Research output per year
Research output per year
PROF
I am interested in the molecular mechanisms that regulate embryonic development of the forebrain and how errors in this process can lead to neurodevelopmental disorders.
We study how the brain normally develops during embryogenesis and how neurodevelopmental disorders arise when normal development goes awry. Much of our work has concentrated on the transcription factors Foxg1, Pax6 and Gli3, in collaboration with David Price, Thomas Pratt and Thomas Theil. These transcription factors act as high level regulators and are crucial for normal development of the brain.
We are using cerebral organoids to explore mechanisms of human brain development, and to understand how neurodevelopmental disorders such as Autism Spectrum Disorders (ASD) and FOXG1 Syndrome arise. Cerebral organoids are small, 3D cultures grown from human stem cells that closely resemble normal brain tissue. This powerful new system allows us to study development of human brain tissue in ways that have not been possible previously.
Undergraduate
Year 3:
Mechanisms of Brain Development 3
Anatomy & Development 3
Year 4:
Honours Anatomy & Development (Programme Organiser 2018-2024)
Development and Disease (Course Organiser 2015-2024)
Honours Biomedical Sciences Core
Postgraduate
MSc by Research Integrative Neuroscience
Wellcome Trust 4-year PhD programme in Translational Neuroscience
Honours Programme Organiser - Anatomy & Development (2018-24)
Convenor, Biomedical Sciences Pre-honours Board of Examiners (2016-2020)
Member, Biomedical Sciences Junior Honours Board of Examiners (2018-2022)
Member, Physiology Honours Board of Examiners (1996-2018)
https://orcid.org/0000-0002-0489-2400
Research output: Chapter in Book/Report/Conference proceeding › Chapter
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Editorial
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Review article › peer-review
1/01/24 → 31/12/26
Project: Research
1/06/21 → 26/07/21
Project: Research
3/06/19 → 28/07/19
Project: Research
Flockhart, J. H. (Creator), Tang, P. (Creator), MacKay, G. E. (Creator), Keighren, M. A. (Creator), Kissenpfennig, A. (Creator), Wilson, L. (Creator), Pratt, T. (Creator), Mason, J. (Creator), Price, D. (Creator) & West, J. (Creator), Edinburgh DataShare, 6 Jun 2017
DOI: 10.7488/ds/2056
Dataset
Sharp, L. (Creator), Pratt, T. (Creator), MacKay, G. E. (Creator), Keighren, M. (Creator), Flockhart, J. H. (Creator), Chandler, E. (Creator), Price, D. (Creator), Mason, J. (Creator) & West, J. (Creator), Edinburgh DataShare, 30 May 2017
DOI: 10.7488/ds/2049
Dataset