Personal profile

My research in a nutshell

The main objective of the Denby lab is to develop therapies that slow/prevent/reverse kidney injury. 

My group’s main research aim is to understand what mechanisms drive kidney injury and how the kidney repairs itself post injury.  

Our three research themes are:

1) The role of the non-coding RNA in kidney injury and repair

2) Novel drivers of kidney fibrosis as therapeutic targets.

3) Novel biomarkers of kidney disease severity.

My group uses a combination of transcriptomic studies (via RNA-, small RNA- and single cell RNA-Seq studies) and informative rodent models of kidney injury and its regression to understand the mechanisms underlying kidney injury and repair. 

Recently we have identified cell specific miRNAs and their target pathways and produced a miRNA atlas of the injured and repairing kidney (Connor et al., JCI Insight, 2020). We also defined myeloid cell heterogeneity in the progression and regression of kidney injury (Conway et al., 2020). Currently we are focussed on understanding the interactions between myeloid cells, kidney parenchyma and fibroblasts which drive injury and repair. 

In addition my group are also interested in identifying new biomarkers of kidney disease severity including miRNAs as biomarkers and methods to improve detection of kidney biomarkers.

Education/Academic qualification

Gene Therapy, Doctor of Philosophy (PhD), Gene Therapy for Cardiovascular Disease, University of Glasgow

Award Date: 6 Jul 2005

Pharmacology, Bachelor of Science (Honours), Institute of Medical Sciences, University of Aberdeen

Award Date: 5 Jul 2000

External positions

Grants Panel Member, Kidney Research UK

Jul 2022 → …

UK Kidney Association Elected Renal Scientist

Apr 2021 → …

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