Douglas Houston

Senior Lecturer, School of Biological Sciences

https://orcid.org/0000-0002-3469-1546

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Personal profile

Biography

https://www.ed.ac.uk/profile/douglas-houston

Keywords

TP Chemical technology
QH301 Biology
QD Chemistry
RM Therapeutics. Pharmacology

Network

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39 Article

Bypassing the requirement for aminoacyl-tRNA by a cyclodipeptide synthase enzyme
Harding, C. J., Sutherland, E., Hanna, J. G., Houston, D. R. & Czekster, C. M., 15 Jan 2021, In: RSC Chemical Biology. 11 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
PRL3-DDX21 transcriptional control of endolysosomal genes restricts melanocyte stem cell differentiation
Johansson, J., Marie, K. L., Lu, Y., Brombin, A., Santoriello, C., Zeng, Z., Zich, J., Gautier, P., von Kriegsheim, A., Brunsdon, H., Wheeler, A. P., Dreger, M., Houston, D. R., Dooley, C. M., Sims, A. H., Busch-Nentwich, E. M., Zon, L. I., Illingworth, R. & Patton, E. E., 10 Aug 2020, In: Developmental Cell. 54, 3, p. 317-332.E9 16 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
Recognition dynamics of cancer mutations on the ERp57-Tapasin interface
Padariya, M., Kalathiya, U., Houston, D. R. & Alfaro, J. A., 20 Mar 2020, In: Cancers. 12, 3, 20 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
An inter-subunit protein-peptide interface that stabilizes the specific activity and oligomerization of the AAA+ chaperone Reptin
Coufalova, D., Remnant, L., Hernychova, L., Muller, P., Healy, A., Kannan, S., Vojtesek, B., Westwood, N., Verma, C. S., Vojtesek, B., Hupp, T. R. & Houston, D. R., 15 May 2019, In: Journal of proteomics. 199, p. 89-101 13 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
Design of drug-like hepsin inhibitors against prostate cancer and kidney stones
Blay, V., Houston, D., Li, M. C., P. Ho, S., Stoller, M. L., Hsieh, H-P. & Houston, D., 28 Sep 2019, In: Acta Pharmaceutica Sinica B. 10, 7, p. 1309-1320
Research output: Contribution to journal › Article › peer-review

Open Access
File

1 External Examiner or Assessor
1 Invited talk

Modelling approaches for rational solvent selection in drug development
Douglas Houston (Examiner)
19 Dec 2019
Activity: Examination types › External Examiner or Assessor
The utility of consensus approaches in virtual drug discovery
Douglas Houston (Invited speaker)
28 Nov 2019
Activity: Academic talk or presentation types › Invited talk

1 Finished
1 Not started

Computer Aided Design via Gaussian Accelerated Molecular Dynamics Simulation of Stabilised Peptidomimetic Inhibitors
Houston, D.
Project: Awarded Facility Time
Sparking Impact Award: S2.2013.0211
Walkinshaw, M. & Houston, D.
BBSRC
1/06/14 → 1/10/14
Project: Research

Mix and Match: Mono-substituted Hydrocarbon Diastereomer Combinations Reveal Stapled Peptides with High Structural Fidelity
McWhinnie, F. (Creator), Sepp, K. (Creator), Kunath, T. (Creator), Houston, D. (Creator), Hupp, T. (Creator) & Hulme, A. (Creator), Edinburgh DataShare, 22 Dec 2017
DOI: 10.7488/ds/2276
Dataset
Lamin A conformation modelling
Spanos, C. (Creator), Cardenal Peralta, C. (Creator), Schirmer, E. (Creator), Makarov, A. (Creator), Solovyova, A. S. (Creator), Houston, D. (Creator), Rappsilber, J. (Creator) & Zou, J. (Creator), Edinburgh DataShare, 1 Nov 2019
DOI: 10.7488/ds/2556
Dataset

Cover of Cell Chemical Biology
Douglas Houston
20/12/18
1 Media contribution
Press/Media: Research
Edinburgh University launches new online masters in next generation drug discovery
Malcolm Walkinshaw, Douglas Houston & Paul Taylor
11/07/12
1 item of Media coverage
Press/Media: Research