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My research in a nutshell

My group’s research is focused on what mechanisms drive kidney injury and how it heals itself.   Our three research themes are:

  • The role of the non-coding RNA in renal injury and repair
  • Novel drivers of renal fibrosis as therapeutic targets.

  • Novel biomarkers of renal disease severity.

My group uses a combination of transcriptomic studies (via RNA-, small RNA- and single cell RNA-Seq studies) and informative rodent models of kidney injury and its regression to understanding the mechanism underlying kidney injury and repair.  Recently we have identified cell specific miRNAs and their target pathways (Connor et al., 2020) and produced a miRNA atlas of the injured and repairing kidney. We also defined myeloid cell heterogeneity in the progression and regression of kidney injury (Conway et al., 2020). Currently we are focussed on understanding the interactions between myeloid cells, tubular cells and fibroblasts which drive injury and repair.  My group are also interested in identifying new biomarkers of kidney disease severity and methods to improve detection. 

 

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