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Personal profile

My research in a nutshell

I am working as a bioinformatician in the group of Professor Andrew Baker since March 2016. I am interested in the identification and characterization of long non-coding RNAs involved in vascular biology and disease, using computational approached. I am currently analysing several ‘vascular’ RNA-seq data obtained in Professor Andrew Baker’s group, such as the differentiation of human embryonic stem cells to endothelial cells as well as clinical studies linked to plaque instability. I would like to identify the lncRNAs that are differentially expressed during development or in pathology. Then, I would like to characterise their function, by integrating them into a gene expression network.

Biography

Previously, I have studied different aspect of RNA biology in different models. During my PhD (2006-2010), I studied the biogenesis of small nucleolar non-coding RNAs in the plant model A.thaliana. As a career development fellow in the group of Professor Javier Caceres (2010-2016 at HGU, Edinburgh), I studied the splicing regulation controlled by two RNA binding protein: Acinus and RBM10 in mammalian cells. Acinus is involved in apoptosis regulation whereas RBM10 gene mutation leads to a syndromic form of cleft palate.

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