Research output per year
Research output per year
Personal profile
Biography
Senior researcher in biological engineering at the Institute for Bioengineering at the University of Edinburgh. Born in Edinburgh, I completed a BSc (Honours) in Physiology at the University of Edinburgh in 1990. After obtaining a Diploma in Education and teaching chemistry and biology, I pursued a research career by completing a PhD in 2002 at the University of Edinburgh Faculty of Medicine (Hepatology) in the Liver Cell Biology Laboratory, working on liver tissue engineering approaches towards the development of bioartificial liver systems. Currently, my research is focused on developing human liver tissue (two/three-dimensional) organotypic models, mechanisms underlying liver disease utilizing in vitro human disease models (drug-induced liver injury; fatty liver disease; cholangiocarcinoma), study of the liver–brain axis in Alzheimer’s disease, as well as synthetic biological engineering approaches for pharmaceutical applications.
Collaborative Activity
CURRENT GRANTS: 1. EPSRC IAA Grant: Synthetic Biological Engineering of human hepatic HepaRG cells; [2018-2019]; £161,134; LJ Nelson; A Elfick 2. AMMF (UK): A Novel Therapeutic Approach for Cholangiocarcinoma; £67,000 [2018-2020]; LJ Nelson, M Avila, J Cubero. 3. H2020 COST Action CA171120: Prospective Drug-induced Liver Injury Network [2018-2022]; Management Committee; WG3 Co-Leader. RECENT PROJECTS: Human Liver Models for Drug Apps: 1. Nanopatterned Human Liver BioChips for Drug Hepatotoxicity Screening [BBSRC; UK]. 2. Human hepatic HepaRG cell-based toxicological platform/ impedance biosensing [SCRM; Biopredic] Tissue Engineering: i. 3D Human Liver Organoids [CSO award, UK]. ii. Non-invasive 3D hepatotoxicity optical assays [SCRM, UoE] iii. 2D-3D HepaRG-NAFLD models of liver disease.
Keywords
- QP Physiology
- cell biology
- Liver
- Synthetic Biology
- Tissue Engineering
- Toxicology
- RZ Other systems of medicine
- Liver disease
- Liver fibrosis
- Alzheimer's disease
- Liver-brain axis
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Non-invasive methods of monitoring Fe3O4 magnetic nanoparticle toxicity in human liver HepaRG cells using impedance biosensing and Coherent anti-Stokes Raman spectroscopic (CARS) microscopy
Kuhn, J., McDonald, A., Mongoin, C., Anderson, G., Lafeuillade, G., Mitchell, S., Elfick, A. P. D., Bagnaninchi, P. O., Yiu, H. H. P. & Nelson, L. J., Apr 2024, In: Toxicology Letters. 394, p. 92-101 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Roadmap to DILI research in Europe. A proposal from COST action ProEuroDILINet
Lucena, M. I., Villanueva-Paz, M., Alvarez-Alvarez, I., Aithal, G. P., Björnsson, E. S., Cakan-Akdogan, G., Cubero, F. J., Esteves, F., Falcon-Perez, J. M., Fromenty, B., Garcia-Ruiz, C., Grove, J. I., Konu, O., Kranendonk, M., Kullak-Ublick, G. A., Miranda, J. P., Remesal-Doblado, A., Sancho-Bru, P., Nelson, L., Andrade, R. J., & 2 others, Feb 2024, In: Pharmacological Research. 200, p. 107046Research output: Contribution to journal › Article › peer-review
Open Access -
Advanced preclinical models for evaluation of drug-induced liver injury - consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET]
Fernandez-Checa, J. C., Bagnaninchi, P., Ye, H., Sancho-Bru, P., Falcon-Perez, J. M., Royo, F., Garcia-Ruiz, C., Konu, O., Miranda, J., Lunov, O., Dejneka, A., Elfick, A., McDonald, A., Sullivan, G. J., Aithal, G. P., Lucena, M. I., Andrade, R. J., Fromenty, B., Kranendonk, M., Cubero, F. J., & 1 others, 24 Jun 2021, (E-pub ahead of print) In: Journal of Hepatology.Research output: Contribution to journal › Review article › peer-review
Open AccessFile -
Crossing kingdoms: How can art open up new ways of thinking about science?
Szymanski, E., Bates, T., Cachat, E., Calvert, J., Catts, O., Nelson, L. J., Rosser, S., Smith, R. & Zurr, I., 3 Jul 2020, In: Frontiers in Bioengineering and Biotechnology. 8, 715.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Reclassifying Hepatic Cell Death during Liver Damage: Ferroptosis-A Novel Form of Non-Apoptotic Cell Death?
Macías-Rodríguez, R. U., Inzaugarat, M. E., Ruiz-Margáin, A., Nelson, L. J., Trautwein, C. & Cubero, F. J., 28 Feb 2020, In: International Journal of Molecular Sciences. 21, 5Research output: Contribution to journal › Review article › peer-review
Open AccessFile
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Halt-RONIN: Halt-RONIN: Discovering Chronic Inflammation Biomarkers That Define Key Stages In The Healthy-to-NASH (non-alcoholic Steatohepatitis) Transition To Inform Early Prevention And Treatment Strategies
Nelson, L., Fallowfield, J., Bagnaninchi, P. & Morton, N.
1/12/22 → 30/11/26
Project: Research
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BALANCE: Development of a bioartificial liver therapy in acute liver failure
Plevris, J., Treskes, P., Eddleston, M., Hayes, P. & Nelson, L.
1/06/12 → 31/05/15
Project: Research Collaboration with external organisation
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Tissue engineering of 3D human heptatic organotypic model using novel cell, biomatrix and bioreactor enabling technologies for pharmaceutical applications
Nelson, L., Hayes, P. & Plevris, J.
UK central government bodies/local authorities, health and hospital authorities
1/12/11 → 1/03/14
Project: Research
Press/Media
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Dr Pierre Bagnaninchi discusses liver damage caused by paracetamol toxicity
Pierre Bagnaninchi & Lenny Nelson
31/01/17
21 items of Media coverage
Press/Media: Research