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Personal profile

Biography

Dr Bogaert joined the Centre for Inflammation Research in September 2016. She worked since 2008 as a physician scientist at the Department of Pediatric Immunology of the UMC Utrecht, The Netherlands. There she initiated several ecological studies of the upper respiratory tract microbiome in relation to pathogenesis and prevention of respiratory infections. A Veni and Vidi career grant (NWO) and Top grant (ZonMW) have lead to the validation and adaptation of a metagenomic pipeline for analysis of low-density respiratory microbiota, the set-up of applied bio-informatic methods and the first analyses of environmental effects on such microbiota including mode of delivery, breastfeeding and outcome. Furthermore, she participates in and facilitates microbiological and immunological research projects linked to clinical studies.

In the past she worked from 2006 to 2008 as a postdoctoral fellow (Professor M Lipsitch and Professor R Malley, Harvard School of Public Health/Boston Children’s Hospital) where she executed in vitro and animal studies on susceptibility of infants to pneumococcal colonization and infection, with specific emphasis on host-immunity.

She obtained her PhD degree cum laude from the Erasmus University in Rotterdam, Netherlands (Supervisors: Professor R de Groot, Professor P Hermans, 1999-2004), for her studies on pathogenesis of pneumococcal infections, focusing on (molecular) epidemiology of bacterial colonization of the upper respiratory tract. Amongst others, she was one of the first to obtain epidemiological evidence for in vivo bacterial interactions occuring at the nasopharyngeal niche.

In parallel, she was also trained as a pediatrician at the Sophia Children's Hospital in Rotterdam, obtaining her license in 2006. She obtained her licence as Paediatric Infectious Diseases and Immunology Specialist at the Wilhelmina Children’s Hospital, Utrecht in 2014.

Qualifications

MD, PhD

Research Interests

 

My research group has a major focus on investigating the physiology and pathophysiology of respiratory infections and inflammation from an ecological perspective, with the ultimate goal to design new or improved treatment and preventive measures for respiratory infections in susceptible populations. To this purpose, the team uses a fully translational approach, combing epidemiological, molecular microbiological, immunological and systems biology approaches to answer their research questions. Moreover, we execute mechanistic studies in vitro and in vivo. She still has a research team in Utrecht, the Netherlands, working on continuation of several birth cohorts and clinical studies.

 

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  • Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission

    Relph, K. A., Russell, C. D., Fairfield, C. J., Turtle, L., De Silva, T., Siggins, M. K., Drake, T. M., Thwaites, R. S., Abrams, S., Moore, S. C., Hardwick, H. E., Oosthuyzen, W., Harrison, E. M., Docherty, A. B., Openshaw, P. J. M., Baillie, J. K., Semple, M. G., Ho, A., Baillie, J. K., Semple, M. G. & 348 others, Openshaw, P. J. M., Carson, G., Alex, B., Bach, B., Barclay, W. S., Bogaert, D., Chand, M., Cooke, G. S., Docherty, A. B., Dunning, J., Filipe, A. D. S., Fletcher, T., Green, C. A., Harrison, E. M., Hiscox, J. A., Ho, A. Y. W., Horby, P. W., Ijaz, S., Khoo, S., Klenerman, P., Law, A., Lim, W. S., Mentzer, A. J., Merson, L., Meynert, A. M., Noursadeghi, M., Moore, S. C., Palmarini, M., Paxton, W. A., Pollakis, G., Price, N., Rambaut, A., Robertson, D. L., Russell, C. D., Sancho-shimizu, V., Scott, J. T., De Silva, T., Sigfrid, L., Solomon, T., Sriskandan, S., Stuart, D., Summers, C., Tedder, R. S., Thomson, E. C., Roger Thompson, A. A., Thwaites, R. S., Turtle, L. C. W., Gupta, R. K., Zambon, M., Hardwick, H., Donohue, C., Lyons, R., Griffiths, F., Oosthuyzen, W., Norman, L., Pius, R., Drake, T. M., Fairfield, C. J., Knight, S. R., Mclean, K. A., Murphy, D., Shaw, C. A., Dalton, J., Girvan, M., Saviciute, E., Roberts, S., Harrison, J., Marsh, L., Connor, M., Halpin, S., Jackson, C., Gamble, C., Leeming, G., Law, A., Wham, M., Clohisey, S., Hendry, R., Scott-brown, J., Greenhalf, W., Shaw, V., Mcdonald, S., Keating, S., Ahmed, K. A., Armstrong, J. A., Ashworth, M., Asiimwe, I. G., Bakshi, S., Barlow, S. L., Booth, L., Brennan, B., Bullock, K., Catterall, B. W. A., Clark, J. J., Clarke, E. A., Cole, S., Cooper, L., Cox, H., Davis, C., Dincarslan, O., Dunn, C., Dyer, P., Elliott, A., Evans, A., Finch, L., Fisher, L. W. S., Foster, T., Garcia-dorival, I., Greenhalf, W., Gunning, P., Hartley, C., Jensen, R. L., Jones, C. B., Jones, T. R., Khandaker, S., King, K., Kiy, R. T., Koukorava, C., Lake, A., Lant, S., Latawiec, D., Lavelle-langham, L., Lefteri, D., Lett, L., Livoti, L. A., Mancini, M., Mcdonald, S., Mcevoy, L., Mclauchlan, J., Metelmann, S., Miah, N. S., Middleton, J., Mitchell, J., Moore, S. C., Murphy, E. G., Penrice-randal, R., Pilgrim, J., Prince, T., Reynolds, W., Matthew Ridley, P., Sales, D., Shaw, V. E., Shears, R. K., Small, B., Subramaniam, K. S., Szemiel, A., Taggart, A., Tanianis-hughes, J., Thomas, J., Trochu, E., Van Tonder, L., Wilcock, E., Eunice Zhang, J., Flaherty, L., Maziere, N., Cass, E., Doce Carracedo, A., Carlucci, N., Holmes, A., Massey, H., Murphy, L., Wrobel, N., Mccafferty, S., Morrice, K., Maclean, A., Adeniji, K., Agranoff, D., Agwuh, K., Ail, D., Aldera, E. L., Alegria, A., Angus, B., Ashish, A., Atkinson, D., Bari, S., Barlow, G., Barnass, S., Barrett, N., Bassford, C., Basude, S., Baxter, D., Beadsworth, M., Bernatoniene, J., Berridge, J., Best, N., Bothma, P., Chadwick, D., Brittain-long, R., Bulteel, N., Burden, T., Burtenshaw, A., Caruth, V., Chadwick, D., Chambler, D., Chee, N., Child, J., Chukkambotla, S., Clark, T., Collini, P., Cosgrove, C., Cupitt, J., Cutino-moguel, M., Dark, P., Dawson, C., Dervisevic, S., Donnison, P., Douthwaite, S., Durand, I., Dushianthan, A., Dyer, T., Evans, C., Eziefula, C., Fegan, C., Finn, A., Fullerton, D., Garg, S., Garg, S., Garg, A., Gkrania-klotsas, E., Godden, J., Goldsmith, A., Graham, C., Hardy, E., Hartshorn, S., Harvey, D., Havalda, P., Hawcutt, D. B., Hobrok, M., Hodgson, L., Hormis, A., Jacobs, M., Jain, S., Jennings, P., Kaliappan, A., Kasipandian, V., Kegg, S., Kelsey, M., Kendall, J., Kerrison, C., Kerslake, I., Koch, O., Koduri, G., Koshy, G., Laha, S., Laird, S., Larkin, S., Leiner, T., Lillie, P., Limb, J., Linnett, V., Little, J., Lyttle, M., Macmahon, M., Macnaughton, E., Mankregod, R., Masson, H., Matovu, E., Mccullough, K., Mcewen, R., Meda, M., Mills, G., Minton, J., Mirfenderesky, M., Mohandas, K., Mok, Q., Moon, J., Moore, E., Morgan, P., Morris, C., Mortimore, K., Moses, S., Mpenge, M., Mulla, R., Murphy, M., Nagel, M., Nagarajan, T., Nelson, M., O’shea, M. K., Otahal, I., Ostermann, M., Pais, M., Panchatsharam, S., Papakonstantinou, D., Paraiso, H., Patel, B., Pattison, N., Pepperell, J., Peters, M., Phull, M., Pintus, S., Pooni, J. S., Post, F., Price, D., Prout, R., Rae, N., Reschreiter, H., Reynolds, T., Richardson, N., Roberts, M., Roberts, D., Rose, A., Rousseau, G., Ryan, B., Saluja, T., Shah, A., Shanmuga, P., Sharma, A., Shawcross, A., Sizer, J., Shankar-hari, M., Smith, R., Snelson, C., Spittle, N., Staines, N., Stambach, T., Stewart, R., Subudhi, P., Szakmany, T., Tatham, K., Thomas, J., Thompson, C., Thompson, R., Tridente, A., Tupper-carey, D., Twagira, M., Ustianowski, A., Vallotton, N., Vincent-smith, L., Visuvanathan, S., Vuylsteke, A., Waddy, S., Wake, R., Walden, A., Welters, I., Whitehouse, T., Whittaker, P., Whittington, A., Papineni, P., Wijesinghe, M., Williams, M., Wilson, L., Cole, S., Winchester, S., Wiselka, M., Wolverson, A., Wootton, D. G., Workman, A., Yates, B. & Young, P., 1 May 2022, In: Open forum infectious diseases. 9, 5

    Research output: Contribution to journalArticlepeer-review

    Open Access
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  • General factors of white matter microstructure from DTI and NODDI in the developing brain

    Vaher, K., Galdi, P., Cabez, M. B., Sullivan, G., Stoye, D. Q., Quigley, A. J., Thrippleton, M. J., Bogaert, D., Bastin, M. E., Cox, S. R. & Boardman, J. P., 1 Apr 2022, (E-pub ahead of print) In: NeuroImage. p. 119169

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • Gut microbiota-derived metabolite Trimethylamine-N-oxide (TMAO) and multiple health outcomes: an umbrella review and updated meta-analysis

    Li, D., Lu, Y., Yuan, S., Cai, X., He, Y., Chen, J., Wu, Q., He, D., Fang, A., Bo, Y., Song, P., Bogaert, D., Tsilidis, K. K., Larsson, S. C., Yu, H., Zhu, H., Theodoratou, E., Zhu, Y. & Li, X., 28 Mar 2022, (E-pub ahead of print) In: American Journal of Clinical Nutrition.

    Research output: Contribution to journalArticlepeer-review

    Open Access
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  • A systematic review of microbial markers for risk prediction of colorectal neoplasia

    Yu, L., Zhao, G., Wang, L., Zhou, X., Sun, J., Li, X., Zhu, Y., He, Y., Kofonikolas, K., Bogaert, D., Dunlop, M., Zhu, Y., Theodoratou, E. & Li, X., 15 Mar 2022, (E-pub ahead of print) In: British Journal of Cancer.

    Research output: Contribution to journalArticlepeer-review

    Open Access
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  • Effects of early-life antibiotics on the developing infant gut microbiome and resistome: a randomized trial

    Reyman, M., Van Houten, M. A., Watson, R. L., Chu, M. L. J. N., Arp, K., De Waal, W. J., Schiering, I., Plötz, F. B., Willems, R. J. L., Van Schaik, W., Sanders, E. A. M. & Bogaert, D., 16 Feb 2022, In: Nature Communications. 13, 1, 893.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    File