David Wyllie

PROF

Personal Chair of Ion Channel Physiology and Pharmacology, Deanery of Biomedical Sciences
Director, Centre for Discovery Brain Sciences
Euan MacDonald Centre for Motor Neurone Disease Research
Edinburgh Neuroscience

https://orcid.org/0000-0002-4957-6049

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Personal profile

Education/Academic qualification

Doctor of Philosophy (PhD), University of London

Award Date: 1 Jan 1992

Bachelor of Science, University of Glasgow

Award Date: 1 Jan 1988

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87 Article
3 Poster
3 Comment/debate
2 Abstract
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Altered network properties in C9ORF72 repeat expansion cortical neurons are due to synaptic dysfunction
Perkins, E. M., Burr, K., Banerjee, P., Mehta, A. R., Dando, O., Selvaraj, B., Suminaite, D., Nanda, J., Henstridge, C. M., Gillingwater, T. H., Hardingham, G. E., Wyllie, D. J. A., Chandran, S. & Livesey, M. R., 4 Mar 2021, In: Molecular Neurodegeneration. 16, 1
Research output: Contribution to journal › Article › peer-review

Open Access
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Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns
Das Sharma, S., Pal, R., Reddy, B. K., Thangaraj Selvaraj, B., Raj, N., Samaga, K. K., Srinivasan, D. J., Ornelas, L., Sareen, D., Livesey, M., Bassell, G. J., Svendsen, C. N., Kind, P., Chandran, S., Chattarji, S. & Wyllie, D., 19 Jun 2020, In: Molecular Autism.
Research output: Contribution to journal › Article › peer-review

Open Access
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Input-output relationship of CA1 pyramidal neurons reveals intact homeostatic mechanisms in a mouse model of Fragile X Syndrome
Booker, S., Simões De Oliveira, L., Anstey, N., Kozic, Z., Dando, O., Jackson, A., Baxter, P., Isom, L. L., Sherman, D., Hardingham, G., Brophy, P., Wyllie, D. & Kind, P., 11 Aug 2020, In: Cell Reports.
Research output: Contribution to journal › Article › peer-review

Open Access
File
Altered dendritic spine function and integration in a mouse model of fragile X syndrome
Booker, S. A., Domanski, A. P. F., Dando, O. R., Jackson, A. D., Isaac, J. T. R., Hardingham, G. E., Wyllie, D. J. A. & Kind, P. C., 23 Oct 2019, In: Nature Communications. 10, 14 p., 4813.
Research output: Contribution to journal › Article › peer-review

Open Access
File
Cellular and synaptic phenotypes lead to disrupted information processing in Fmr1-KO mouse layer 4 barrel cortex
Domanski, A. P. F., Booker, S. A., Wyllie, D. J. A., Isaac, J. T. R. & Kind, P. C., 23 Oct 2019, In: Nature Communications. 10, 18 p., 4814.
Research output: Contribution to journal › Article › peer-review

Open Access
File

19 Finished

GluN2A haploinsufficiency: a novel pre-clinical model of epilepsy
Wyllie, D., Hardingham, G., Kind, P. & Marwick, K.
UK-based charities
13/03/17 → 30/09/19
Project: Research
The role of the GluN2A NMDAR subunit in determining synaptic function and plasticity
Wyllie, D., Hardingham, G., Kind, P. & Wood, E.
BBSRC
1/10/16 → 31/07/19
Project: Research
The role of the GluN2A NMDAR subunit in determining synaptic function and plasticity
Wyllie, D., Hardingham, G., Kind, P. & Wood, E.
BBSRC
1/10/16 → 31/07/19
Project: Research
MICA: Correction of behavioural, circuit and cellular deficits in rat models of ID/ASD
Kind, P., Wood, E. & Wyllie, D.
MRC
1/09/16 → 28/02/21
Project: Research
Understanding and rescuing core deficits underlying CDKL5
Kind, P., Cousin, M., Hardingham, G. & Wyllie, D.
Other
1/11/15 → 31/10/20
Project: Research