Research output per year
Research output per year
- 22 results
Search results
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2020
Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling
Lepelley, A., Martin-niclós, M. J., Le Bihan, M., Marsh, J. A., Uggenti, C., Rice, G. I., Bondet, V., Duffy, D., Hertzog, J., Rehwinkel, J., Amselem, S., Boulisfane-el Khalifi, S., Brennan, M., Carter, E., Chatenoud, L., Chhun, S., Coulomb L’hermine, A., Depp, M., Legendre, M., Mackenzie, K. J., & 12 others, 28 Jul 2020, (E-pub ahead of print) In: Journal of Experimental Medicine. 217, 11Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2017
Enteric helminth-induced type I interferon signaling protects against pulmonary virus infection through interaction with the microbiota
McFarlane, A. J., McSorley, H. J., Davidson, D. J., Fitch, P. M., Errington, C., Mackenzie, K. J., Gollwitzer, E. S., Johnston, C. J. C., MacDonald, A. S., Edwards, M. R., Harris, N. L., Marsland, B. J., Maizels, R. M. & Schwarze, J., 1 Oct 2017, In: Journal of Allergy and Clinical Immunology. 140, 4, p. 1068-1078.e6Research output: Contribution to journal › Article › peer-review
Open AccessFile -
cGAS surveillance of micronuclei links genome instability to innate immunity
Mackenzie, K. J., Carroll, P., Martin, C-A., Murina, O., Fluteau, A., Simpson, D. J., Olova, N., Sutcliffe, H., Rainger, J. K., Leitch, A., Osborn, R. T., Wheeler, A. P., Nowotny, M., Gilbert, N., Chandra, T., Reijns, M. A. M. & Jackson, A. P., 24 Aug 2017, In: Nature. 548, 7668, p. 461–465 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Differential lower airway dendritic cell patterns may reveal distinct endotypes of RSV bronchiolitis
Kerrin, A., Fitch, P., Errington, C., Kerr, D., Waxman, L., Riding, K., McCormack, J., Mehendale, F., McSorley, H., Mackenzie, K., Wronski, S., Braun, A., Leven, R., Theilen, U. & Schwarze, J., 16 Jun 2017, In: Thorax. 72, 7, p. 620-627Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2016
Mutations in genes encoding condensin complex proteins cause microcephaly through decatenation failure at mitosis
The DDD Study, Wood, A. J., Vagnarelli, P. & Jackson, A. P., Oct 2016, In: Genes and Development. 30, 19, p. 2158-2172 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response
Mackenzie, K. J., Carroll, P., Lettice, L., Tarnauskaite, Z., Reddy, K., Dix, F., Revuelta, A., Abbondati, E., Rigby, R. E., Rabe, B., Kilanowski, F., Grimes, G. R., Fluteau, A., Devenney, P. S., Hill, R. E., Reijns, M. A. M. & Jackson, A. P., 15 Apr 2016, In: EMBO Journal. 35, 8, p. 831-844 14 p.Research output: Contribution to journal › Article › peer-review
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TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism
Harley, M. E., Murina, O., Leitch, A., Higgs, M., Bicknell, L. S., Yigit, G., Blackford, A., Zlatanou, A., Mackenzie, K. J., Reddy, K., Halachev, M., McGlasson, S., Reijns, M. A. M., Fluteau, A., Martin, C-A., Sabbioneda, S., Elcioglu, N. H., Altmuller, J., Thiele, H., Greenhalgh, L., & 10 others, Jan 2016, In: Nature Genetics. 48, 1, p. 36-43 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2014
Cathelicidin Host Defence Peptide Augments Clearance of Pulmonary Pseudomonas aeruginosa Infection by Its Influence on Neutrophil Function In Vivo
Beaumont, P. E., McHugh, B., Gwyer Findlay, E., Mackellar, A., Mackenzie, K. J., Gallo, R. L., Govan, J. R. W., Simpson, A. J. & Davidson, D. J., 2 Jun 2014, In: PLoS ONE. 9, 6, e99029.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
RNA:DNA hybrids are a novel molecular pattern sensed by TLR9
Rigby, R. E., Webb, L. M., Mackenzie, K. J., Li, Y., Leitch, A., Reijns, M. A. M., Lundie, R. J., Revuelta, A., Davidson, D. J., Diebold, S., Modis, Y., MacDonald, A. S. & Jackson, A. P., 18 Mar 2014, In: EMBO Journal. 33, 6, p. 542-558 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Effector and central memory T helper 2 cells respond differently to peptide immunotherapy
Mackenzie, K. J., Nowakowska, D. J., Leech, M. D., McFarlane, A. J., Wilson, C., Fitch, P. M., O'Connor, R. A., Howie, S. E. M., Schwarze, J. & Anderton, S. M., 25 Feb 2014, In: Proceedings of the National Academy of Sciences (PNAS). 111, 8, p. E784-E793 10 p.Research output: Contribution to journal › Article › peer-review
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Viral respiratory tract infections and asthma in early life: cause and effect?
Mackenzie, K. J., Anderton, S. M. & Schwarze, J., Jan 2014, In: Clinical & Experimental Allergy. 44, 1, p. 9-19 11 p.Research output: Contribution to journal › Literature review › peer-review
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2013
Combination peptide immunotherapy based on T cell epitope mapping reduces allergen-specific IgE and eosinophilia in allergic airway inflammation
Mackenzie, K. J., Fitch, P. M., Leech, M. D., Ilchmann, A., Wilson, C., McFarlane, A., Howie, S. E., Anderton, S. M. & Schwarze, J., Mar 2013, In: Immunology . 138, 3, p. 258-268 11 p.Research output: Contribution to journal › Article › peer-review
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Novel insights into immune and inflammatory responses to respiratory viruses
Schwarze, J. & Mackenzie, K. J., Jan 2013, In: Thorax. 68, 1, p. 108-110 3 p.Research output: Contribution to journal › Review article › peer-review
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2012
Efficacious peptide-based immunotherapy in a model of allergic airways inflammation occurs independently of IL-10
Mackenzie, K. J., Fitch, P. M., Nowakowska, D., Leech, M. D., McFarlane, A., Ilchmann, A., Howie, S. E. M., Schwarze, J. & Anderton, S. M., Sept 2012, In: Immunology . 137, p. 446-446 1 p.Research output: Contribution to journal › Meeting abstract
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Heligmosomoides polygyrus co-infection reduces lung immune cell responses to respiratory syncytial virus
McFarlane, A., McSorley, H. J., Mackenzie, K. J., Fitch, P. M., Ilchmann, A., Maizels, R. M. & Schwarze, J., Sept 2012, In: Immunology . 137, p. 638-639 2 p.Research output: Contribution to journal › Meeting abstract
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2011
Cathelicidins induce protective inflammation and cell death and enhance host defence in murine models of pulmonary bacterial and viral infection
Beaumont, P. E., Barlow, P. G., Mackellar, A., MacKenzie, K., Svoboda, P., Nash, A., York, I. A., Pohl, J., Gallo, R. L., Donis, R. O., Govan, J. R. & Davidson, D. J., Dec 2011, In: Immunology . 135, p. 46-46 1 p.Research output: Contribution to journal › Meeting abstract
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CD11c(+) lung antigen presenting cells (APCs) from RSV infected mice have an enhanced ability to induce Th2, but not Th1, recall responses to allergen
Ilchmann, A., Mackenzie, K., Fitch, P. & Schwarze, J., Dec 2011, In: Immunology . 135, p. 131-131 1 p.Research output: Contribution to journal › Meeting abstract
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Peptide-based immunotherapy significantly reduces the severity of disease in an adoptive transfer model of ovalbumin-induced allergic airways inflammation
Mackenzie, K., Fitch, P., Ilchmann, A., Nowakowska, D., Anderton, S. & Schwarze, J., Dec 2011, In: Immunology . 135, p. 191-191 1 p.Research output: Contribution to journal › Meeting abstract
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Neosensitization to allergens after resolution of allergic airways inflammation: a new role for airway dendritic cells
Schwarze, J. & Mackenzie, K. J., 2011, In: American Journal of Respiratory and Critical Care Medicine. 184, 3, p. 283-4 2 p.Research output: Contribution to journal › Editorial
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Peptide immunotherapy for childhood allergy - addressing translational challenges
Mackenzie, K. J., Anderton, S. M. & Schwarze, J., 2011, In: Clinical and translational allergy. 1, 1, p. 13Research output: Contribution to journal › Literature review › peer-review
Open AccessFile -
2010
Inhibition of eosinophil migration by lactoferrin
Bournazou, I., Mackenzie, K. J., Duffin, R., Rossi, A. G. & Gregory, C. D., Feb 2010, In: Immunology & Cell Biology. 88, 2, p. 220-223 4 p.Research output: Contribution to journal › Article › peer-review
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2007
Distinct T cell recognition of naturally processed and cryptic epitopes within the immunodominant 35-55 region of myelin oligodendrocyte glycoprotein
Sweenie, C. H., Mackenzie, K. J., Rone-Orugboh, A., Liu, M. & Anderton, S. M., 2007, In: Journal of Neuroimmunology. 183, 1-2, p. 7-16 10 p.Research output: Contribution to journal › Article › peer-review