Research output per year
Research output per year
Personal profile
Biography
Dr Hope obtained a BSc (Hons) degree in Biological Sciences (Microbiology) from the University of Birmingham in 1991, and a PhD degree from the University of Manchester in 1994. She then carried out postdoctoral research at the University of Manchester (1994-1996) and Kings College School of Medicine and Dentistry (1996-1997). Between 1997 and 2011 Dr Hope was employed at the Institute for Animal Health where her research focused on research into innate and adaptive immune mechanisms in cattle specifically in relation into bovine tuberculosis. Dr Hope joined The Roslin Institute in August 2011; her research group focusses on innate immune responses to Mycoabcteria and other bovine pathogens.
Research students
Current Students:
Emily Anderson PhD Student 2016-2022 (part-time)
Conor O'Halloran PhD Student 2015-2019 (second supervisor)
Lindsey Waddell PhD Student 2014-2020 (part time)
Laura Vezza PhD Student 2014-2018 (second supervisor)
Heather Mathie PhD Student 2013-2017
Rebecca Mclean PhD Student 2013-2017 (second supervisor)
Previous Students:
Carly Hamilton PhD Student 2011-2015
Nazneen Siddiqui PhD Student 2007-2011
Sally Price PhD Student 2006-2009
Andrew McCormick PhD Student 2004-2007
Current Research Interests
Immune responses to Mycobacterial infections in cattle.
Research Interests
The group focuses on cellular immune responses aiming to define the mechanisms whereby natural immunity is achieved and how protective immunity is induced by vaccination. We focus specifically on antigen presenting cells and their interactions with other cells of the innate immune system including natural killer cells and gamma delta TCR+ T lymphocytes. The overall aim is to define the functional and phenotypic characteristics of innate immune cells and to assess their role in protective immunity to mycobacterial pathogens including Mycobacterium bovis and M. avium paratuberculosis. These pathogens cause economically important diseases in cattle: bovine tuberculosis and Johne’s disease. Alongside this we are interested in defining host-pathogen interactions in feline tuberculosis. Effective control of mycobacterial diseases requires the development of effective vaccines and/or diagnostic tests: this requires detailed knowledge of protective immune mechanisms. The development of new immunological tools, reagents and assays and validation across species is also an important area of research. This will provide the capacity to determine immunological correlates of protection against a number of strategically important diseases.
Administrative Roles
British Society for Immunology Forum Regional Representative for Scotland
Editorial Board Member for Veterinary Immunology & Immunopathology
Associate Editor (immunology) for Veterinary Research
Member of British Society for Immunology Vaccine Affinity Group
Research Groups
Liz Glass group
Liam Morrison group
Ivan Morrison group
Gary Entrican group (Moredun Research Institute)
John Hammond group (The Pirbright Institute)
Education/Academic qualification
Doctor of Philosophy (PhD), Cytokine Regulation of Primary Contact Sensitisation, University of Manchester
1994
Award Date: 1 Jan 1994
Bachelor of Science, University of Birmingham
1991
Award Date: 1 Jan 1991
External positions
Group Leader, Bovine Immune Mechanisms, Institute for Animal Health
1999 → 2011
Postdoctoral Research Assistant, Institute for Animal Health
1997 → 1999
Postdoctoral Research Assistant, Economic and Social Research Council, UK
1996 → 1997
Research Assistant, University of Manchester
1995 → 1996
Keywords
- QR180 Immunology
- innate immunity
- dendritic cells
- bovine
- Mycobacteria
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Modified Vaccinia Virus Ankara-Based Vaccine Vectors Induce Apoptosis in Dendritic Cells Draining from the Skin via both the Extrinsic and Intrinsic Caspase Pathways, Preventing Efficient Antigen Presentation
Guzman, E., Cubillos-Zapata, C., Cottingham, M. G., Gilbert, S. C., Prentice, H., Charleston, B. & Hope, J. C., 2012, In: Journal of Virology. 86, 10, p. 5452-5466 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Migratory sub-populations of afferent lymphatic dendritic cells differ in their interactions with Mycobacterium bovis Bacille Calmette Guerin
Hope, J., Guzman, E., Cubillos-Zapata, C., Stephens, S. A., Gilbert, S. C., Prentice, H., Sopp, P., Howard, C. J. & Charleston, B., 2012, In: Vaccine. 30, 13, p. 2357-2367Research output: Contribution to journal › Article › peer-review
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Differential Effects of Viral Vectors on Migratory Afferent Lymph Dendritic Cells In Vitro Predict Enhanced Immunogenicity In Vivo
Cubillos-Zapata, C., Guzman, E., Turner, A., Gilbert, S. C., Prentice, H., Hope, J. C. & Charleston, B., 2011, In: Journal of Virology. 85, 18, p. 9385-9394 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Development of a simple, sensitive, rapid test which discriminates BCG-vaccinated from Mycobacterium bovis-infected cattle
Sopp, P., Coad, M., Hewinson, G., Howard, C. J., Cheallaigh, C. N., Keane, J., Harris, J. & Hope, J. C., Oct 2008, In: Vaccine. 26, 43, p. 5470-5476 7 p.Research output: Contribution to journal › Article › peer-review
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Opportunities and challenges for the adoption of novel platform technologies to develop veterinary bacterial vaccines
Entrican, G., Bredell, H., Charlier, J., Cunningham, A. F., Jarvis, M. A., Wood, P. R., Wren, B. W. & Hope, J. C., 14 Apr 2025, (E-pub ahead of print) In: Vaccine. 54, p. 1-7 7 p., 127117.Research output: Contribution to journal › Article › peer-review
Open AccessFile
Activities
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2nd International Antibody Validation Conference
Hope, J. (Chair)
15 Sept 2016Activity: Participating in or organising an event types › Participation in workshop, seminar, course
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10th International Veterinary Immunology Symposium
Hope, J. (Chair)
18 Aug 2016Activity: Participating in or organising an event types › Participation in conference
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Invited speaker
Hope, J. (Speaker)
17 Aug 2016Activity: Academic talk or presentation types › Invited talk
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Royal Highland Show 2016
Hope, J. (Contributor)
2016Activity: Participating in or organising an event types › Public Engagement – Festival/Exhibition
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Invited plenary speaker 'Innate Immune Responses and Bovine Tuberculosis'
Hope, J. (Speaker)
23 Jan 2015Activity: Academic talk or presentation types › Invited talk
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Analysis of morphological and inflammation-related phenotypic changes in peripheral blood mononuclear cells of dogs with immune mediated disease and their correlation to therapeutic success and long-term outcome.
Boag, A. (Principal Investigator) & Hope, J. (Co-investigator)
Petsavers, British Small Animal Veterinary Association
1/09/24 → 31/08/27
Project: Research
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ISP 2023/28 Consumables - Immunology
Whitelaw, B. (Principal Investigator), Connelley, T. (Co-investigator), Hassan, M. (Co-investigator), Hope, J. (Co-investigator), Houston, F. (Co-investigator), Mabbott, N. (Co-investigator), Morrison, L. (Co-investigator), Regan, T. (Co-investigator), Sutton, K. (Co-investigator) & Vervelde, L. (Co-investigator)
1/04/23 → 31/03/28
Project: Research
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Dissecting Bacterial Abscess Formation for Vaccine Design
Pickering, A. (Principal Investigator) & Hope, J. (Co-investigator)
1/06/25 → 31/05/28
Project: Research
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IDG2023/28 - PP2024 - Capability - Determining differentiation pathways for bovine myeloid cells to enable vaccinology studies
Hope, J. (Principal Investigator)
1/07/24 → 31/03/25
Project: Research
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Development of a prime-boost multistage DIVA vaccine for durable control of bTB in cattle.
Hope, J. (Principal Investigator)
1/06/24 → 31/03/25
Project: Research
Datasets
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2189N and 2190N Ruminant cattle myeloid cell subsets
Glass, E. (Owner), Simpson, C. (Data Manager), Hope, J. (Creator), Entrican, G. (Creator), Corripio-Miyar, Y. (Project Member) & Doull, L. E. (Project Member), Edinburgh DataVault, 2 Oct 2018
DOI: 10.7488/775660a6-2d55-4416-979e-0d9e597787ea
Dataset