Research output per year
Research output per year
- 16 results
Search results
-
2024
Characterisation of autophagy induction by the thiopurine drugs azathioprine, mercaptopurine and thioguanine in THP-1 macrophages
Masson, C., Findlay-Greene, F., Henderson Sousa, F., Henderson, P., Fraser, J., Barlow, P. & Stevens, C., 1 Nov 2024, (E-pub ahead of print) In: Naunyn-Schmiedeberg's Archives of Pharmacology. p. 1-12 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2020
Precision Medicine and the Role of Biomarkers of Radiotherapy Response in Breast Cancer
Meehan, J., Gray, M., Martinez-Perez, C., Kay, C., Pang, L., Fraser, J., Poole, A., Kunkler, I., Langdon, S., Argyle, D. & Turnbull, A., 24 Apr 2020, (E-pub ahead of print) In: Frontiers in Oncology.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2019
hASH1 nuclear localization persists in neuroendocrine transdifferentiated prostate cancer cells, even upon reintroduction of androgen
Fraser, J. A., Sutton, J. E., Tazayoni, S., Bruce, I. & Poole, A. V., 13 Dec 2019, In: Scientific Reports. 9, 1, 19076.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2018
Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations
Fraser, J., Kemp, S., Young, L., Ross, M. D., Prach, M., Hutchison, G. R. & Malone, E., 14 May 2018, (E-pub ahead of print) In: Scientific Reports.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2017
Preferential activation of HIF-2α adaptive signalling in neuronal-like cells in response to acute hypoxia
Baudel, M. A. S. M-A., Rae, M. T., Darlison, M. G., Poole, A. & Fraser, J., 2 Oct 2017, In: PLoS ONE. 12, 10, e0185664.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2015
Phosphomimetic mutation of the N-terminal lid of MDM2 enhances the polyubiquitination of p53 through stimulation of E2-ubiquitin thioester hydrolysis
Fraser, J., Worrall, E. G., Lin, Y., Landre, V., Pettersson, S., Blackburn, E., Walkinshaw, M., Muller, P., Vojtesek, B., Ball, K. & Hupp, T. R., 24 Apr 2015, In: Journal of Molecular Biology. 427, 8, p. 1728-1747Research output: Contribution to journal › Article › peer-review
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2014
Imaging of activated complement using ultrasmall superparamagnetic iron oxide particles (USPIO) - conjugated vectors: an in vivo in utero non-invasive method to predict placental insufficiency and abnormal fetal brain development
Girardi, G., Fraser, J., Lennen, R., Vontell, R., Jansen, M. & Hutchison, G., 23 Sept 2014, In: Molecular Psychiatry. 20, p. 1017-1026Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2010
A Novel p53 Phosphorylation Site within the MDM2 Ubiquitination Signal I. PHOSPHORYLATION AT SER269 IN VIVO IS LINKED TO INACTIVATION OF p53 FUNCTION
Fraser, J. A., Vojtesek, B. & Hupp, T. R., 26 Nov 2010, In: Journal of Biological Chemistry. 285, 48, p. 37762-37772 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
A Novel p53 Phosphorylation Site within the MDM2 Ubiquitination Signal: II. A model in which phosphorylation at Ser269 induces a mutant conformation to p53.
Fraser, J. A., Madhumalar, A., Blackburn, E., Bramham, J., Walkinshaw, M. D., Verma, C. & Hupp, T. R., Nov 2010, In: Journal of Biological Chemistry. 285, 48, p. 37773-37786 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Regulation and Function of the Original p53- Inducible p21 Gene
Fraser, J., 2010, P53. Ayeda, A. & Hupp, T. (eds.). Springer, p. 100 116 p. (Molecular Biology Intelligence Unit).Research output: Chapter in Book/Report/Conference proceeding › Chapter
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2008
A central role for CK1 in catalyzing phosphorylation of the p53 transactivation domain at serine 20 after HHV-6B viral infection
MacLaine, N. J., Oster, B., Bundgaard, B., Fraser, J. A., Buckner, C., Lazo, P. A., Meek, D. W., Hoellsberg, P. & Hupp, T. R., 17 Oct 2008, In: Journal of Biological Chemistry. 283, 42, p. 28563-28573 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2007
The MDM2 ubiquitination signal in the DNA-binding domain of p53 forms a docking site for calcium calmodulin kinase superfamily members
Craig, A. L., Chrystal, J. A., Fraser, J. A., Sphyris, N., Lin, Y., Harrison, B. J., Scott, M. T., Dornreiter, I. & Hupp, T. R., May 2007, In: Molecular and Cellular Biology. 27, 9, p. 3542-55 14 p.Research output: Contribution to journal › Article › peer-review
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Chemical genetics approach to identify peptide ligands that selectively stimulate DAPK-1 kinase activity
Fraser, J. A. & Hupp, T. R., 13 Mar 2007, In: Biochemistry. 46, 10, p. 2655-73 19 p.Research output: Contribution to journal › Article › peer-review
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2004
Antioxidant and cytoprotective responses to redox stress
Mathers, J., Fraser, J., McMahon, M., Saunders, R. D. C., Hayes, J. D. & McMillan, L., 1 Mar 2004, In: Biochemical Society Symposia.Research output: Contribution to journal › Review article › peer-review
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2003
The modifier subunit of Drosophila Glutamate Cysteine Ligase regulates catalytic activity by covalent and noncovalent interactions and influences glutathione homeostasis in vivo.
Fraser, J., Kansagra, P., Kotecki, C., Saunders, R. D. C. & McMillan, L., 3 Sept 2003, In: Journal of Biological Chemistry.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2001
Drosophila melanogaster Glutamate Cysteine Ligase activity is regulated by a modifier subunit with a mechanism of action similar to that of the mammalian form
Fraser, J., Saunders, R. D. C. & McMillan, L., 6 Nov 2001, In: Journal of Biological Chemistry.Research output: Contribution to journal › Article › peer-review
Open AccessFile