Research output per year
Research output per year
Personal profile
Keywords
- TP Chemical technology
- QH301 Biology
- QD Chemistry
- RM Therapeutics. Pharmacology
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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SCORCH: Improving structure-based virtual screening with machine learning classifiers, data augmentation, and uncertainty estimation
McGibbon, M., Money-Kyrle, S., Blay, V. & Houston, D. R., 25 Jul 2022, (E-pub ahead of print) In: Journal of Advanced Research.Research output: Contribution to journal › Article › peer-review
Open Access -
Comparison of ATP-binding pockets and discovery of homologous recombination inhibitors
Blay, V., Gailiunaite, S., Lee, C.-Y., Chang, H.-Y., Hupp, T., Houston, D. R. & Chi, P., 15 Sept 2022, In: Bioorganic and Medicinal Chemistry. 70, 10 p., 116923.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Demonstration of the Anthelmintic Potency of Marimastat in the Heligmosomoides Polygyrus Rodent Model
Robertson, E., Harcus, Y., Johnston, C. J. C., Page, A. P., Walkinshaw, M. D., Maizels, R. M. & Houston, D., 1 Dec 2018, In: The journal of parasitology. 104, 6, p. 705-709 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Discovery of a novel ligand that modulates the protein-protein interactions of the AAA+ superfamily oncoprotein reptin
Healy, A. R., Houston, D. R., Remnant, L., Huart, A. S., Brychtova, V., Maslon, M. M., Meers, O., Muller, P., Krejci, A., Blackburn, E. A., Vojtesek, B., Hernychova, L., Walkinshaw, M. D., Westwood, N. J. & Hupp, T. R., 1 May 2015, In: Chemical Science. 6, 5, p. 3109-3116 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Consensus Docking: Improving the Reliability of Docking in a Virtual Screening Context
Houston, D. R. & Walkinshaw, M. D., 2013, In: Journal of Chemical Information and Modeling. 53, 2, p. 384-390 7 p.Research output: Contribution to journal › Article › peer-review
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The Use of AI for the Development of Two New Early Drug Discovery Techniques: Deep and Transfer Learning for LogP Prediction and Dimensionality Reduction for Sequence-based Virtual Screening
Houston, D. (Examiner)
9 Jan 2023Activity: Examination types › Examination
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Interpreting the effects of missense variants through the lens of protein structure and molecular mechanisms
Houston, D. (Examiner)
17 Mar 2023Activity: Examination types › Examination
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Modelling Approaches for Rational Solvent Selection in Drug Development
Houston, D. (Examiner)
19 Dec 2019Activity: Examination types › External Examiner or Assessor
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The utility of consensus approaches in virtual drug discovery
Houston, D. (Invited speaker)
28 Nov 2019Activity: Academic talk or presentation types › Invited talk
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A Robust Machine Learning Approach for the Prediction of Allosteric Binding Sites
Houston, D. (Examiner)
13 Dec 2016Activity: Examination types › External Examiner or Assessor
Projects
- 5 Finished
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Gaussian Accelerated Molecular Dynamics Study of the Activation States of Phosphofructokinase
Houston, D. (Principal Investigator)
1/02/22 → 31/01/23
Project: Awarded Facility Time
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Critical Assessment Of Computational Hit-finding Experiments Challenge #2
Houston, D. (Principal Investigator)
22/06/22 → 15/05/24
Project: Research Collaboration with external organisation
File -
CACHE: Critical Assessment Of Computational Hit-finding Experiments Challenge #3
Houston, D. (Principal Investigator)
22/11/22 → 1/09/24
Project: Research Collaboration with external organisation
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Computer Aided Design via Gaussian Accelerated Molecular Dynamics Simulation of Stabilised Peptidomimetic Inhibitors
Houston, D. (Principal Investigator)
1/02/21 → 31/01/22
Project: Awarded Facility Time
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Sparking Impact Award: S2.2013.0211
Walkinshaw, M. (Principal Investigator) & Houston, D. (Co-investigator)
1/06/14 → 1/10/14
Project: Research
Datasets
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Mix and Match: Mono-substituted Hydrocarbon Diastereomer Combinations Reveal Stapled Peptides with High Structural Fidelity
McWhinnie, F. (Creator), Sepp, K. (Creator), Kunath, T. (Creator), Houston, D. (Creator), Hupp, T. (Creator) & Hulme, A. (Creator), Edinburgh DataShare, 22 Dec 2017
DOI: 10.7488/ds/2276
Dataset
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Lamin A conformation modelling
Spanos, C. (Creator), Cardenal Peralta, C. (Creator), Schirmer, E. (Creator), Makarov, A. (Creator), Solovyova, A. S. (Creator), Houston, D. (Creator), Rappsilber, J. (Creator) & Zou, J. (Creator), Edinburgh DataShare, 1 Nov 2019
DOI: 10.7488/ds/2556
Dataset
Press/Media
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Edinburgh University launches new online masters in next generation drug discovery
Walkinshaw, M., Houston, D. & Taylor, P.
11/07/12
1 item of Media coverage
Press/Media: Research