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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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Mifepristone alone and in combination with scAAV9-SMN1 gene therapy improves disease phenotypes in Smn2B/- spinal muscular atrophy mice
Sutton, E. R., McCallion, E., Hoolachan, J. M., Çetin, Ö., Torres, P. P., Rashid, S., Bouhmidi, S., Haynes, K., Churchill, L., Scaife, T., Chaytow, H., Huang, Y.-T., Duguez, S., Schneider, B. L., Gillingwater, T. H., Dimitriadi, M. & Bowerman, M., 17 Nov 2025, (E-pub ahead of print) In: Scientific Reports. 15, 40225.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Prenatal SMN-dependent defects in translation uncover reversible primary cilia phenotypes in spinal muscular atrophy
Genovese, F., Huang, Y.-T., Motyl, A. A., Paganin, M., Sharma, G., Signoria, I., Donzel, D., Lai, N. C., Pronot, M., Kline, R. A., Chaytow, H., Morris, K. J., Faller, K. M., Wishart, T. M., Groen, E. J., Cousin, M. A., Viero, G. & Gillingwater, T. H., 22 Oct 2025, In: JCI Insight. 10, 20, p. 1-17 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
The CCL2-CCR2 axis drives neuromuscular denervation in amyotrophic lateral sclerosis
Nógrádi, B., Molnár, K., Kristóf, R., Horváth, O., Huang, Y.-T., Ridgway, Z., Elicegui, A., Fuertes-Alvarez, S., Alonso-Martin, S., J. Szebeni, G., Gémes, N., Ramadan, A., Smith, H., A Krizbai, I., Patai, R., Siklós, L., Klivényi, P., Chaytow, H. & Gillingwater, T. H., 1 Aug 2025, In: Nature Communications. 16, 1, 7053.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Dynamic modulation of the motor neuron translatome during developmental synapse elimination
van der Hoorn, D., Lauria, F., Chaytow, H., Faller, K. M. E., Huang, Y.-T., Kline, R. A., Signoria, I., Morris, K., Wishart, T., Groen, E. J. N., Viero, G. & Gillingwater, T. H., 15 Apr 2025, In: Science Signaling. 18, 882, eadr0176.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Phosphoglycerate kinase 1 as a therapeutic target in neurological disease
McHale-Owen, H., Faller, K. M. E., Chaytow, H. & Gillingwater, T. H., 14 Apr 2025, (E-pub ahead of print) In: Trends in Molecular Medicine. 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile
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Targeting CCL2-CCR2 pathways to protect Neuromuscular Junctions in ALS
Gillingwater, T. (Principal Investigator) & Chaytow, H. (Co-investigator)
1/04/26 → 31/03/29
Project: Research
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Investigating the neuroprotective action of terazosin as a therapy for motor neuron disease
Chaytow, H. (Principal Investigator)
Scottish Universities Life Science Alliance
1/03/23 → 29/02/24
Project: Research
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Repurposing terazosin for ALS: how treatment changes the proteome in a TDP-43 mouse model
Chaytow, H. (Principal Investigator)
UK central government bodies/local authorities, health and hospital authorities
2/09/21 → 31/07/22
Project: Research
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Repurposing terazosin for ALS: how treatment changes the proteome in a TDP-43 mouse model
Chaytow, H. (Principal Investigator)
2/09/21 → 30/11/22
Project: Research
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Moving small molecules targeting UBA1 towards the clinic for the treatment of neurodegenerative disease
Faller, K. (Principal Investigator), Chaytow, H. (Co-investigator) & Gillingwater, T. (Co-investigator)
20/11/19 → 31/08/21
Project: Research
Datasets
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Timing of SMN replacement therapies in models of spinal muscular atrophy: a systematic review and meta-analysis
Chaytow, H. (Creator), Motyl, A. (Creator), Huang, N. (Creator), Wong, C. (Creator), Currie, G. (Creator), Bahor, Z. (Creator), Sena, E. (Creator) & Gillingwater, T. (Creator), Edinburgh DataShare, 13 Oct 2023
DOI: 10.7488/ds/7526, https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020200180&ID=CRD42020200180
Dataset
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van der Hoorn et al_Gene Clusters with Modified Expression in Motor Neurons Undergoing Synapse Elimination_2024
Faller, K. (Creator), Huang, Y.-T. (Creator), Kline, R. (Creator), Wishart, T. (Creator), Groen, E. J. N. (Creator), Viero, G. (Creator), Gillingwater, T. (Creator), van der Hoorn, D. (Creator), Lauria, F. (Creator) & Chaytow, H. (Creator), Edinburgh DataShare, 3 May 2024
DOI: 10.7488/ds/7728
Dataset
Press/Media
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Targeting common disease pathomechanisms to treat amyotrophic lateral sclerosis
2/01/25
1 Media contribution
Press/Media: Research
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AI is a viable alternative to high throughput screening: a 318-target study
2/04/24
1 Media contribution
Press/Media: Research