Jim Wilson, FRSE

Search results

• 2022

  Large-scale genome-wide association study of food liking reveals genetic determinants and genetic correlations with distinct neurophysiological traits

  May-Wilson, S., Matoba, N., Wade, K. H., Hottenga, J-J., Concas, M. P. & Wilson, J. F., 18 May 2022, In: Nature Communications. 13, 2743 .

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • genome 100%
  • food 84%
  • determinants 81%
  • Genome-Wide Association Study 80%
  • Food 54%

• Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects

  Social Science Genetic Association Consortium, 9 May 2022, (E-pub ahead of print) In: Nature Genetics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Genome-Wide Association Study 100%
  • Demography 30%
  • Phenotype 28%
  • Mendelian Randomization Analysis 25%
  • Birth Order 19%

• Gene-based whole genome sequencing meta-analysis of 250 circulating proteins in three isolated European populations

  Gilly, A., Klaric, L., Park, Y-C., Png, G., Barysenka, A., Marsh, J. A., Tsafantakis, E., Karaleftheri, M., Dedoussis, G., Wilson, J. F. & Zeggini, E., 30 Apr 2022, (E-pub ahead of print) In: Molecular Metabolism. p. 101509

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Whole Genome Sequencing 100%
  • Meta-Analysis 64%
  • Genes 34%
  • Population 33%
  • Proteins 31%

• Serum metabolomic profiles associated with subclinical and clinical cardiovascular phenotypes in people with type 2 diabetes

  Huang, Z., Klaric, L., Krasauskaite, J., McLachlan, S., Strachan, M. W. J., Wilson, J. F. & Price, J. F., 27 Apr 2022, In: Cardiovascular diabetology. 21, 62.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ankle Brachial Index 100%
  • Metabolomics 87%
  • Type 2 Diabetes Mellitus 59%
  • Cardiovascular Diseases 57%
  • Phenotype 47%

• Genetic Landscape of the ACE2 Coronavirus Receptor

  GenOMICC Consortium and the IMI-DIRECT Consortium, 7 Apr 2022, (E-pub ahead of print) In: Circulation.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • coronavirus receptor 100%
  • angiotensin converting enzyme 2 80%
  • Vascular Diseases 8%
  • Odds Ratio 8%
  • Mendelian Randomization Analysis 7%

• Genetic and phenotypic links between obesity and extracellular vesicles

  Zhai, R., Pan, L., Yang, Z., Li, T., Ning, Z., Pawitan, Y., Wilson, J. F., Wu, D. & Shen, X., 31 Mar 2022, (E-pub ahead of print) In: Human Molecular Genetics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Extracellular Vesicles 100%
  • Obesity 59%
  • Membrane Proteins 30%
  • Adiposity 25%
  • Genome-Wide Association Study 25%

• Genetic regulation of post-translational modification of two distinct proteins

  Landini, A., Trbojević-Akmačić, I., Navarro, P., Tsepilov, Y. A., Sharapov, S. Z., Vučković, F., Polašek, O., Hayward, C., Petrović, T., Vilaj, M., Aulchenko, Y. S., Lauc, G., Wilson, J. F. & Klarić, L., 24 Mar 2022, In: Nature Communications. 13, 1, p. 1586

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Post Translational Protein Processing 100%
  • Glycosylation 99%
  • proteins 77%
  • Transferrin 62%
  • genes 56%

• Genome-wide Association Study of Liking for Several Types of Physical Activity in the UK Biobank and Two Replication Cohorts

  Klimentidis, Y. C., Newell, M., van der Zee, M. D., Bland, V. L., May-Wilson, S., Arani, G., Menni, C., Mangino, M., Arora, A., Raichlen, D. A., Alexander, G. E., Wilson, J. F., Boomsma, D. I., Hottenga, J-J., de Geus, E. J. C. & Pirastu, N., 11 Mar 2022, (E-pub ahead of print) In: Medicine and Science in Sports and Exercise.

  Research output: Contribution to journal › Article › peer-review

  • Genome-Wide Association Study 100%
  • Netherlands 92%
  • Health 23%

• Whole genome sequencing reveals host factors underlying critical Covid-19

  GenOMICC Investigators, Kousathanas, A., Pairo-Castineira, E., Rawlik, K., Stuckey, A., Odhams, C. A., Walker, S., Russell, C. D., Malinauskas, T., Wu, Y., Millar, J., Shen, X., Elliott, K. S., Griffiths, F., Oosthuyzen, W., Morrice, K., Keating, S., Wang, B., Rhodes, D., Klaric, L. & 57 others, Zechner, M., Parkinson, N., Siddiq, A., Goddard, P., Donovan, S., Maslove, D., Nichol, A., Semple, M. G., Zainy, T., Maleady-Crowe, F., Todd, L., Salehi, S., Knight, J., Elgar, G., Chan, G., Arumugam, P., Patch, C., Rendon, A., Bentley, D., Kingsley, C., Kosmicki, J. A., Horowitz, J. E., Baras, A., Abecasis, G. R., Ferreira, M. A. R., Justice, A., Mirshahi, T., Oetjens, M., Rader, D. J., Ritchie, M. D., Verma, A., Fowler, T. A., Shankar-Hari, M., Summers, C., Hinds, C., Horby, P., Ling, L., McAuley, D., Montgomery, H., Openshaw, P. J. M., Elliott, P., Walsh, T., Tenesa, A., Fawkes, A., Murphy, L., Rowan, K., Ponting, C. P., Vitart, V., Wilson, J. F., Yang, J., Bretherick, A. D., Scott, R. H., Hendry, S. C., Moutsianas, L., Law, A., Caulfield, M. J. & Baillie, J. K., 7 Mar 2022, (E-pub ahead of print) In: Nature.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Whole Genome Sequencing 100%
  • Critical Illness 64%
  • Population Control 41%
  • SARS Virus 25%
  • Blood Coagulation Factors 19%

• Meta-GWAS Reveals Novel Genetic Variants Associated with Urinary Excretion of Uromodulin

  Joseph, C., Mariniello, M., Ayumi Yoshifuji, A., Schiano, G., Lake, J., Marten, J., Richmond, A., Huffman, J. E., Campbell, A., Harris, S., Troyanov, S., Cocca, M., Robino, A., Theriault, S., Eckardt, K-U., Wuttke, M., Cheng, Y., Corre, T., Kolcic, I., Black, C. & 23 others, Bruat, V., Pina Concas, M., Sala, C., Aeschbacher, S., Schaefer, F., Bergmann, S., Campbell, H., Olden, M., Polasek, O., Porteous, D. J., Deary, I. J., Madore, F., Awadalla, P., Girotto, G., Ulivi, S., Conen, D., Wuehl, E., Olinger, E., Wilson, J. F., Bochud, M., Köttgen, A., Hayward, C. & Devuyst, O., 1 Mar 2022, In: Journal of the American Society of Nephrology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Ancient DNA at the edge of the world: Continental immigration and the persistence of Neolithic male lineages in Bronze Age Orkney

  Scottish Genomes Partnership, 22 Feb 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 8, e2108001119.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ancient DNA 100%
  • Burial 92%
  • Emigration and Immigration 73%
  • Iron 52%
  • Grassland 45%

• A catalogue of omics biological ageing clocks reveals substantial commonality and associations with disease risk

  Macdonald-Dunlop, E., Taba, N., Klarić, L., Frkatović, A., Walker, R., Hayward, C., Esko, T., Haley, C., Fischer, K., Wilson, J. F. & Joshi, P. K., 24 Jan 2022, (E-pub ahead of print) In: Aging. 14

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Biological Clocks 100%
  • Catalogs 86%
  • Acceleration 45%
  • Epigenomics 40%
  • Glycomics 34%

• Mendelian randomization of genetically independent aging phenotypes identifies LPA and VCAM1 as biological targets for human aging

  Timmers, P. R. H. J., Tiys, E. S., Sakaue, S., Akiyama, M., Kiiskinen, T. T. J., Zhou, W., Hwang, S., Yao, C., Kamatani, Y., Zhou, W., Deelen, J., Levy, D., Ganna, A., Kamatani, Y., Okada, Y., Joshi, P. K., Wilson, J. F. & Tsepilov, Y. A., 20 Jan 2022, In: Nature Aging. 2, 1, p. 19-30

  Research output: Contribution to journal › Article › peer-review

  • Random Allocation 100%
  • Longevity 91%
  • Phenotype 61%
  • Apoprotein(a) 38%
  • Vascular Cell Adhesion Molecule-1 29%

• A multi-omics study of circulating phospholipid markers of blood pressure

  Liu, J., de Vries, P. S., Del Greco M, F., Johansson, Å., Schraut, K. E., Hayward, C., van Dijk, K. W., Franco, O. H., Hicks, A. A., Vitart, V., Rudan, I., Campbell, H., Polašek, O., Pramstaller, P. P., Wilson, J. F., Gyllensten, U., van Duijn, C. M., Dehghan, A. & Demirkan, A., 12 Jan 2022, In: Scientific Reports. 12, 1, p. 574

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Phospholipids 100%
  • Blood Pressure 70%
  • Hypertension 36%
  • Random Allocation 27%
  • Phosphatidylethanolamines 21%
• 2021

  The power of genetic diversity in genome-wide association studies of lipids

  VA Million Veteran Program, 9 Dec 2021, In: Nature. 600, 7890, p. 675-679 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Genome-Wide Association Study 100%
  • Genetic Variation 92%
  • Lipids 62%
  • Genome 48%
  • Cardiovascular Diseases 34%

• Mapping the serum proteome to neurological diseases using whole genome sequencing

  Png, G., Barysenka, A., Repetto, L., Navarro, P., Shen, X., Pietzner, M., Wheeler, E., Wareham, N. J., Langenberg, C., Tsafantakis, E., Karaleftheri, M., Dedoussis, G., Mälarstig, A., Wilson, J. F., Gilly, A. & Zeggini, E., 2 Dec 2021, In: Nature Communications. 12, 1, p. 7042

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • proteome 100%
  • sequencing 79%
  • genome 75%
  • serums 69%
  • Whole Genome Sequencing 67%

• Lifestyle and Genetic Factors Modify Parent-of-Origin Effects on the Human Methylome

  Zeng, Y., Amador, C., Gao, C., Walker, R. M., Morris, S. W., Campbell, A., Frkatović, A., Madden, R. A., Adams, M. J., He, S., Bretherick, A. D., Hayward, C., Porteous, D. J., Wilson, J. F., Evans, K. L., McIntosh, A. M., Navarro, P. & Haley, C. S., Dec 2021, In: EBioMedicine. 74, 103730.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Epigenome 100%
  • Environmental Exposure 87%
  • DNA Methylation 79%
  • Life Style 65%
  • Psychological Imprinting 38%

• Investigation of the causal relationships between human IgG N-glycosylation and twelve common diseases associated with changes in the IgG N-glycome

  Zaytseva, O. O., Sharapov, S. Z., Perola, M., Esko, T., Landini, A., Hayward, C., Wilson, J. F., Lauc, G., Aulchenko, Y. S., Klarić, L. & Tsepilov, Y. A., 15 Nov 2021, (E-pub ahead of print) In: Human Molecular Genetics.

  Research output: Contribution to journal › Article › peer-review

  • Glycosylation 100%
  • Immunoglobulin G 73%
  • Genome-Wide Association Study 22%
  • Random Allocation 21%
  • Systemic Lupus Erythematosus 20%

• Mendelian Randomization Identifies the Potential Causal Impact of Dietary Patterns on Circulating Blood Metabolites

  Taba, N., Valge, H-K., Metspalu, A., Esko, T., Wilson, J. F., Fischer, K. & Pirastu, N., 1 Nov 2021, In: Frontiers in genetics. 12, p. 738265

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Random Allocation 100%
  • Food 71%
  • Genome-Wide Association Study 71%
  • LDL Lipoproteins 69%
  • Coffee 40%

• Inbreeding, native American ancestry and child mortality: Linking human selection and paediatric medicine

  Koenigstein, F., Boekstegers, F., Wilson, J. F., Fuentes-Guajardo, M., Gonzalez-Jose, R., Bedoya, G., Bortolini, M. C., Acuña-Alonzo, V., Gallo, C., Linares, A. R., Rothhammer, F. & Bermejo, J. L., 21 Oct 2021, (E-pub ahead of print) In: Human Molecular Genetics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Inbreeding 100%
  • Child Mortality 86%
  • North American Indians 85%
  • Traumatic Intracranial Hemorrhage 59%
  • Medicine 51%

• Genome-wide Analysis Identifies Novel Gallstone-susceptibility Loci Including Genes Regulating Gastrointestinal Motility

  Fairfield, C., Drake, T., Pius, R., Bretherick, A. D., Campbell, A., Clark, D., Fallowfield, J. A., Hayward, C., Henderson, N. C., Iakovliev, A., Joshi, P. K., Mills, N. L., Porteous, D. J., Ramachandran, P., Semple, R. K., Shaw, K., Sudlow, C. L. M., Timmers, P., Wilson, J. F., Wigmore, S. J. & 2 others, Spiliopoulou, A. & Harrison, E. M., 15 Oct 2021, (E-pub ahead of print) In: Hepatology. p. 1-33 33 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Gastrointestinal Motility 100%
  • Gallstones 91%
  • Genome 55%
  • Genes 33%
  • Genome-Wide Association Study 32%

• Genome-Wide Association Study of Non-Alcoholic Fatty Liver Disease using Electronic Health Records

  Fairfield, C., Drake, T., Pius, R., Bretherick, A. D., Campbell, A., Clark, D., Fallowfield, J. A., Hayward, C., Henderson, N. C., Joshi, P. K., Mills, N. L., Porteous, D. J., Ramachandran, P., Semple, R. K., Shaw, K., Sudlow, C. L. M., Timmers, P., Wilson, J. F., Wigmore, S. J., Harrison, E. M. & 1 others, Spiliopoulou, A., 17 Sep 2021, In: Hepatology Communications.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Non-alcoholic Fatty Liver Disease 100%
  • Genome-Wide Association Study 97%
  • Electronic Health Records 95%
  • Alcohols 23%
  • Alleles 22%

• Genome-wide methylation data improves dissection of the effect of smoking on body mass index

  Amador, C., Zeng, Y., Barber, M., Walker, R., Campbell, A., McIntosh, A. M., Evans, K. L., Porteous, D. J., Hayward, C., Wilson, J. F., Navarro, P. & Haley, C. S., 9 Sep 2021, (E-pub ahead of print) In: PLoS Genetics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Genetic insights into biological mechanisms governing human ovarian ageing

  Biobank-based Integrative Omics Study (BIOS) Consortium, 4 Aug 2021, (E-pub ahead of print) In: Nature.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • DNA Damage 100%
  • Fertility 80%
  • Menopause 59%
  • Ovarian Reserve 38%
  • Healthy Aging 35%

• Mapping the human genetic architecture of COVID-19

  COVID-19 Host Genetics Initiative, Baillie, J. K., Wilson, J. F., Bulteel, N., Hayward, C., Klaric, L., Porteous, D. J., Russell, C. D., Tenesa, A., Norman, L., Scott-Brown, J., Rambaut, A. & Swann, O., 8 Jul 2021, (E-pub ahead of print) In: Nature.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • SARS Virus 100%
  • Human Genetics 82%
  • Infections 32%
  • Mendelian Randomization Analysis 27%
  • Research Personnel 23%

• Multivariate genome-wide analysis of immunoglobulin G N-glycosylation identifies new loci pleiotropic with immune function

  Shadrina, A. S., Zlobin, A. S., Zaytseva, O. O., Klarić, L., Sharapov, S. Z., D Pakhomov, E., Perola, M., Esko, T., Hayward, C., Wilson, J. F., Lauc, G., Aulchenko, Y. S. & Tsepilov, Y. A., 1 Jul 2021, In: Human Molecular Genetics. 30, 13, p. 1259-1270 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Glycosylation 100%
  • Immunoglobulin G 73%
  • Genome 66%
  • Genome-Wide Association Study 25%
  • Autoimmune Diseases 21%

• Retinal arteriolar tortuosity and fractal dimension are associated with long-term cardiovascular outcomes in people with type 2 diabetes

  Sandoval Garcia, E., McLachlan, S., Price, A. H., MacGillivray, T., Strachan, M. W. J., Wilson, J. F. & Price, J. F., 23 Jun 2021, In: Diabetologia. p. 2215-2227

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Fractals 100%
  • Coronary Disease 67%
  • Type 2 Diabetes Mellitus 56%
  • Stroke 51%
  • Retinal Vessels 35%

• Contribution of common risk variants to multiple sclerosis in Orkney and Shetland

  Barnes, C. L. K., Hayward, C., Porteous, D. J., Campbell, H., Joshi, P. K. & Wilson, J. F., 4 Jun 2021, (E-pub ahead of print) In: European Journal of Human Genetics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Scotland 100%
  • Multiple Sclerosis 89%
  • Single Nucleotide Polymorphism 24%
  • HLA-DRB1 Chains 19%
  • Vitamin D Deficiency 16%

• Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals

  Regeneron Genetics Center, 3 Jun 2021, (E-pub ahead of print) In: American Journal of Human Genetics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Coronavirus 100%
  • Exome 95%
  • Severe Acute Respiratory Syndrome 14%
  • Genes 13%
  • Interferons 10%

• The trans-ancestral genomic architecture of glycemic traits

  The Meta-Analysis of Glucose and Insulin-related Traits Consortium (MAGIC), 31 May 2021, In: Nature Genetics. 149

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Glucose 100%
  • Fasting 84%
  • Glycated Hemoglobin A 55%
  • Genome-Wide Association Study 55%
  • Psychological Power 49%

• Variants associated with HHIP expression have sexdifferential effects on lung function

  Fawcett, K. A., Obeidat, M., Melbourne, C., Shrine, N., Guyatt, A. L., John, C., Luan, J., Richmond, A., Moksnes, M. R., Granell, R., Weiss, S., Imboden, M., May-Wilson, S., Hysi, P., Boutin, T. S., Portas, L., Flexeder, C., Harris, S. E., Wang, C. A., Lyytikäinen, L. P. & 55 others, Palviainen, T., Foong, R. E., Keidel, D., Minelli, C., Langenberg, C., Bossé, Y., Berge, M. V. D., Sin, D. D., Hao, K., Campbell, A., Porteous, D., Padmanabhan, S., Smith, B. H., Evans, D. M., Ring, S., Langhammer, A., Hveem, K., Willer, C., Ewert, R., Stubbe, B., Pirastu, N., Klaric, L., Joshi, P. K., Patasova, K., Massimo, M., Polasek, O., Starr, J. M., Karrasch, S., Strauch, K., Meitinger, T., Rudan, I., Rantanen, T., Pietiläinen, K., Kähönen, M., Raitakari, O. T., Hall, G. L., Sly, P. D., Pennell, C. E., Kaprio, J., Lehtimäki, T., Vitart, V., Deary, I. J., Jarvis, D., Wilson, J. F., Spector, T., Probst-Hensch, N., Wareham, N. J., Völzke, H., Henderson, J., Strachan, D. P., Brumpton, B. M., Hayward, C., Hall, I. P., Tobin, M. D. & Wain, L. V., 24 May 2021, In: Wellcome Open Research. 5, p. 1-20 20 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Hedgehog Proteins 100%
  • Lung 42%
  • Protein 32%
  • Forced Expiratory Volume 31%
  • Volume 27%

• Variants associated with HHIP expression have sex-differential effects on lung function

  Fawcett, K. A., Obeidat, M., Melbourne, C., Shrine, N., Guyatt, A. L., John, C., Luan, J., Richmond, A., Moksnes, M. R., Granell, R., Weiss, S., Imboden, M., May-wilson, S., Hysi, P., Boutin, T. S., Portas, L., Flexeder, C., Harris, S. E., Wang, C. A., Lyytikäinen, L. & 55 others, Palviainen, T., Foong, R. E., Keidel, D., Minelli, C., Langenberg, C., Bossé, Y., Van Den Berge, M., Sin, D. D., Hao, K., Campbell, A., Porteous, D., Padmanabhan, S., Smith, B. H., Evans, D. M., Ring, S., Langhammer, A., Hveem, K., Willer, C., Ewert, R., Stubbe, B., Pirastu, N., Klaric, L., Joshi, P. K., Patasova, K., Massimo, M., Polasek, O., Starr, J. M., Karrasch, S., Strauch, K., Meitinger, T., Rudan, I., Rantanen, T., Pietiläinen, K., Kähönen, M., Raitakari, O. T., Hall, G. L., Sly, P. D., Pennell, C. E., Kaprio, J., Lehtimäki, T., Vitart, V., Deary, I. J., Jarvis, D., Wilson, J. F., Spector, T., Probst-hensch, N., Wareham, N. J., Völzke, H., Henderson, J., Strachan, D. P., Brumpton, B. M., Hayward, C., Hall, I. P., Tobin, M. D. & Wain, L. V., 24 May 2021, In: Wellcome Open Research . 5, p. 111

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

  Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC), 8 Feb 2021, In: Nature Communications. 12, 1, p. 995

  Research output: Contribution to journal › Comment/debate

• Nontrivial Replication of Loci Detected by Multi-Trait Methods

  Ning, Z., Tsepilov, Y. A., Sharapov, S. Z., Wang, Z., Grishenko, A. K., Feng, X., Shirali, M., Joshi, P. K., Wilson, J. F., Pawitan, Y., Haley, C. S., Aulchenko, Y. S. & Shen, X., 3 Feb 2021, In: Frontiers in genetics. 12

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Genome-Wide Association Study 100%
  • Genotype 34%
  • Phenotype 28%

• Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

  Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC), 5 Jan 2021, In: Nature Communications. 12, 1, 24.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • fasting 100%
  • insulin 81%
  • glucose 65%
  • loci 64%
  • Insulin Derivative 58%
• 2020

  Genetic mechanisms of critical illness in Covid-19

  Pairo-Castineira, E., Clohisey, S., Klaric, L., Bretherick, A., Rawlik, K., Parkinson, N., Pasko, D., Walker, S., Richmond, A., Fourman, M. H., Law, A., Furniss, J., Gountouna, E., Wrobel, N., Russell, C. D., Moutsianas, L., Wang, B., Meynert, A. M., Yang, Z., Zhai, R. & 39 others, Zheng, C., Griffith, F., Oosthuyzen, W., Shih, B., Keating, S., Zechner, M., Haley, C. S., Porteous, D., Hayward, C., Knight, J., Summers, C., Shankar-Hari, M., Turtle, L., Ho, A., Hinds, C., Horby, P., Nichol, A., Maslove, D. M., Ling, L., Klenerman, P., McAuley, D. F., Montgomery, H. E., Walsh, T. S., The GenOMICC Investigators, The ISARIC4C Investigators, The Covid-19 Human Genetics Initiative, Shen, X., Rowan, K., Fawkes, A., Murphy, L., Ponting, C. P., Tenesa, A., Caulfield, M., Scott, R., Openshaw, P., Semple, M. G., Vitart, V., Wilson, J. & Baillie, J. K., 11 Dec 2020, (E-pub ahead of print) In: Nature. n/a, n/a.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Critical Illness 100%
  • Genome-Wide Association Study 56%
  • Intensive Care Units 44%
  • Dipeptidyl-Peptidases and Tripeptidyl-Peptidases 44%
  • Interferon Receptors 42%

• Autozygosity influences cardiometabolic disease-associated traits in the AWI-Gen sub-Saharan African study

  Ceballos, F. C., Hazelhurst, S., Clark, D. W., Agongo, G., Asiki, G., Boua, P. R., Xavier Gómez-Olivé, F., Mashinya, F., Norris, S., Wilson, J. F. & Ramsay, M., 13 Nov 2020, In: Nature Communications. 11, 1, p. 5754

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Inbreeding Depression 100%
  • Wit and Humor 74%
  • Low-Density Lipoprotein 66%
  • Cholesterol 50%
  • Urban Renewal 48%

• Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals

  Folkersen, L., Gustafsson, S., Wang, Q., Hansen, D. H., Hedman, A. K., Schork, A. W., Page, K., Zhernakova, D. V., Wu, Y., Peters, J., Eriksson, N., Bergen, S. E., Boutin, T., Bretherick, A. D., Enroth, S., Kalnapenkis, A., Gådin, J. R., Suur, B., Chen, Y., Matic, L. & 25 others, Gale, J. D., Lee, J., Zhang, W., Quazi, A., Ala-Korpela, M., Choi, S. H., Claringbould, A., Danesh, J., Davey Smith, G., o de Masi, F., Elmståhl, S., Engström, G., Fauman, E., Fernandez, C., Franke, L., Franks, P., Giedraitis, V., Haley, C., Hayward, C., Wilson, J. F., Wallentin, L., Butterworth, A. S., Holmes, M. V., Ingelsson, E. & Mälarstig, A., 16 Oct 2020, (E-pub ahead of print) In: Nature Metabolism.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Glycosylation Alterations in Multiple Sclerosis Show Increased Proinflammatory Potential

  Cvetko, A., Kifer, D., Gornik, O., Klarić, L., Visser, E., Lauc, G., Wilson, J. F. & Štambuk, T., 13 Oct 2020, In: Biomedicines. 8, 10

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • N-Glycan 100%
  • Glycosylation 80%
  • Multiple Sclerosis 69%
  • Plasma 48%
  • Polysaccharides 42%

• Genetic mechanisms of critical illness in Covid-19

  Pairo-Castineira, E., Clohisey, S., Klaric, L., Bretherick, A. D., Rawlik, K., Parkinson, N., Pasko, D., Walker, S., Richmond, A., Fourman, M. H., Law, A., Furniss, J., Gountouna, E., Wrobel, N., Russell, C. D., Moutsianas, L., Wang, B., Meynert, A. M., Yang, Z., Zhai, R. & 39 others, Zheng, C., Griffith, F., Oosthuyzen, W., Shih, B., Keating, S., Zechner, M., Haley, C., Porteus, D. J., Hayward, C., Knight, J., Summers, C., Shankar-Hari, M., Turtle, L., Ho, A., Hinds, C., Horby, P., Nichol, A., Maslove, D. M., Ling, L., Klenerman, P., McAuley, D. F., Montgomery, H., Walsh, T. S., The GenOMICC Investigators, The ISARIC4C Investigators, The Covid-19 Human Genetics Initiative, Shen, X., Rowan, K., Fawkes, A., Murphy, L., Ponting, C. P., Tenesa, A., Caulfield, M., Scott, R., Openshaw, P. J. M., Semple, M. G., Vitart, V., Wilson, J. F. & Baillie, J. K., 25 Sep 2020, medRxiv.

  Research output: Working paper

  • Critical Illness 100%
  • Genome-Wide Association Study 56%
  • Intensive Care Units 44%
  • Dipeptidyl-Peptidases and Tripeptidyl-Peptidases 44%
  • Interferon Receptors 42%

• Global variability of the human IgG glycome

  Štambuk, J., Nakić, N., Vučković, F., Pučić-Baković, M., Razdorov, G., Trbojević-Akmačić, I., Novokmet, M., Keser, T., Vilaj, M., Štambuk, T., Gudelj, I., Šimurina, M., Song, M., Wang, H., Salihović, M. P., Campbell, H., Rudan, I., Kolčić, I., Eller, L. A., McKeigue, P. & 22 others, Robb, M. L., Halfvarson, J., Kurtoglu, M., Annese, V., Škarić-Jurić, T., Molokhia, M., Polašek, O., Hayward, C., Kibuuka, H., Thaqi, K., Primorac, D., Gieger, C., Nitayaphan, S., Spector, T., Wang, Y., Tillin, T., Chaturvedi, N., Wilson, J. F., Schanfield, M., Filipenko, M., Wang, W. & Lauc, G., 12 Aug 2020, (E-pub ahead of print) In: Aging. 12

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Immunoglobulin G 100%
  • Glycosylation 45%
  • Population 28%
  • Polysaccharides 27%
  • Developing Countries 26%

• Multivariate genomic scan implicates novel loci and haem metabolism in human ageing

  Timmers, P. R. H. J., Wilson, J., Joshi, P. & Deelen, J., 16 Jul 2020, (E-pub ahead of print) In: Nature Communications. 11, 1, p. 3570

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • phenotype 100%
  • genome 92%
  • metabolism 87%
  • genes 82%
  • loci 79%

• Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts

  Moll, M., Sakornsakolpat, P., Shrine, N., Hobbs, B. D., DeMeo, D. L., John, C., Guyatt, A. L., McGeachie, M. J., Gharib, S. A., Obeidat, M., Lahousse, L., Wijnant, S. R. A., Brusselle, G., Meyers, D. A., Bleecker, E. R., Li, X., Tal-Singer, R., Manichaikul, A., Rich, S. S., Won, S. & 67 others, Kim, W. J., Do, A. R., Washko, G. R., Barr, R. G., Psaty, B. M., Bartz, T. M., Hansel, N. N., Barnes, K., Hokanson, J. E., Crapo, J. D., Lynch, D., Bakke, P., Gulsvik, A., Hall, I. P., Wain, L., Soler Artigas, M., Jackson, V. E., Strachan, D. P., Hui, J., James, A. L., Kerr, S. M., Polasek, O., Vitart, V., Marten, J., Rudan, I., Kähönen, M., Surakka, I., Gieger, C., Karrasch, S., Rawal, R., Schulz, H., Deary, I. J., Harris, S. E., Enroth, S., Gyllensten, U., Imboden, M., Probst-Hensch, N. M., Lehtimäki, T., Raitakari, O. T., Langenberg, C., Luan, J., Wareham, N., Zhao, J. H., Hayward, C., Murray, A., Porteous, D. J., Smith, B. H., Jarvelin, M. R., Wielscher, M., Joshi, P. K., Kentistou, K. A., Timmers, P. RHJ., Wilson, J. F., Cook, J. P., Lind, L., Mahajan, A., Morris, A. P., Ewert, R., Homuth, G., Stubbe, B., Weiss, S., Zeggini, E., Weiss, S. T., Silverman, E. K., Dudbridge, F., Tobin, M. D. & Cho, M. H., 7 Jul 2020, (E-pub ahead of print) In: The Lancet Respiratory Medicine. 8, 7, p. 696-708 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chronic Obstructive Pulmonary Disease 100%
  • Phenotype 67%
  • Population 44%
  • Emphysema 31%
  • Vital Capacity 20%

• Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits

  Bretherick, A. D., Canela-Xandri, O., Joshi, P. K., Clark, D. W., Rawlik, K., Boutin, T. S., Zeng, Y., Amador, C., Navarro, P., Rudan, I., Wright, A. F., Campbell, H., Vitart, V., Hayward, C., Wilson, J. F., Tenesa, A., Ponting, C. P., Baillie, J. K. & Haley, C., 6 Jul 2020, In: PLoS Genetics. 16, 7, e1008785.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • human disease 100%
  • phenotype 81%
  • human diseases 80%
  • Random Allocation 73%
  • protein 53%

• Prioritization of causal genes for coronary artery disease based on cumulative evidence from experimental and in silico studies

  Shadrina, A. S., Shashkova, T. I., Torgasheva, A. A., Sharapov, S. Z., Klaric, L., Pakhomov, E. D., Alexeev, D. G., Wilson, J., Tsepilov, Y. A., Joshi, P. K. & Aulchenko, Y. S., 26 Jun 2020, In: Scientific Reports. 10, 1, p. 10486

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • coronary artery disease 100%
  • prioritization 90%
  • loci 32%
  • genes 23%
  • genome-wide association study 8%

• Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

  Ntalla, I., Weng, L-C., Cartwright, J. H., Hall, A. W., Sveinbjornsson, G., Tucker, N. R., Choi, S. H., Chaffin, M. D., Roselli, C., Barnes, M. R., Mifsud, B., Warren, H. R., Hayward, C., Marten, J., Cranley, J. J., Concas, M. P., Gasparini, P., Boutin, T., Kolcic, I., Rudan, I. & 165 others, Araujo, N. M., Lima-Costa, M. F., Ribeiro, A. L. P., Souza, R. P., Tarazona-Santos, E., Giedraitis, V., Ingelsson, E., Mahajan, A., Morris, A. P., Del Greco M, F., Foco, L., Gögele, M., Hicks, A. A., Lind, L., Lindgren, C. M., Sundström, J., Nelson, C. P., Riaz, M. B., Samani, N. J., Sinagra, G., Ulivi, S., Kähönen, M., Mishra, P. P., Mononen, N., Nikus, K., Caulfield, M. J., Dominiczak, A., Padmanabhan, S., Montasser, M. E., O'Connell, J. R., Ryan, K., Shuldiner, A. R., Aeschbacher, S., Conen, D., Risch, L., Thériault, S., Hutri-Kähönen, N., Lehtimäki, T., Lyytikäinen, L-P., Raitakari, O. T., Barnes, C. L. K., Campbell, H., Joshi, P. K., Wilson, J., Isaacs, A., Kors, J. A., van Duijn, C. M., Huang, P. L., Gudnason, V., Harris, T. B., Launer, L. J., Smith, A. V., Bottinger, E. P., Loos, R. J. F., Nadkarni, G. N., Preuss, M. H., Correa, A., Mei, H., Wilson, J., Meitinger, T., Müller-Nurasyid, M., Peters, A., Waldenberger, M., Mangino, M., Spector, T. D., Rienstra, M., van de Vegte, Y. J., van der Harst, P., Verweij, N., Kääb, S., Schramm, K., Sinner, M. F., Strauch, K., Cutler, M. J., Fatkin, D., London, B., Olesen, M., Roden, D. M., Benjamin Shoemaker, M., Gustav Smith, J., Biggs, M. L., Bis, J. C., Brody, J. A., Psaty, B. M., Rice, K., Sotoodehnia, N., De Grandi, A., Fuchsberger, C., Pattaro, C., Pramstaller, P. P., Ford, I., Wouter Jukema, J., Macfarlane, P. W., Trompet, S., Dörr, M., Felix, S. B., Völker, U., Weiss, S., Havulinna, A. S., Jula, A., Sääksjärvi, K., Salomaa, V., Guo, X., Heckbert, S. R., Lin, H. J., Rotter, J. I., Taylor, K. D., Yao, J., de Mutsert, R., Maan, A. C., Mook-Kanamori, D. O., Noordam, R., Cucca, F., Ding, J., Lakatta, E. G., Qian, Y., Tarasov, K. V., Levy, D., Lin, H., Newton-Cheh, C. H., Lunetta, K. L., Murray, A. D., Porteous, D. J., Smith, B. H., Stricker, B. H., Uitterlinden, A., van den Berg, M. E., Haessler, J., Jackson, R. D., Kooperberg, C., Peters, U., Reiner, A. P., Whitsel, E. A., Alonso, A., Arking, D. E., Boerwinkle, E., Ehret, G. B., Soliman, E. Z., Avery, C. L., Gogarten, S. M., Kerr, K. F., Laurie, C. C., Seyerle, A. A., Stilp, A., Assa, S., Abdullah Said, M., Yldau van der Ende, M., Lambiase, P. D., Orini, M., Ramirez, J., Van Duijvenboden, S., Arnar, D. O., Gudbjartsson, D. F., Holm, H., Sulem, P., Thorleifsson, G., Thorolfsdottir, R. B., Thorsteinsdottir, U., Benjamin, E. J., Tinker, A., Stefansson, K., Ellinor, P. T., Jamshidi, Y., Lubitz, S. A. & Munroe, P. B., 21 May 2020, In: Nature Communications. 11, 1, p. 2542

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • PR Interval 100%
  • loci 54%
  • Genome-Wide Association Study 50%
  • intervals 35%
  • genes 34%

• Smoking-by-genotype interaction in type 2 diabetes risk and fasting glucose

  Wu, P., Rybin, D., Bielak, L. F., Feitosa, M. F., Franceschini, N., Li, Y., Lu, Y., Marten, J., Musani, S. K., Noordam, R., Raghavan, S., Rose, L. M., Schwander, K., Smith, A. V., Tajuddin, S. M., Vojinovic, D., Amin, N., Arnett, D. K., Bottinger, E. P., Demirkan, A. & 38 others, Florez, J. C., Ghanbari, M., Harris, T. B., Launer, L. J., Liu, J., Liu, J., Mook-Kanamori, D. O., Murray, A. D., Nalls, M. A., Peyser, P. A., Uitterlinden, A. G., Voortman, T., Bouchard, C., Chasman, D., Correa, A., de Mutsert, R., Evans, M. K., Gudnason, V., Hayward, C., Kao, L., Kardia, S. L. R., Kooperberg, C., Loos, R. J. F., Province, M. M., Rankinen, T., Redline, S., Ridker, P. M., Rotter, J. I., Siscovick, D., Smith, B. H., van Duijn, C., Zonderman, A. B., Rao, D. C., Wilson, J. G., Dupuis, J., Meigs, J. B., Liu, C. T. & Vassy, J. L., 7 May 2020, In: PLoS ONE. 15, 5, e0230815.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Fasting 100%
  • Type 2 Diabetes Mellitus 93%
  • Smoking 90%
  • Genotype 89%
  • Glucose 78%

• Trends in disease incidence and survival and their effect on mortality in Scotland: nationwide cohort study of linked hospital admission and death records 2001–2016

  Timmers, P., Kerssens, J. J., Minton, J., Grant, I., Wilson, J., Campbell, H., Fischbacher, C. M. & Joshi, P. K., 25 Mar 2020, In: BMJ Open.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Death Certificates 100%
  • Scotland 95%
  • Hospital Records 94%
  • Cohort Studies 56%
  • Survival 45%

• Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases

  Klaric, L., Tsepilov, Y. A., Stanton, C. M., Mangino, M., Sikka, T. T., Esko, T., Pakhomov, E., Salo, P., Deelen, J., McGurnaghan, S. J., Keser, T., Vučković, F., Ugrina, I., Krištić, J., Gudelj, I., Štambuk, J., Plomp, R., Pučić-Baković, M., Pavić, T., Vilaj, M. & 34 others, Trbojević Akmačić, I., Drake, C., Dobrinić, P., Timofeeva, M., Mlinarec, J., Jelušić, B., Richmond, A., Timofeeva, M., Grishchenko, A. K., Dmitrieva, J., Bermingham, M. L., Sharapov, S. Z., Farrington, S., Theodoratou, E., Uh, H-W., Beekman, M., Slagboom, E. P., Louis, E., Georges, M., Wuhrer, M., Colhoun, H. M., Dunlop, M. G., Perola, M., Fischer, K., Polasek, O., Campbell, H., Rudan, I., Wilson, J. F., Zoldos, V., Vitart, V., Spector, T., Aulchenko, Y. S., Lauc, G. & Hayward, C., 19 Feb 2020, In: Science Advances. 6, 8, eaax0301.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Genetic Pleiotropy 100%
  • Gene Regulatory Networks 68%
  • Glycosylation 64%
  • Immunoglobulin G 47%
  • Polysaccharides 29%
• 2019

  Coffee consumption and kidney function: A Mendelian randomisation study

  Kennedy, O. J., Pirastu, N., Poole, R., Fallowfield, J., Hayes, P., Grzeszkowiak, E. J., Taal, M. W., Wilson, J., Parkes, J. & Roderick, P., 11 Dec 2019, (E-pub ahead of print) In: American Journal of Kidney Diseases.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Coffee 100%
  • Random Allocation 82%
  • Chronic Renal Insufficiency 46%
  • Kidney 45%
  • Albuminuria 29%