Douglas Vernimmen

2021

JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells

Lawson, H., Sepulveda, C., van de Lagemaat, L. N., Durko, J., Barile, M., Tavosanis, A., Georges, E., Shmakova, A., Timms, P., Carter, R. N., Allen, L., Campos, J., Vukovic, M., Guitart, A. V., Giles, P., O'Shea, M., Vernimmen, D., Morton, N. M., Rodrigues, N. P., Göttgens, B. & 4 others, Schofield, C. J., Lengeling, A., O'Carroll, D. & Kranc, K. R., 9 Feb 2021, In: Blood advances. 5, 3, p. 889-899 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

2020

Alveolar macrophage chromatin is modified to orchestrate host response to Mycobacterium bovis infection

Hall, T., Vernimmen, D., Browne, J. A., Mullen, M. P., Gordon, S. V., MacHugh, D. E. & O'Doherty, A. M., 7 Feb 2020, In: Frontiers in genetics.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Identification of MAZ as a novel transcription factor regulating erythropoiesis

Deen, D., Butter, F., Holland, M. L., Samara, V., Sloane-Stanley, J. A., Ayyub, H., Mann, M., Garrick, D. & Vernimmen, D., 10 May 2020, (Unpublished).

Research output: Working paper

2019

Targeting the RNA m⁶A reader YTHDF2 selectively compromises cancer stem cells in acute myeloid leukemia

Paris, J., Morgan, M., Monteiro De Campos, J., Spencer, G. J., Shmakova, A., Ivanova, I., Mapperley, C., Lawson, H., Wotherspoon, D., Pires Sepulveda, C., Vukovic, M., Allen, L., Sarapuu, A., Tavosanis, A., Guitart, A., Villacreces, A., Much, C., Choe, J., Anvari Azar, A., Van De Lagemaat, L. & 7 others, Vernimmen, D., Nehme, A., Mazurier, F., Somervaille, T. C. P., Gregory, R. I., O'Carroll, D. & Kranc, K., 3 Jul 2019, In: Cell Stem Cell. 25, 1, p. 137-148.E6 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

2018

CpG binding protein (CFP1) occupies open chromatin regions of active genes, including enhancers and non-CpG islands

Van De Lagemaat, L., Flenley, M., Lynch, M. D., Garrick, D., Tomlinson, S., Kranc, K. & Vernimmen, D., 6 Oct 2018, In: Epigenetics and Chromatin. 11, 1, 59.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Globins, from Genes to Physiology and Diseases

Vernimmen, D., May 2018, In: Blood Cells, Molecules and Diseases. 70, S1, p. 1 1 p.

Research output: Contribution to journal › Editorial

Open Access

File

The STAT3-IL10-IL6 pathway is a novel regulator of macrophage efferocytosis and phenotypic conversion in sterile liver injury

Campana, L., Starkey Lewis, P., Pellicoro, A., Aucott, R., Man, J., O'Duibhir, E., Mok, S. E., Ferreira-Gonzalez, S., Livingstone, E., Greenhalgh, S., Hull, K. L., Kendall, T. J., Vernimmen, D., Henderson, N. C., Boulter, L., Gregory, C. D., Feng, Y., Anderton, S. M., Forbes, S. J. & Iredale, J. P., Feb 2018, In: Journal of Immunology. 200, 3, p. 1169-1187

Research output: Contribution to journal › Article › peer-review

Open Access

2017

Coming of Age: The Legacy of Dolly at 20 Scientific Scientific Symposium

Brazel, A., Devailly, G., Vernimmen, D. & Lengeling, A., 1 Jan 2017, Genetics Society News, 76, p. 20-22 3 p.

Research output: Contribution to specialist publication › Featured article

Open Access

File

Enhancer deletion generates cellular phenotypic diversity due to bimodal gene expression

De Gobbi, M., Brazel, A. J., Sharpe, J. A., Sloane-stanley, J. A., Smith, A., Wood, W. G. & Vernimmen, D., May 2017, In: Blood Cells, Molecules and Diseases. 64, p. 10-12

Research output: Contribution to journal › Letter

Open Access

File

Fumarate hydratase is a critical metabolic regulator of haematopoietic stem cell functions

Guitart, A., Panagopoulou, T., Villacreces, A., Vukovic, M., Sepulveda, C., Allen, L., Carter, R. N., van de Lagemaat, L., Morgan, M., Giles, P., Sas, Z., Vila Gonzalez, M., Lawson, H., Paris, J., Edward-Hicks, J., Schaak, K., Subramani, C., Gezer, D., Armesilla-Diaz, A., Bukowski-Wills, J. & 10 others, Easterbrook, A., Coman, D., So, C. W. E., O'Carroll, D., Vernimmen, D., Rodrigues, N. P., Pollard, P. J., Morton, N. M., Finch, A. & Kranc, K. R., 15 Feb 2017, In: Journal of Experimental Medicine. 214, 3, p. 719-735

Research output: Contribution to journal › Article › peer-review

Open Access

File

2016

The complexity of epigenetic diseases

Brazel, A. J. & Vernimmen, D., Jan 2016, In: The Journal of Pathology. 238, 2, p. 333-344

Research output: Contribution to journal › Literature review › peer-review

Open Access

File

The hierarchy of transcriptional activation: from enhancer to promoter

Vernimmen, D. & Bickmore, W., 2 Feb 2016

Research output: Non-textual form › Web publication/site

Open Access

2015

The Hierarchy of Transcriptional Activation: From Enhancer to Promoter

Vernimmen, D. & Bickmore, W. A., 12 Dec 2015, In: Trends in Genetics. 31, 12, p. 696-708

Research output: Contribution to journal › Literature review › peer-review

Open Access

File

2014

Analysis of neonatal brain lacking ATRX or MeCP2 reveals changes in nucleosome density, CTCF binding and chromatin looping

Kernohan, K. D., Vernimmen, D., Gloor, G. B. & Bérubé, N. G., 2 Jul 2014, In: Nucleic Acids Research. 42, 13, p. 8356-8368

Research output: Contribution to journal › Article › peer-review

Open Access

File

Differential regulation of the alpha-globin locus by Kruppel-like factor 3 in erythroid and non-erythroid cells

Funnell, A. P., Vernimmen, D., Lim, W. F., Mak, K. S., Wienert, B., Martyn, G. E., Artuz, C. M., Burdach, J., Quinlan, K. G., Higgs, D. R., Whitelaw, E., Pearson, R. C. & Crossley, M., 16 May 2014, In: BMC Molecular Biology. 15, 1, p. 8

Research output: Contribution to journal › Article › peer-review

Open Access

File

The Molecular Basis of Normal Erythroid/Megakaryocyte Development and Mechanisms of Epigenetic/Transcriptional Deregulation Leading to Erythroleukemia and Thalassaemia

Vernimmen, D., 5 Feb 2014, Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development. Bonifer, C. & Cockerill, P. N. (eds.). Springer Berlin Heidelberg, p. 247-266 Chapter 10. (Epigenetics and Human Health).

Research output: Chapter in Book/Report/Conference proceeding › Other chapter contribution

Uncovering Enhancer Functions Using the α-Globin Locus

Vernimmen, D., 16 Oct 2014, In: PLoS Genetics. 10, 10, e1004668.

Research output: Contribution to journal › Literature review › peer-review

Open Access

File

2013

Analysis of Sequence Variation Underlying Tissue-specific Transcription Factor Binding and Gene Expression

Lower, K. M., De Gobbi, M., Hughes, J. R., Derry, C. J., Ayyub, H., Sloane-Stanley, J. A., Vernimmen, D., Garrick, D., Gibbons, R. J. & Higgs, D. R., 24 Apr 2013, In: Human Mutation. E-pub 24 April

Research output: Contribution to journal › Article › peer-review

High-resolution analysis of cis-acting regulatory networks at the α-globin locus

Hughes, J. R., Lower, K. M., Dunham, I., Taylor, S., De Gobbi, M., Sloane-Stanley, J. A., McGowan, S., Ragoussis, J., Vernimmen, D., Gibbons, R. J. & Higgs, D. R., 2013, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 368, 1620, 20120361.

Research output: Contribution to journal › Article › peer-review

2012

An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment

Lynch, M. D., Smith, A., De Gobbi, M., Flenley, M., Hughes, J. R., Vernimmen, D., Ayyub, H., Sharpe, J. A., Sloane-Stanley, J. A., Sutherland, L., Meek, S., Burdon, T., Gibbons, R. J., Garrick, D. & Higgs, D. R., Jan 2012, In: EMBO Journal. 31, 2, p. 317-329 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Intragenic enhancers act as alternative promoters

Kowalczyk, M. S., Hughes, J. R., Garrick, D., Lynch, M. D., Sharpe, J. A., Sloane-Stanley, J. A., McGowan, S. J., De Gobbi, M., Hosseini, M., Vernimmen, D., Brown, J. M., Gray, N. E., Collavin, L., Gibbons, R. J., Flint, J., Taylor, S., Buckle, V. J., Milne, T. A., Wood, W. G. & Higgs, D. R., 2012, In: Molecular Cell. 45, 4, p. 447-58 12 p.

Research output: Contribution to journal › Article › peer-review

2011

Generation of bivalent chromatin domains during cell fate decisions

De Gobbi, M., Garrick, D., Lynch, M., Vernimmen, D., Hughes, J. R., Goardon, N., Luc, S., Lower, K. M., Sloane-Stanley, J. A., Pina, C., Soneji, S., Renella, R., Enver, T., Taylor, S., Jacobsen, S. E. W., Vyas, P., Gibbons, R. J. & Higgs, D. R., 2011, In: Epigenetics and Chromatin. 4, 9, p. 1-12 12 p.

Research output: Contribution to journal › Article › peer-review

File

Polycomb eviction as a new distant enhancer function

Vernimmen, D., Lynch, M. D., De Gobbi, M., Garrick, D., Sharpe, J. A., Sloane-Stanley, J. A., Smith, A. J. H. & Higgs, D. R., Aug 2011, In: Genes & Development. 25, 15, p. 1583-1588 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

2009

Adventitious changes in long-range gene expression caused by polymorphic structural variation and promoter competition

Lower, K. M., Hughes, J. R., De Gobbi, M., Henderson, S., Viprakasit, V., Fisher, C., Goriely, A., Ayyub, H., Sloane-Stanley, J., Vernimmen, D., Langford, C., Garrick, D., Gibbons, R. J. & Higgs, D. R., 2009, In: Proceedings of the National Academy of Sciences. 106, 51, p. 21771-6 6 p.

Research output: Contribution to journal › Article › peer-review

Chromosome looping at the human alpha-globin locus is mediated via the major upstream regulatory element (HS-40)

Vernimmen, D., Marques-Kranc, F., Sharpe, J. A., Sloane-Stanley, J. A., Wood, W. G., Wallace, H. A. C., Smith, A. & Higgs, D. R., 5 Nov 2009, In: Blood. 114, 19, p. 4253-4260 8 p.

Research output: Contribution to journal › Article › peer-review

File

2008

Long-range regulation of alpha-globin gene expression

Higgs, D. R., Vernimmen, D. & Wood, B., 2008, Long-Range Control of Gene Expression. van Heyningen, V. & Hill, R. E. (eds.). Elsevier, Vol. 61. p. 143-73 31 p. (Advances in Genetics).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2007

Long-range chromosomal interactions regulate the timing of the transition between poised and active gene expression

Vernimmen, D., De Gobbi, M., Sloane-Stanley, J. A., Wood, W. G. & Higgs, D. R., 2007, In: EMBO Journal. 26, 8, p. 2041-51 11 p.

Research output: Contribution to journal › Article › peer-review

Using genomics to study how chromatin influences gene expression

Higgs, D. R., Vernimmen, D., Hughes, J. & Gibbons, R., 2007, In: Annual review of genomics and human genetics. 8, p. 299-325 27 p.

Research output: Contribution to journal › Article › peer-review

2006

A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter

De Gobbi, M., Viprakasit, V., Hughes, J. R., Fisher, C., Buckle, V. J., Ayyub, H., Gibbons, R. J., Vernimmen, D., Yoshinaga, Y., de Jong, P., Cheng, J-F., Rubin, E. M., Wood, W. G., Bowden, D. & Higgs, D. R., 2006, In: Science. 312, 5777, p. 1215-7 3 p.

Research output: Contribution to journal › Article › peer-review

How transcriptional and epigenetic programmes are played out on an individual mammalian gene cluster during lineage commitment and differentiation

Higgs, D. R., Vernimmen, D., De Gobbi, M., Anguita, E., Hughes, J., Buckle, V., Iborra, F., Garrick, D. & Wood, W. G., 2006, In: Biochemical Society Symposia. 73, p. 11-22 12 p.

Research output: Contribution to journal › Article › peer-review

File

2005

Mechanisms responsible for ERBB2 gene overexpression in human breast and non-breast cancer cells. The role of AP-2 transcription factors

Delacroix, L., Vernimmen, D., Begon, D. Y., Jackers, P. & Winkler, R., 2005, Cancer Therapy. p. 365-368 4 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed)

File

Understanding alpha-globin gene regulation: Aiming to improve the management of thalassemia

Higgs, D. R., Garrick, D., Anguita, E., De Gobbi, M., Hughes, J., Muers, M., Vernimmen, D., Lower, K., Law, M., Argentaro, A., Deville, M. A. & Gibbons, R., 2005, In: Annals of the New York Academy of Sciences. 1054, p. 92-102 11 p.

Research output: Contribution to journal › Article › peer-review

Yin Yang 1 cooperates with activator protein 2 to stimulate ERBB2 gene expression in mammary cancer cells

Begon, D. Y., Delacroix, L., Vernimmen, D., Jackers, P. & Winkler, R., 2005, In: Journal of Biological Chemistry. 280, 26, p. 24428-34 7 p.

Research output: Contribution to journal › Article › peer-review

2003

Different mechanisms are implicated in ERBB2 gene overexpression in breast and in other cancers

Vernimmen, D., Gueders, M., Pisvin, S., Delvenne, P. & Winkler, R., 2003, In: British Journal of Cancer. 89, 5, p. 899-906 8 p.

Research output: Contribution to journal › Article › peer-review

Identification of HTF (HER2 transcription factor) as an AP-2 (activator protein-2) transcription factor and contribution of the HTF binding site to ERBB2 gene overexpression

Vernimmen, D., Begon, D., Salvador, C., Gofflot, S., Grooteclaes, M. & Winkler, R., 2003, In: Biochemical Journal. 370, Pt 1, p. 323-9 7 p.

Research output: Contribution to journal › Article › peer-review

File

2000

Cofactor competition between the ligand-bound oestrogen receptor and an intron 1 enhancer leads to oestrogen repression of ERBB2 expression in breast cancer

Newman, S. P., Bates, N. P., Vernimmen, D., Parker, M. G. & Hurst, H. C., 27 Jan 2000, In: Oncogene. 19, 4, p. 490-7 8 p.

Research output: Contribution to journal › Article › peer-review

1999

A new cis element is involved in the HER2 gene overexpression in human breast cancer cells

Grooteclaes, M., Vernimmen, D., Plaza, S., Pasleau, F., Hodzic, D. & Winkler-Gol, R., 1999, In: Cancer Research. 59, 11, p. 2527-31 5 p.

Research output: Contribution to journal › Article › peer-review

Search results