Emily Watts

2023

NRF2 activation reprogrammes defects in oxidative metabolism to restore macrophage function in COPD

Ryan, E., Sadiku, P., Coelho, P., Watts, E. R., Zhang, A., Howden, A. J. M., Sanchez Garcia, M. A., Bewley, M. A., Cole, J., McHugh, B., Vermaelen, W., Ghesquiere, B., Carmeliet, P., Rodriguez Blanco, G., von Kriegsheim, A., Sanchez, Y., Rumsey, W., Callahan, J. F., Cooper, G. & Parkinson, N. & 8 others, Baillie, J. K., Cantrell, D., McCafferty, J., Choudhury, G., Singh, D., Dockrell, D. H., Whyte, M. K. B. & Walmsley, S. R., 1 Feb 2023, (E-pub ahead of print) In: American Journal of Respiratory and Critical Care Medicine.

Research output: Contribution to journal › Article › peer-review

Open Access

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2022

The emerging role for metabolism in fueling neutrophilic inflammation

Morrison, T., Watts, E. R., Sadiku, P. & Walmsley, S. R., 3 Nov 2022, In: Immunological reviews.

Research output: Contribution to journal › Review article › peer-review

Open Access

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Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation

Mirchandani, A. S., Jenkins, S. J., Bain, C. C., Sanchez Garcia, M. A., Lawson, H., Coelho, P., Murphy, F., Griffith, D., Zhang, A., Morrison, T., Ly, T., Arienti, S., Sadiku, P., Watts, E. R., Dickinson, R., Reyes, L., Cooper, G., Clark, S., Lewis, D. & Kelly, V. & 22 others, Spanos, C., Musgrave, K. M., Delaney, L., Harper, I., Scott, J., Parkinson, N., Rostron, A. J., Baillie, J. K., Clohisey, S., Pridans, C., Campana, L., Starkey Lewis, P., Simpson, A. J., Dockrell, D. H., Schwarze, J., Hirani, N., Ratcliffe, P. J., Pugh, C. W., Kranc, K., Forbes, S. J., Whyte, M. K. B. & Walmsley, S. R., 27 May 2022, In: Nature Immunology.

Research output: Contribution to journal › Article › peer-review

Open Access

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Hypoxia shapes the immune landscape in lung injury promoting inflammation persistence

Mirchandani, A. S., Jenkins, S. J., Bain, C. C., Lawson, H., Coelho, P., Murphy, F., Griffith, D., Zhang, A., Sanchez-Garcia, M. A., Reyes, L., Morrison, T., Arienti, S., Sadiku, P., Watts, E. R., Dickinson, R. S., Clark, S., Ly, T., Lewis, D., Kelly, V. & Spanos, C. & 21 others, Musgrave, K. M., Delaney, L., Harper, I., Scott, J., Parkinson, N. J., Rostron, A. J., Baillie, K. J., Clohisey, S., Pridans, C., Campana, L., Starkey-Lewis, P., Simpson, A. J., Dockrell, D., Schwarze, J., Hirani, N., Ratcliffe, P. J., Pugh, C. W., Kranc, K., Forbes, S. J., Whyte, M. K. & Walmsley, S. R., 12 Mar 2022, bioRxiv, p. 1-53, 53 p.

Research output: Working paper › Preprint

2021

A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS

Reyes, L., Sanchez Garcia, M. A., Morrison, T., Howden, A. J. M., Watts, E. R., Arienti, S., Sadiku, P., Coelho, P., Mirchandani, A. S., Zhang, A., Hope, D., Clark , S. K., Singleton, J., Johnston, S., Grecian, R., Poon, A. S., McNamara, S., Harper, I., Fourman, M. H. & Brenes, A. J. & 14 others, Pathak, S., Lloyd, A., Rodriguez Blanco, G., von Kriegsheim, A., Ghesquiere, B., Vermaelen, W., Cologna, C. T., Dhaliwal, K., Hirani, N., Dockrell, D. H., Whyte, M. K. B., Griffith, D. M., Cantrell, D. & Walmsley, S. R., 25 Jun 2021, (E-pub ahead of print) Wellcome Open Research, (wellcome Open Research).

Research output: Working paper

Open Access

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Hypoxia drives murine neutrophil protein scavenging to maintain central carbon metabolism

Watts, E. R., Howden, A. J. M., Morrison, T., Sadiku, P., Hukelmann, J. L., Von Kriegsheim, A., Ghesquière, B., Murphy, F., Mirchandani, A. S., Humphries, D. C., Grecian, R., Ryan, E. M., Coelho, P., Rodriguez-blanco, G., Plant, T. M., Dickinson, R. S., Finch, A. J., Vermaelen, W., Cantrell, D. A. & Whyte, M. K. B. & 1 others, Walmsley, S. R., 6 Apr 2021, (E-pub ahead of print) In: Journal of Clinical Investigation.

Research output: Contribution to journal › Article › peer-review

Open Access

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A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS

Reyes, L., Sanchez Garcia, M. A., Morrison, T., Howden, A. J. M., Watts, E. R., Arienti, S., Sadiku, P., Coelho, P., Mirchandani, A. S., Zhang, A., Hope, D., Clark , S. K., Singleton, J., Johnston, S., Grecian, R., Poon, A. S., McNamara, S., Harper, I., Fourman, M. H. & Brenes, A. J. & 14 others, Pathak, S., Lloyd, A., Rodriguez Blanco, G., von Kriegsheim, A., Ghesquiere, B., Vermaelen, W., Cologna, C. T., Dhaliwal, K., Hirani, N., Dockrell, D. H., Whyte, M. K. B., Griffith, D. M., Cantrell, D. & Walmsley, S. R., 22 Feb 2021, In: Wellcome Open Research .

Research output: Contribution to journal › Article › peer-review

Open Access

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Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis

Sadiku, P., Willson, J. A., Ryan, E. M., Sammut, D., Coelho, P., Watts, E. R., Grecian, R., Young, J. M., Bewley, M., Arienti, S., Mirchandani, A. S., Sanchez Garcia, M. A., Morrison, T., Zhang, A., Reyes, L., Griessler, T., Jheeta, P., Paterson, G. G., Graham, C. J. & Thompson, J. P. & 16 others, Baillie, K., Thompson, A. A. R., Morgan, J.-M., Acosta-Sanchez, A., Dardé, V. M., Duran, J., Guinovart, J. J., Rodriguez-Blanco, G., Von Kriegsheim, A., Meehan, R. R., Mazzone, M., Dockrell, D. H., Ghesquiere, B., Carmeliet, P., Whyte, M. K. B. & Walmsley, S. R., 2 Feb 2021, In: Cell Metabolism. 33, 2, p. 411-423.e4

Research output: Contribution to journal › Article › peer-review

Open Access

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2020

Semaphorin 3F signaling actively retains neutrophils at sites of inflammation

Plant, T., Eamsamarng, S., Sanchez-Garcia, M. A., Reyes, L., Renshaw, S. A., Coelho, P., Mirchandani, A. S., Morgan, J.-M., Ellett, F. E., Morrison, T., Humphries, D., Watts, E. R., Murphy, F., Raffo-Iraolagoitia, X. L., Zhang, A., Cash, J. L., Loynes, C., Elks, P. M., Van Eeden, F. & Carlin, L. M. & 3 others, Furley, A. J. W., Whyte, M. K. B. & Walmsley, S. R., 1 Jun 2020, In: Journal of Clinical Investigation. 130, 6, p. 3221-3237

Research output: Contribution to journal › Article › peer-review

Open Access

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2019

IL4Rα signaling abrogates hypoxic neutrophil survival and limits acute lung injury responses in vivo

Harris, A. J., Mirchandani, A. S., Lynch, R. W., Murphy, F., Delaney, L., Small, D., Coelho, P., Watts, E. R., Sadiku, P., Griffith, D., Dickinson, R. S., Clark, E., Willson, J. A., Morrison, T., Mazzone, M., Carmeliet, P., Ghesquiere, B., O'Kane, C., McAuley, D. & Jenkins, S. J. & 2 others, Whyte, M. K. B. & Walmsley, S. R., 15 Jul 2019, In: American Journal of Respiratory and Critical Care Medicine. 200, 2, p. 235–246 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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2017

Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses

Sadiku, P., Willson, J. A., Dickinson, R., Murphy, F., Harris, A., Lewis, A., Sammut, D., Mirchandani, A. S., Ryan, E., Watts, E. R., Thompson, A. A. R., Marriott, H. M., Dockrell, D. H., Taylor, C. T., Schneider, M., Maxwell, P. H., Chilvers, E. R., Mazzone, M., Moral, V. & Pugh, C. W. & 6 others, Ratcliffe, P. J., Schofield, C. J., Ghesquiere, B., Carmeliet, P., Whyte, M. K. B. & Walmsley, S. R., 1 Sept 2017, In: Journal of Clinical Investigation. 127, 9, p. 3407-3420 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Hypoxia determines survival outcomes of bacterial infection through HIF-1α–dependent reprogramming of leukocyte metabolism

Thompson, A. A. R., Dickinson, R. S., Murphy, F., Thomson, J. P., Marriott, H. M., Tavares, A., Willson, J., Williams, L., Lewis, A., Mirchandani, A., Dos Santos Coelho, P., Doherty, C., Ryan, E., Watts, E., Morton, N. M., Forbes, S., Stimson, R. H., Hameed, A. G., Arnold, N. & Preston, J. A. & 15 others, Lawrie, A., Finisguerra, V., Mazzone, M., Sadiku, P., Goveia, J., Taverna, F., Carmeliet, P., Foster, S. J., Chilvers, E. R., Cowburn, A. S., Dockrell, D. H., Johnson, R. S., Meehan, R. R., Whyte, M. K. B. & Walmsley, S. R., 24 Feb 2017, In: Science Immunology. 2, 8, eaal2861.

Research output: Contribution to journal › Article › peer-review

Open Access

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Emily Watts

Research output

Search results