Elizabeth Patton

2022

Fate mapping melanoma persister cells through regression and into recurrent disease in adult zebrafish

Travnickova, J., Muise, S., Wojciechowska, S., Brombin, A., Zeng, Z., Young, A. I. J., Wyatt, C. & Patton, E. E., 20 Sept 2022, In: Disease Models and Mechanisms.

Research output: Contribution to journal › Article › peer-review

Open Access

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Aldh2 is a lineage-specific metabolic gatekeeper in melanocyte stem cells

Brunsdon, H., Brombin, A., Peterson, S., Postlethwait, J. H. & Patton, E. E., 29 Apr 2022, (E-pub ahead of print) In: Development.

Research output: Contribution to journal › Article › peer-review

Open Access

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Long-term non-invasive drug treatments in adult zebrafish that lead to melanoma drug resistance

Lu, Y. & Patton, E. E., 8 Apr 2022, (E-pub ahead of print) In: Disease Models and Mechanisms.

Research output: Contribution to journal › Article › peer-review

Open Access

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Tfap2b specifies an embryonic melanocyte stem cell that retains adult multifate potential

Brombin, A., Simpson, D. J., Travnickova, J., Brunsdon, H., Zeng, Z., Lu, Y., Young, A. I. J., Chandra, T. & Patton, E. E., 11 Jan 2022, In: Cell Reports. 38, 2, p. 110234

Research output: Contribution to journal › Article › peer-review

Open Access

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2021

Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss

He, S., Zimmerman, M. W., Layden, H. M., Berezovskaya, A., Etchin, J., Martel, M. W., Thurston, G., Jing, C-B., van Rooijen, E., Kaufman, C. K., Rodig, S. J., Zon, L. I., Patton, E. E., Mansour, M. R. & Look, A. T., 1 Sept 2021, In: Oncogene.

Research output: Contribution to journal › Article › peer-review

Open Access

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Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials

Patton, E. E., Zon, L. I. & Langenau, D. M., 11 Jun 2021, (E-pub ahead of print) In: Nature Reviews Drug Discovery.

Research output: Contribution to journal › Review article › peer-review

Open Access

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Melanoma Models for the Next Generation of Therapies

Patton, E. E., Mueller, K. L., Adams, D. J., Anandasabapathy, N., Aplin, A. E., Bertolotto, C., Bosenberg, M., Ceol, C., Chi, P., Herlyn, M., Holmen, S. L., Karreth, F. A., Kaufman, C., Khan, S., Kobold, S., Leucci, E., Levy, C., Lombard, D. B., Lund, A. W., Marie, K. L., & 15 othersMarine, J-C., Marais, R., McMahon, M., Robles-Espinoza, C. D., Ronai, Z. A., Samuels, Y., Soengas, M. S., Villanueva, J., Weeraratna, A. T., White, R. M., Yeh, I., Zhu, J., Zon, L. I., Hurlbert, M. S. & Merlino, G., 10 May 2021, In: Cancer Cell.

Research output: Contribution to journal › Review article › peer-review

Open Access

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2020

Deciphering melanoma cell states and plasticity with zebrafish models

Travnickova, J. & Patton, E. E., 16 Dec 2020, (E-pub ahead of print) In: Journal of Investigative Dermatology.

Research output: Contribution to journal › Review article › peer-review

Open Access

NRASQ61K melanoma tumor formation is reduced by p38-MAPK14 activation in zebrafish models and NRAS-mutated human melanoma cells

Banik, I., Cheng, P. F., Dooley, C. M., Travnickova, J., Merteroglu, M., Dummer, R., Patton, E. E., Busch-Nentwich, E. M. & Levesque, M. P., 10 Sept 2020, (E-pub ahead of print) In: Pigment Cell & Melanoma Research.

Research output: Contribution to journal › Article › peer-review

Open Access

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Spontaneously occurring melanoma in animals and their relevance to human melanoma

van der Weyden, L., Brenn, T., Patton, E. E., Wood, G. A. & Adams, D. J., 1 Sept 2020, In: The Journal of Pathology.

Research output: Contribution to journal › Review article › peer-review

Open Access

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PRL3-DDX21 transcriptional control of endolysosomal genes restricts melanocyte stem cell differentiation

Johansson, J., Marie, K. L., Lu, Y., Brombin, A., Santoriello, C., Zeng, Z., Zich, J., Gautier, P., von Kriegsheim, A., Brunsdon, H., Wheeler, A. P., Dreger, M., Houston, D. R., Dooley, C. M., Sims, A. H., Busch-Nentwich, E. M., Zon, L. I., Illingworth, R. & Patton, E. E., 10 Aug 2020, In: Developmental Cell. 54, 3, p. 317-332.E9 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Tuning transcription factor availability through acetylation-mediated genomic redistribution

Louphrasitthiphol, P., Siddaway, R., Loffreda, A., Pogenberg, V., Friedrichsen, H., Schepsky, A., Faria-Shayler, P., Zeng, Z., Lu, M., Strub, T., Freter, R., Lisle, R., Suer, E., Thomas, B., Schuster-Bockler, B., Filippakopoulos, P., Middleton, M., Lu, X., Patton, E., Davidson, I., & 5 othersLambert, J-P., Wilmanns, M., Steingrimsson, E., Mazza, D. & Goding, C. R., 11 Jun 2020, (E-pub ahead of print) In: Molecular Cell.

Research output: Contribution to journal › Article › peer-review

Open Access

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2019

Zebrafish MITF-low melanoma subtype models reveal transcriptional subclusters and MITF-independent residual disease

Travnickova, J., Wojciechowska, S., Khamseh, A., Gautier, P., Brown, D. V., Lefevre, T., Brombin, A., Ewing, A., Capper, A., Spitzer, M., Dilshat, R., Semple, C. A., Mathers, M. E., Lister, J. A., Steingrimsson, E., Voet, T., Ponting, C. P. & Patton, E. E., Nov 2019, In: Cancer Research. 79, 22, p. 5769-5784 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Endothelin receptor Aa regulates proliferation and differentiation of Erb-dependant pigment progenitors in zebrafish

Camargo-Sosa, K., Colanesi, S., Muller, J., Schulte-Merker, S., Stemple, D., Patton, E. & Kelsh, R. N., 27 Feb 2019, (E-pub ahead of print) In: PLoS Genetics.

Research output: Contribution to journal › Article › peer-review

Open Access

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2018

Notochord Injury Assays that Stimulate Transcriptional Responses in Zebrafish Larvae

Zeng, Z., Lopez-Baez, J. C., LLeras Forero, L., Brunsdon, H., Wyatt, C., Rybski, W., Hastie, N., Schulte-Merker, S. & Patton, E., 23 Dec 2018, In: Bio-protocol. 8, 23, p. e3100

Research output: Contribution to journal › Article › peer-review

Open Access

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ALDH1 bio-activates nifuroxazide to eradicate ALDH^High melanoma-initiating cells

Sarvi, S., Crispin, R., Lu, Y., Zeng, L., Hurley, T. D., Houston, D. R., von Kriegsheim, A., Chen, C-H., Mochly-Rosen, D., Ranzani, M., Mathers, M. E., Xu, X., Xu, W., Adams, D. J., Carragher, N. O., Fujita, M., Schuchter, L., Unciti-Broceta, A., Brunton, V. G. & Patton, E. E., 20 Dec 2018, In: Cell Chemical Biology. 25, 12, p. 1456-1469.e6 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Bright insights into Palladium-triggered local chemotherapy

Bray, T. L., Salji, M., Brombin, A., Pérez-López, A. M., Rubio Ruiz, B., Galbraith, L. C. A., Patton, E. E., Leung, H. Y. & Unciti-Broceta, A., 7 Oct 2018, In: Chemical Science.

Research output: Contribution to journal › Article › peer-review

Open Access

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BRAF/MAPK and GSK3 signaling converge to control MITF nuclear export

Ngeow, K. C., Friedrichsen, H. J., Li, L., Zeng, Z., Andrews, S., Volpon, L., Brunsdon, H., Berridge, G., Picaud, S., Fischer, R., Lisle, R., Knapp, S., Filippakopoulos, P., Knowles, H., Steingrimsson, E., Borden, K. L. B., Patton, E. & Goding, C. R., 11 Sept 2018, In: Proceedings of the National Academy of Sciences (PNAS).

Research output: Contribution to journal › Article › peer-review

Open Access

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Fishing for ancestry

Brunsdon, H. & Patton, E. E., 2 Aug 2018, In: eLIFE. 7

Research output: Contribution to journal › Comment/debate

Open Access

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Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy

Al-Olabi, L., Polubothu, S., Dowsett, K., Andrews, K. A., Stadnik, P., Joseph, A. P., Knox, R., Pittman, A., Clark, G., Baird, W., Bulstrode, N., Glover, M., Gordon, K., Hargrave, D., Hudson, S., Jacques, T. S., James, G., Kondolf, H., Kangesu, L., Keppler-Noreuil, K. M., & 26 othersKhan, A., Lindhurst, M. J., Lipson, M., Mansour, S., O'Hara, J., Mahon, C., Mosica, A., Moss, C., Murthy, A., Ong, J., parker, V., Rivière, J-B., Sapp, J. C., Sebire, N. J., Shah, R., Sivakumar, B., Thomas, A., Virasami, A., Waelchli, R., Zeng, Z., Biesecker, L. G., Barnacle, A., Topf, M., Semple, R. K., Patton, E. E. & Kinsler, V. A., 2 Apr 2018, In: Journal of Clinical Investigation. 128, 4, p. 1496-1508 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Wilms Tumor 1b defines a wound-specific sheath cell subpopulation associated with notochord repair

Lopez-Baez, J. C., Simpson, D. J., LLeras Forero, L., Zeng, Z., Brunsdon, H., Salzano, A., Brombin, A., Rybski, W., Wyatt, C., Huitema, L. F. A., Dale, R. M., Kawakami, K., Englert, C., Chandra, T., Schulte-Merker, S., Hastie, N. D. & Patton, E. E., 13 Feb 2018, In: eLIFE. 7, 26 p., e30657.

Research output: Contribution to journal › Article › peer-review

Open Access

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2017

Cell signalling: Red alert about lipid's role in skin cancer

Jackson, I. J. & Patton, E. E., 21 Sept 2017, In: Nature. 549, 7672, p. 337-339 3 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

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Loss of the chromatin modifier Kdm2aa causes BrafV600E-independent spontaneous melanoma in zebrafish

Scahill, C. M., Digby, Z., Sealy, I. M., Wojciechowska, S., White, R. J., Collins, J. E., Stemple, D. L., Bartke, T., Mathers, M. E., Patton, E. E. & Busch-Nentwich, E. M., 14 Aug 2017, In: PLoS Genetics. 13, 8, p. e1006959

Research output: Contribution to journal › Article › peer-review

Open Access

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2016

Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines that Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase

Fraser, C., Dawson, J. C., Dowling, R., Houston, D. R., Weiss, J. T., Munro, A. F., Muir, M., Harrington, L., Webster, S. P., Frame, M. C., Brunton, V. G., Patton, E. E., Carragher, N. O. & Unciti-Broceta, A., 26 May 2016, In: Journal of Medicinal Chemistry.

Research output: Contribution to journal › Article › peer-review

Open Access

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Mosaic Activating Mutations in GNA11 and GNAQ Are Associated with Phakomatosis Pigmentovascularis and Extensive Dermal Melanocytosis

Thomas, A. C., Zeng, Z., Rivière, J-B., O'Shaughnessy, R., Al-Olabi, L., St.-Onge, J., Atherton, D. J., Aubert, H., Bagazgoitia, L., Barbarot, S., Bourrat, E., Chiaverini, C., Chong, W. K., Duffourd, Y., Glover, M., Groesser, L., Hadj-Rabia, S., Hamm, H., Happle, R., Mushtaq, I., & 6 othersLacour, J-P., Waelchli, R., Wobser, M., Vabres, P., Patton, E. E. & Kinsler, V. A., 1 Apr 2016, In: Journal of Investigative Dermatology. 136, 4, p. 770-778

Research output: Contribution to journal › Article › peer-review

Open Access

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Fish from Head to Tail: The 9th European Zebrafish Meeting in Oslo

Griffiths, G. W., Müller, F., Ledin, J., Patton, E. E., Gjøen, T., Lobert, V. H., Winther-Larsen, H. C., Mullins, M., Joly, J-S., Weltzien, F-A., Press, C. M. & Aleström, P., 9 Feb 2016, In: Zebrafish.

Research output: Contribution to journal › Article › peer-review

Open Access

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Assessment of biocompatibility of 3D printed photopolymers using zebrafish embryo toxicity assays

Macdonald, N. P., Zhu, F., Hall, C. J., Reboud, J., Crosier, P. S., Patton, E. E., Wlodkowic, D. & Cooper, J. M., 5 Jan 2016, In: Lab on a Chip. 16, 2, p. 291-7 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Cross-species models of human melanoma

van der Weyden, L., Patton, E., Wood, G. A., Foote, A., Brenn, T., Arends, M. & Adams, D. J., 1 Jan 2016, In: The Journal of Pathology.

Research output: Contribution to journal › Article › peer-review

Open Access

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2015

Let's make it happen: for gender equality in science!

Kos, L., Patton, E. E. & Soengas, M. S., Nov 2015, In: Pigment Cell & Melanoma Research. 28, 6, p. 641-2 2 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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MEK Inhibitors Reverse cAMP-Mediated Anxiety in Zebrafish

Lundegaard, P. R., Anastasaki, C., Grant, N. J., Sillito, R. R., Zich, J., Zeng, Z., Paranthaman, K., Larsen, A. P., Armstrong, J. D., Porteous, D. J. & Patton, E. E., 22 Oct 2015, In: Chemistry and Biology.

Research output: Contribution to journal › Article › peer-review

Open Access

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Correction - The melanocyte lineage in development and disease

Mort, R. L., Jackson, I. J. & Patton, E. E., 1 Apr 2015, In: Development. 142, 7, p. 1387-1387 1 p.

Research output: Contribution to journal › Comment/debate › peer-review

Temperature-sensitive splicing of mitfa by an intron mutation in zebrafish

Zeng, Z., Johnson, S. L., Lister, J. A. & Patton, E. E., Mar 2015, In: Pigment Cell & Melanoma Research. 28, 2, p. 229-32 4 p.

Research output: Contribution to journal › Letter › peer-review

Open Access

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The melanocyte lineage in development and disease

Mort, R. L., Jackson, I. J. & Patton, E. E., 15 Feb 2015, In: Development. 142, 4, p. 620-632 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Going forward together: cooperative invasion in melanoma

Wojciechowska, S. & Patton, E. E., Jan 2015, In: Pigment Cell & Melanoma Research. 28, 1, p. 6-7 2 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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2014

N-alkynyl derivatives of 5-fluorouracil: susceptibility to palladium-mediated dealkylation and toxigenicity in cancer cell culture

Weiss, J. T., Fraser, C., Rubio Ruiz, B., Myers, S. H., Crispin, R., Dawson, J. C., Brunton, V. G., Patton, E. E., Carragher, N. O. & Unciti-Broceta, A., 29 Jul 2014, In: Frontiers in chemistry. 2, p. 56

Research output: Contribution to journal › Article › peer-review

Open Access

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SYNFORM ISSUE 2014/07

Unciti-Broceta, A., Carragher, N., Weiss, J. T., Dawson, J., Macleod, K., Fraser, C., Patton, E., Bradley, M. & Zanda, M., 1 Jul 2014, In: Synfacts: Highlights in Current Synthetic Organic Chemistry. 10, 07, p. A88-A100

Research output: Contribution to journal › Article › peer-review

Open Access

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Spotlight on zebrafish: translational impact

Patton, E. E., Dhillon, P., Amatruda, J. F. & Ramakrishnan, L., Jul 2014, In: Disease Models and Mechanisms. 7, 7, p. 731-3 3 p.

Research output: Contribution to journal › Editorial › peer-review

Open Access

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Development and bioorthogonal activation of palladium-labile prodrugs of gemcitabine

Weiss, J. T., Dawson, J. C., Fraser, C., Rybski, W., Torres-Sánchez, C., Bradley, M., Patton, E. E., Carragher, N. O. & Unciti-Broceta, A., 26 Jun 2014, In: Journal of Medicinal Chemistry. 57, 12, p. 5395-404 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Extracellular palladium-catalysed dealkylation of 5-fluoro-1-propargyl-uracil as a bioorthogonally activated prodrug approach

Weiss, J. T., Dawson, J. C., Macleod, K. G., Rybski, W., Fraser, C., Torres-Sanchez, C., Patton, E. E., Bradley, M., Carragher, N. O. & Unciti-Broceta, A., 13 Feb 2014, In: Nature Communications. 5, 9 p., 3277.

Research output: Contribution to journal › Article › peer-review

Open Access

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A Conditional Zebrafish MITF Mutation Reveals MITF Levels Are Critical for Melanoma Promotion vs. Regression In Vivo

Lister, J. A., Capper, A., Zeng, Z., Mathers, M. E., Richardson, J., Paranthaman, K., Jackson, I. J. & Patton, E. E., Jan 2014, In: Journal of Investigative Dermatology. 134, 1, p. 133-140 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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2013

The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models

Yen, J., White, R. M., Wedge, D. C., Van Loo, P., de Ridder, J., Capper, A., Richardson, J., Jones, D., Raine, K., Watson, I. R., Wu, C-J., Cheng, J., Martincorena, I., Nik-Zainal, S., Mudie, L., Moreau, Y., Marshall, J., Ramakrishna, M., Tarpey, P., Shlien, A., & 20 othersWhitmore, I., Gamble, S., Latimer, C., Langdon, E., Kaufman, C., Dovey, M., Taylor, A., Menzies, A., McLaren, S., O Meara, S., Butler, A., Teague, J., Lister, J., Chin, L., Campbell, P., Adams, D. J., Zon, L. I., Patton, E. E., Stemple, D. L. & Futreal, P. A., 23 Oct 2013, In: Genome Biology. 14, 10, R113.

Research output: Contribution to journal › Article › peer-review

Open Access

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DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans

Longman, D., Hug, N., Keith, M., Anastasaki, C., Patton, E. E., Grimes, G. & Cáceres, J. F., 1 Sept 2013, In: Nucleic Acids Research. 41, 17, p. 8319-31 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Dopamine from the Brain Promotes Spinal Motor Neuron Generation during Development and Adult Regeneration

Reimer, M. M., Norris, A., Ohnmacht, J., Patani, R., Zhong, Z., Dias, T. B., Kuscha, V., Scott, A. L., Chen, Y-C., Rozov, S., Frazer, S. L., Wyatt, C., Higashijima, S-I., Patton, E. E., Panula, P., Chandran, S., Becker, T. & Becker, C. G., 10 Jun 2013, In: Developmental Cell. 25, 5, p. 478–491

Research output: Contribution to journal › Article › peer-review

Cancer: Trouble upstream

Patton, E. E. & Harrington, L., 21 Mar 2013, In: Nature. 495, 7441, p. 320-1 2 p.

Research output: Contribution to journal › Article › peer-review

2012

Live imaging in zebrafish reveals neu(trophil) insight into the metastatic niche

Patton, E. E., Aug 2012, In: The Journal of Pathology. 227, 4, p. 381-4 4 p.

Research output: Contribution to journal › Article › peer-review

ALDH2 Mediates 5-Nitrofuran Activity in Multiple Species

Zhou, L., Ishizaki, H., Spitzer, M., Taylor, K. L., Temperley, N. D., Johnson, S. L., Brear, P., Gautier, P., Zeng, Z., Mitchell, A., Narayan, V., McNeil, E. M., Melton, D. W., Smith, T. K., Tyers, M., Westwood, N. J. & Patton, E. E., 27 Jul 2012, In: Chemistry and Biology. 19, 7, p. 883-892 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Continual low-level MEK inhibition ameliorates cardio-facio-cutaneous phenotypes in zebrafish

Anastasaki, C., Rauen, K. A. & Patton, E. E., Jul 2012, In: Disease Models and Mechanisms. 5, 4, p. 546-52 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Small molecule screening identifies targetable zebrafish pigmentation pathways

Colanesi, S., Taylor, K. L., Temperley, N. D., Lundegaard, P. R., Liu, D., North, T. E., Ishizaki, H., Kelsh, R. N. & Patton, E. E., Mar 2012, In: Pigment Cell & Melanoma Research. 25, 2, p. 131-43 13 p.

Research output: Contribution to journal › Article › peer-review

2011

Differentiated melanocyte cell division occurs in vivo and is promoted by mutations in Mitf

Taylor, K. L., Lister, J. A., Zeng, Z., Ishizaki, H., Anderson, C., Kelsh, R. N., Jackson, I. J. & Patton, E. E., Aug 2011, In: Development. 138, 16, p. 3579-3589 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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A zebrafish model for nevus regeneration

Richardson, J., Zeng, Z., Ceol, C., Mione, M., Jackson, I. & Patton, E. E., Apr 2011, In: Pigment Cell & Melanoma Research. 24, 2, p. 378-381 4 p.

Research output: Contribution to journal › Letter › peer-review

Open Access

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Elizabeth Patton

Research output

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