Denis Headon

2024

Novel Aspects in Pattern Formation Arise from Coupling Turing Reaction-Diffusion and Chemotaxis

Fraga Delfino Kunz, C., Gerisch, A., Glover, J., Headon, D., Painter, K. J. & Matthäus, F., Jan 2024, In: Bulletin of Mathematical Biology. 86, 1, p. 1-37 37 p., 4.

Research output: Contribution to journal › Article › peer-review

Open Access

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2023

GWASs Identify Genetic Loci Associated with Human Scalp Hair Whorl Direction

Luo, J., Huang, H., Qiao, H., Tan, J., Chen, W., Zhang, M., Ruiz-Linares, A., Wang, J., Yang, Y., Jin, L., Headon, D. J. & Wang, S., Oct 2023, In: Journal of Investigative Dermatology. 143, 10, p. 2065-2068.e10 14 p.

Research output: Contribution to journal › Letter › peer-review

Open Access

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Rapid mechanosensitive migration and dispersal of newly divided mesenchymal cells aid their recruitment into dermal condensates

Riddell, J., Noureen, S. R., Sedda, L., Glover, J. D., Ho, W. K. W., Bain, C. A., Berbeglia, A., Brown, H., Anderson, C., Chen, Y., Crichton, M. L., Yates, C. A., Mort, R. L. & Headon, D. J., Sept 2023, In: PLoS Biology. 21, 9, p. 1-21 21 p., e3002316.

Research output: Contribution to journal › Article › peer-review

Open Access

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The Developmental Basis of Fingerprint Pattern Formation and Variation

Glover, J., Sudderick, Z., Shih, B., Batho-Samblas, C., Charlton, L., Krause, A. L., Anderson, C., Riddell, J., Balic, A., Li, J., Klika, V., Woolley, T. E., Gaffney, E. A., Corsinotti, A., Anderson, R. A., Johnston, L., Brown, S., Wang, S., Chen, Y., Crichton, M. L., & 1 othersHeadon, D., 2 Mar 2023, In: Cell. 186, p. 1-17

Research output: Contribution to journal › Article › peer-review

Open Access

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2022

The Enrichment of Specific Hair Follicle-Associated Cell Populations in Plucked Hairs Offers an Opportunity to Study Gene Expression Underlying Hair Traits

Naboulsi, R., Cieślak, J., Headon, D., Jouni, A., Negro, J. J., Andersson, G. & Lindgren, G., 29 Dec 2022, (E-pub ahead of print) In: International Journal of Molecular Sciences. 24, 1, p. 1-13

Research output: Contribution to journal › Article › peer-review

Open Access

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The EDA deficient mouse has Zymbal’s gland hypoplasia and acute otitis externa

Del-Pozo, J., Headon, D., Glover, J., Anvari Azar, A., Schuepbach-Mallepell, S., Bhutta, M. F., Maxwell, S., Milne, E., Schneider, P. & Cheeseman, M., 30 Mar 2022, In: Disease Models and Mechanisms. 15, 3, (2022) 15 (3) dmm 049034.

Research output: Contribution to journal › Article › peer-review

Open Access

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Limb development genes underlie variation in human fingerprint patterns

Li, J., Glover, J. D., Zhang, H., Peng, M., Tan, J., Mallick, C. B., Hou, D., Yang, Y., Wu, S., Liu, Y., Peng, Q., Zheng, S. C., Crosse, E. I., Medvinsky, A., Anderson, R. A., Brown, H., Yuan, Z., Zhou, S., Xu, Y., Kemp, J. P., & 26 othersHo, Y. Y. W., Loesch, D. Z., Wang, L., Li, Y., Tang, S., Wu, X., Walters, R. G., Lin, K., Meng, R., Lv, J., Chernus, J. M., Neiswanger, K., Feingold, E., Evans, D. M., Medland, S. E., Martin, N. G., Weinberg, S. M., Marazita, M. L., Chen, G., Chen, Z., Zhou, Y., Cheeseman, M., Wang, L., Jin, L., Headon, D. J. & Wang, S., 6 Jan 2022, In: Cell. 185, 1, p. 95-112.e18 95-112.e18.

Research output: Contribution to journal › Article › peer-review

Open Access

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2021

Systems for intricate patterning of the vertebrate anatomy

Painter, K. J., Ptashnyk, M. & Headon, D., 27 Dec 2021, (E-pub ahead of print) In: Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences. 379, 2213, 20200270.

Research output: Contribution to journal › Review article › peer-review

Open Access

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Elevated EDAR signalling promotes mammary gland tumourigenesis with squamous metaplasia

Williams, R., Jobling, S., Sims, A. H., Mou, C., Wilkinson, L., Collu, G. M., Streuli, C. H., Gilmore, A. P., Headon, D. J. & Brennan, K., 16 Dec 2021, (E-pub ahead of print) In: Oncogene.

Research output: Contribution to journal › Article › peer-review

Open Access

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A genome-wide association analysis for body weight at 35 days measured on 137,343 broiler chickens

Dadousis, C., Somavilla, A., Ilska, J., Johnsson, M., Batista, L., Mellanby, R., Headon, D., Gottardo, P., Whalen, A., Wilson, D., Dunn, I., Gorjanc, G., Kranis, A. & Hickey, J., 8 Sept 2021, (E-pub ahead of print) In: Genetics Selection Evolution. 53, 1, p. 70

Research output: Contribution to journal › Article › peer-review

Open Access

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Isolating Patterns in Open Reaction-Diffusion Systems

Krause, A. L., Klika, V., Maini, P. K., Headon, D. & Gaffney, E. A., 4 Jun 2021, In: Bulletin of Mathematical Biology. 83, 7, p. 82

Research output: Contribution to journal › Article › peer-review

Open Access

File

2020

Methods for the Administration of EDAR Pathway Modulators in Mice

Schuepbach-Mallepell, S., Kowalczyk-Quintas, C., Dick, A., Eslami, M., Vigolo, M., Headon, D. J., Cheeseman, M., Schneider, H. & Schneider, P., 14 Nov 2020, (E-pub ahead of print) In: Methods in molecular biology (Clifton, N.J.). 2248, p. 167-183 17 p.

Research output: Contribution to journal › Book/Film/Article review › peer-review

Characterisation of a second gain of function EDAR variant, encoding EDAR380R, in East Asia

Riddell, J., Basu Mallick, C., Jacobs, G. S., Schoenebeck, J. & Headon, D., 4 Jun 2020, (E-pub ahead of print) In: European Journal of Human Genetics.

Research output: Contribution to journal › Article › peer-review

Open Access

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2019

Role of Ectodysplasin signalling in middle ear and nasal pathology in rat and mouse models of hypohidrotic ectodermal dysplasia

Del-Pozo, J., Macintyre, N., Anvari Azar, A., Headon, D., Schneider, P. & Cheeseman, M., 25 Apr 2019, In: Disease Models and Mechanisms. 12, 4, dmm037804.

Research output: Contribution to journal › Article › peer-review

Open Access

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Feather arrays are patterned by interacting signalling and cell density waves

Ho, W., Freem, L., Zhao, D., Painter, K. J., Woolley, T. E., Gaffney, E. A., McGrew, M., Tzika, A., Milinkovitch, M. C., Schneider, P., Drusko, A., Matthäus, F., Glover, J., Wells, K., Johansson, J., Davey, M., Sang, H., Clinton, M. & Headon, D., 21 Feb 2019, In: PLoS Biology. 17, 2, p. 1-38 38 p., e3000132.

Research output: Contribution to journal › Article › peer-review

Open Access

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Edar is a downstream target of beta-catenin and drives collagen accumulation in the mouse prostate

Wegner, K. A., Mehta, V., Johansson, J. A., Mueller, B. R., Keil, K. P., Abler, L. L., Marker, P. C., Taketo, M. M., Headon, D. J. & Vezina, C. M., 11 Feb 2019, (E-pub ahead of print) In: Biology Open.

Research output: Contribution to journal › Article › peer-review

Open Access

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2018

A chemotaxis model of feather primordia pattern formation during avian development

Painter, K. J., Ho, W. & Headon, D. J., 21 Jan 2018, In: Journal of Theoretical Biology. 437, p. 225-238 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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2017

Mutations in ACTRT1 and its enhancer RNA elements lead to aberrant activation of Hedgehog signaling in inherited and sporadic basal cell carcinomas

Bal, E., Park, H-S., Belaid-Choucair, Z., Kayserili, H., Naville, M., Madrange, M., Chiticariu, E., Hadj-Rabia, S., Cagnard, N., Kuonen, F., Bachmann, D., Huber, M., Le Gall, C., Côté, F., Hanein, S., Rosti, R. Ö., Aslanger, A. D., Waisfisz, Q., Bodemer, C., Hermine, O., & 17 othersMorice-Picard, F., Labeille, B., Caux, F., Mazereeuw-Hautier, J., Philip, N., Levy, N., Taieb, A., Avril, M-F., Headon, D. J., Gyapay, G., Magnaldo, T., Fraitag, S., Crollius, H. R., Vabres, P., Hohl, D., Munnich, A. & Smahi, A., Oct 2017, In: Nature Medicine. 23, 10, p. 1226-1233

Research output: Contribution to journal › Letter › peer-review

Open Access

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The Impact of the Eda Pathway on Tooth Root Development

Fons Romero, J. M., Star, H., Lav, R., Watkins, S., Harrison, M., Hovorakova, M., Headon, D. & Tucker, A. S., Oct 2017, In: Journal of Dental Research. 96, 11, p. 1290-1297

Research output: Contribution to journal › Article › peer-review

Open Access

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Hierarchical patterning modes orchestrate hair follicle morphogenesis

Glover, J., Wells, K., Matthäus, F., Painter, K., Ho, W., Riddell, J., Johansson, J., Ford, M. J., Jahoda, C. A. B., Klika, V., Mort, R. & Headon, D., 11 Jul 2017, In: PLoS Biology. 15, 7, p. 1-31 32 p., e2002117.

Research output: Contribution to journal › Article › peer-review

Open Access

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Reversing stratification during wound healing

Headon, D., 31 May 2017, In: Nature Cell Biology. 19, 6, p. 595-597 3 p.

Research output: Contribution to journal › Review article

Open Access

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Derivation of marker gene signatures from human skin and their use in the interpretation of the transcriptional changes associated with dermatological disorders

Shih, B-J., Nirmal, A. J., Headon, D., Akbar, A. N., Mabbott, N. & Freeman, T., Apr 2017, In: The Journal of Pathology. 241, 5, p. 600-613

Research output: Contribution to journal › Article › peer-review

Open Access

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Ectodysplasin A in Biological Fluids and Diagnosis of Ectodermal Dysplasia

Podzus, J., Kowalczyk-quintas, C., Schuepbach-mallepell, S., Willen, L., Staehlin, G., Vigolo, M., Tardivel, A., Headon, D., Kirby, N., Mikkola, M. L., Schneider, H. & Schneider, P., 2017, In: Journal of Dental Research. 96, 2, p. 217-224

Research output: Contribution to journal › Article › peer-review

Open Access

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2016

FGF and EDA pathways control initiation and branching of distinct subsets of developing nasal glands

May, A., Headon, D., Rice, D., Noble, A. & Tucker, A. S., 15 Nov 2016, In: Developmental Biology. 419, 2, p. 348–356

Research output: Contribution to journal › Article › peer-review

Open Access

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Candidate mutation responsible for inherited skeletal developmental abnormalities in Cheviot sheep

Matika, O., Davey, M., Del-Pozo, J., Finlayson, H., Farquharson, C., Headon, D., Kijas, J. W., Lu, Z., McTeir, L., Riggio, V., Schoenebeck, J., Schwarz, T., Staines, K., Woolliams, J., Archibald, A. & Bishop, S., 29 Aug 2016, p. 165. 1 p.

Research output: Contribution to conference › Abstract › peer-review

EGFR: Stopping Stathmin to Start the Cycle

Headon, D., Aug 2016, In: Experimental Dermatology. 25, 8, p. 594-595

Research output: Contribution to journal › Comment/debate

Open Access

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Ectodysplasin signalling deficiency in mouse models of Hypohidrotic Ectodermal Dysplasia leads to middle ear and nasal pathology

Anvari Azar, A., Piccinelli, C., Brown, H., Headon, D. & Cheeseman, M., 4 Jul 2016, (E-pub ahead of print) In: Human Molecular Genetics. 25, 16, p. 3564-3577

Research output: Contribution to journal › Article › peer-review

Open Access

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A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation

Adhikari, K., Fuentes-Guajardo, M., Quinto-Sánchez, M., Mendoza-Revilla, J., Camilo Chacón-Duque, J., Acuña-Alonzo, V., Jaramillo, C., Arias, W., Lozano, R. B., Pérez, G. M., Gómez-Valdés, J., Villamil-Ramírez, H., Hunemeier, T., Ramallo, V., Silva de Cerqueira, C. C., Hurtado, M., Villegas, V., Granja, V., Gallo, C., Poletti, G., & 12 othersSchuler-Faccini, L., Salzano, F. M., Bortolini, M-C., Canizales-Quinteros, S., Cheeseman, M., Rosique, J., Bedoya, G., Rothhammer, F., Headon, D., González-José, R., Balding, D. & Ruiz-Linares, A., 19 May 2016, In: Nature Communications. 7, 11616.

Research output: Contribution to journal › Article › peer-review

Open Access

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Hair follicle bulge stem cells appear dispensable for the acute phase of wound re-epithelialisation

Garcin, C. L., Ansell, D. M., Headon, D. J., Paus, R. & Hardman, M. J., May 2016, In: STEM CELLS. 34, 5, p. 1377-1385

Research output: Contribution to journal › Article › peer-review

Open Access

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A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features

Adhikari, K., Fontanil, T., Cal, S., Mendoza-Revilla, J., Fuentes-Guajardo, M., Chacón-Duque, J-C., Al-Saadi, F., Johansson, J. A., Quinto-Sanchez, M., Acuña-Alonzo, V., Jaramillo, C., Arias, W., Barquera Lozano, R., Macín Pérez, G., Gómez-Valdés, J., Villamil-Ramírez, H., Hunemeier, T., Ramallo, V., Silva de Cerqueira, C. C., Hurtado, M., & 16 othersVillegas, V., Granja, V., Gallo, C., Poletti, G., Schuler-Faccini, L., Salzano, F. M., Bortolini, M-C., Canizales-Quinteros, S., Rothhammer, F., Bedoya, G., Gonzalez-José, R., Headon, D., López-Otín, C., Tobin, D. J., Balding, D. & Ruiz-Linares, A., 1 Mar 2016, In: Nature Communications. 7, 10815.

Research output: Contribution to journal › Article › peer-review

Open Access

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2015

Maintenance of Distinct Melanocyte Populations in the Interfollicular Epidermis

Glover, J., Knolle, S., Wells, K., Liu, D., Jackson, I., Mort, R. & Headon, D., Jul 2015, In: Pigment Cell & Melanoma Research. 28, 4, p. 476-480

Research output: Contribution to journal › Article › peer-review

Open Access

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A genome-wide association study identifies multiple loci for variation in human ear morphology

Adhikari, K., Reales, G., Smith, A. J. P., Konka, E., Palmen, J., Quinto-Sanchez, M., Acuña-Alonzo, V., Jaramillo, C., Arias, W., Fuentes, M., Pizarro, M., Barquera Lozano, R., Macín Pérez, G., Gómez-Valdés, J., Villamil-Ramírez, H., Hunemeier, T., Ramallo, V., Silva de Cerqueira, C. C., Hurtado, M., Villegas, V., & 18 othersGranja, V., Gallo, C., Poletti, G., Schuler-Faccini, L., Salzano, F. M., Bortolini, M-C., Canizales-Quinteros, S., Rothhammer, F., Bedoya, G., Calderón, R., Rosique, J., Cheeseman, M., Bhutta, M. F., Humphries, S. E., Gonzalez-José, R., Headon, D., Balding, D. & Ruiz-Linares, A., 24 Jun 2015, In: Nature Communications. 6, 7500.

Research output: Contribution to journal › Article › peer-review

Open Access

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Morphological Mutations: Lessons from the Cockscomb

Headon, D., 19 Mar 2015, In: PLoS Genetics. 11, 3, e1004979.

Research output: Contribution to journal › Article › peer-review

Open Access

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Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron

Lindstrom, N., Lawrence, M. L., Burn, S. F., Johansson, J. A., Bakker, E. R., Ridgway, R. A., Chang, C., Karolak, M. J., Oxburgh, L., Headon, D. J., Sansom, O. J., Smits, R., Davies, J. A. & Hohenstein, P., 3 Feb 2015, In: eLIFE. 4, e04000.

Research output: Contribution to journal › Article › peer-review

Open Access

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Pharmacological Stimulation of Edar Signaling in the Adult Enhances Sebaceous Gland Size and Function

Kowalczyk-Quintas, C., Schuepbach-Mallepell, S., Willen, L., Smith, T. K., Huttner, K., Kirby, N., Headon, D. J. & Schneider, P., 2015, In: Journal of Investigative Dermatology. 135, 2, p. 359-368

Research output: Contribution to journal › Article › peer-review

Open Access

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2014

Pharmacological Activation of the EDA/EDAR Signaling Pathway Restores Salivary Gland Function following Radiation-Induced Damage

Hill, G., Headon, D., Harris, Z. I., Huttner, K. & Limesand, K. H., 19 Nov 2014, In: PLoS ONE. 9, 11, p. e112840

Research output: Contribution to journal › Article › peer-review

Open Access

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Periderm prevents pathological epithelial adhesions during embryogenesis

Richardson, R. J., Hammond, N. L., Coulombe, P. A., Saloranta, C., Nousiainen, H. O., Salonen, R., Berry, A., Hanley, N., Headon, D., Karikoski, R. & Dixon, M. J., 2 Sept 2014, In: Journal of Clinical Investigation. 124, 9, p. 3891-3900 10 p.

Research output: Contribution to journal › Article › peer-review

Generation and Characterization of Function Blocking Anti-Ectodysplasin A (EDA) Monoclonal Antibodies that Induce Ectodermal Dysplasia

Kowalczyk-Quintas, C., Willen, L., Dang, A. T., Sarrasin, H., Tardivel, A., Hermes, K., Schneider, H., Gaide, O., Donzé, O., Kirby, N., Headon, D. J. & Schneider, P., 3 Jan 2014, In: Journal of Biological Chemistry. 289, 7, p. 4273-4285

Research output: Contribution to journal › Article › peer-review

Regionalisation of the skin

Johansson, J. A. & Headon, D. J., Jan 2014, In: Seminars in Cell and Developmental Biology. 25-26, p. 3-10

Research output: Contribution to journal › Article › peer-review

2013

Genetic factors controlling wool shedding in a composite Easycare sheep flock

Matika, O., Bishop, S. C., Pong-Wong, R., Riggio, V. & Headon, D. J., Dec 2013, In: Animal Genetics. 44, 6, p. 742-749

Research output: Contribution to journal › Article › peer-review

Open Access

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The Interfollicular Epidermis of Adult Mouse Tail Comprises Two Distinct Cell Lineages that Are Differentially Regulated by Wnt, Edaradd, and Lrig1

Gomez, C., Chua, W., Miremadi, A., Quist, S., Headon, D. & Watt, F., 4 Jun 2013, In: Stem Cell Reports. 1, 1, p. 19-27 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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2012

The Cell Cycle Regulator Protein 14-3-3 sigma Is Essential for Hair Follicle Integrity and Epidermal Homeostasis

Hammond, N. L., Headon, D. J. & Dixon, M. J., Jun 2012, In: Journal of Investigative Dermatology. 132, 6, p. 1543-1553 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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The EDAR370A allele attenuates the severity of hypohidrotic ectodermal dysplasia caused by EDA gene mutation

Cluzeau, C., Hadj-Rabia, S., Bal, E., Clauss, F., Munnich, A., Bodemer, C., Headon, D. & Smahi, A., Mar 2012, In: British journal of dermatology. 166, 3, p. 678-681 4 p.

Research output: Contribution to journal › Letter › peer-review

Activators of the ectodysplasin pathway are redefining the timing and opportunities for modulation of ectoderm development

Huttner, K., Casal, M., Gaide, O., Kowalczyk, C., Headon, D. & Schneider, P., 2012, In: Journal of Investigative Dermatology. 132, S2, p. S90-S90

Research output: Contribution to journal › Meeting abstract › peer-review

Computational and mathematical models of chondrogenesis in vertebrate limbs

Glimm, T., Headon, D. & Kiskowski, M. A., 2012, In: Birth Defects Research Part C: Embryo Today: Reviews. 96, 2, p. 176-92 17 p.

Research output: Contribution to journal › Article › peer-review

Genetic factors controlling wool shedding in an Easycare composite sheep flock

Matika, O., Bishop, S., Pong-Wong, R., Riggio, V. & Headon, D., 2012, In: Advances in Animal Biosciences. 3, 1, p. 132 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

Denis Headon

Research output

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