John Govan

2018

In situ identification of Gram-negative bacteria in human lungs using a topical fluorescent peptide targeting lipid A

Akram, A. R., Chankeshwara, S. V., Scholefield, E., Aslam, T., McDonald, N., Megia-Fernandez, A., Marshall, A., Mills, B., Avlonitis, N., Craven, T. H., Smyth, A. M., Collie, D. S., Gray, C., Hirani, N., Hill, A. T., Govan, J. R., Walsh, T., Haslett, C., Bradley, M. & Dhaliwal, K., 24 Oct 2018, In: Science Translational Medicine. 10, 464, 12 p., eaal0033.

Research output: Contribution to journal › Article › peer-review

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2017

A randomised control trial of atorvastatin in bronchiectasis patients infected with Pseudomonas aeruginosa- a proof of concept study

Bedi, P., Chalmers, J. D., Graham, C., Clarke, A., Donaldson, S., Doherty, C., Govan, J. R., Davidson, D. J., Rossi, A. G. & Hill, A. T., 26 May 2017, (E-pub ahead of print) In: Chest Journal.

Research output: Contribution to journal › Article › peer-review

Open Access

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2016

Optimum Condition for Storage of Sputum from Patients with Bronchiectasis Infected with Haemophilus influenzae

Hill, A., Zhang, Y., Singh Kang, K., Clarke, A., Donaldson, S., Cartlidge, M., Bedi, P., Doherty, C., Dorai-Schneiders, T. & Govan, J., 13 Jun 2016, In: Archives of Clinical Microbiology. 7, 4:22

Research output: Contribution to journal › Article › peer-review

Open Access

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2015

Lung Microbiota Changes Associated with Chronic Pseudomonas aeruginosa Lung Infection and the Impact of Intravenous Colistimethate Sodium

Collie, D., Glendinning, L., Govan, J., Wright, S., Thornton, E., Tennant, P., Doherty, C. & McLachlan, G., 7 Nov 2015, In: PLoS ONE. 10, 11, p. e0142097

Research output: Contribution to journal › Article › peer-review

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2014

Garlic Revisited: Antimicrobial Activity of Allicin-Containing Garlic Extracts against Burkholderia cepacia Complex

Wallock-richards, D., Doherty, C. J., Doherty, L., Clarke, D. J., Place, M., Govan, J. R. W., Campopiano, D. J. & Coenye, T. (Editor), 1 Dec 2014, In: PLoS ONE. 9, 12, e112726.

Research output: Contribution to journal › Article › peer-review

Open Access

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Cathelicidin Host Defence Peptide Augments Clearance of Pulmonary Pseudomonas aeruginosa Infection by Its Influence on Neutrophil Function In Vivo

Beaumont, P. E., McHugh, B., Gwyer Findlay, E., Mackellar, A., Mackenzie, K. J., Gallo, R. L., Govan, J. R. W., Simpson, A. J. & Davidson, D. J., 2 Jun 2014, In: PLoS ONE. 9, 6, e99029.

Research output: Contribution to journal › Article › peer-review

Open Access

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Atorvastatin as a stable treatment in bronchiectasis: a randomised controlled trial

Mandal, P., Chalmers, J. D., Graham, C., Harley, C., Sidhu, M. K., Doherty, C., Govan, J. W., Sethi, T., Davidson, D. J., Rossi, A. G. & Hill, A. T., 1 Jun 2014, In: The Lancet Respiratory Medicine. 2, 6, p. 455-463 9 p.

Research output: Contribution to journal › Article › peer-review

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2013

Phase II studies of nebulised Arikace in CF patients with Pseudomonas aeruginosa infection

Arikace Study Group, Clancy, J. P., Dupont, L., Konstan, M. W., Billings, J., Fustik, S., Goss, C. H., Lymp, J., Minic, P., Quittner, A. L., Rubenstein, R. C., Young, K. R., Saiman, L., Burns, J. L., Govan, J. R. W., Ramsey, B. & Gupta, R., Sept 2013, In: Thorax. 68, 9, p. 818-25 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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A Lung Segmental Model of Chronic Pseudomonas Infection in Sheep

Collie, D., Govan, J., Wright, S., Thornton, E., Tennant, P., Smith, S., Doherty, C. & McLachlan, G., 9 Jul 2013, In: PLoS ONE. 8, 7, e67677.

Research output: Contribution to journal › Article › peer-review

Open Access

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Mannose-binding lectin deficiency and disease severity in non-cystic fibrosis bronchiectasis: a prospective study

Chalmers, J. D., McHugh, B. J., Doherty, C., Smith, M. P., Govan, J. R., Kilpatrick, D. C. & Hill, A. T., May 2013, In: The Lancet Respiratory Medicine. 1, 3, p. 224-232 9 p.

Research output: Contribution to journal › Article › peer-review

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Vitamin-D deficiency is associated with chronic bacterial colonisation and disease severity in bronchiectasis

Chalmers, J. D., McHugh, B. J., Docherty, C., Govan, J. R. W. & Hill, A. T., Jan 2013, In: Thorax. 68, 1, p. 39-U161 9 p.

Research output: Contribution to journal › Article › peer-review

Draft Genome Sequence of a Stable Mucoid Strain of Pseudomonas aeruginosa PAO581 with a mucA25 Mutation

Yin, Y., Withers, T. R., Govan, J. R. W., Johnson, S. L. & Yu, H. D., 2013, In: Genome announcements. 1, 5

Research output: Contribution to journal › Article › peer-review

Open Access

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2012

Short- and Long-Term Antibiotic Treatment Reduces Airway and Systemic Inflammation in Non–Cystic Fibrosis Bronchiectasis

Chalmers, J. D., Smith, M. P., Mchugh, B. J., Doherty, C., Govan, J. R. & Hill, A. T., 1 Oct 2012, In: American Journal of Respiratory and Critical Care Medicine. 186, 7, p. 657-665 9 p.

Research output: Contribution to journal › Article › peer-review

The role of cathelicidins in protection against pathogenic lung infections

Findlay, E. G., Logermann, S. M., Beaumont, P., Barlow, P. G., Mackellar, A., Gallo, R. L., Govan, J. R. W., Fitch, P. M., Schwarze, J. & Davidson, D. J., Sept 2012, In: Immunology . 137, p. 219-219 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

2011

Can Early Burkholderia cepacia Complex Infection in Cystic Fibrosis be Eradicated with Antibiotic Therapy?

Horsley, A., Webb, K., Bright-thomas, R., Govan, J. & Jones, A., 21 Dec 2011, In: Frontiers in Cellular and Infection Microbiology. 1

Research output: Contribution to journal › Article › peer-review

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Cathelicidins induce protective inflammation and cell death and enhance host defence in murine models of pulmonary bacterial and viral infection

Beaumont, P. E., Barlow, P. G., Mackellar, A., MacKenzie, K., Svoboda, P., Nash, A., York, I. A., Pohl, J., Gallo, R. L., Donis, R. O., Govan, J. R. & Davidson, D. J., Dec 2011, In: Immunology . 135, p. 46-46 1 p.

Research output: Contribution to journal › Meeting abstract

A Randomized Controlled Trial of Nebulized Gentamicin in Non–Cystic Fibrosis Bronchiectasis

Murray, M. P., Govan, J. R. W., Doherty, C. J., Simpson, A. J., Wilkinson, T. S., Chalmers, J. D., Greening, A. P., Haslett, C. & Hill, A. T., 15 Feb 2011, In: American Journal of Respiratory and Critical Care Medicine. 183, 4, p. 491-499 9 p.

Research output: Contribution to journal › Article › peer-review

2010

Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex

Bodewits, K., Raetz, C. R. H., Govan, J. R. & Campopiano, D. J., Aug 2010, In: Antimicrobial Agents and Chemotherapy. 54, 8, p. 3531-3 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Do processing time and storage of sputum influence quantitative bacteriology in bronchiectasis?

Murray, M. P., Doherty, C. J., Govan, J. R. W. & Hill, A. T., Jul 2010, In: Journal of Medical Microbiology. 59, 7, p. 829-833 5 p.

Research output: Contribution to journal › Article › peer-review

Clinical Outcome for Cystic Fibrosis Patients Infected With Transmissible Pseudomonas aeruginosa An 8-Year Prospective Study

Jones, A. M., Dodd, M. E., Morris, J., Doherty, C., Govan, J. R. W. & Webb, A. K., Jun 2010, In: Chest Journal. 137, 6, p. 1405-1409 5 p.

Research output: Contribution to journal › Article › peer-review

Peptide Fragments of a β-Defensin Derivative with Potent Bactericidal Activity

Reynolds, N. L., De Cecco, M., Taylor, K., Stanton, C., Kilanowski, F., Kalapothakis, J., Seo, E., Uhrin, D., Campopiano, D., Govan, J., Macmillan, D., Barran, P. & Dorin, J. R., May 2010, In: Antimicrobial Agents and Chemotherapy. 54, 5, p. 1922-1929 8 p.

Research output: Contribution to journal › Article › peer-review

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Diagnostic importance of pulmonary interleukin-1 beta and interleukin-8 in ventilator-associated pneumonia

Conway-Morris, A., Kefala, K., Wilkinson, T. S., Moncayo-Nieto, O. L., Dhaliwal, K., Farrell, L., Walsh, T. S., Mackenzie, S. J., Swann, D. G., Andrews, P. J. D., Anderson, N., Govan, J. R. W., Laurenson, I. F., Reid, H., Davidson, D. J., Haslett, C., Sallenave, J.-M. & Simpson, A. J., Mar 2010, In: Thorax. 65, 3, p. 201-207 7 p.

Research output: Contribution to journal › Article › peer-review

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Early Pseudomonas aeruginosa infection in individuals with cystic fibrosis: is susceptibility testing justified?

Macdonald, D., Cuthbertson, L., Doherty, C., Campana, S., Ravenni, N., Taccetti, G. & Govan, J. R. W., 2010, In: Journal of Antimicrobial Chemotherapy. 65, 11, p. 2373-5 3 p.

Research output: Contribution to journal › Article › peer-review

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Subdivision of the bacterioferritin comigratory protein family of bacterial peroxiredoxins based on catalytic activity

Clarke, D. J., Ortega, X. P., Mackay, C. L., Valvano, M. A., Govan, J. R. W., Campopiano, D. J., Langridge-Smith, P. & Brown, A. R., 2010, In: Biochemistry. 49, 6, p. 1319-30 12 p.

Research output: Contribution to journal › Article › peer-review

The human cathelicidin LL-37 preferentially promotes apoptosis of infected airway epithelium

Barlow, P. G., Beaumont, P. E., Cosseau, C., Mackellar, A., Wilkinson, T. S., Hancock, R. E. W., Haslett, C., Govan, J. R. W., Simpson, A. J. & Davidson, D. J., 2010, In: American Journal of Respiratory Cell and Molecular Biology. 43, 6, p. 692-702 11 p.

Research output: Contribution to journal › Article › peer-review

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2009

LONG-TERM NEBULISED GENTAMICIN IN NON-CYSTIC FIBROSIS BRONCHIECTASIS IMPROVES MICROBIAL LOAD, EXERCISE TOLERANCE, EXACERBATION FREQUENCY AND HEALTH-RELATED QUALITY OF LIFE

Murray, M. P., Govan, J. R. W., Doherty, C. J., Greening, A. P., Gray, R. D., Simpson, J., Haslett, C., Wilkinson, T. S., Chalmers, J. D. & Hill, A. T., Dec 2009, In: Thorax. 64, p. A63-A63 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

Efficient Production of Human beta-Defensin 2 (HBD2) in Escherichia coli

Vargues, T., Morrison, G. J., Seo, E. S., Clarke, D. J., Fielder, H. L., Bennani, J., Pathania, U., Kilanowski, F., Dorin, J. R., Govan, J. R. W., Mackay, C. L., Uhrin, D. & Campopiano, D. J., Jun 2009, In: Protein and Peptide Letters. 16, 6, p. 668-676 9 p.

Research output: Contribution to journal › Article › peer-review

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Trappin-2 promotes early clearance of Pseudomonas aeruginosa through CD14-dependent macrophage activation and neutrophil recruitment

Wilkinson, T. S., Dhaliwal, K., Hamilton, T. W., Lipka, A. F., Farrell, L., Davidson, D. J., Duffin, R., Morris, A. C., Haslett, C., Govan, J. R. W., Gregory, C. D., Sallenave, J.-M. & Simpson, A. J., Apr 2009, In: The American Journal of Pathology. 174, 4, p. 1338-1346 9 p.

Research output: Contribution to journal › Article › peer-review

The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients

Holden, M. T. G., Seth-Smith, H. M. B., Crossman, L. C., Sebaihia, M., Bentley, S. D., Cerdeño-Tárraga, A. M., Thomson, N. R., Bason, N., Quail, M. A., Sharp, S., Cherevach, I., Churcher, C., Goodhead, I., Hauser, H., Holroyd, N., Mungall, K., Scott, P., Walker, D., White, B. & Rose, H. & 12 others, Iversen, P., Mil-Homens, D., Rocha, E. P. C., Fialho, A. M., Baldwin, A., Dowson, C., Barrell, B. G., Govan, J. R., Vandamme, P., Hart, C. A., Mahenthiralingam, E. & Parkhill, J., Jan 2009, In: Journal of Bacteriology. 191, 1, p. 261-77 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Contributions of two UDP-glucose dehydrogenases to viability and polymyxin B resistance of Burkholderia cenocepacia

Loutet, S. A., Bartholdson, S. J., Govan, J. R. W., Campopiano, D. J. & Valvano, M. A., 2009, In: Microbiology. 155, 6, p. 2029-39 11 p.

Research output: Contribution to journal › Article › peer-review

2008

The changing epidemiology of Burkholderia species infection at an adult cystic fibrosis centre

France, M. W., Dodd, M. E., Govan, J. R., Doherty, C. J., Webb, A. K. & Jones, A. M., Sept 2008, In: Journal of Cystic Fibrosis. 7, 5, p. 368-372 5 p.

Research output: Contribution to journal › Article › peer-review

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Plant host and sugar alcohol induced exopolysaccharide biosynthesis in the Burkholderia cepacia complex

Bartholdson, S. J., Brown, A. R., Mewburn, B. R., Clarke, D. J., Fry, S. C., Campopiano, D. J. & Govan, J. R. W., Aug 2008, In: Microbiology. 154, 8, p. 2513-2521 9 p.

Research output: Contribution to journal › Article › peer-review

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Analysis and Separation of Residues Important for the Chemoattractant and Antimicrobial Activities of β-Defensin 3

Taylor, K., Clarke, D. J., McCullough, B., Chin, W., Seo, E., Yang, D., Oppenheim, J., Uhrin, D., Govan, J. R. W., Campopiano, D. J., MacMillan, D., Barran, P. & Dorin, J., Mar 2008, In: Journal of Biological Chemistry. 283, 11, p. 6631-6639 9 p.

Research output: Contribution to journal › Article › peer-review

2007

A putative gene cluster for aminoarabinose biosynthesis is essential for Burkholderia cenocepacia viability

Ortega, X. P., Cardona, S. T., Brown, A. R., Loutet, S. A., Flannagan, R. S., Campopiano, D. J., Govan, J. R. W. & Valvano, M. A., Mar 2007, In: Journal of Bacteriology. 189, 9, p. 3639-3644 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Covalent dimer species of beta-defensin Defr1 display potent antimicrobial activity against multidrug-resistant bacterial pathogens

Taylor, K., McCullough, B., Clarke, D. J., Langley, R. J., Pechenick, T., Hill, A., Campopiano, D. J., Barran, P. E., Dorin, J. R. & Govan, J. R. W., 2007, In: Antimicrobial Agents and Chemotherapy. 51, 5, p. 1719-24 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Hypermutability in environmental Pseudomonas aeruginosa and in populations causing pulmonary infection in individuals with cystic fibrosis

Kenna, D. T., Doherty, C. J., Foweraker, J., Macaskill, L., Barcus, V. A. & Govan, J. R. W., 2007, In: Microbiology. 153, Pt 6, p. 1852-9 8 p.

Research output: Contribution to journal › Article › peer-review

2005

Multilocus sequence typing scheme that provides both species and strain differentiation for the Burkholderia cepacia complex

Baldwin, A., Mahenthiralingam, E., Thickett, K. M., Honeybourne, D., Maiden, M. C. J., Govan, J. R., Speert, D. P., Lipuma, J. J., Vandamme, P. & Dowson, C. G., Sept 2005, In: Journal of Clinical Microbiology. 43, 9, p. 4665-73 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Antimicrobial Activity of Murine Lung Cells against Staphylococcus aureus Is Increased In Vitro and In Vivo after Elafin Gene Transfer

Mcmichael, J. W., Maxwell, A. I., Hayashi, K., Taylor, K., Wallace, W., Govan, J. R., Dorin, J. R. & Sallenave, J.-M., 1 Jun 2005, In: Infection and Immunity. 73, 6, p. 3609-3617

Research output: Contribution to journal › Article › peer-review

Open Access

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Is it biologically relevant to measure the structures of small peptides in the gas-phase?

Barran, P. E., Polfer, N. C., Campopiano, D. J., Clarke, D. J., Langridge-Smith, P. R. R., Langley, R. J., Govan, J. R. W., Maxwell, A., Dorin, J. R., Millar, R. P. & Bowers, M. T., 1 Feb 2005, In: International Journal of Mass Spectrometry. 240, 3, p. 273-284 12 p.

Research output: Contribution to journal › Article › peer-review

Temperate bacteriophages DK4 and BcepMu from Burkholderia cenocepacia J2315 are identical

Langley, R. J., Kenna, D., Bartholdson, J., Campopiano, D. J. & Govan, J. R. W., 2005, In: FEMS Immunology and Medical Microbiology. 45, 2, p. 349-50 2 p.

Research output: Contribution to journal › Article › peer-review

2004

Lung pathology in response to repeated exposure to Staphylococcus aureus in congenic residual function cystic fibrosis mice does not increase in response to decreased CFTR levels or increased bacterial load

Davidson, D. J., Webb, S., Teague, P., Govan, J. R. W. & Dorin, J. R., 2004, In: Pathobiology: The Journal of Translational Pathology. 71, 3, p. 152-8 7 p.

Research output: Contribution to journal › Article › peer-review

Structure-activity relationships in defensin dimers: a novel link between beta-defensin tertiary structure and antimicrobial activity

Campopiano, D. J., Clarke, D. J., Polfer, N. C., Barran, P. E., Langley, R. J., Govan, J. R. W., Maxwell, A. & Dorin, J. R., 2004, In: Journal of Biological Chemistry. 279, 47, p. 48671-9 9 p.

Research output: Contribution to journal › Article › peer-review

1998

Mouse beta defensin-1 is a functional homolog of human beta defensin-1

Morrison, G. M., Davidson, D. J., Kilanowski, F. M., Borthwick, D. W., Crook, K., Maxwell, A. I., Govan, J. R. & Dorin, J. R., 1998, In: Mammalian Genome. 9, 6, p. 453-7 5 p.

Research output: Contribution to journal › Article › peer-review

1995

Lung disease in the cystic fibrosis mouse exposed to bacterial pathogens

Davidson, D. J., Dorin, J. R., McLachlan, G., Ranaldi, V., Lamb, D., Doherty, C., Govan, J. & Porteous, D. J., 1995, In: Nature Genetics. 9, 4, p. 351-357 7 p.

Research output: Contribution to journal › Article › peer-review

1993

In vitro activities of meropenem, PD 127391, PD 131628, ceftazidime, chloramphenicol, co-trimoxazole, and ciprofloxacin against Pseudomonas cepacia

Lewin, C., Doherty, C. & Govan, J., 1 Jan 1993, In: Antimicrobial Agents and Chemotherapy. 37, 1, p. 123-125 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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John Govan

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