Lesley Stark

Phone0131 467 8447
Emaillesley.starkIGMM.ed.acuk

Accepting PhD Students

PhD projects

1. Use of proteomics and High resolution imaging to identify the RelA nucleolar interactome and the mechanisms of nucleolar RelA-mediated apoptosis<br/><br/>2. Determine the role of the nucleolus in the early stages of colorectal cancer

26 Article
2 Meeting abstract
2 Review article
1 Editorial

26 results

Filter

2020
A role for the autophagic receptor, SQSTM1/p62, in trafficking NF-κB/RelA to nucleolar aggresomes
Lobb, I. T., Morin, P., Martin, K. J., Thoms, H., Wills, J., Lieshi, X., Olsen, K. C. F., Duncan, R. R. & Stark, L. A., 23 Oct 2020, (E-pub ahead of print) In: Molecular Cancer Research.
Research output: Contribution to journal › Article › peer-review

Open Access
File
2018
Crosstalk between NF-KB and Nucleoli in the Regulation of Cellular Homeostasis: NF- kappaB nucleoli crosstalk in stress response and the regulation of apoptosis
Chen, J. & Stark, L., 5 Oct 2018, (E-pub ahead of print) In: Cells.
Research output: Contribution to journal › Article › peer-review

Open Access
File
Identification of a novel TIF-IA–NF-κB nucleolar stress response pathway
Chen, J., Lobb, I. T., Morin, P., Novo, S. M., Simpson, J., Kennerknecht, K., von Kriegsheim, A., Batchelor, E. E., Oakley, F. & Stark, L. A., 6 Jul 2018, In: Nucleic Acids Research. 46, 12, p. 6188–6205 18 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
2017
Ex vivo treatment of patient biopsies as a novel method to assess colorectal tumour response to the MEK1/2 inhibitor, Selumetinib
Novo, S. M., Wedge, S. R. & Stark, L. A., 20 Sept 2017, In: Scientific Reports.
Research output: Contribution to journal › Article › peer-review

Open Access
File
2016
A proteomic approach to analyse the aspirin-mediated lysine acetylome
Tatham, M. H., Cole, C., Scullion, P., Wilkie, R., Westwood, N. J., Stark, L. A. & Hay, R. T., 2 Dec 2016, In: Molecular & Cellular Proteomics (MCP).
Research output: Contribution to journal › Article › peer-review

Open Access
File
2014
Identification of aspirin analogues that repress NF-κB signalling and demonstrate anti-proliferative activity towards colorectal cancer in vitro and in vivo
Claudius, A-K., Kankipati, C. S., Kilari, R. S., Hassan, S., Guest, K., Russell, S. T., Perry, C. J., Stark, L. A. & Nicholl, I. D., Oct 2014, In: Oncology reports. 32, 4, p. 1670-1680 11 p.
Research output: Contribution to journal › Article › peer-review
p300-mediated acetylation of COMMD1 regulates its stability, and the ubiquitylation and nucleolar translocation of the RelA NF-kappa B subunit
O'Hara, A., Simpson, J., Morin, P., Loveridge, C. J., Williams, A. C., Novo, S. M. & Stark, L. A., 1 Sept 2014, In: Journal of Cell Science. 127, 17, p. 3659-3665 7 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
2011
Nucleolar NF-κB/RelA mediates apoptosis by causing cytoplasmic relocalization of nucleophosmin
Khandelwal, N., Simpson, J., Taylor, G., Rafique, S., Whitehouse, A., Hiscox, J. & Stark, L. A., Dec 2011, In: Cell Death & Differentiation (CDD). 18, 12, p. 1889-1903 15 p.
Research output: Contribution to journal › Article › peer-review
Cigarette Smoke Extract (CSE) Delays NOD2 Expression and Affects NOD2/RIPK2 Interactions in Intestinal Epithelial Cells
Aldhous, M. C., Soo, K., Stark, L. A., Ulanicka, A. A., Easterbrook, J. E., Dunlop, M. G. & Satsangi, J., 12 Sept 2011, In: PLoS ONE. 6, 9, p. - 15 p., e24715.
Research output: Contribution to journal › Article › peer-review

Open Access
File
c-Src dependency of NSAID-induced effects on NF-κB-mediated apoptosis in colorectal cancer cells
Brady, R. R. W., Loveridge, C. J., Dunlop, M. G. & Stark, L. A., 2011, In: Carcinogenesis: Integrative Cancer Research. 32, 7, p. 1069-1077 9 p.
Research output: Contribution to journal › Article › peer-review
2010
Effect of aspirin and NSAIDs on risk and survival from colorectal cancer
Din, F., Theodoratou, E., Farrington, S. M., Tenesa, A., Barnetson, R. A., Cetnarskyj, R., Stark, L., Porteous, M. E., Campbell, H. & Dunlop, M. G., Dec 2010, In: Gut. 59, 12, p. 1670-1679 10 p.
Research output: Contribution to journal › Article › peer-review
Nucleolar Targeting of RelA(p65) Is Regulated by COMMD1-Dependent Ubiquitination
Thoms, H. C., Loveridge, C. J., Simpson, J., Clipson, A., Reinhardt, K., Dunlop, M. G. & Stark, L. A., 1 Jan 2010, In: Cancer Research. 70, 1, p. 139-149 11 p.
Research output: Contribution to journal › Article › peer-review
2008
The proapoptotic effects of sulindac, sulindac sulfone and indomethacin are mediated by nucleolar translocation of the RelA(p65) subunit of NF-kappaB
Loveridge, C. J., MacDonald, A. D. H., Thoms, H. C., Dunlop, M. G. & Stark, L. A., Apr 2008, In: Oncogene. 27, 18, p. 2648-2655 8 p.
Research output: Contribution to journal › Article › peer-review
2007
CDK4 inhibitors and apoptosis: a novel mechanism requiring nucleolar targeting of RelA
Thoms, H. C., Dunlop, M. G. & Stark, L. A., 1 Jun 2007, In: Cell Cycle. 6, 11, p. 1293-7 5 p.
Research output: Contribution to journal › Article › peer-review
Aspirin activates the NF-kappaB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer
Stark, L. A., Reid, K., Sansom, O. J., Din, F. V., Guichard, S., Mayer, I., Jodrell, D. I., Clarke, A. R. & Dunlop, M. G., 2007, In: Carcinogenesis: Integrative Cancer Research. 28, 5, p. 968-76 9 p.
Research output: Contribution to journal › Article › peer-review
p38-mediated inactivation of cyclin D1/cyclin-dependent kinase 4 stimulates nucleolar translocation of RelA and apoptosis in colorectal cancer cells
Thoms, H. C., Dunlop, M. G. & Stark, L. A., 2007, In: Cancer Research. 67, 4, p. 1660-9 10 p.
Research output: Contribution to journal › Article › peer-review
2005
Nucleolar sequestration of RelA (p65) regulates NF-kappaB-driven transcription and apoptosis
Stark, L. A. & Dunlop, M. G., Jul 2005, In: Molecular and Cellular Biology. 25, 14, p. 5985-6004 20 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
Aspirin-induced nuclear translocation of NFkappaB and apoptosis in colorectal cancer is independent of p53 status and DNA mismatch repair proficiency
Din, F. V. N., Stark, L. A. & Dunlop, M. G., 2005, In: British Journal of Cancer. 92, 6, p. 1137-43 7 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
2004
Evidence for colorectal cancer cell specificity of aspirin effects on NF kappa B signalling and apoptosis
Din, F. V. N., Dunlop, M. G. & Stark, L. A., 2004, In: British Journal of Cancer. 91, 2, p. 381-8 8 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
2001
Suppression of intestinal and mammary neoplasia by lifetime administration of aspirin in Apc(Min/+) and Apc(Min/+), Msh2(-/-) mice
Sansom, O. J., Stark, L. A., Dunlop, M. G. & Clarke, A. R., 1 Oct 2001, In: Cancer Research. 61, 19, p. 7060-4 5 p.
Research output: Contribution to journal › Article › peer-review
Aspirin-induced activation of the NF-kappaB signaling pathway: a novel mechanism for aspirin-mediated apoptosis in colon cancer cells
Stark, L. A., Din, F. V., Zwacka, R. M. & Dunlop, M. G., May 2001, In: The FASEB Journal. 15, 7, p. 1273-5 3 p.
Research output: Contribution to journal › Article › peer-review
2000
NF-kappaB kinetics predetermine TNF-alpha sensitivity of colorectal cancer cells
Zwacka, R. M., Stark, L. & Dunlop, M. G., 25 Oct 2000, In: The Journal of Gene Medicine. 2, 5, p. 334-43 10 p.
Research output: Contribution to journal › Article › peer-review
1998
Human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) interacts with Lys-tRNA synthetase: implications for priming of HIV-1 reverse transcription
Stark, L. A. & Hay, R. T., Apr 1998, In: Journal of Virology. 72, 4, p. 3037-44 8 p.
Research output: Contribution to journal › Article › peer-review
1997
Renal allograft recipients with high susceptibility to cutaneous malignancy have an increased prevalence of human papillomavirus DNA in skin tumours and a greater risk of anogenital malignancy
Arends, M. J., Benton, E. C., McLaren, K. M., Stark, L. A., Hunter, J. A. & Bird, C. C., 1997, In: British Journal of Cancer. 75, 5, p. 722-8 7 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
1994
Accumulation of p53 is associated with tumour progression in cutaneous lesions of renal allograft recipients
Stark, L. A., Arends, M. J., McLaren, K. M., Benton, E. C., Shahidullah, H., Hunter, J. A. & Bird, C. C., Oct 1994, In: British Journal of Cancer. 70, 4, p. 662-7 6 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
Prevalence of human papillomavirus DNA in cutaneous neoplasms from renal allograft recipients supports a possible viral role in tumour promotion
Stark, L. A., Arends, M. J., McLaren, K. M., Benton, E. C., Shahidullah, H., Hunter, J. A. & Bird, C. C., Feb 1994, In: British Journal of Cancer. 69, 2, p. 222-9 8 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File

Lesley Stark

Research output

Search results