Analysis of complex mixtures

We are developing multidimensional NMR methods and mass spectrometry approaches, in combination with chemical modification schemes, to investigate the most complex mixtures on earth - humic substances - heterogeneous mixtures containing thousands of organic molecules produced by the degradation of plant and animal residues. We also study other, more pleasant mixtures, like Scotch whisky.

Carbohydrate structures and protein-carbohydrate interactions

Glycosaminoglycans isolated from marine environment are complex, heterogeneous polysaccharides that represent a considerable challenge for the NMR structure determination. We investigate interactions between glycosaminoglycans and selectins – proteins involved in inflammation and metastasis progression.  We also study the conformation of carbohydrates using scalar and residual dipolar coupling constants.

NMR methodology

Using our 400-800 MHz NMR spectrometers equipped with cryoprobes we are developing NMR methodologies for efficient acquisition of NMR spectra applicable across the field of chemistry and biochemistry. This includes fast NMR methods for kinetic and mechanistic studies.

• I am the Head of NMR facility of the School of Chemsitry
• I am the organiser of the 3^rd year Physical Chemistry Labs

Development of NMR methodology and its application to studies of complex mixtures, chemical reactions, carbohydrate structures and protein-carbohydrate interactions.