Research output per year
Research output per year
Personal profile
Current Research Interests
I am currently working on a DiabetesUK grant to investigate the role of palmitoylation of BK channels and their accessory β-subunits within β-cells of the pancreas. The primary function of these cells is to release the hormone insulin to regulate blood glucose levels. It may be predicted that by influencing the electrical excitability of the β-cells that the BK channel is linked to the control of glucose stimulated insulin secretion.
Cell surface expression and activity of the channel is directly influenced by palmitoylation, either of itself or potentially by the palmitoylation of the accessory β-subunits. The project aims to discover if BK channel and β-subunit palmitoylation modulate the function of β-cells.
Fingerprint
Dive into the research topics where Heather McClafferty is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
-
Long-term, Dynamic Remodelling of the Corticotroph Transcriptome and Excitability After a Period of Chronic Stress
Duncan, P. J., Romanò, N., Nair, S. V., McClafferty, H., Le Tissier, P. & Shipston, M. J., Dec 2024, In: Endocrinology . 165, 12, bqae139.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
AMPK deficiency in smooth muscles causes persistent pulmonary hypertension of the new-born and premature death
Moral-Sanz, J., Lewis, S., Macmillan, S., Meloni, M., McClafferty, H., Viollet, B., Foretz, M., Del-Pozo, J. & Evans, A. M., 26 Aug 2022, (E-pub ahead of print) In: Nature Communications.Research output: Contribution to journal › Article › peer-review
Open Access -
Corticotroph isolation from Pomc-eGFP mice reveals sustained transcriptional dysregulation characterising a mouse model of glucocorticoid-induced suppression of the Hypothalamus-Pituitary-Adrenal axis
Duncan, P., McClafferty, H., Nolan, O., Homer, N. Z. M., Le Tissier, P., Walker, B. R., Shipston, M. J., Romanò, N. & Chambers, T., 16 May 2022, (E-pub ahead of print) In: Journal of Neuroendocrinology.Research output: Contribution to journal › Article › peer-review
Open Access -
Site specific deacylation by ABHD17a controls BK channel splice variant activity
McClafferty, H., Runciman, H. & Shipston, M., 10 Sept 2020, (E-pub ahead of print) In: Journal of Biological Chemistry.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
LINGO1 is a regulatory subunit of large conductance, Ca2+-activated potassium channels
Dudem, S., Large, R. J., Kulkarni, S., McClafferty, H., Tikhonova, I. G., Sergeant, G. P., Thornbury, K. D., Shipston, M. J., Perrino, B. A. & Hollywood, M. A., 28 Jan 2020, In: Proceedings of the National Academy of Sciences (PNAS). 117, 4, p. 2194-2200 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile
Datasets
-
Supplementary material - Long-term, dynamic remodelling of the corticotroph transcriptome and excitability after a period of chronic stress
Nair, S. (Creator), McClafferty, H. (Creator), Shipston, M. (Creator), Duncan, P. (Creator), Le Tissier, P. (Creator) & Romano, N. (Creator), Edinburgh DataShare, 14 Oct 2024
DOI: 10.7488/ds/7791
Dataset
Press/Media
-
Edinburgh scientists set sights on drug to limit the effects of hearts attacks
Heather McClafferty, Lijun Tian & Michael Shipston
25/11/14
1 item of Media coverage
Press/Media: Research