James Minchin

Phone+44 (0)131 242 7930
Emailjames.minchined.acuk

Accepting PhD Students

PhD projects

We are currently looking for students interested in understanding how genetics influences early-onset obesity and body fat distribution. Techniques employed include analysis of large-scale human genetic data, CRISPR-Cas9 mutagenesis and in vivo imaging in zebrafish.

15 Article
2 Review article
1 Chapter (peer-reviewed)
1 Patent

19 results

2020
RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro
Loh, N. Y., Minchin, J. E. N., Pinnick, K. E., Verma, M., Todorčević, M., Denton, N., El-Sayed Moustafa, J., P. Kemp, J., Gregson, C. L., Evans, D. M., Neville, M. J., Small, K. S., McCarthy, M. I., Mahajan, A., Rawls, J. F., Karpe, F. & Christodoulides, C., 3 Jun 2020, In: Nature Communications. 11, 2797.
Research output: Contribution to journal › Article › peer-review

Open Access
File
2019

Quantitative analyses of adiposity dynamics in zebrafish
Elemans, L., Prunonosa Cervera, I., Riley, S. E., Wafer, R., Fong, R., Tandon, P. & Minchin, J., 14 Aug 2019, In: Adipocyte.
Research output: Contribution to journal › Article › peer-review

Open Access
File
Adaptation of blind cavefish to nutrient poor environments: uncovering diverse new mechanisms that regulate body fat levels
Minchin, J. E. N., 7 Feb 2019, (E-pub ahead of print) In: Developmental Biology.
Research output: Contribution to journal › Article › peer-review

Open Access
File
Human semaphorin 3 variants link melanocortin circuit development and energy balance
Van Der Klaauw, A. A., Croizier, S., Mendes De Oliveira, E., Stadler, L. K. J., Park, S., Kong, Y., Banton, M. C., Tandon, P., Hendricks, A. E., Keogh, J. M., Riley, S. E., Papadia, S., Henning, E., Bounds, R., Bochukova, E. G., Mistry, V., O’rahilly, S., Simerly, R. B., INTERVAL, UK10K Consortium, & 5 othersMinchin, J. E. N., Barroso, I., Jones, E. Y., Bouret, S. G. & Farooqi, I. S., 7 Feb 2019, In: Cell. 176, 4, p. 729-742 22 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
2018

Deep phenotyping in zebrafish reveals genetic and diet-induced adiposity changes that may inform disease risk
Minchin, J. E. N., Scahill, C. M., Staudt, N., Busch-nentwich, E. M. & Rawls, J. F., 23 May 2018, (E-pub ahead of print) In: Journal of lipid research. p. jlr.D084525
Research output: Contribution to journal › Article › peer-review

Open Access
File
Adipose morphology and metabolic disease
Tandon, P., Wafer, R. & Minchin, J., 7 Mar 2018, (E-pub ahead of print) In: Journal of Experimental Biology.
Research output: Contribution to journal › Review article › peer-review

Open Access
File
2017
Elucidating the role of plexin D1 in body fat distribution and susceptibility to metabolic disease using a zebrafish model system
Minchin, J. E. N. & Rawls, J. F., 9 Aug 2017, In: Adipocyte. p. 1-7 7 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
The role of Peroxisome proliferator-activated receptor gamma (PPARG) in adipogenesis: applying knowledge from the fish aquaculture industry to biomedical research
Wafer, R., Tandon, P. & Minchin, J., 22 May 2017, In: Frontiers in Endocrinology.
Research output: Contribution to journal › Review article › peer-review

Open Access
File
A classification system for zebrafish adipose tissues
Minchin, J. E. M. & Rawls, J. F., 27 Mar 2017, (E-pub ahead of print) In: Disease Models and Mechanisms.
Research output: Contribution to journal › Article › peer-review

Open Access
File
In vivo imaging and quantification of regional adiposity in zebrafish
Minchin, J. E. N. & Rawls, J. F., 25 Jan 2017, (E-pub ahead of print) Methods in Cell Biology. Elsevier, Vol. 138. p. 3-27 25 p.
Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review
2016

Compositions and methods for identifying and modulating metabolic health
Rawls, J. F. & Minchin, J., 22 Sept 2016, IPC No. G01N33/50, A61P3/00, C12N15/63, Priority date 17 Mar 2015
Research output: Patent
2015
Plexin D1 determines body fat distribution by regulating the type V collagen microenvironment in visceral adipose tissue
Minchin, J. E. N., Dahlman, I., Harvey, C. J., Mejhert, N., Singh, M. K., Epstein, J. A., Arner, P., Torres-Vázquez, J. & Rawls, J. F., 7 Apr 2015, In: Proceedings of the National Academy of Sciences (PNAS). 112, 14, p. 4363-4368 6 p.
Research output: Contribution to journal › Article › peer-review
2013
Oesophageal and sternohyal muscle fibres are novel Pax3-dependent migratory somite derivatives essential for ingestion
Minchin, J. E. N., Williams, V. C., Hinits, Y., Low, S. H., Tandon, P., Fan, C. M., Rawls, J. F. & Hughes, S. M., 15 Jul 2013, In: Development. 140, 14, p. 2972-2984 13 p.
Research output: Contribution to journal › Article › peer-review
Dwarfism and increased adiposity in the gh1 mutant zebrafish vizzini
McMenamin, S. K., Minchin, J. E. N., Gordon, T. N., Rawls, J. F. & Parichy, D. M., 1 Apr 2013, In: Endocrinology . 154, 4, p. 1476-1487 12 p.
Research output: Contribution to journal › Article › peer-review
2011

Cellular and molecular investigations into the development of the pectoral girdle
Valasek, P., Theis, S., DeLaurier, A., Hinits, Y., Luke, G. N., Otto, A. M., Minchin, J., He, L. W., Christ, B., Brooks, G., Sang, H., Evans, D. J., Logan, M., Huang, R. J. & Patel, K., 2011, In: Developmental Biology. 357, 1, p. 108-116 9 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
In vivo Analysis of White Adipose Tissue in Zebrafish
Minchin, J. E. N. & Rawls, J. F., 2011, In: Methods in cell biology. 105, p. 63-86 24 p.
Research output: Contribution to journal › Article › peer-review
2008
Sequential actions of Pax3 and Pax7 drive xanthophore development in zebrafish neural crest
Minchin, J. E. N. & Hughes, S. M., 15 May 2008, In: Developmental Biology. 317, 2, p. 508-522 15 p.
Research output: Contribution to journal › Article › peer-review
2007
Signals and myogenic regulatory factors restrict pax3 and pax7 expression to dermomyotome-like tissue in zebrafish
Hammond, C. L., Hinits, Y., Osborn, D. P. S., Minchin, J. E. N., Tettamanti, G. & Hughes, S. M., 15 Feb 2007, In: Developmental Biology. 302, 2, p. 504-521 18 p.
Research output: Contribution to journal › Article › peer-review
2005
Variant surface glycoprotein RNA interference triggers a precytokinesis cell cycle arrest in African trypanosomes
Sheader, K., Vaughan, S., Minchin, J., Hughes, K., Gull, K. & Rudenko, G., 14 Jun 2005, In: Proceedings of the National Academy of Sciences (PNAS). 102, 24, p. 8716-8721 6 p.
Research output: Contribution to journal › Article › peer-review

James Minchin

Research output

Search results