Research output per year
Research output per year
Search results
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2023
NRF2 activation reprogrammes defects in oxidative metabolism to restore macrophage function in COPD
Ryan, E., Sadiku, P., Coelho, P., Watts, E. R., Zhang, A., Howden, A. J. M., Sanchez Garcia, M. A., Bewley, M. A., Cole, J., McHugh, B., Vermaelen, W., Ghesquiere, B., Carmeliet, P., Rodriguez Blanco, G., von Kriegsheim, A., Sanchez, Y., Rumsey, W., Callahan, J. F., Cooper, G. & Parkinson, N. & 8 others, , 1 Feb 2023, (E-pub ahead of print) In: American Journal of Respiratory and Critical Care Medicine.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2022
Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation
Mirchandani, A. S., Jenkins, S. J., Bain, C. C., Sanchez Garcia, M. A., Lawson, H., Coelho, P., Murphy, F., Griffith, D., Zhang, A., Morrison, T., Ly, T., Arienti, S., Sadiku, P., Watts, E. R., Dickinson, R., Reyes, L., Cooper, G., Clark, S., Lewis, D. & Kelly, V. & 22 others, , 27 May 2022, In: Nature Immunology.Research output: Contribution to journal › Article › peer-review
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2021
Hypoxia drives murine neutrophil protein scavenging to maintain central carbon metabolism
Watts, E. R., Howden, A. J. M., Morrison, T., Sadiku, P., Hukelmann, J. L., Von Kriegsheim, A., Ghesquière, B., Murphy, F., Mirchandani, A. S., Humphries, D. C., Grecian, R., Ryan, E. M., Coelho, P., Rodriguez-blanco, G., Plant, T. M., Dickinson, R. S., Finch, A. J., Vermaelen, W., Cantrell, D. A. & Whyte, M. K. B. & 1 others, , 6 Apr 2021, (E-pub ahead of print) In: Journal of Clinical Investigation.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS
Reyes, L., Sanchez Garcia, M. A., Morrison, T., Howden, A. J. M., Watts, E. R., Arienti, S., Sadiku, P., Coelho, P., Mirchandani, A. S., Zhang, A., Hope, D., Clark , S. K., Singleton, J., Johnston, S., Grecian, R., Poon, A. S., McNamara, S., Harper, I., Fourman, M. H. & Brenes, A. J. & 14 others, , 22 Feb 2021, In: Wellcome Open Research .Research output: Contribution to journal › Article › peer-review
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Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis
Sadiku, P., Willson, J. A., Ryan, E. M., Sammut, D., Coelho, P., Watts, E. R., Grecian, R., Young, J. M., Bewley, M., Arienti, S., Mirchandani, A. S., Sanchez Garcia, M. A., Morrison, T., Zhang, A., Reyes, L., Griessler, T., Jheeta, P., Paterson, G. G., Graham, C. J. & Thompson, J. P. & 16 others, , 2 Feb 2021, In: Cell Metabolism. 33, 2, p. 411-423.e4Research output: Contribution to journal › Article › peer-review
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2020
Semaphorin 3F signaling actively retains neutrophils at sites of inflammation
Plant, T., Eamsamarng, S., Sanchez-Garcia, M. A., Reyes, L., Renshaw, S. A., Coelho, P., Mirchandani, A. S., Morgan, J.-M., Ellett, F. E., Morrison, T., Humphries, D., Watts, E. R., Murphy, F., Raffo-Iraolagoitia, X. L., Zhang, A., Cash, J. L., Loynes, C., Elks, P. M., Van Eeden, F. & Carlin, L. M. & 3 others, , 1 Jun 2020, In: Journal of Clinical Investigation. 130, 6, p. 3221-3237Research output: Contribution to journal › Article › peer-review
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2019
IL4Rα signaling abrogates hypoxic neutrophil survival and limits acute lung injury responses in vivo
Harris, A. J., Mirchandani, A. S., Lynch, R. W., Murphy, F., Delaney, L., Small, D., Coelho, P., Watts, E. R., Sadiku, P., Griffith, D., Dickinson, R. S., Clark, E., Willson, J. A., Morrison, T., Mazzone, M., Carmeliet, P., Ghesquiere, B., O'Kane, C., McAuley, D. & Jenkins, S. J. & 2 others, , 15 Jul 2019, In: American Journal of Respiratory and Critical Care Medicine. 200, 2, p. 235–246 12 p.Research output: Contribution to journal › Article › peer-review
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2017
Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses
Sadiku, P., Willson, J. A., Dickinson, R., Murphy, F., Harris, A., Lewis, A., Sammut, D., Mirchandani, A. S., Ryan, E., Watts, E. R., Thompson, A. A. R., Marriott, H. M., Dockrell, D. H., Taylor, C. T., Schneider, M., Maxwell, P. H., Chilvers, E. R., Mazzone, M., Moral, V. & Pugh, C. W. & 6 others, , 1 Sept 2017, In: Journal of Clinical Investigation. 127, 9, p. 3407-3420 14 p.Research output: Contribution to journal › Article › peer-review
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Hypoxia determines survival outcomes of bacterial infection through HIF-1α–dependent reprogramming of leukocyte metabolism
Thompson, A. A. R., Dickinson, R. S., Murphy, F., Thomson, J. P., Marriott, H. M., Tavares, A., Willson, J., Williams, L., Lewis, A., Mirchandani, A., Dos Santos Coelho, P., Doherty, C., Ryan, E., Watts, E., Morton, N. M., Forbes, S., Stimson, R. H., Hameed, A. G., Arnold, N. & Preston, J. A. & 15 others, , 24 Feb 2017, In: Science Immunology. 2, 8, eaal2861.Research output: Contribution to journal › Article › peer-review
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