Research output per year
Research output per year
Personal profile
My research in a nutshell
I am interested in glucocorticoid signaling and its wide-ranging effects particularly on cardiovascular disease risk.
Projects:
1. Glucocorticoid receptor in the early life programming of cardiac resilience (Current)
The heart is one of the first organs in which the glucocorticoid receptor is expressed. The number of heart cells (cardiomyocytes) you have is determined in late development and this is set for life. In this project we explore the role that glucocorticoid signaling has on cardiomyocyte endowment and in the maturation of these heart cells.
2. Glucocorticoid signaling and blood pressure rhythm
Molecular clocks exist in just about every cell in the human body; this allows predictive adaptations to our environment of light/dark. Blood pressure also follows a cyclical pattern, being at least 10% higher during the active hours than at rest. An absence of a decrease in resting BP is called non-dipping and is associated with increased cardiovascular risk. Glucocorticoids can evoke non-dipping blood pressure. This project aims to investigate the mechanisms of glucocorticoid-induced non-dipping blood pressure.
I would like to acknowledge the Society for Endocrinology for Summer Studentship funding to investigate “The effect of glucocorticoid signaling on the binucleation and proliferation of cardiomyocytes”.
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Collaborations and top research areas from the last five years
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Dissociation of sodium-chloride cotransporter expression and blood pressure during chronic high dietary potassium supplementation
Little, R., Murali, S. K., Poulsen, S. B., Grimm, P. R., Assmus, A., Cheng, L., Ivy, J. R., Hoorn, E. J., Matchkov, V. V., Welling, P. A. & Fenton, R. A., 31 Jan 2023, In: JCI Insight.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Endothelin blockade prevents the long-term cardiovascular & renal sequelae of acute kidney injury
Czopek, A., Moorhouse, R., Gallacher, P. J., Pugh, D., Ivy, J. R., Farrah, T., Godden, E., Hunter, R. W., Webb, D. J., Tharaux, P. L., Kluth, D. C., Dear, J. W., Bailey, M. A. & Dhaun, N., 14 Dec 2022, In: Science Translational Medicine.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Toward Precision Medicine: Circadian Rhythm of Blood Pressure and Chronotherapy for Hypertension - 2021 NHLBI Workshop Report
Gumz, M. L., Shimbo, D., Abdalla, M., Balijepalli, R. C., Benedict, C., Chen, Y., Earnest, D. J., Gamble, K. L., Garrison, S. R., Gong, M. C., Hogenesch, J. B., Hong, Y., Ivy, J. R., Joe, B., Laposky, A. D., Liang, M., Maclaughlin, E. J., Martino, T. A., Pollock, D. M., Redline, S., & 8 others, 30 Nov 2022, In: Hypertension.Research output: Contribution to journal › Review article › peer-review
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High salt intake activates the hypothalamic-pituitary-adrenal axis, amplifies the stress response, and alters tissue glucocorticoid exposure in mice
Costello, H., Krilis, G., Grenier, C., Severs, D., Czopek, A., Ivy, J. R., Nixon, M., Holmes, M. C., Livingstone, D. E. W., Hoorn, E. J., Dhaun, N. & Bailey, M. A., 11 Nov 2022, (E-pub ahead of print) In: Cardiovascular Research.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Pressure natriuresis induced alterations in renal sodium transporters in diabetic and non-diabetic rats
Jones, N., Ivy, J. R., Culshaw, G., Stewart, K., Binnie, D. & Bailey, M. A., 17 Sept 2022.Research output: Contribution to conference › Poster › peer-review
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Glucocorticoids and non-dipping blood pressure: renal tubular and vascular mechanisms
1/12/19 → 30/09/25
Project: Research
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Defining the effect of glucocorticoids on the renal artery circadian transcriptome
1/11/21 → 31/12/22
Project: Research
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Defining the effect of glucocorticoids on the renal artery circadian transcriptome
1/11/21 → 31/10/22
Project: Research
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Glucocorticoids and non-dipping blood pressure: renal tubular and vascular mechanisms
1/12/19 → 30/11/22
Project: Research
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Does glucocorticoid action regulate cardiomyocyte proliferation and binucleation?
28/05/18 → 3/08/18
Project: Research