Gwo-Tzer Ho

2025

Age-related impairment of intestinal inflammation resolution through an eicosanoid-immune-microbiota axis

Goepp, M., Milburn, J., Zhang, B., Dong, Y., Tyrrell, V., Zheng, X., Marshall, J., Bolsega, S., Basic, M., Glendinning, L., Ho, G.-T., Satsangi, J., Breyer, R. M., Narumiya, S., McSorley, H. J., Schwarze, J., Anderson, C., Dockrell, D. H., Rossi, A. G. & Bleich, A. & 6 others, Lucas, C. D., O'Donnell, V. B., Mole, D. J., Arends, M. J., Zhou, Y. & Yao, C., 14 May 2025, (E-pub ahead of print) In: Cell Host & Microbe. 33, 5, p. 671-687.e6

Research output: Contribution to journal › Article › peer-review

Open Access

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2024

Altered DNA methylation within DNMT3A, AHRR, LTA/TNF loci mediates the effect of smoking on inflammatory bowel disease

Zhang, H., Kalla, R., Chen, J., Zhao, J., Zhou, X., Adams, A., Noble, A., Ventham, N. T., Wellens, J., Ho, G.-T., Dunlop, M. G., Krzysztof Nowak, J., Ding, Y., Liu, Z., Satsangi, J., Theodoratou, E. & Li, X., 18 Jan 2024, In: Nature Communications. 15, 14 p., 595 .

Research output: Contribution to journal › Article › peer-review

Open Access

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2023

The contribution of genetic risk and lifestyle factors in the development of adult-onset inflammatory bowel disease: a prospective cohort study

Sun, Y., Yuan, S., Chen, X., Sun, J., Kalla, R., Yu, L., Wang, L., Zhou, X., Kong, X., Hesketh, T., Ho, G.-T., Ding, K., Dunlop, M. G., Larsson, S. C., Satsangi, J., Chen, J., Wang, X., Li, X., Theodoratou, E. & Giovannucci, E. L., 1 Mar 2023, In: The American Journal of Gastroenterology. 118, 3, p. 511-522

Research output: Contribution to journal › Article › peer-review

Open Access

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2022

Bi-directional Mendelian randomization analysis provides evidence for the causal involvement of dysregulation of CXCL9, CCL11 and CASP8 in the pathogenesis of ulcerative colitis

Chen, J., Zhou, Y., Sun, Y., Yuan, S., Kalla, R., Sun, J., Zhao, J., Wang, L., Chen, X., Zhou, X., Dai, S., Zhang, Y., Ho, G.-T., Xia, D., Cao, Q., Liu, Z., Larsson, S. C., Wang, X., Ding, K. & Halfvarson, J. & 3 others, Li, X., Theodoratou, E. & Satsangi, J., 28 Dec 2022, (E-pub ahead of print) In: Journal of Crohn's and Colitis.

Research output: Contribution to journal › Article › peer-review

Open Access

File

2021

Intestinal Protein Characterisation of SARS-CoV-2 Entry Molecules ACE2 and TMPRSS2 in Inflammatory Bowel Disease (IBD) and Fatal COVID-19 Infection

McAllister, M. J., Kirkwood, K., Chuah, S. C., Thompson, E. J., Cartwright, J. A., Russell, C. D., Dorward, D. A., Lucas, C. D. & Ho, G.-T., 25 Oct 2021, (E-pub ahead of print) In: Inflammation. 45, 2, p. 567-572 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Immunofluorescence on FFPE tissue sections from inflamed and non-inflamed human gut

Porter, R., Smith, K., Ho, G.-T. & Gwyer Findlay, E. L., 23 Mar 2021

Research output: Other contribution › Protocols

Open Access

Neutrophil Extracellular Traps in Inflammatory Bowel Disease: Pathogenic Mechanisms and Clinical Translation

Drury, B., Hardisty, G., Gray, R. D. & Ho, G.-T., 6 Mar 2021, In: Cellular and Molecular Gastroenterology and Hepatology.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Prostaglandin E2 promotes intestinal inflammation via inhibiting microbiota-dependent regulatory T cells

Crittenden, S., Goepp, M., Pollock, J., Robb, C., Smyth, D. J., Zhou, Y., Andrews, R., Tyrrell, V., Gkikas, K., Adima, A., O'Connor, R. A., Davies, L., Li, X.-F., Yao, H. X., Ho, G.-T., Zheng, X., Mair, A., Vermeren, S., Qian, B.-Z. & Mole, D. J. & 12 others, Gerasimidis, K., Schwarze, J., Breyer, R. M., Arends, M. J., O'donnell, V. B., Iredale, J. P., Anderton, S. M., Narumiya, S., Maizels, R. M., Rossi, A. G., Howie, S. E. M. & Yao, C., 12 Feb 2021, In: Science Advances.

Research output: Contribution to journal › Article › peer-review

Open Access

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2020

Whole blood profiling of T-cell derived miRNA allows the development of prognostic models in inflammatory bowel disease

IBD CHARACTER consortium, 1 Dec 2020, In: Journal of Crohn's and Colitis. 14, 12, p. 1724–1733

Research output: Contribution to journal › Article › peer-review

Open Access

File

Ulcerative colitis: Recent advances in the understanding of disease pathogenesis

Porter, R. J., Kalla, R. & Ho, G.-T., 24 Apr 2020, In: F1000Research. 9, p. 294

Research output: Contribution to journal › Article › peer-review

Open Access

File

Resolution of Inflammation and Gut Repair in IBD: Translational Steps Towards Complete Mucosal Healing

Ho, G.-T., Cartwright, J. A., Thompson, E. J., Bain, C. C. & Rossi, A. G., 31 Mar 2020, In: Inflammatory Bowel Diseases.

Research output: Contribution to journal › Article › peer-review

Open Access

File

2019

IBD prevalence in Lothian, Scotland, derived by capture–recapture methodology

Jones, G.-R., Lyons, M., Plevris, N., Jenkinson, P. W., Bisset, C., Burgess, C., Din, S., Fulforth, J., Henderson, P., Ho, G.-T., Kirkwood, K., Noble, C., Shand, A. G., Wilson, D. C., Arnott, I. D. & Lees, C. W., Nov 2019, In: Gut. 68, 11, p. 1953-1960 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

2018

Implementation of CT-P13 via a Managed Switch Programme in Crohn's Disease: 12-Month Real-World Outcomes

Plevris, N., Jones, G. R., Jenkinson, P. W., Lyons, M., Chuah, C. S., Merchant, L. M., Pattenden, R. J., Watson, E. F., Ho, G.-T., Noble, C. L., Din, S., Shand, A. G., Arnott, I. D. & Lees, C. W., 7 Dec 2018, (E-pub ahead of print) In: Digestive Diseases and Sciences.

Research output: Contribution to journal › Article › peer-review

The prevalence and transcriptional activity of the mucosal microbiota of ulcerative colitis patients

Moen, A. E. F., Lindstrøm, J. C., Tannæs, T. M., Vatn, S., Ho, G.-T. (Member of Consortium), Ricanek, P., Vatn, M. H. & Jahnsen, J., 1 Dec 2018, In: Scientific Reports. 8, 1

Research output: Contribution to journal › Article › peer-review

Open Access

File

Higher Adalimumab Drug Levels During Maintenance Therapy for Crohn's Disease Are Associated With Biologic Remission

Plevris, N., Lyons, M., Jenkinson, P. W., Chuah, C. S., Merchant, L. M., Pattenden, R. J., Watson, E. F., Ho, G.-T., Noble, C. L., Shand, A. G., Din, S., Arnott, I. D., Jones, G. R. & Lees, C. W., 17 Oct 2018, (E-pub ahead of print) In: Inflammatory Bowel Diseases.

Research output: Contribution to journal › Article › peer-review

Purine metabolism controls innate lymphoid cell function and protects against intestinal injury

Crittenden, S., Cheyne, A., Adams, A., Forster, T., Robb, C. T., Felton, J., Ho, G.-T., Ruckerl, D., Rossi, A. G., Anderton, S. M., Ghazal, P., Satsangi, J., Howie, S. E. & Yao, C., 14 May 2018, (E-pub ahead of print) In: Immunology & Cell Biology.

Research output: Contribution to journal › Article › peer-review

Open Access

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Mitochondrial DNA Is a Pro-Inflammatory Damage-Associated Molecular Pattern Released During Active IBD

Boyapati, R. K., Dorward, D. A., Tamborska, A., Kalla, R., Ventham, N. T., Doherty, M. K., Whitfield, P. D., Gray, M., Loane, J., Rossi, A. G., Satsangi, J. & Ho, G.-T., 1 May 2018, (E-pub ahead of print) In: Inflammatory Bowel Diseases.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases

The Inflammatory Bowel Disease Biomarkers Consortium & Ho, G.-T. (Member of Consortium), Apr 2018, In: Gastroenterology. 154, 5, p. 1320-1333.e10

Research output: Contribution to journal › Article › peer-review

Top-down in the Long Term in Crohn’s Disease

Boyapati, R. K., Ho, G. T. & Satsangi, J., 14 Mar 2018, In: Journal of Crohn's and Colitis.

Research output: Contribution to journal › Article › peer-review

Open Access

File

2017

MDR1 deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation

Ho, G.-T., Aird, R. E., Liu, B., Boyapati, R. K., Kennedy, N. A., Dorward, D. A., Noble, C. L., Shimizu, T., Carter, R. N., Chew, E. T. S., Morton, N. M., Rossi, A. G., Sartor, R. B., Iredale, J. P. & Satsangi, J., 12 Apr 2017, (E-pub ahead of print) In: Mucosal Immunology.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Advances in the understanding of mitochondrial DNA as a pathogenic factor in inflammatory diseases

Boyapati, R. K., Tamborska, A., Dorward, D. A. & Ho, G.-T., 20 Feb 2017, (E-pub ahead of print) In: F1000Research. 6, p. 169

Research output: Contribution to journal › Article › peer-review

Open Access

File

2016

Biomarkers in search of Precision Medicine in IBD

BOYAPATI, R. K., Kalla, R., Satsangi, J. & Ho, G.-T., Dec 2016, In: The American Journal of Gastroenterology. 111, 12

Research output: Contribution to journal › Article › peer-review

Open Access

File

Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease

Ventham, N. T., Kennedy, N. A., Adams, A. T., Kalla, R., Heath, S., O'Leary, K. R., Drummond, H., IBD BIOM consortium, IBD CHARACTER consortium, Wilson, D. C., Gut, I. G., Nimmo, E. R., Satsangi, J. & Ho, G.-T. (Member of Consortium), 25 Nov 2016, In: Nature Communications. 7, 13507.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Can Thiopurines Prevent Formation of Antibodies Against Tumor Necrosis Factor Antagonists After Failure of These Therapies

BOYAPATI, R. K., Ho, G.-T. & Satsangi, J., 5 Oct 2016, (E-pub ahead of print) In: Clinical Gastroenterology and Hepatology.

Research output: Contribution to journal › Editorial › peer-review

Open Access

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Serum Calprotectin - A novel diagnostic and prognostic marker in Inflammatory Bowel Diseases

Kalla, R., Kennedy, N., Ventham, N. T., BOYAPATI, R. K., Adams, A. T., Nimmo, E., Visconti, M., Drummond, H., Ho, G.-T., Pattenden, R., Wilson, D. C. & Satsangi, J., 6 Sept 2016, (E-pub ahead of print) In: The American Journal of Gastroenterology.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Gut mucosal DAMPs in IBD: From mechanisms to therapeutic implications

Boyapati, R. K., Rossi, A., Satsangi, J. & Ho, G.-T., 2 Mar 2016, (E-pub ahead of print) In: Mucosal Immunology.

Research output: Contribution to journal › Literature review › peer-review

Open Access

File

What can be done when infliximab stops working in ulcerative colitis?

Boayapati, R. K. (Invited Reviewer), Ho, G.-T. & Satsangi, J., Jan 2016, In: Alimentary Pharmacology and Therapeutics. 43, 1, p. 164

Research output: Contribution to journal › Editorial › peer-review

Open Access

File

2015

Ulcerative colitis

Ho, G.-T., Boyapati, R. & Satsangi, J., 1 May 2015, In: Medicine. 43, 5

Research output: Contribution to journal › Article › peer-review

Open Access

File

Pathogenesis of Crohn's disease

Boyapati, R., Satsangi, J. & Ho, G.-T., 2 Apr 2015, In: F1000prime reports. 7

Research output: Contribution to journal › Article › peer-review

Open Access

File

2014

Multiple sclerosis in the context of TNF blockade and inflammatory bowel disease

Hare, N. C., Hunt, D. P. J., Venugopal, K., Ho, G. T., Beez, T., Lees, C. W., Gibson, R., Weller, B. & Satsangi, J., 2014, In: QJM: An International Journal of Medicine. 107, 1, p. 51-55 5 p., hcr237.

Research output: Contribution to journal › Article › peer-review

2011

Guidelines for the management of inflammatory bowel disease in adults

Ho, G.-T., May 2011, In: Gut. 60, 5, p. 571 36 p.

Research output: Contribution to journal › Article › peer-review

A British Society of Paediatric Gastroenterology, Hepatology and Nutrition survey of the effectiveness and safety of adalimumab in children with inflammatory bowel disease

Russell, R. K., Wilson, M. L., Loganathan, S., Bourke, B., Kiparissi, F., Mahdi, G., Torrente, F., Rodrigues, A., Davies, I., Thomas, A., Akobeng, A. K., Fagbemi, A., Hyer, W., Spray, C., Vaish, S., Rogers, P., McGrogan, P., Heuschkel, R. B., Ayub, N. & Fell, J. M. & 8 others, Afzal, N. A., Green, M., Murphy, M. S., Rao, P., Shah, N., Ho, G.-T., Naik, S. & Wilson, D. C., 15 Apr 2011, In: Alimentary Pharmacology and Therapeutics. 33, 8, p. 946-953 8 p.

Research output: Contribution to journal › Article › peer-review

Cyclooxygenase-2 (COX-2) Polymorphisms and Risk of Inflammatory Bowel Disease in a Scottish and Danish Case-Control Study

Andersen, V., Nimmo, E., Krarup, H. B., Drummond, H., Christensen, J., Ho, G.-T., Ostergaard, M., Ernst, A., Lees, C., Jacobsen, B. A., Satsangi, J. & Vogel, U., Apr 2011, In: Inflammatory Bowel Diseases. 17, 4, p. 937-946 10 p.

Research output: Contribution to journal › Article › peer-review

2009

A UK-WIDE AUDIT OF THE EFFECTIVENESS AND SAFETY OF ADALIMUMAB IN CHILDREN AND YOUNG PEOPLE WITH CROHN'S DISEASE

Russell, R. K., Wilson, M. L., Shah, N., Mahdi, G., Hyer, W., Spray, C., Daman, C., Heuschkel, R., Afzal, N. A., Elawad, M., Torrente, F., Ayub, N., Fell, J. M. E., Ho, G., Naik, S. & Wilson, D. C., Apr 2009, In: Gut. 58, p. A100-A101 2 p.

Research output: Contribution to journal › Meeting abstract › peer-review

IDENTIFICATION OF BIOMARKERS PREDICTING STEROID RESPONSE IN ACUTE SEVERE ULCERATIVE COLITIS USING SURFACE-ENHANCED LASER DESORPTION/IONISATION TIME OF FLIGHT MASS SPECTROMETRY

Hare, N. C., Imrie, M., Smith, A. J., Soo, K., Smith, L., Gray, R., Ho, G., Arnott, I. D. & Satsangi, J., Apr 2009, In: Gut. 58, p. A96-A97 2 p., PT249.

Research output: Contribution to journal › Meeting abstract › peer-review

Efficacy and complications of adalimumab treatment for medically-refractory Crohn's disease: analysis of nationwide experience in Scotland (2004-2008)

Ho, G. T., Mowat, A., Potts, L., Cahill, A., Mowat, C., Lees, C. W., Hare, N. C., Wilson, J. A., Boulton-Jones, R., Priest, M., Watts, D. A., Shand, A. G., Arnott, I. D., Russell, R. K., Wilson, D. C., Morris, A. J. & Satsangi, J., 1 Mar 2009, In: Alimentary Pharmacology and Therapeutics. 29, 5, p. 527-534 8 p.

Research output: Contribution to journal › Article › peer-review

Fecal Calprotectin Predicts the Clinical Course of Acute Severe Ulcerative Colitis

Ho, G. T., Lee, H. M., Brydon, G., Ting, T., Hare, N., Drummond, H., Shand, A. G., Bartolo, D. C., Wilson, R. G., Dunlop, M. G., Arnott, I. D. & Satsangi, J., Mar 2009, In: The American Journal of Gastroenterology. 104, 3, p. 673-678 6 p.

Research output: Contribution to journal › Article › peer-review

The safety profile of anti-tumour necrosis factor therapy in inflammatory bowel disease in clinical practice: analysis of 620 patient-years follow-up

Lees, C. W., Ali, A. I., Thompson, A. I., Ho, G.-T., Forsythe, R., Marquez, L., Cochrane, C. J., Aitken, S., Fennell, J. .., Rogers, P., Shand, A. G., Penman, I. D., Palmer, K. R., Wilson, D. C., Arnott, I. D. R. & Satsangi, J., Feb 2009, In: Alimentary Pharmacology and Therapeutics. 29, 3, p. 286–297 12 p.

Research output: Contribution to journal › Article › peer-review

2008

Analysis of Germline GLI1 Variation Implicates Hedgehog Signalling in the Regulation of Intestinal Inflammatory Pathways

Lees, C. W., Zacharias, W. J., Tremelling, M., Noble, C. L., Nimmo, E. R., Tenesa, A., Cornelius, J., Torkvist, L., Kao, J., Farrington, S., Drummond, H. E., Ho, G.-T., Arnott, I. D. R., Appelman, H. D., Diehl, L., Campbell, H., Dunlop, M. G., Parkes, M., Howie, S. E. M. & Gumucio, D. L. & 1 others, Satsangi, J., Dec 2008, In: PLoS Medicine. 5, 12, 15 p., e239.

Research output: Contribution to journal › Article › peer-review

Open Access

File

2006

Lack of association of the pregnane X receptor (PXR/NR1I2) gene with inflammatory bowel disease: parallel allelic association study and gene wide haplotype analysis

Ho, G.-T., Soranzo, N., Tate, S. K., Drummond, H., Nimmo, E. R., Tenesa, A., Arnott, I. D. & Satsangi, J., Nov 2006, In: Gut. 55, 11, p. 1676-7 2 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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ABCB1/MDR1 gene determines susceptibility and phenotype in ulcerative colitis: discrimination of critical variants using a gene-wide haplotype tagging approach

Ho, G.-T., Soranzo, N., Nimmo, E. R., Tenesa, A., Goldstein, D. B. & Satsangi, J., 1 Mar 2006, In: Human Molecular Genetics. 15, 5, p. 797-805 9 p.

Research output: Contribution to journal › Article › peer-review

2005

The contribution of OCTN1/2 variants within the IBD5 locus to disease susceptibility and severity in Crohn's disease

Noble, C. L., Nimmo, E. R., Drummond, H., Ho, G.-T., Tenesa, A., Smith, L., Anderson, N., Arnott, I. D. R. & Satsangi, J., Dec 2005, In: Gastroenterology. 129, 6, p. 1854-64 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Allelic variations of the multidrug resistance gene determine susceptibility and disease behavior in ulcerative colitis

Ho, G.-T., Nimmo, E. R., Tenesa, A., Fennell, J., Drummond, H., Mowat, C., Arnott, I. D. & Satsangi, J., Feb 2005, In: Gastroenterology. 128, 2, p. 288-96 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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The clinical course of ulcerative colitis after orthotopic liver transplantation for primary sclerosing cholangitis: further appraisal of immunosuppression post transplantation

Ho, G.-T., Seddon, A. J., Therapondos, G., Satsangi, J. & Hayes, P. C., 2005, In: European Journal of Gastroenterology & Hepatology. 17, 12, p. 1379-85 7 p.

Research output: Contribution to journal › Article › peer-review

Gwo-Tzer Ho

Research output

Search results