Lonneke Vervelde

PROF

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Personal profile

Current Research Interests

Host-pathogen interactions and immunomodulation in avian species, with a particular focus on mucosal surfaces.

Research Interests

My research is focussed on the immune responses to pathogens and vaccines in poultry and with the aim to determine how the early innate responses modulate the adaptive responses and assess their role in the induction of protective immunity, particularly at musosal surfaces. The research focuses on economically important pathogens such as avian influenza virus, infectious bronchitis virus, Eimeria species, avian pathogenic E. coli and Campylobacter. For the past years, the fundamental immunological research is focussed on understanding antigen uptake at the mucosae, the phenotype antigen presenting cells in the chicken and their interaction with natural killer cells and B and T cells driving innate and adaptive responses. Ultimately, this knowledge will improve the immune responses leading to clearance of pathogens, strong memory responses and novel vaccine approaches through antigen targeting and development of novel adjuvants.

More recently, I expanded into the field of avian in vitro and ex vivo organ cultures, and have made substantial progress in growing 3D and 2D intestinal enteroids and precision cut lung slices. These systems are multifunctional and can be used to investigate the mode of action of adjuvants, drug and toxicology screening, host-pathogen interaction, diagnostic tool, feed additives, and many other purposes.  

Research students

Esther Nash

Safieh Zeinali Lathore

Marwa Hussein

Guillermo Tellez

Archana Jadhav

Sarah Keep

Abi Bremner

Carina Conceição

Biography

Prof Lonneke Vervelde gained a BSc and MSc in Biology (Immunology, Parasitology and Ethology) at the Wageningen University The Netherlands, followed by a PhD on the immune responses in chicken to Eimeria tenella performed at the Central Veterinary Institute in Lelystad in collaboration with Intervet. She continued her research on immune responses to avian diseases at the Institute for Animal Health in Compton, U.K.. In 1998 she took a position at the Dept. of Parasitology and Tropical Veterinary Medicine at the Faculty of Veterinary Medicine in Utrecht, The Netherlands, to work on the mucosal immune responses of ruminants to helminth infections and the development of a vaccine against Haemonchus based on secreted proteins. In 2003 she started the Avian Immunology group in the Dept. of Infectious Diseases & Immunology investigating the immune responses to pathogens and vaccines in poultry with the ultimate goal to enhance immune-mediated resistance. In 2013 she moved to the Roslin Institute, Edinburgh University, where she became chair of Veterinary Immunology and Infectious Diseases in 2018.

Her research is focussed on the immune responses to pathogens and vaccines in poultry and with the aim to determine how the early innate responses modulate the adaptive responses and assess their role in the induction of protective immunity, particularly at musosal surfaces. The research focuses on economically important pathogens such as avian influenza virus, infectious bronchitis virus, Eimeria species, avian pathogenic E. coli and Campylobacter. For the past years, the fundamental immunological research is focussed on understanding antigen uptake at the mucosae, the phenotype antigen presenting cells in the chicken and their interaction with natural killer cells and B and T cells driving innate and adaptive responses. Ultimately, this knowledge will improve the immune responses leading to clearance of pathogens, strong memory responses and novel vaccine approaches through antigen targeting and development of novel adjuvants.

More recently, she expanded into the field of avian in vitro and ex vivo organ cultures, and have made substantial progress in growing 3D and 2D intestinal enteroids and precision cut lung slices. These systems are multifunctional and can be used to investigate the mode of action of adjuvants, drug and toxicology screening, host-pathogen interaction, diagnostic tool, feed additives, and many other purposes.  

Administrative Roles

Editorial Board Veterinary Immunology and Immunopathology

Editor Avian Patholog

Houghton Trust member travel fund committee

Roslin Institute:

Chair Poultry Users Committee

Member NARF management team

Member Translation and Commercialisation Board

 

Education/Academic qualification

Doctor of Science, Cent Vet Inst Wageningen UR, Wageningen University & Research Center

19901994

Award Date: 13 Jan 1995

Master of Science, Wageningen University

19841990

External positions

Group leader Avian Immunology , Department Infectious Diseases & Immunology, Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University

20032013

Senior Scientist, Department Parasitology and Tropical Veterinary Medicine, Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University

19982003

Post-Doctoral Scientist, Avian Immunology Group, Institute for Animal Health, Compton

19951998

Houghton Trust travel committee

Editorial Board: Veterinary Immunology and Immunopathology

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