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Personal profile

Qualifications

1993 BSc (Hons) Genetics, University of Birmingham

2009 MSc Science Open University

Websites

Biography

I am Head of the Genetics Core at the Edinburgh Clinical Research Facility. This is a joint University of Edinburgh and NHS Lothian facility for conducting multidisciplinary clinical research. My team of expert technicians provides support to studies investigating the role of genetics in disease and health. The laboratory provides sample processing, biobanking and high-throughput genomics with quality systems in place to ensure processes are conducted in accordance with clinical trial legislation. 

 

I am a member of the University Technician Steering Commitee leading on the development and implementation of the national Technician Commitment action plan. The University has over a thousand highly trained and experienced individuals with diverse skills working across all subject areas. These technical staff play an important, but often overlooked role in research, teaching and supporting our students.

 

Current Research Interests

  • Utilising genome technologies (sequencing, digital PCR, arrays) to understand health and disease
  • The ethical, legal and social aspects of genetics and biobanking

My research in a nutshell

I run a team of technicians providing genomics support to researchers. We provide help by biobanking samples from patients, extracting DNA and RNA and then analysing the samples using a variety of high-end analysis platforms including digital PCR, arrays and sequencing. Our aim is to provide equitable access to University researchers at all stages of their career to the very best equipment run by skilled technicians. 

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  • Whole genome sequencing reveals host factors underlying critical Covid-19

    GenOMICC Investigators, Kousathanas, A., Pairo-Castineira, E., Rawlik, K., Stuckey, A., Odhams, C. A., Walker, S., Russell, C. D., Malinauskas, T., Wu, Y., Millar, J., Shen, X., Elliott, K. S., Griffiths, F., Oosthuyzen, W., Morrice, K., Keating, S., Wang, B., Rhodes, D., Klaric, L., & 57 othersZechner, M., Parkinson, N., Siddiq, A., Goddard, P., Donovan, S., Maslove, D., Nichol, A., Semple, M. G., Zainy, T., Maleady-Crowe, F., Todd, L., Salehi, S., Knight, J., Elgar, G., Chan, G., Arumugam, P., Patch, C., Rendon, A., Bentley, D., Kingsley, C., Kosmicki, J. A., Horowitz, J. E., Baras, A., Abecasis, G. R., Ferreira, M. A. R., Justice, A., Mirshahi, T., Oetjens, M., Rader, D. J., Ritchie, M. D., Verma, A., Fowler, T. A., Shankar-Hari, M., Summers, C., Hinds, C., Horby, P., Ling, L., McAuley, D., Montgomery, H., Openshaw, P. J. M., Elliott, P., Walsh, T., Tenesa, A., Fawkes, A., Murphy, L., Rowan, K., Ponting, C. P., Vitart, V., Wilson, J. F., Yang, J., Bretherick, A. D., Scott, R. H., Hendry, S. C., Moutsianas, L., Law, A., Caulfield, M. J. & Baillie, J. K., 7 Jul 2022, In: Nature. 607, p. 97-103

    Research output: Contribution to journalArticlepeer-review

    Open Access
    File
  • Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects

    Robertson, N. A., Latorre Crespo, E., Terradas Terradas, M., Lemos Portela, J., Purcell, A. C., Livesey, B., Hillary, R., Murphy, L., Fawkes, A., MacGillivray, L., Copland, M., Marioni, R. E., Marsh, J. A., Harris, S. A., Cox, S. R., Deary, I. J., Schumacher, L. J., Kirschner, K. & Chandra, T., 4 Jul 2022, In: Nature Medicine.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    File
  • FutureMS cohort profile: a Scottish multicentre inception cohort study of relapsing-remitting multiple sclerosis

    Kearns, P. K. A., Martin, S. J., Chang, J., Meijboom, R., York, E. N., Chen, Y., Weaver, C., Stenson, A., Hafezi, K., Thomson, S., Freyer, E., Murphy, L., Harroud, A., Foley, P., Hunt, D., Mcleod, M., O'riordan, J., Carod-artal, F. J., Macdougall, N. J. J., Baranzini, S. E., & 3 othersWaldman, A. D., Connick, P. & Chandran, S., 29 Jun 2022, In: BMJ Open. 12, 6, p. e058506

    Research output: Contribution to journalArticlepeer-review

    Open Access
    File
  • Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission

    Relph, K. A., Russell, C. D., Fairfield, C. J., Turtle, L., De Silva, T., Siggins, M. K., Drake, T. M., Thwaites, R. S., Abrams, S., Moore, S. C., Hardwick, H. E., Oosthuyzen, W., Harrison, E. M., Docherty, A. B., Openshaw, P. J. M., Baillie, J. K., Semple, M. G., Ho, A., Baillie, J. K., Semple, M. G., & 348 othersOpenshaw, P. J. M., Carson, G., Alex, B., Bach, B., Barclay, W. S., Bogaert, D., Chand, M., Cooke, G. S., Docherty, A. B., Dunning, J., Filipe, A. D. S., Fletcher, T., Green, C. A., Harrison, E. M., Hiscox, J. A., Ho, A. Y. W., Horby, P. W., Ijaz, S., Khoo, S., Klenerman, P., Law, A., Lim, W. S., Mentzer, A. J., Merson, L., Meynert, A. M., Noursadeghi, M., Moore, S. C., Palmarini, M., Paxton, W. A., Pollakis, G., Price, N., Rambaut, A., Robertson, D. L., Russell, C. D., Sancho-shimizu, V., Scott, J. T., De Silva, T., Sigfrid, L., Solomon, T., Sriskandan, S., Stuart, D., Summers, C., Tedder, R. S., Thomson, E. C., Roger Thompson, A. A., Thwaites, R. S., Turtle, L. C. W., Gupta, R. K., Zambon, M., Hardwick, H., Donohue, C., Lyons, R., Griffiths, F., Oosthuyzen, W., Norman, L., Pius, R., Drake, T. M., Fairfield, C. J., Knight, S. R., Mclean, K. A., Murphy, D., Shaw, C. A., Dalton, J., Girvan, M., Saviciute, E., Roberts, S., Harrison, J., Marsh, L., Connor, M., Halpin, S., Jackson, C., Gamble, C., Leeming, G., Law, A., Wham, M., Clohisey, S., Hendry, R., Scott-brown, J., Greenhalf, W., Shaw, V., Mcdonald, S., Keating, S., Ahmed, K. A., Armstrong, J. A., Ashworth, M., Asiimwe, I. G., Bakshi, S., Barlow, S. L., Booth, L., Brennan, B., Bullock, K., Catterall, B. W. A., Clark, J. J., Clarke, E. A., Cole, S., Cooper, L., Cox, H., Davis, C., Dincarslan, O., Dunn, C., Dyer, P., Elliott, A., Evans, A., Finch, L., Fisher, L. W. S., Foster, T., Garcia-dorival, I., Greenhalf, W., Gunning, P., Hartley, C., Jensen, R. L., Jones, C. B., Jones, T. R., Khandaker, S., King, K., Kiy, R. T., Koukorava, C., Lake, A., Lant, S., Latawiec, D., Lavelle-langham, L., Lefteri, D., Lett, L., Livoti, L. A., Mancini, M., Mcdonald, S., Mcevoy, L., Mclauchlan, J., Metelmann, S., Miah, N. S., Middleton, J., Mitchell, J., Moore, S. C., Murphy, E. G., Penrice-randal, R., Pilgrim, J., Prince, T., Reynolds, W., Matthew Ridley, P., Sales, D., Shaw, V. E., Shears, R. K., Small, B., Subramaniam, K. S., Szemiel, A., Taggart, A., Tanianis-hughes, J., Thomas, J., Trochu, E., Van Tonder, L., Wilcock, E., Eunice Zhang, J., Flaherty, L., Maziere, N., Cass, E., Doce Carracedo, A., Carlucci, N., Holmes, A., Massey, H., Murphy, L., Wrobel, N., Mccafferty, S., Morrice, K., Maclean, A., Adeniji, K., Agranoff, D., Agwuh, K., Ail, D., Aldera, E. L., Alegria, A., Angus, B., Ashish, A., Atkinson, D., Bari, S., Barlow, G., Barnass, S., Barrett, N., Bassford, C., Basude, S., Baxter, D., Beadsworth, M., Bernatoniene, J., Berridge, J., Best, N., Bothma, P., Chadwick, D., Brittain-long, R., Bulteel, N., Burden, T., Burtenshaw, A., Caruth, V., Chadwick, D., Chambler, D., Chee, N., Child, J., Chukkambotla, S., Clark, T., Collini, P., Cosgrove, C., Cupitt, J., Cutino-moguel, M., Dark, P., Dawson, C., Dervisevic, S., Donnison, P., Douthwaite, S., Durand, I., Dushianthan, A., Dyer, T., Evans, C., Eziefula, C., Fegan, C., Finn, A., Fullerton, D., Garg, S., Garg, S., Garg, A., Gkrania-klotsas, E., Godden, J., Goldsmith, A., Graham, C., Hardy, E., Hartshorn, S., Harvey, D., Havalda, P., Hawcutt, D. B., Hobrok, M., Hodgson, L., Hormis, A., Jacobs, M., Jain, S., Jennings, P., Kaliappan, A., Kasipandian, V., Kegg, S., Kelsey, M., Kendall, J., Kerrison, C., Kerslake, I., Koch, O., Koduri, G., Koshy, G., Laha, S., Laird, S., Larkin, S., Leiner, T., Lillie, P., Limb, J., Linnett, V., Little, J., Lyttle, M., Macmahon, M., Macnaughton, E., Mankregod, R., Masson, H., Matovu, E., Mccullough, K., Mcewen, R., Meda, M., Mills, G., Minton, J., Mirfenderesky, M., Mohandas, K., Mok, Q., Moon, J., Moore, E., Morgan, P., Morris, C., Mortimore, K., Moses, S., Mpenge, M., Mulla, R., Murphy, M., Nagel, M., Nagarajan, T., Nelson, M., O’shea, M. K., Otahal, I., Ostermann, M., Pais, M., Panchatsharam, S., Papakonstantinou, D., Paraiso, H., Patel, B., Pattison, N., Pepperell, J., Peters, M., Phull, M., Pintus, S., Pooni, J. S., Post, F., Price, D., Prout, R., Rae, N., Reschreiter, H., Reynolds, T., Richardson, N., Roberts, M., Roberts, D., Rose, A., Rousseau, G., Ryan, B., Saluja, T., Shah, A., Shanmuga, P., Sharma, A., Shawcross, A., Sizer, J., Shankar-hari, M., Smith, R., Snelson, C., Spittle, N., Staines, N., Stambach, T., Stewart, R., Subudhi, P., Szakmany, T., Tatham, K., Thomas, J., Thompson, C., Thompson, R., Tridente, A., Tupper-carey, D., Twagira, M., Ustianowski, A., Vallotton, N., Vincent-smith, L., Visuvanathan, S., Vuylsteke, A., Waddy, S., Wake, R., Walden, A., Welters, I., Whitehouse, T., Whittaker, P., Whittington, A., Papineni, P., Wijesinghe, M., Williams, M., Wilson, L., Cole, S., Winchester, S., Wiselka, M., Wolverson, A., Wootton, D. G., Workman, A., Yates, B. & Young, P., 1 May 2022, In: Open forum infectious diseases. 9, 5

    Research output: Contribution to journalArticlepeer-review

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  • A comparison of blood and brain-derived ageing and inflammation-related DNA methylation signatures and their association with microglial burdens

    Stevenson, A., McCartney, D., Gadd, D., Shireby, G., Hillary, R., King, D., Tzioras, M., Wrobel, N., Mccafferty, S., Murphy, L., McColl, B. W., Redmond, P., Taylor, A., Harris, S., Russ, T., McIntosh, A. M., Mill, J., Smith, C., Deary, I. J., Cox, S. R., & 2 othersMarioni, R. E. & Spires-Jones, T., 6 Apr 2022, (E-pub ahead of print) In: European Journal of Neuroscience.

    Research output: Contribution to journalArticlepeer-review

    Open Access