Don Mahad

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37 Article
3 Literature review
1 Chapter
1 Comment/debate
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- 1 Review article

Axonal response of mitochondria to demyelination and complex IV activity within demyelinated axons in experimental models of multiple sclerosis
Licht-Mayer, S., Campbell, G. R., Mehta, A. R., McGill, K., Symonds, A., Al-Azki, S., Pryce, G., Zandee, S., Zhao, C., Kipp, M., Smith, K. J., Baker, D., Altmann, D., Anderton, S. M., Kap, Y. S., Laman, J. D., 't Hart, B. A., Rodriguez, M., Franklin, R. J. M., Chandran, S., & 3 othersLassmann, H., Trapp, B. D. & Mahad, D. J., 30 Sep 2022, In: Neuropathology and Applied Neurobiology. p. e12851
Research output: Contribution to journal › Article › peer-review

Open Access
File
MRI-derived g-ratio and lesion severity in newly diagnosed multiple sclerosis
York, E., Martin, S. J., Meijboom, R., Thrippleton, M. J., Bastin, M. E., Carter, E., Overell, J., Connick, P., Chandran, S., Waldman, A., Hunt, D., Akula, A., Artal, J. C., Baranzini, S., Barret, F., Bastin, M. E., Batchelor, C., Beswick, E., Brown, F., Chandran, S., & 63 othersChang, J., Chen, Y., Colville, S., Connick, P., Cranley, D., Dakin, R., Dhillon, B., Elliot, E., Finlayson, J., Foley, P., Glasmacher, S., Grossart, A., Haagenrud, H., Hafezi, K., Harrison, E., Harroud, A., Hathorn, S., Hopkins, T., Hunt, D., Hutchinson, A., Jayprakash, K., Justin, M., Kampaite, A., Kearns, P., Kennedy, G., Kleynhans, M., Kwong, J. N. K., Larraz, J., Love, K., Lyle, D., Macdonald, J., Macdougall, N., Macfarlane, L., Maclennan, B., Maclean, A., Macleod, M. A., Macleod, N., Mahad, D., Martin, S. J., Mcmahon, L., Megson, I., Meijboom, R., Mollison, D., Monaghan, M., Murphy, L., Murray, K., Newton, J., O’riordan, J., Perry, D., Quigley, S., Scotson, A., Stenson, A., Thrippleton, M. J., Hernandez, M. V., Waldman, A., Weaver, C., Webb, S., Weller, B., Williams, A., Wiseman, S., Wong, C., Wong, M. & York, E., 3 Nov 2021, In: Brain Communications.
Research output: Contribution to journal › Article › peer-review

Open Access
File
Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis
Mehta, A. R., Gregory, J. M., Dando, O., Carter, R. N., Burr, K., Nanda, J., Story, D., Mcdade, K., Smith, C., Morton, N. M., Mahad, D. J., Hardingham, G. E., Chandran, S. & Selvaraj, B. T., 4 Jan 2021, In: Acta Neuropathologica.
Research output: Contribution to journal › Article › peer-review

Open Access
File
Safety and efficacy of MD1003 (high-dose biotin) in patients with progressive multiple sclerosis (SPI2): a randomised, double-blind, placebo-controlled, phase 3 trial
SPI2 investigator team, Dec 2020, In: The Lancet Neurology. 19, 12, p. 988-997
Research output: Contribution to journal › Article › peer-review
Exercise-induced changes in gait kinematics in multiple sclerosis with minimal neurological disability
Andreopoulou, G., Mercer, T. H., Enriquez, J. G., Justin, M., MacLeod, N., Harrison, E., Mahad, D. J. & van der Linden, M. L., 18 Nov 2020, In: Multiple Sclerosis and Related Disorders. 47, p. 102630
Research output: Contribution to journal › Article › peer-review

Open Access
File

1 Active
11 Finished

MS Society Edinburgh Centre for MS Research 2021
Chandran, S., Bastin, M., Carragher, N., Connick, P., Grant, S., Hunt, D., Mahad, D., Marshall, I., Miron, V., Priller, J., Smith, C., Tavares, A., Waldman, A. & Wardlaw, J.
UK-based charities
1/01/21 → 31/12/25
Project: Research
Understanding the neuronal cell body response to demyelination to protect axons in MS
Mahad, D.
Non-EU-based charities
1/10/21 → 30/09/22
Project: Research
A pilot study to explore the natural history of exercise induced fatigability in people with MS and minimal neurological disability: implications for the early detection of progressive MS
Mahad, D.
UK-based charities
1/02/20 → 30/04/22
Project: Research
Targeting mitochondria to protect axons in progressive MS
Mahad, D.
Non-EU-based charities
1/04/19 → 31/03/21
Project: Research
A study of the synaptic proteome to understand and target motor fatigability due to neuronal energy failure in progressive MS
Mahad, D.
UK-based charities
1/11/18 → 1/11/21
Project: Research

Nerve cells of MS patients struggle to meet brain’s energy needs, finds Don Mahad
Don Mahad
31/05/17
1 item of Media coverage
Press/Media: Research
Don Mahad applauds Multiple Sclerosis discovery, but warns treatment is still far off
Don Mahad
24/04/17
1 item of Media coverage
Press/Media: Expert Comment
Dr Don Mahad heads new bid to create therapies able to tackle progressive MS
Don Mahad
12/09/14
1 item of Media coverage
Press/Media: Research

Don Mahad

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Axonal response of mitochondria to demyelination and complex IV activity within demyelinated axons in experimental models of multiple sclerosis

MRI-derived g-ratio and lesion severity in newly diagnosed multiple sclerosis

Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis

Safety and efficacy of MD1003 (high-dose biotin) in patients with progressive multiple sclerosis (SPI2): a randomised, double-blind, placebo-controlled, phase 3 trial

Exercise-induced changes in gait kinematics in multiple sclerosis with minimal neurological disability

MS Society Edinburgh Centre for MS Research 2021

Understanding the neuronal cell body response to demyelination to protect axons in MS

A pilot study to explore the natural history of exercise induced fatigability in people with MS and minimal neurological disability: implications for the early detection of progressive MS

Targeting mitochondria to protect axons in progressive MS

A study of the synaptic proteome to understand and target motor fatigability due to neuronal energy failure in progressive MS

Nerve cells of MS patients struggle to meet brain’s energy needs, finds Don Mahad

Don Mahad applauds Multiple Sclerosis discovery, but warns treatment is still far off

Dr Don Mahad heads new bid to create therapies able to tackle progressive MS

Don Mahad

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Press/Media