Research output per year
Research output per year
Personal profile
Current Research Interests
Research summary
I am an academic neurosurgical trainee and am passionate about trying to find solutions to the consequences of acute brain injury. I combine preclinical and clinical methodologies to understand processes of of disease that are harmful or protective in patients and aim to use these to develop new treatments or optimise current management strategies.
Current interests
I use in vitro and in vivo models of brain haemorrhage to investigate how microglia and recruited peripheral immune cells, sculpt astrocyte and neuronal responses to brain haemorrhage. Using brain tissue and clinical data of patients with brain haemorrhage, I aim to identify mechanisms of injury and neuroprotection that are conserved in patients and harness them therapeutically. This work builds on that of my PhD, supervised by Prof. Giles Hardingham, Dr. Barry McColl and Prof. Rustam Salman and funded by the Wellcome Trust and supported by the UK Dementia Research Institute.
Websites
https://www.ed.ac.uk/profile/james-jm-loan
https://www.ed.ac.uk/discovery-brain-sciences/our-staff/phd-student/james-loan
Research Groups
I work within the following research groups at the University of Edinburgh:
Education/Academic qualification
Neuroimmunology, Doctor of Philosophy (PhD), Modulation of inflammation after brain haemorrhage by myelomononuclear Nrf2, University of Edinburgh
1 Aug 2018 → 22 Mar 2022
Award Date: 8 Jul 2022
Surgical Sciences, Master of Science (with Distinction), University of Edinburgh
2014 → 2016
Award Date: 23 Jul 2016
Medicine, Bachelor of Medicine and Bachelor of Surgery, University of Edinburgh
2008 → 2014
Award Date: 5 Jul 2014
Neuroscience, Bachelor of Science (First Class Honours), University of Edinburgh
2010 → 2011
Award Date: 24 Jun 2011
External positions
Honorary Specialty Registrar, Neurosurgery, NHS Grampian
2 Aug 2023 → …
Honorary Specialty Registrar, Neurosurgery, Department of Clinical Neurosciences, NHS Lothian
1 Aug 2018 → 1 Aug 2023
Honorary Specialty Registrar: ST1 Neurosurgery, NHS Greater Glasgow and Clyde
2 Aug 2017 → 31 Jul 2018
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Collaborations and top research areas from the last five years
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Factors associated with cognitive impairment before intracerebral haemorrhage: community-based neuropathological study
Xiang, Y., Rodrigues, M. A., Lerpiniere, C., Moullaali, T. J., Loan, J. J. M., Wilkinson, T., Humphreys, C. A., Smith, C., Al-Shahi Salman, R. & Samarasekera, N., 22 Aug 2024, In: Brain Communications. 6, 5, p. fcae275Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Influence of preoperative embolisation on resection of brain arteriovenous malformations: cohort study
Lee, S. H., Loan, J. JM., Downer, J., Duplessis, J., Keston, P., Wiggins, A. N., Fouyas, I. & Sokol, D., 21 Aug 2024, In: Acta Neurochirurgica. 166, 1Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Perihaematomal oedema evolution over two weeks after spontaneous intracerebral haemorrhage and association with outcome: prospective cohort study
Samarasekera, N., Ferguson, K., Parry-Jones, A. R., Rodrigues, M., Loan, J., Moullaali, T. J., Hughes, J., Shoveller, L., Wardlaw, J., McColl, B., Allan, S. M., Selim, M., Norrie, J., Smith, C. & Salman, R. A-S., 17 Jul 2024, (E-pub ahead of print) In: Cerebrovascular diseases (Basel, Switzerland).Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Addressing barriers and identifying facilitators to support informed consent and recruitment in the Cavernous malformations A Randomised Effectiveness (CARE) pilot phase trial: insights from the integrated QuinteT recruitment intervention (QRI)
Wade, J., Farrar, N., Realpe, A. X., Donovan, J. L., Forsyth, L., Harkness, K. A., Hutchinson, P. J. A., Kitchen, N., Lewis, S. C., Loan, J. J. M., Stephen, J., Al-Shahi salman, R. & The CARE pilot trial collaboration, 18 Apr 2024, In: EClinicalMedicine. 71, p. 102557Research output: Contribution to journal › Article › peer-review
Open Access -
Medical management and surgery versus medical management alone for symptomatic cerebral cavernous malformation (CARE): a feasibility study and randomised, open, pragmatic, pilot phase trial
The CARE pilot trial collaboration, 18 Apr 2024, In: The Lancet Neurology.Research output: Contribution to journal › Article › peer-review
Open AccessFile
Prizes
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British Neurosurgical Trainees Association/ASiT Research Prize
Loan, James (Recipient), 1 Mar 2015
Prize: Prize (including medals and awards)
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British Neurovascular Group: Best Oral Presentation
Loan, James (Recipient), 9 Sept 2021
Prize: Prize (including medals and awards)
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Edinburgh School of Surgery Chiene Medal
Loan, James (Recipient), 26 Nov 2021
Prize: Prize (including medals and awards)
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Lister Medal In Surgical Sciences
Loan, James (Recipient), Oct 2017
Prize: Prize (including medals and awards)