Personal profile
My research in a nutshell
Our focus is on improving how biomedical studies are designed, reported and evaluated so they are more reliable and translate to better health.
Current Research Interests
Meta-research; neuroscience; research reproducibility; research improvement interventions; systematic review and meta-analysis; automation of evidence synthesis; preclinical research; in vitro research methodology; evidence triangulation; translational medicine
Education/Academic qualification
Doctor of Philosophy (PhD), Systematic review and meta-analysis of neuroprotective drugs in animal models of ischemic stroke, University of Edinburgh
Award Date: 1 Jan 2010
Bachelor of Science, Systematic review and meta-analysis of the efficacy of tirilazad in experimental stroke, University of Edinburgh
Award Date: 1 Jan 2005
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Collaborations and top research areas from the last five years
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Systematic review and meta-analysis of cognitive assessments used to detect deficits in the bilateral carotid artery stenosis model for vascular cognitive impairment
Padgett, M. J., Fucelova, N., Boltze, J., England, T. J., Hietamies, T., Horsburgh, K., Quinn, T. J., Sena, E. S., Work, L. M., Zille, M., Trueman, R. C. & Farr, T. D., 17 Jan 2026, (E-pub ahead of print) In: Journal of Cerebral Blood Flow and Metabolism.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Preclinical Ischemic Stroke Multicenter (PRISM) Trials Collective Statement: Opportunities, Challenges, and Recommendations for a New Era
Ayata, C., Bath, P. M., Planas, A. M., Allan, S. M., Boltze, J., Cabeen, R. P., Gibson, C. L., Cipolla, M. J., Diniz, M. A., Fumagalli, S., Hyder, F., Koehler, R. C., Liesz, A., McCann, S. K., Magnus, T., McCullough, L. D., Sena, E. S., Beretta, S., Aronowski, J. & Bosetti, F. & 3 others, , 11 Sept 2025, (E-pub ahead of print) In: Stroke.Research output: Contribution to journal › Review article › peer-review
Open AccessFile -
The therapeutic potential of exercise in post-traumatic stress disorder and its underlying mechanisms: A living systematic review of human and non-human studies [version 4; peer review: 1 approved, 2 approved with reservations]
Wright, S., Chiocchia, V., Elugbadebo, O., Simple, O., Furukawa, T. A., Friedrich, C., Austin, C., Dehdarirad, H., Gilbert, D., Kennett, J., Ostinelli, E. G., Potts, J., Ramage, F., Sena, E., Siafis, S., Stansfield, C., Thomas, J., Tinsdeall, F., Tonia, T. & Macleod, M. & 3 others, , 27 May 2025, In: Wellcome Open Research. 9, 720.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
A machine learning-assisted systematic review of preclinical glioma modeling: Is practice changing with the times?
Hirst, T. C., Wilson, E., Browne, D. & Sena, E. S., 28 Dec 2024, In: Neuro-Oncology Advances. 6, 1, p. vdae193Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Connecting the dots in neuroscience research: The future of evidence synthesis
Hair, K., Araujo, M. A., Vojvodic, S., Economou, M., Wong, C., Tinsdeall, F., Smith, S., Rackoll, T., Sena, E. S. & McCann, S. K., 5 Nov 2024, (E-pub ahead of print) In: Experimental neurology. p. 115047Research output: Contribution to journal › Article › peer-review
Open AccessFile
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Race Against Dementia: Team Vascular - Prevention and Treatment of Vascular Cognitive Impairment and Dementia.
Wardlaw, J. (Principal Investigator), MacLeod, M. (Co-investigator), Russ, T. (Co-investigator), Sena, E. (Co-investigator), Stringer, M. (Co-investigator) & Williams, A. (Co-investigator)
1/10/24 → 30/09/29
Project: Research
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iRISE: improving Reproducibility In SciencE
Sena, E. (Principal Investigator)
1/09/23 → 31/08/26
Project: Research
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Improving the credibility and utility of in vitro research
Sena, E. (Principal Investigator) & McColl, B. (Co-investigator)
1/11/22 → 31/08/26
Project: Research
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Connecting the dots: emerging tools to synthesise evidence in translational neuroscience
Sena, E. (Principal Investigator)
1/02/24 → 31/01/25
Project: Research
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A web based, continuously updated summary of primary research relevant to AD
Sena, E. (Principal Investigator), Currie, G. (Co-investigator) & MacLeod, M. (Co-investigator)
1/01/22 → 30/06/23
Project: Research
Datasets
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Data from: A systematic review and meta-analysis of gene therapy in animal models of cerebral glioma: why did promise not translate to human therapy?
Hirst, T. C. (Creator), Vesterinen, H. M. (Creator), Conlin, S. (Creator), Egan, K. J. (Creator), Antonic, A. (Creator), Lawson McLean, A. (Creator), Macleod, M. R. (Creator), Grant, R. (Creator), Brennan, P. M. (Creator), Sena, E. S. (Creator) & Whittle, I. R. (Creator), Dryad, 9 Jan 2016
DOI: 10.5061/dryad.bs8c4, https://datadryad.org/stash/dataset/doi:10.5061/dryad.bs8c4 and one more link, https://zenodo.org/records/4985252 (show fewer)
Dataset
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Data from: Drug repurposing: a systematic approach to evaluate candidate oral neuroprotective interventions for secondary progressive multiple sclerosis
Vesterinen, H. M. (Creator), Connick, P. (Creator), Irvine, C. M. J. (Creator), Sena, E. S. (Creator), Egan, K. J. (Creator), Carmichael, G. G. (Creator), Tariq, A. (Creator), Pavitt, S. (Creator), Chattaway, J. (Creator), Macleod, M. R. (Creator), Chandran, S. (Creator) & Chataway, J. (Creator), Dryad, 23 Mar 2016
DOI: 10.5061/dryad.8qd33, https://zenodo.org/records/5024204
Dataset
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Data from: Risk of bias in reports of in vivo research: a focus for improvement
Macleod, M. R. (Creator), McLean, A. L. (Creator), Kyriakopoulou, A. (Creator), Serghiou, S. (Creator), De Wilde, A. (Creator), Sherratt, N. (Creator), Hirst, T. (Creator), Hemblade, R. (Creator), Bahor, Z. (Creator), Nunes-Fonseca, C. (Creator), Potluru, A. (Creator), Thomson, A. (Creator), Baginskaite, J. (Creator), Egan, K. (Creator), Vesterinen, H. (Creator), Currie, G. L. (Creator), Churilov, L. (Creator), Howwels, D. W. (Creator), Sena, E. S. (Creator), Serghiou, S. (Creator), Baginskitae, J. (Creator) & Howells, D. W. (Creator), Dryad, 13 Aug 2016
DOI: 10.5061/dryad.cs3t8, https://zenodo.org/records/4968391
Dataset
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Timing of SMN replacement therapies in models of spinal muscular atrophy: a systematic review and meta-analysis
Chaytow, H. (Creator), Motyl, A. (Creator), Huang, N. (Creator), Wong, C. (Creator), Currie, G. (Creator), Bahor, Z. (Creator), Sena, E. (Creator) & Gillingwater, T. (Creator), Edinburgh DataShare, 13 Oct 2023
DOI: 10.7488/ds/7526, https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020200180&ID=CRD42020200180
Dataset
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MRI Variability in a Rat Model of Stroke
Milidonis, X. (Creator), Sena, E. (Creator), MacLeod, M. (Creator) & Marshall, I. (Creator), Edinburgh DataShare, 11 Oct 2016
DOI: 10.7488/ds/1496
Dataset
Press/Media
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Emily Sena says poorly-designed medical tests cause avoidable animal deaths and poor results
28/07/16
1 item of Media coverage
Press/Media: Expert Comment