Research output per year
Research output per year
- 1 - 50 out of 149 results
Search results
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2025
Clearance of protein aggregates during cell division
Du, S., Wang, Y., Chen, B., Xie, S., Chan, K. Y., Hay, D. & Chew, T. G., 6 Jun 2025, In: eLIFE.Research output: Contribution to journal › Article › peer-review
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Genome editing of TXNIP in human pluripotent stem cells for the generation of hepatocyte-like cells and insulin-producing islet-like aggregates
Traini, L., Negueruela, J., Elvira, B., St-Pierre-Wijckmans, W., Vandenbempt, V., Buss, C., Li, A., Perez-Chavez, I., Ribeiro-Costa, F., Nunes, M., Messens, J., Ezeriņa, D., Hay, D. C., Bansal, M. & Gurzov, E. N., 4 May 2025, In: Stem Cell Research and Therapy. 16, 225.Research output: Contribution to journal › Article › peer-review
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Modeling Human Liver Steatosis in Induced Pluripotent Stem Cell-Derived Liver Spheres
Kasarinaite, A. & Hay, D. C., 1 May 2025, In: Methods in molecular biology (Clifton, N.J.). 2924, p. 145-161 17 p.Research output: Contribution to journal › Article › peer-review
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Linking epidemiology and genomics of maternal smoking during pregnancy in utero and in aging: a population-based study using human foetuses and the UK Biobank cohort
Mihov, M., Shoctor, H., Douglas, A., Hay, D. C., O’Shaughnessy, P. J., Iredale, J. P., Shaw, S., Fowler, P. A. & Grassmann, F., 12 Mar 2025, (E-pub ahead of print) In: EBioMedicine.Research output: Contribution to journal › Article › peer-review
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Hormone correction of dysfunctional metabolic gene expression in stem cell-derived liver tissue
Kasarinaite, A., Mateos Jimenez, M., Sierra Beltran, M., Sutherland, E., Arede Rei, P., Zhao, M., Chi, Y., Beniazza, M., Corsinotti, A., Kendall, T. J., Henderson, N. C., Fallowfield, J. A., Saunders, P. T. K. & Hay, D., 11 Mar 2025, In: Stem Cell Research and Therapy. 16, 1, 130.Research output: Contribution to journal › Article › peer-review
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Combining transcriptomic and metabolomic insights to guide the clinical application of adipose- and bone marrow-derived mesenchymal stem cells
Zhou, W., Lin, J., Hay, D. C., Yao, X. & Ouyang, H., 25 Feb 2025, In: Medical review (2021). 5, 1, p. 76-82 7 p.Research output: Contribution to journal › Article › peer-review
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Single-cell morphological tracking of cell states to identify small-molecule modulators of liver differentiation
Graham, R., Zeng, R., Wagner, J., Unciti-Broceta, A., Hay, D., Forbes, S. J., Gadd, V. & Carragher, N. O., 21 Feb 2025, In: iScience. 28, 2, 111871.Research output: Contribution to journal › Article › peer-review
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Standard Protocols for Characterising Primary and In Vitro-Generated Human Hepatocytes
Heydari, Z., Gramignoli, R., Piryaei, A., Zahmatkesh, E., Pooyan, P., Seydi, H., Nussler, A., Szkolnicka, D., Rashidi, H., Najimi, M., Hay, D. C. & Vosough, M., 5 Feb 2025, In: Journal of Cellular and Molecular Medicine. 29, 3, p. e70390Research output: Contribution to journal › Review article › peer-review
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Therapeutic potential of stem cell-derived somatic cells to treat metabolic dysfunction–associated steatotic liver disease and diabetes
Gilglioni, E. H., Bansal, M., St Pierre-Wijckmans, W., Talamantes, S., Kasarinaite, A., Hay, D. C. & Gurzov, E. N., 17 Jan 2025, (E-pub ahead of print) In: Obesity Reviews.Research output: Contribution to journal › Review article › peer-review
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2024
PTPRK regulates glycolysis and de novo lipogenesis to promote hepatocyte metabolic reprogramming in obesity
Gilglioni, E. H., Li, A., St-Pierre-Wijckmans, W., Shen, T.-K., Pérez-Chávez, I., Hovhannisyan, G., Lisjak, M., Negueruela, J., Vandenbempt, V., Bauzá-Martinez, J., Herranz, J. M., Ezeriņa, D., Demine, S., Feng, Z., Vignane, T., Otero Sanchez, L., Lambertucci, F., Prašnická, A., Devière, J. & Hay, D. C. & 8 others, , 4 Nov 2024, In: Nature Communications. 15, 9522.Research output: Contribution to journal › Article › peer-review
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Screening a compound library to identify additives which boost cytochrome P450 enzyme function in vascularised liver spheres
Lucendo-Villarin, B., Wang, C., Mallanna, S. K., Kimbrel, E. & Hay, D. C., 22 Sept 2024, In: Cells. 13, 18, 1594.Research output: Contribution to journal › Article › peer-review
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Chemically programmed metabolism drives a superior cell fitness for cartilage regeneration
Chen, Y., Yan, Y., Tian, R., Sheng, Z., Li, L., Chen, J., Liao, Y., Wen, Y., Lu, J., Liu, X., Sun, W., Wu, H., Liao, Y., Zhang, X., Chen, X., An, C., Zhao, K., Liu, W., Gao, J. & Hay, D. C. & 1 others, , 11 Sept 2024, In: Science Advances. 10, 37Research output: Contribution to journal › Article › peer-review
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Revolutionizing Drug Discovery: The Impact of Distinct Designs and Biosensor Integration in Microfluidics-Based Organ-on-a-Chip Technology
Yuan, S., Yuan, H., Hay, D. C., Hu, H. & Wang, C., 30 Aug 2024, In: Biosensors. 14, 9, 425.Research output: Contribution to journal › Review article › peer-review
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Early interferon lambda production is induced by double-stranded RNA in iPS-derived hepatocyte-like cells
Sularea, V. M., Sharma, R., Hay, D. C. & O'Farrelly, C., 6 Jun 2024, In: Oxford Open Immunology. 5, 1, iqae004.Research output: Contribution to journal › Article › peer-review
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In-utero exposures to per- and polyfluoroalkyl substances and the human fetal liver metabolome: a cross-sectional study
Hyötyläinen, T., McGlinchey, A., Salihovic, S., Schubert, A., Douglas, A., Hay, D. C., O'Shaughnessy, P. J., Iredale, J. P., Shaw, S., Fowler, P. A. & Orešič, M., 9 Jan 2024, In: The Lancet Planetary Health. 8, 1Research output: Contribution to journal › Article › peer-review
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2023
Chemically cross-linked hydrogels from repetitive protein arrays
Boni, R., Blackburn, E. A., Kleinjan, D.-J., Jonaitis, M., Hewitt-Harris, F., Murdoch, M., Rosser, S., Hay, D. C. & Regan, L., 1 Sept 2023, In: Journal of Structural Biology. 215, 3, 8 p., 107981.Research output: Contribution to journal › Article › peer-review
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The Influence of Sex Hormones in Liver Function and Disease
Kasarinaite, A., Sinton, M., Saunders, P. T. K. & Hay, D. C., 11 Jun 2023, In: Cells. 12, 12Research output: Contribution to journal › Review article › peer-review
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2022
Identification of an FXR-modulated liver-intestine hybrid state in iPSC-derived hepatocyte-like cells
Nell, P., Kattler, K., Feuerborn, D., Hellwig, B., Rieck, A., Salhab, A., Lepikhov, K., Gasparoni, G., Thomitzek, A., Belgasmi, K., Bluthgen, N., Morkel, M., Kuppers-Munther, B., Godoy, P., Hay, D. C., Cadenas, C., Marchan, R., Vartak, N., Edlund, K. & Rahnenfuhrer, J. & 2 others, , 19 Jul 2022, In: Journal of Hepatology.Research output: Contribution to journal › Article › peer-review
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HIV- 1 lentivirus tethering to the genome is associated with transcription factor binding sites found in genes that favour virus survival.
Suleman, S., Payne, A., Bowden, J., Al Haque, S., Zahn, M., Fawaz, S., Khalifa, M., Jobling, S., Hay, D. C., Franco, M., Fronza, R., Wang, W., Strobel-Freidekind, O., Deichmann, A., Takeuchi, Y., Waddington, S., Gil-Farina, I., Schmidt, M. & Themis, M., 5 May 2022, (E-pub ahead of print) In: Gene Therapy.Research output: Contribution to journal › Article › peer-review
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Maternal over-the-counter analgesics use during pregnancy and adverse perinatal outcomes: Cohort study of 151,141 singleton pregnancies
Zafeiri, A., Raja, E., Mitchell, R. T., Hay, D. C., Bhattacharya, S. & Fowler, P. A., 3 May 2022, (E-pub ahead of print) In: BMJ Paediatrics Open.Research output: Contribution to journal › Article › peer-review
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Nuclear factor programming improves stem-cell-derived hepatocyte phenotype
Rashidi, H. & Hay, D. C., 1 May 2022, In: Cell Stem Cell.Research output: Contribution to journal › Article › peer-review
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Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease
Hallett, J., Ferreira-Gonzalez, S., Man, J., Kilpatrick, A., Esser, H., Thirwell, K., Macmillan, M., Rodrigo Torres, D., Dwyer, B., Gadd, V., Ashmore-Harris, C., Lu, W.-Y., Thomson, J., Jansen, M., O'Duibhir, E., Starkey Lewis, P., Campana, L., Aird, R., Bate, T. & Fraser, A. R. & 5 others, , 3 Mar 2022, In: Cell Stem Cell.Research output: Contribution to journal › Article › peer-review
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2021
Pluripotent Stem Cell-Derived Hepatocytes Inhibit T Cell Proliferation In Vitro through Tryptophan Starvation
Romano, M., Elgueta, R., McCluskey, D., Ortega-Prieto, A. M., Stolarczyk, E., Dazzi, F., Lucendo Villarin, B., Meseguer Ripolles, J., Williams, J., Fanelli, G., Hay, D. C., Watt, F. & Lombardi, G., 22 Dec 2021, In: Cells.Research output: Contribution to journal › Article › peer-review
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Dimethyl fumarate reduces hepatocyte senescence following paracetamol exposure
Meseguer Ripolles, J., Lucendo Villarin, B., Tucker, C., Ferreira-Gonzalez, S., Homer, N. Z. M., Wang, Y., Starkey Lewis, P., Toledo Maldonado, E., Mellado-Gomez, E., Simpson, J., Flint, O., Jaiswal, H., Beer, N. L., Karlsen, A. E., Forbes, S. J., Dear, J. W., Hughes, J. & Hay, D. C., 19 May 2021, In: iScience.Research output: Contribution to journal › Article › peer-review
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Protocol for automated production of human stem cell derived liver spheres
Meseguer Ripolles, J., Kasarinaite, A., Lucendo Villarin, B. & Hay, D. C., 30 Apr 2021, (E-pub ahead of print) In: Star Protocols.Research output: Contribution to journal › Article › peer-review
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Modelling human hepatic steatosis in pluripotent stem cell-derived hepatocytes
Sinton, M., Meseguer Ripolles, J., Lucendo Villarin, B., Drake, A. J. & Hay, D. C., 21 Apr 2021, (E-pub ahead of print) In: Star Protocols.Research output: Contribution to journal › Article › peer-review
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Mathematical modelling of oxygen gradients in stem cell-derived liver tissue
Leedale, J., Lucendo-Villarin, B., Meseguer Ripolles, J., Kasarinaite, A., Webb, S. D. & Hay, D. C., 8 Feb 2021, In: PLoS ONE. 16, 2, 16 p., e0244070.Research output: Contribution to journal › Article › peer-review
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A human pluripotent stem cell model for the analysis of metabolic dysfunction in hepatic steatosis
Sinton, M. C., Meseguer-Ripolles, J., Lucendo-Villarin, B., Wernig-Zorc, S., Thomson, J. P., Carter, R. N., Lyall, M. J., Walker, P. D., Thakker, A., Meehan, R. R., Lavery, G. G., Morton, N. M., Ludwig, C., Tennant, D. A., Hay, D. C. & Drake, A. J., 22 Jan 2021, In: iScience. 24, 1, 101931.Research output: Contribution to journal › Article › peer-review
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2020
Genome-wide expression changes induced by bisphenol A, F and S in human stem cell derived hepatocyte-like cells
Lucendo Villarin, B., Nell, P., Hellwig, B., Filis, P., Feuerborn, D., O'Shaughnessy, P. J., Godoy, P., Rahnenfuhrer, J., Hengstler, J. G., Cherianidou, A., Sachinidis, A., Fowler, P. A. & Hay, D. C., 4 Nov 2020, In: EXCLI. 19Research output: Contribution to journal › Article › peer-review
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Over-the-counter analgesics during pregnancy: a comprehensive review of global prevalence and offspring safety
Zafeiri, A., Mitchell, R. T., Hay, D. C. & Fowler, P., 29 Oct 2020, In: Human Reproduction Update.Research output: Contribution to journal › Article › peer-review
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Development of a cost effective automated platform to produce human liver spheroids for basic and applied research
Lucendo-Villarin, B., Meseguer Ripolles, J., Drew, J., Fisher, L., Ma, E., Flint, O., Simpson, K. J., Machesky, L. M., Mountford, J. C. & Hay, D. C., 28 Oct 2020, (E-pub ahead of print) In: Biofabrication. 13, 1, 015009.Research output: Contribution to journal › Article › peer-review
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Human PSC-derived hepatocytes express low levels of viral pathogen recognition receptors, but are capable of mounting an effective innate immune response
Fischer, L., Lucendo Villarin, B., Hay, D. & O'Farrelly, C., 28 May 2020, In: International Journal of Molecular Sciences. 21, 11, 18 p., 3831.Research output: Contribution to journal › Article › peer-review
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Hepatic Progenitor Specification from Pluripotent Stem Cells Using a Defined Differentiation System
Meseguer Ripolles, J., Wang, Y., Sorteberg, A., Sharma, A., Ding, N.-L., Lucendo Villarin, B., Krämer, P., Segeritz, C.-P. & Hay, D., 10 May 2020, In: Journal of Visualized Experiments (JoVE). 159, 8 p., e61256 .Research output: Contribution to journal › Article › peer-review
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Introducing Point Mutations into Human Pluripotent Stem Cells using Seamless Genome Editing
Wang, Y., Smith, A. & Hay, D., 10 May 2020, In: Journal of Visualized Experiments (JoVE).Research output: Contribution to journal › Article › peer-review
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Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease
Campos, G., Schmidt-Heck, W., De Smedt, J., Widera, A., Ghallab, A., Pütter, L., González, D., Edlund, K., Cadenas, C., Marchan, R., Guthke, R., Verfaillie, C., Hetz, C., Sachinidis, A., Braeuning, A., Schwarz, M., Weiß, T. S., Banhart, B. K., Hoek, J. & Vadigepalli, R. & 5 others, , 9 Jan 2020, In: Archives of toxicology. 94, p. 205–217Research output: Contribution to journal › Article › peer-review
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2019
Liver biopsy derived induced pluripotent stem cells provide unlimited supply for the generation of hepatocyte-like cells
Calabrese, D., Roma, G., Bergling, S., Carbone, W., Mele, V., Nuciforo, S., Fofana, I., Campana, B., Szkolnicka, D., Hay, D., Tchorz, J., Bouwmeester, T., Wieland, S. & Heim, M. H., 29 Aug 2019, In: PLoS ONE.Research output: Contribution to journal › Article › peer-review
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Serum Free Production of Three-Dimensional Human Hepatospheres from Pluripotent Stem Cells
Lucendo-villarin, B., Rashidi, H., Alhaque, S., Fischer, L., Meseguer-ripolles, J., Wang, Y., O'farrelly, C., Themis, M. & Hay, D. C., 20 Jul 2019, In: Journal of Visualized Experiments (JoVE). 149Research output: Contribution to journal › Article › peer-review
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Metabolic control of gene transcription in non-alcoholic fatty liver disease: the role of the epigenome
Sinton, M., Hay, D. & Drake, A., 18 Jul 2019, In: Clinical Epigenetics. 11, 104.Research output: Contribution to journal › Article › peer-review
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Multiomics analyses of HNF4a protein domain function during human pluripotent stem cell differentiation
Wang, Y., Tatham, M. H., Schmidt-Heck, W., Swann, C., Singh Dolt, K., Meseguer Ripolles, J., Lucendo-Villarin, B., Kunath, T., Rudd, T. R., Smith, A., Hengstler, J. G., Godoy, P. & Hay, D. C., 24 May 2019, In: iScience.Research output: Contribution to journal › Article › peer-review
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Blended electrospinning with human liver extracellular matrix for engineering new hepatic microenvironments
Grant, R., Hallett, J., Forbes, S., Hay, D. & Callanan, A., 18 Apr 2019, In: Scientific Reports. 9, 6293.Research output: Contribution to journal › Article › peer-review
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The Hippo Pathway Regulates Caveolae Expression and Mediates Flow Response via Caveolae
Rausch, V., Bostrom, J. R., Park, J., Bravo, I. R., Feng, Y., Hay, D. C., Link, B. A. & Hansen, C. G., 21 Jan 2019, In: Current Biology. 29, 2, p. 242-255.e6 20 p.Research output: Contribution to journal › Article › peer-review
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3D Tissue Models for Toxicology
Skeldon G, Hay DC and Shu W, 3 Jan 2019, Biofabrication and 3D Tissue Modeling. Royal Society of ChemistryResearch output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review
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2018
Combining stem cell-derived hepatocytes with impedance sensing to better predict human drug toxicity
Zhou, W., Graham, K., Lucendo-Villarin, B., Flint, O., Hay, D. & Bagnaninchi, P., 20 Dec 2018, (E-pub ahead of print) In: Expert Opinion on Drug Metabolism and Toxicology.Research output: Contribution to journal › Article › peer-review
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Methylcellulose as a scaffold in the culture of liver-organoids for the potential of treating acute live failure
Chandrashekran, A., Mitry, R. R., Prema-chandra, T., Starling, C., Lehec, S., Iansante, V., Fitzpatrick, E., Filippi, C., Deheragoda, M., Hay, D. & Dhawan, A., 18 Dec 2018, In: Cell and Gene Therapy Insights. 4, 11, p. 1087-1103Research output: Contribution to journal › Article › peer-review
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Science-based assessment of source materials for cell-based medicines: report of a stakeholders workshop
Stacey, G., Andrews, P., Asante, C., Barbaric, I., Barry, J., Bisset, L., Braybrook, J., Buckle, R., Chandra, A., Coffey, P., Crouch, S., Driver, P., Evans, A., Gardner, J., Ginty, P., Goldring, C., Hay, D. C., Healy, L., Hows, A. & Hutchinson, C. & 24 others, , 1 Dec 2018, In: Regenerative medicine. 13, 8, p. 935-944Research output: Contribution to journal › Article › peer-review
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3D human liver tissue from pluripotent stem cells displays stable phenotype in vitro and supports compromised liver function in vivo
Rashidi, H., Luu, N.-T., Alwahsh, S. M., Ginai, M., Alhaque, S., Dong, H., Tomaz, R. A., Vernay, B., Vigneswara, V., Hallett, J. M., Chandrashekran, A., Dhawan, A., Vallier, L., Bradley, M., Callanan, A., Forbes, S. J., Newsome, P. N. & Hay, D. C., Oct 2018, In: Archives of toxicology. 92, 10, p. 3117–3129Research output: Contribution to journal › Article › peer-review
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Semi-automated Production of Hepatocyte like Cells from Pluripotent Stem Cells
Meseguer ripollés, J., Lucendo-Villarin, B., Wang, Y. & Hay, D., 27 Jul 2018, In: Journal of Visualized Experiments (JoVE). 137, e57995.Research output: Contribution to journal › Article › peer-review
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A human iPSC line capable of differentiating into functional macrophages expressing ZsGreen: a tool for the study and in vivo tracking of therapeutic cells
Lopez-yrigoyen, M., Fidanza, A., Cassetta, L., Axton, R. A., Taylor, A. H., Meseguer-ripolles, J., Tsakiridis, A., Wilson, V., Hay, D. C., Pollard, J. W. & Forrester, L. M., 5 Jul 2018, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 373, 1750, 9 p., 20170219.Research output: Contribution to journal › Article › peer-review
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Designer human tissue: Coming to a lab near you
Hay, D. & O'Farrelly, C., 5 Jul 2018, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 373, 1750Research output: Contribution to journal › Article › peer-review
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From scaffold to structure: the synthetic production of cell derived extracellular matrix for liver tissue engineering
Grant, R., Hay, D. & Callanan, A., 12 Jun 2018, (E-pub ahead of print) In: Biomedical Physics & Engineering Express.Research output: Contribution to journal › Article › peer-review
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