H., Jul 2020, In: Brain, Behavior, and Immunity. 87

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Immunity 100%
  • Monocyte 100%
  • Parkinson's Disease 100%
  • Alpha-Synuclein 64%
  • Caspase 1 42%

• Parkinson's Disease, NOTCH3 Genetic Variants, and White Matter Hyperintensities

  Ontario Neurodegenerative Disease Research Initiative Investigators, 23 Jun 2020, In: Movement Disorders. 35, 11, p. 2090-2095

  Research output: Contribution to journal › Article › peer-review

  • Parkinson's Disease 100%
  • White Matter 100%
  • Genetic Variability 100%
  • Patient 37%
  • Cognition 25%

• Impact of GBA1 variants on long-term clinical progression and mortality in incident Parkinson’s disease

  Stoker, T. B., Camacho, M., Winder-rhodes, S., Liu, G., Scherzer, C. R., Foltynie, T., Evans, J., Breen, D. P., Barker, R. A. & Williams-gray, C. H., 17 Apr 2020, In: Journal of Neurology, Neurosurgery & Psychiatry. p. jnnp-2020-322857

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Mild dopa-responsive dystonia in heterozygous tyrosine hydroxylase mutation carrier: Evidence of symptomatic enzyme deficiency? Response from the authors

  Lang, A. E., Bally, J. F., Breen, D. P., Schaake, S., Trinh, J., Rakovic, A. & Klein, C., 9 Apr 2020, (E-pub ahead of print) In: Parkinsonism & Related Disorders.

  Research output: Contribution to journal › Article › peer-review

• Cerebrospinal Fluid Cytokines and Neurodegeneration‐Associated Proteins in Parkinson's Disease

  Wijeyekoon, R. S., Moore, S. F., Farrell, K., Breen, D. P., Barker, R. A. & Williams‐gray, C. H., 4 Mar 2020, In: Movement Disorders.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Progression of Neuropsychiatric Symptoms over Time in an Incident Parkinson’s Disease Cohort (ICICLE-PD)

  Dlay, J. K., Duncan, G. W., Khoo, T. K., Williams-gray, C. H., Breen, D. P., Barker, R. A., Burn, D. J., Lawson, R. A. & Yarnall, A. J., 2 Feb 2020, In: Brain Sciences. 10, 2, p. 78

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Mild dopa-responsive dystonia in heterozygous tyrosine hydroxylase mutation carrier: Evidence of symptomatic enzyme deficiency?

  Bally, J. F., Breen, D. P., Schaake, S., Trinh, J., Rakovic, A., Klein, C. & Lang, A. E., 30 Jan 2020, (E-pub ahead of print) In: Parkinsonism & Related Disorders. 71, p. 44-45 2 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Mutation 100%
  • Tyrosine Hydroxylase 100%
  • Lysozyme 100%
  • Dystonia 100%
  • Enzyme Deficiency 100%
• 2019

  New awakenings: current understanding of sleep dysfunction and its treatment in Parkinson’s disease

  Keir, L. H. M. & Breen, D. P., 5 Dec 2019, In: Journal of Neurology.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  File

• Genomewide association study of Parkinson's disease clinical biomarkers in 12 longitudinal patients' cohorts

  International Parkinson's Disease Genomics Consortium, Dec 2019, In: Movement Disorders. 34, 12

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Association 100%
  • Parkinson's Disease 100%
  • Phenotype 33%
  • Genetic Determinism 33%
  • Cognition 16%

• Physio4FMD: protocol for a multicentre randomised controlled trial of specialist physiotherapy for functional motor disorder

  Physio4FMD Collaborative Group, 21 Oct 2019, In: Bmc neurology. 19, 1, p. 242

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Stereotypic Movement Disorder 100%
  • Randomized Controlled Trial 100%
  • Physiotherapy 100%
  • Medical Specialist 100%
  • Motor Dysfunction 100%

• The clinical significance of lower limb tremors

  Rajalingam, R., Breen, D. P., Chen, R., Fox, S., Kalia, L. V., Munhoz, R. P., Slow, E., Strafella, A. P., Lang, A. E. & Fasano, A., Aug 2019, In: Parkinsonism & Related Disorders. 65

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Genetic risk of Parkinson disease and progression: An analysis of 13 longitudinal cohorts

  Iwaki, H., Blauwendraat, C., Leonard, H. L., Liu, G., Maple-grødem, J., Corvol, J., Pihlstrøm, L., Van Nimwegen, M., Hutten, S. J., Nguyen, K. H., Rick, J., Eberly, S., Faghri, F., Auinger, P., Scott, K. M., Wijeyekoon, R., Van Deerlin, V. M., Hernandez, D. G., Day-williams, A. G., Brice, A., & 21 othersAlves, G., Noyce, A. J., Tysnes, O., Evans, J. R., Breen, D. P., Estrada, K., Wegel, C. E., Danjou, F., Simon, D. K., Ravina, B., Toft, M., Heutink, P., Bloem, B. R., Weintraub, D., Barker, R. A., Williams-gray, C. H., Van De Warrenburg, B. P., Van Hilten, J. J., Scherzer, C. R., Singleton, A. B. & Nalls, M. A., 9 Jul 2019, In: Neurology Genetics. 5, 4, p. e348

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Bioinformatics-Based Identification of Expanded Repeats: A Non-reference Intronic Pentamer Expansion in RFC1 Causes CANVAS

  Rafehi, H., Szmulewicz, D. J., Bennett, M. F., Sobreira, N. L. M., Pope, K., Smith, K. R., Gillies, G., Diakumis, P., Dolzhenko, E., Eberle, M. A., Barcina, M. G., Breen, D. P., Chancellor, A. M., Cremer, P. D., Delatycki, M. B., Fogel, B. L., Hackett, A., Halmagyi, G. M., Kapetanovic, S., Lang, A., & 13 othersMossman, S., Mu, W., Patrikios, P., Perlman, S. L., Rosemergy, I., Storey, E., Watson, S. R. D., Wilson, M. A., Zee, D. S., Valle, D., Amor, D. J., Bahlo, M. & Lockhart, P. J., 20 Jun 2019, (E-pub ahead of print) In: American Journal of Human Genetics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Sleep and cognitive aging in the eighth decade of life

  Cox, S. R., Ritchie, S. J., Allerhand, M., Hagenaars, S. P., Radakovic, R., Breen, D. P., Davies, G., Riha, R. L., Harris, S., Starr, J. M. & Deary, I. J., Apr 2019, In: Sleep. 42, 4, 12 p., zsz019.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cognitive Aging 100%
  • Sleep 100%
  • Sleep Time 45%
  • Processing Speed 36%
  • Reasoning 36%

• Successful pallidotomy for post-hyperglycemic hemichorea-ballism

  De Vloo, P., Breen, D. P., Milosevic, L., Lee, D. J., Dallapiazza, R. F., Hutchison, W. D., Lang, A. E. & Lozano, A. M., Apr 2019, In: Parkinsonism & Related Disorders. 61, p. 228-230 3 p.

  Research output: Contribution to journal › Article › peer-review

• Risk of Parkinson's disease dementia related to level I MDS PD-MCI

  MDS Study Group “Validation of Mild Cognitive Impairment in Parkinson Disease”, Mar 2019, In: Movement Disorders. 34, 3, p. 430-435 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Dementia 100%
  • Parkinson Disease 100%
  • Parkinson's Disease 100%
  • Mild Cognitive Impairment 85%
  • Movement Disorder 42%

• Identifying Parkinson's disease and parkinsonism cases using routinely collected healthcare data: A systematic review

  Harding, Z., Wilkinson, T., Stevenson, A., Horrocks, S., Ly, A., Schnier, C., Breen, D. P., Rannikmae, K. & Sudlow, C., 31 Jan 2019, In: PLoS ONE. 14, 1, 19 p., 0198736.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Parkinson's Disease 100%
  • Systematic Review 100%
  • Parkinsonism 100%
  • Parkinson Disease 100%
  • Accuracy 50%

• Gut-brain axis and the spread of α-synuclein pathology: vagal highway or dead end?

  Breen, D. P., Halliday, G. M. & Lang, A. E., 17 Jan 2019, (E-pub ahead of print) In: Movement Disorders.

  Research output: Contribution to journal › Review article › peer-review
• 2018

  Detecting Mild Cognitive Deficits in Parkinson's Disease: Comparison of Neuropsychological Tests

  IPMDS Study Group “Validation of Mild Cognitive Impairment in Parkinson Disease”, Nov 2018, In: Movement Disorders. 33, 11, p. 1750-1759 10 p.

  Research output: Contribution to journal › Review article › peer-review

  • Neuropsychological Test 100%
  • Cognitive Disorders 100%
  • Parkinson's Disease 100%
  • Cognitive Deficit 100%
  • Cognitive Decline 40%

• Essential tremor plus is more common than essential tremor: Insights from the reclassification of a cohort of patients with lower limb tremor

  Rajalingam, R., Breen, D. P., Lang, A. E. & Fasano, A., Nov 2018, In: Parkinsonism & Related Disorders. 56, p. 109-110 2 p.

  Research output: Contribution to journal › Article › peer-review

• α-Synuclein strains in multiple system atrophy: A product of their environment?

  Breen, D. P. & Fasano, A., 1 Aug 2018, In: Movement Disorders. 33, 8, p. 1270

  Research output: Contribution to journal › Article › peer-review

• Sleep-related motor and behavioral disorders: Recent advances and new entities

  Breen, D. P., Högl, B., Fasano, A., Trenkwalder, C. & Lang, A. E., Jul 2018, In: Movement Disorders. 33, 7, p. 1042-1055 14 p.

  Research output: Contribution to journal › Review article › peer-review

  • Sleep 100%
  • Behavior Disorder 100%
  • Psychiatry 25%
  • Recognition 25%
  • Movement Disorder 25%

• Functional movement disorders arising after successful deep brain stimulation

  Breen, D. P., Rohani, M., Moro, E., Mayberg, H. S., Zurowski, M., Lozano, A. M. & Fasano, A., 15 May 2018, In: Neurology. 90, 20, p. 931-932 2 p.

  Research output: Contribution to journal › Article › peer-review

• Infantile-onset hand dystonia with intellectual disability: Clues to ARX mutations

  Breen, D. P., Mercimek-Andrews, S. & Lang, A. E., 13 Feb 2018, In: Neurology. 90, 7, p. 333-335 3 p.

  Research output: Contribution to journal › Article › peer-review
• 2017

  Soft tissue plasmacytomas in multiple myeloma

  Breen, D. P., Freeman, C. L., De Silva, R. N., Derakhshani, S. & Stevens, J., 4 Nov 2017, In: The Lancet. 390, 10107, p. 2083

  Research output: Contribution to journal › Article › peer-review

• Prediction of cognition in Parkinson's disease with a clinical–genetic score: A longitudinal analysis of nine cohorts

  Liu, G., Locascio, J. J., Corvol, J-C., Boot, B., Liao, Z., Page, K., Franco, D., Burke, K., Jansen, I. E., Trisini-Lipsanopoulos, A., Winder-Rhodes, S., Tanner, C. M., Lang, A. E., Eberly, S., Elbaz, A., Brice, A., Mangone, G., Ravina, B., Shoulson, I., Cormier-Dequaire, F., & 13 othersHeutink, P., Van Hilten, J. J., Barker, R. A., Williams-Gray, C. H., Marinus, J., Scherzer, C., HBS, CamPaIGN, PICNICS Investigators, PROPARK Investigators, PSG Investigators, DIGPD Investigators & PDBP Investigators, 1 Aug 2017, In: Lancet Neurology. 16, 8, p. 620-629 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Cognition 100%
  • Cognitive Disorders 100%
  • Parkinson's Disease 100%
  • Cognitive Impairment 100%
  • Mental State 60%

• Discontinuation and non-publication of neurodegenerative disease trials: a cross-sectional analysis

  Stefaniak, J. D., Lam, T. C. H., Sim, N. E., Salman, R. & Breen, D. P., Aug 2017, In: European Journal of Neurology. 24, 8, p. 1071-1076 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cross Sectional Study 100%
  • Blindness 100%
  • Degenerative Disease 100%
  • Neurodegenerative Disorder 100%
  • Phase IV 66%

• Mild cognitive impairment as a risk factor for Parkinson's disease dementia

  MDS Study Group “Validation of Mild Cognitive Impairment in Parkinson Disease”, Jul 2017, In: Movement Disorders. 32, 7, p. 1056-1065 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Dementia 100%
  • Parkinson Disease 100%
  • Mild Cognitive Impairment 100%
  • Predictive Validity 33%
  • Motor Dysfunction 22%

• Stability of mild cognitive impairment in newly diagnosed Parkinson's disease

  ICICLE-PD study group, Lawson, R. A., Yarnall, A. J., Duncan, G. W., Breen, D. P., Khoo, T. K., Williams-Gray, C. H., Barker, R. A. & Burn, D. J., 1 Mar 2017, In: Journal of Neurology, Neurosurgery & Psychiatry.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Parkinson's Disease 100%
  • Mild Cognitive Impairment 100%
  • Cognition 44%
  • Dementia 11%
  • Neuropsychological Assessment 11%

• Anxiety is associated with cognitive impairment in newly-diagnosed Parkinson's disease

  ICICLE-PD study group, Dissanayaka, N. N. W., Lawson, R. A., Yarnall, A. J., Duncan, G. W., Breen, D. P., Khoo, T. K., Barker, R. A. & Burn, D. J., Mar 2017, In: Parkinsonism & Related Disorders. 36, p. 63-68 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cognitive Disorders 100%
  • Parkinson's Disease 100%
  • Anxiety 100%
  • Cognitive Impairment 100%
  • Memory Disorder 4%

• Neuroendocrine abnormalities in Parkinson's disease

  De Pablo-Fernández, E., Breen, D. P., Bouloux, P. M., Barker, R. A., Foltynie, T. & Warner, T. T., Feb 2017, In: Journal of Neurology, Neurosurgery & Psychiatry. 88, 2, p. 176-185 10 p.

  Research output: Contribution to journal › Review article › peer-review

  • Parkinson's Disease 100%
  • Neuroprotective Agent 33%
  • Development 33%
  • Glucose 16%
  • Melatonin 16%

• Tracking the course of prodromal Parkinson's disease

  Breen, D. P. & Lang, A. E., Feb 2017, In: Brain. 140, 2, p. 259-262 4 p.

  Research output: Contribution to journal › Article › peer-review

• A hill walker with long chains

  Breen, D. P., Stinton, V. & De Silva, R. N., Jan 2017, In: Practical Neurology. 17, 1, p. 71-73 3 p.

  Research output: Contribution to journal › Article › peer-review

• Exploiting the aggregation properties of alpha-synuclein for diagnostic purposes

  Breen, D. P. & Kalia, L. V., Jan 2017, In: Movement Disorders. 32, 1, p. 106

  Research output: Contribution to journal › Article › peer-review
• 2016

  Specifically neuropathic Gaucher's mutations accelerate cognitive decline in Parkinson's

  International Genetics of Parkinson Disease Progression (IGPP) Consortium, Nov 2016, In: Annals of Neurology. 80, 5, p. 674-685 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  • Glucosylceramidase 100%
  • Gene 83%
  • Parkinson's Disease 66%
  • Valerian 16%
  • Cognitive Disorders 16%