Research output per year
Research output per year
Personal profile
My research in a nutshell
The main objective of the Denby lab is to develop therapies that slow/prevent/reverse kidney injury.
My group’s main research aim is to understand what mechanisms drive kidney injury and how the kidney repairs itself post injury.
Our three research themes are:
1) The role of the non-coding RNA in kidney injury and repair
2) Novel drivers of kidney fibrosis as therapeutic targets.
3) Novel biomarkers of kidney disease severity.
My group uses a combination of transcriptomic studies (via RNA-, small RNA- and single cell RNA-Seq studies) and informative rodent models of kidney injury and its regression to understand the mechanisms underlying kidney injury and repair.
Recently we have identified cell specific miRNAs and their target pathways and produced a miRNA atlas of the injured and repairing kidney (Connor et al., JCI Insight, 2020). We also defined myeloid cell heterogeneity in the progression and regression of kidney injury (Conway et al., 2020). Currently we are focussed on understanding the interactions between myeloid cells, kidney parenchyma and fibroblasts which drive injury and repair.
In addition my group are also interested in identifying new biomarkers of kidney disease severity including miRNAs as biomarkers and methods to improve detection of kidney biomarkers.
Education/Academic qualification
Gene Therapy, Doctor of Philosophy (PhD), Gene Therapy for Cardiovascular Disease, School of Cardiovascular & Metabolic Health , University of Glasgow , Glasgow , UK
Award Date: 6 Jul 2005
Pharmacology, Bachelor of Science (Honours), Institute of Medical Sciences, University of Aberdeen
Award Date: 5 Jul 2000
External positions
Grants Panel Member, Kidney Research UK
Jul 2022 → …
UK Kidney Association Elected Renal Scientist
Apr 2021 → …
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Single-cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis
O’sullivan, E. D., Mylonas, K. J., Bell, R., Carvalho, C., Baird, D. P., Cairns, C., Gallagher, K. M., Campbell, R., Docherty, M., Laird, A., Henderson, N. C., Chandra, T., Kirschner, K., Conway, B., Dihazi, G. H., Zeisberg, M., Hughes, J., Denby, L., Dihazi, H. & Ferenbach, D. A., 22 Nov 2022, In: JCI Insight. 7, 22Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Sonoporation of human renal proximal tubular epithelial cells in vitro to enhance the liberation of intracellular miRNA biomarkers.
Teenan, O., Sahni, V., Henderson, R. B., Conway, B. R., Moran, C. M., Hughes, J. & Denby, L., 17 Mar 2022, (E-pub ahead of print) In: Ultrasound in Medicine and Biology (UMB).Research output: Contribution to journal › Article › peer-review
Open AccessFile -
MicroRNAs and Their Delivery in Diabetic Fibrosis
Wonnacott, A., Denby, L., Coward, R. JM., Fraser, D. J. & Bowen, T., 9 Nov 2021, In: Advanced Drug Delivery Reviews. p. 114045Research output: Contribution to journal › Review article › peer-review
Open AccessFile -
Myeloid heterogeneity in kidney disease as revealed through single cell RNA sequencing
Bell, R. M. B. & Denby, L., 2 Sep 2021, (E-pub ahead of print) In: Kidney360. p. 10.34067/KID.0003682021Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Role of Tim4 in the regulation of ABCA1+ adipose tissue macrophages and post-prandial cholesterol levels
Magalhaes, M. S., Smith, P., Portman, J., Jackson-Jones, L. H., Bain, C. C., Ramachandran, P., Michailidou, Z., Stimson, R. H., Dweck, M. R., Denby, L., Henderson, N. C., Jenkins, S. J. & Benezech, C., 21 Jul 2021, (E-pub ahead of print) In: Nature Communications.Research output: Contribution to journal › Article › peer-review
Open AccessFile
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Selective targeting of GPR176 as a paradigm for the development of novel renal anti-fibrotic drugs
1/06/19 → 30/11/24
Project: Research
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Identification of novel strategies to induce regulatory T-cells as a therapy for chronic kidney disease
Hughes, J., Conway, B. & Denby, L.
1/10/19 → 30/09/22
Project: Research
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MicroRNAs regulate heme-oxygenase-1 (HO-1) response to heme arginate in renal transplant recipients
Denby, L. & Connor, K.
1/11/18 → 31/10/19
Project: Research
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MicroRNAs Regulate Heme Oxygenase-1 expression in Renal Transplantation
Wigmore, S., Denby, L. & Marson, L.
1/08/18 → 31/01/21
Project: Research