Louise Macgillivray

Search results

• 2023

  International Pediatric COVID-19 Severity Over the Course of the Pandemic

  International Severe Acute Respiratory Infection Consortium (ISARIC4C) groupPediatric Active Enhanced Disease Surveillance (PAEDS) Network group, Baillie, K., Britton, P. N. & Short, K. R., 1 Oct 2023, In: JAMA pediatrics. 177, 10, p. 1073-1084 12 p.

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  • COVID-19 100%
  • Pediatrics 100%
  • Child 100%
  • Severe Acute Respiratory Syndrome Coronavirus 2 88%
  • Severe Acute Respiratory Syndrome 88%

• A second update on mapping the human genetic architecture of COVID-19

  The COVID-19 Host Genetics Initiative, 6 Sept 2023, In: Nature. 621, 7977, p. E7-E26

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• Genome-Wide Methylation Profiling in 229 Patients With Crohn's Disease Requiring Intestinal Resection: Epigenetic Analysis of the Trial of Prevention of Post-operative Crohn's Disease (TOPPIC).

  TOPPIC Study Group, IBD-BIOM Consortium, Ventham, N. T., Kennedy, N. A., Kalla, R., Adams, A. T., Noble, A., Ennis, H., Consortium, IBD-BIOM., Mowat, C., Dunlop, M. G. & Satsangi, J., 16 Jun 2023, In: Cellular and Molecular Gastroenterology and Hepatology. 16, 3, p. 431-450

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  • Bowel Resection 100%
  • Patient with Crohn's Disease 100%
  • Epigenomics 100%
  • Analysis 100%
  • Methylation 100%
• 2022

  SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination

  ISARIC4C Investigators, Liew, F., Talwar, S., Cross, A., Willett, B. J., Scott, S., Logan, N., Siggins, M. K., Swieboda, D., Sidhu, J. K., Efstathiou, C., Moore, S. C., Davis, C., Mohamed, N., Nunag, J., King, C., Thompson, A. A. R., Rowland-Jones, S. L., Docherty, A. B., Chalmers, J. D., & 22 othersHo, L-P., Horsley, A., Raman, B., Poinasamy, K., Marks, M., Kon, O. M., Howard, L., Wootton, D. G., Dunachie, S., Quint, J. K., Evans, R. A., Wain, L. V., Fontanella, S., de Silva, T. I., Ho, A., Harrison, E., Baillie, J. K., Semple, M. G., Brightling, C., Thwaites, R. S., Turtle, L. & Openshaw, P. J. M., 16 Dec 2022, (E-pub ahead of print) In: EBioMedicine. p. 104402

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  • Immunoglobulin A 100%
  • COVID-19 100%
  • Plasma 100%
  • Severe Acute Respiratory Syndrome Coronavirus 2 100%
  • Immunity 25%

• Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study

  ISARIC4C Investigators, 9 Nov 2022, In: Open forum infectious diseases. 9, 11, ofac531.

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  • Mixed Infection 100%
  • Diseases 100%
  • Infection 100%
  • Coronavirinae 100%
  • COVID-19 100%

• Whole genome sequencing reveals host factors underlying critical Covid-19

  GenOMICC Investigators, Kousathanas, A., Pairo-Castineira, E., Rawlik, K., Stuckey, A., Odhams, C. A., Walker, S., Russell, C. D., Malinauskas, T., Wu, Y., Millar, J., Shen, X., Elliott, K. S., Griffiths, F., Oosthuyzen, W., Morrice, K., Keating, S., Wang, B., Rhodes, D., Klaric, L., & 57 othersZechner, M., Parkinson, N., Siddiq, A., Goddard, P., Donovan, S., Maslove, D., Nichol, A., Semple, M. G., Zainy, T., Maleady-Crowe, F., Todd, L., Salehi, S., Knight, J., Elgar, G., Chan, G., Arumugam, P., Patch, C., Rendon, A., Bentley, D., Kingsley, C., Kosmicki, J. A., Horowitz, J. E., Baras, A., Abecasis, G. R., Ferreira, M. A. R., Justice, A., Mirshahi, T., Oetjens, M., Rader, D. J., Ritchie, M. D., Verma, A., Fowler, T. A., Shankar-Hari, M., Summers, C., Hinds, C., Horby, P., Ling, L., McAuley, D., Montgomery, H., Openshaw, P. J. M., Elliott, P., Walsh, T., Tenesa, A., Fawkes, A., Murphy, L., Rowan, K., Ponting, C. P., Vitart, V., Wilson, J. F., Yang, J., Bretherick, A. D., Scott, R. H., Hendry, S. C., Moutsianas, L., Law, A., Caulfield, M. J. & Baillie, J. K., 7 Jul 2022, In: Nature. 607, p. 97-103

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  • Whole Genome Sequencing 100%
  • Host Factor 100%
  • Host 100%
  • Association 40%
  • Population Dynamics 40%

• Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects

  Robertson, N. A., Latorre Crespo, E., Terradas Terradas, M., Lemos Portela, J., Purcell, A. C., Livesey, B., Hillary, R., Murphy, L., Fawkes, A., Macgillivray, L., Copland, M., Marioni, R. E., Marsh, J. A., Harris, S. A., Cox, S. R., Deary, I. J., Schumacher, L. J., Kirschner, K. & Chandra, T., 4 Jul 2022, In: Nature Medicine.

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  • Fitness 100%
  • Dynamics 100%
  • Hematopoiesis 100%
  • Nested Gene 100%
  • Mutation 83%

• Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study

  ISARIC4C Investigators, Narhi, F., Moonesinghe, R., Shenkin, S. D., Drake, T. M., Mulholland, R., Donegan, C., Dunning, J., Fairfield, C., Girvan, M., Hardwick, H. E., Ho, A., Leeming, G., Nguyen-Van-Tam, J. S., Pius, R., Russell, C. D., Shaw, C. A., Spencer, R. G., Turtle, L., Openshaw, P. J. M., & 4 othersBaillie, K., Harrison, E. M., Semple, M. G. & Docherty, A. B., 22 Mar 2022, (E-pub ahead of print) In: The Lancet Digital Health. 4, 4, p. e220-e234 15 p.

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  • Dexamethasone 100%
  • Methylprednisolone 50%
  • Neurologic Disease 50%

• SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses

  OPTIC Consortium, 3 Feb 2022, In: Cell. 185, 3, p. 467-484.e15

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  • Virus 100%
  • Antibody Response 100%
  • Neutralizing Antibody 100%
  • Neutralization 100%
  • Severe Acute Respiratory Syndrome Coronavirus 2 100%
• 2021

  Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity

  WES/WGS Working Group Within the HGI, 10 Dec 2021, (E-pub ahead of print) In: Human Genetics.

  Research output: Contribution to journal › Article › peer-review

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  • COVID-19 100%
  • Genetics 60%
  • Nested Gene 60%
  • Host 40%
  • Genome Wide Association Study 40%

• Mapping the human genetic architecture of COVID-19

  COVID-19 Host Genetics Initiative, Baillie, J. K., Wilson, J. F., Bulteel, N., Hayward, C., Klaric, L., Porteous, D. J., Russell, C. D., Tenesa, A., Norman, L., Scott-Brown, J. & Swann, O., 8 Jul 2021, (E-pub ahead of print) In: Nature.

  Research output: Contribution to journal › Article › peer-review

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  • SARS Coronavirus 100%
  • Genetic Architecture 100%
  • Human Genetics 100%
  • Host 75%
  • Genetics 75%
• 2020

  Genetic mechanisms of critical illness in Covid-19

  The GenOMICC Investigators, The ISARIC4C Investigators, The Covid-19 Human Genetics Initiative, 23andMe Investigators, BRACOVID Investigators, Gen-COVID Investigators, Pairo-Castineira, E., Clohisey, S., Klaric, L., Bretherick, A., Rawlik, K., Parkinson, N., Pasko, D., Walker, S., Richmond, A., Fourman, M. H., Law, A., Furniss, J., Gountouna, E., Wrobel, N., & 42 othersRussell, C. D., Moutsianas, L., Wang, B., Meynert, A. M., Yang, Z., Zhai, R., Zheng, C., Griffith, F., Oosthuyzen, W., Shih, B., Keating, S., Zechner, M., Haley, C. S., Porteous, D., Hayward, C., Knight, J., Summers, C., Shankar-Hari, M., Turtle, L., Ho, A., Hinds, C., Horby, P., Nichol, A., Maslove, D. M., Ling, L., Klenerman, P., McAuley, D. F., Montgomery, H. E., Walsh, T. S., Shen, X., Rowan, K., Fawkes, A., Murphy, L., Ponting, C. P., Tenesa, A., Caulfield, M., Scott, R., Openshaw, P., Semple, M. G., Vitart, V., Wilson, J. & Baillie, J. K., 11 Dec 2020, (E-pub ahead of print) In: Nature. n/a, n/a.

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  • Genetics 100%
  • Genome-Wide Association Study 66%
  • Mutation 33%
  • Host 33%
  • Interferon 33%
• 2019

  Assessment of dried blood spots for DNA methylation profiling

  Walker, R. M., MacGillivray, L., McCafferty, S., Wrobel, N., Murphy, L., Kerr, S. M., Morris, S. W., Campbell, A., McIntosh, A. M., Porteous, D. J. & Evans, K. L., 6 Mar 2019, In: Wellcome Open Research . 4, p. 44

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• 2018

  Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases

  The Inflammatory Bowel Disease Biomarkers Consortium & Ho, G-T., Apr 2018, In: Gastroenterology. 154, 5, p. 1320-1333.e10

  Research output: Contribution to journal › Article › peer-review

  • Clinical Feature 100%
  • Immunoglobulin G 100%
  • Inflammatory Bowel Disease 100%
  • Association 100%
  • Glycosylation 100%
• 2017

  Age-related gene expression changes, and transcriptome wide association study of physical and cognitive aging traits, in the Lothian Birth Cohort 1936

  Harris, S. E., Riggio, V., Evenden, L., Gilchrist, T., Mccafferty, S., Murphy, L., Wrobel, N., Taylor, A. M., Corley, J., Pattie, A., Cox, S. R., Martin-ruiz, C., Prendergast, J., Starr, J. M., Marioni, R. E. & Deary, I. J., 1 Dec 2017, In: Aging. 9, 12, p. 2489-2503 15 p.

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  • Birth 100%
  • Gene Expression 100%
  • Association 100%
  • Smoking 100%
  • Transcriptome 100%

• Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants

  Nagy, R., Boutin, T. S., Marten, J., Huffman, J. E., Kerr, S. M., Campbell, A., Evenden, L., Gibson, J., Amador, C., Howard, D. M., Navarro, P., Morris, A., Deary, I. J., Hocking, L. J., Padmanabhan, S., Smith, B. H., Joshi, P., Wilson, J. F., Hastie, N. D., Wright, A. F., & 5 othersMcIntosh, A. M., Porteous, D. J., Haley, C. S., Vitart, V. & Hayward, C., 7 Mar 2017, In: Genome Medicine. 9, 14 p., 23.

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  • Association 100%
  • Haplotype 100%
  • Family Health 100%
  • Exploratory Behavior 100%
  • Genome Wide Association Study 100%
• 2016

  Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease

  Ventham, N. T., Kennedy, N. A., Adams, A. T., Kalla, R., Heath, S., O'Leary, K. R., Drummond, H., IBD BIOM consortium, IBD CHARACTER consortium, Wilson, D. C., Gut, I. G., Nimmo, E. R., Satsangi, J. & Ho, G-T., 25 Nov 2016, In: Nature Communications. 7, 13507.

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  • Genetic Risk 100%
  • DNA Methylation 100%
  • Epigenome 100%
  • Epigenetics 66%
  • Gene Expression 66%