Personal profile
Current Research Interests
Translational genomics in critical care medicine.
Biography
Kenneth Baillie graduated from the University of Edinburgh with a BSc(Hons) in Physiology in 1999 and MBChB in 2002. He completed basic training in medicine in Glasgow, and in anesthesia in Edinburgh. During this time he led a series of high altitude research projects in Bolivia, and founded a high-altitude research charity, Apex. He was appointed as a clinical lecturer on the ECAT (Edinburgh Clinical Academic Track) at the University of Edinburgh in 2008, and completed a Wellcome Trust-funded PhD in statistical genetics in 2012. He was awarded a Wellcome-Beit Prize Intermediate Clinical Fellowship in 2013. He led a global consensus on harmonisation of research studies in outbreaks for the International Severe Acute Respiratory Infection Consortium (ISARIC), and worked with WHO on H1N1 influenza, MERS, and Ebola. After completing clinical training in 2014 he worked as a visiting scientist at the Broad Institute of Harvard and MIT, before returning to the Roslin Institute, University of Edinburgh to establish a research program in translational applications of genomics in critical care medicine. He works as a consultant in the intensive care unit at the Royal Infirmary, Edinburgh. During the Covid outbreak in 2020-21, he led the UK-wide GenOMICC and ISARIC4C studies, and contributed to the design and delivery of the RECOVERY trial. He discovered new biological mechanisms underlying critical illness in Covid, and contributed to the discovery of effective drug treatments to reduce mortality.
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Collaborations and top research areas from the last five years
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Translational genomics. Targeting the host immune response to fight infection
Baillie, J. K., 23 May 2014, In: Science. 344, 6186, p. 807-808 2 p.Research output: Contribution to journal › Editorial › peer-review
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An atlas of active enhancers across human cell types and tissues
Andersson, R., Gebhard, C., Miguel-Escalada, I., Hoof, I., Bornholdt, J., Boyd, M., Chen, Y., Zhao, X., Schmidl, C., Suzuki, T., Ntini, E., Arner, E., Valen, E., Li, K., Schwarzfischer, L., Glatz, D., Raithel, J., Lilje, B., Rapin, N. & Bagger, F. O. & 31 others, , 26 Mar 2014, In: Nature. 507, 7493, p. 455-61 7 p.Research output: Contribution to journal › Article › peer-review
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IFITM3 restricts the morbidity and mortality associated with influenza
GenISIS Investigators, The MOSAIC Investigators & Haley, C. (Member of Group Organisation), 26 Apr 2012, In: Nature. 484, 7395, p. 519-23 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Somatic retrotransposition alters the genetic landscape of the human brain
Baillie, J. K., Barnett, M. W., Upton, K. R., Gerhardt, D. J., Richmond, T. A., De Sapio, F., Brennan, P., Rizzu, P., Smith, S., Fell, M., Talbot, R. T., Gustincich, S., Freeman, T. C., Mattick, J. S., Hume, D. A., Heutink, P., Carninci, P., Jeddeloh, J. A. & Faulkner, G. J., Nov 2011, In: Nature. 479, 7374, p. 534-537 4 p.Research output: Contribution to journal › Article › peer-review
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Immune-adaptive pathogen variation reveals targetable mediators of gram-positive bacterial killing in macrophages
Russell, C. D., Marshall, J., McHugh, B. J., Michno, B. J., Cholewa-Waclaw, J., Chepsat, J., Jones, G.-R., McHugh, M. P., Lynskey, N., Yebra, G., Renshaw, S. A., Prajsnar, T. K., Baillie, J. K., Fitzgerald, J. R. & Dockrell, D. H., 27 Feb 2026, In: Science Advances. 12, 9, eaea0375.Research output: Contribution to journal › Article › peer-review
Open AccessFile
Prizes
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Chancellor's Award for Research Excellence
Baillie, K. (Recipient), 2023
Prize: Prize (including medals and awards)
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Fellow of the Academy of Medical Sciences
Baillie, K. (Recipient), 2022
Prize: Election to learned society
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Fellow of the Royal Society of Edinburgh
Baillie, K. (Recipient), 2022
Prize: Election to learned society
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Pride of Scotland Award
Baillie, K. (Recipient), 1 Aug 2021
Prize: Prize (including medals and awards)
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Edinburgh Human Brain Cluster: Enhancing Investigation of Live Human Brain Slice Models with Deep Patient Phenotyping
Brennan, P. (Principal Investigator), Baillie, K. (Co-investigator), Booker, S. (Co-investigator), Durrant, C. (Co-investigator), Smith, C. (Co-investigator) & Spires-Jones, T. (Co-investigator)
14/11/25 → 13/11/29
Project: Research
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Evaluation of monitoring equipment at high altitude
Baillie, K. (Principal Investigator)
19/05/25 → 18/05/27
Project: Research
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CHAI - EPSRC AI Hub for Causality in Healthcare AI with Real Data
Tsaftaris, S. (Principal Investigator), Baillie, K. (Co-investigator), Beentjes, S. (Co-investigator), Crowley, E. (Co-investigator), Escudero Rodriguez, J. (Co-investigator), Gouk, H. (Co-investigator), Guthrie, B. (Co-investigator), Harrison, E. (Co-investigator), Khamseh, A. (Co-investigator), King, R. (Co-investigator), Nazarpour, K. (Co-investigator), Parsons, M. (Co-investigator), Ramamoorthy, R. (Co-investigator), Seth, S. (Co-investigator), Simpson, I. (Co-investigator) & Whiteley, W. (Co-investigator)
Engineering and Physical Sciences Research Council
1/02/24 → 31/01/29
Project: Research
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ISP 2023/28 Consumables - Translational Bioscience
Whitelaw, B. (Principal Investigator), Baillie, K. (Co-investigator), Collie, D. (Co-investigator), Donadeu, X. (Co-investigator), Donadeu, X. (Co-investigator), McGrew, M. (Co-investigator), McLachlan, G. (Co-investigator), Robledo, D. (Co-investigator), Wilson, A. (Co-investigator) & Wishart, T. (Co-investigator)
Biotechnology and Biological Sciences Research Council
1/04/23 → 31/03/28
Project: Research
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Time critical precision medicine for acute critical illness using treatable trait principles: Data enabled adaptive platform trial with embedded biological characterisation [TRAITS Program]
Shankar-Hari, M. (Principal Investigator), Baillie, K. (Co-investigator), Dhaliwal, K. (Co-investigator), Docherty, A. (Co-investigator), Norrie, J. (Co-investigator), Porteous, C. (Co-investigator) & Weir, C. (Co-investigator)
1/08/22 → 31/07/27
Project: Research
Datasets
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ISARIC4C OAS data
Baillie, K. (Creator), Edinburgh DataShare, 20 Sept 2021
DOI: 10.7488/ds/3139, https://doi.org/10.1101/2021.05.05.21256681
Dataset
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DataVault: Baillie Lab baillie_fantom5 'Vault B'
Clohisey Hendry, S. (Creator), Baillie, K. (Creator) & Pairo-Castineira, E. (Creator), Edinburgh DataVault, 31 Aug 2022
Dataset
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DataVault: Baillie Lab Longterm Storage Vault A
Parkinson, N. (Creator), Clohisey Hendry, S. (Creator), Baillie, K. (Creator) & Neyton, L. P. A. (Creator), Edinburgh DataVault, 29 Aug 2022
Dataset
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Raw red counts from a CRISPR screen for host factors required for influenza virus replication
Clohisey Hendry, S. (Creator), Chia, B. S. (Creator), Wang, B. (Creator), Cui, A. (Creator), Eisenhaure, T. (Creator), Schweitzer, L. D. (Creator), Hoover, P. (Creator), Nachshon, A. (Creator), Smith, N. (Creator), Regan, T. (Creator), Farr, D. (Creator), Gutmann, M. (Creator), Bukhari, S. I. (Creator), Law, A. (Creator), Sangesland, M. (Creator), Gat-Viks, I. (Creator), Digard, P. (Creator), Vasudevan, S. (Creator), Lingwood, D. (Creator), Dockrell, D. (Creator), Doench, J. G. (Creator), Baillie, K. (Creator), Hacohen, N. (Creator), Parkinson, N. J. (Creator) & Li, B. (Creator), Edinburgh DataShare, 14 Oct 2024
DOI: 10.7488/ds/7818
Dataset
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GenOMICC release 3 GWAS summary statistics
Baillie, K. (Creator), Pairo-Castineira, E. (Creator) & Rawlik, K. (Creator), Edinburgh DataShare, 10 Oct 2023
DOI: 10.7488/ds/7517, https://www.medrxiv.org/content/10.1101/2022.03.07.22271833v1
Dataset
Press/Media
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Sepsis hope as study examines how DNA affects infection risk
28/03/19
1 Media contribution
Press/Media: Research
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Dr Ken Baillie on the medical conundrum of plane stowaways
24/06/15
1 Media contribution
Press/Media: Public Engagement Activities