Research output per year
Research output per year
Personal profile
Biography
I'm a developmental biologist who wants to know how tissues mineralise. I use fluorescent markers in bones and scales to track mineralisation on the subcellular scale using cool imaging techniques along the way! I have studied protein localisation in chicken, mouse, fish and cells to better understand signalling and development in ciliopathies and immunology at The University of Manchester, CRUK Beatson Institute and here at The Roslin Institute. I moved to The Roslin Institute in 2019 and translated this background to better understand bone disorders and mineralisation in mouse and human bone. In 2022 I was awarded a BBSRC Discovery Fellowship to translate this work into fish scales and wound healing in aquaculture. I am developing tools to better understand the mechanisms underpinning mineralisation, using scales as a model system. I use zebrafish, salmon and tilapia in my research.
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Collaborations and top research areas from the last five years
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Nanofiber-Coated CF/PEEK Composite: Boosting Osteogenesis for Enhanced Bone Grafting
Yang, DL., Stephen, L., Qayyum, J., Yang, D., Farquharson, C. & Radacsi, N., 30 Oct 2024, (E-pub ahead of print) In: Macromolecular materials and engineering. p. 1-6 6 p., 2400286.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Mitochondrial dysfunction and mitophagy blockade contribute to renal osteodystrophy in chronic kidney disease-mineral bone disorder
Hsu, S-N., Stephen, L. A., Phadwal, K., Dillon, S., Carter, R., Morton, N. M., Luijten, I., Emelianova, K., Amin, A. K., Macrae, V. E., Freeman, T. C., Staines, K. A. & Farquharson, C., 26 Dec 2023, bioRxiv, p. 1-60, 60 p.Research output: Working paper › Preprint
Open AccessFile -
Anti-RANKL therapy prevents glucocorticoid induced bone loss and promotes muscle function 1 in a mouse model of Duchenne muscular dystrophy
Jayash, S., Hamoudi, D., Stephen, L., Argaw, A., Huesa, C., Joseph, S., wong, S. C., Frenette, J. & Farquharson, C., 20 Jul 2023, (E-pub ahead of print) In: Calcified Tissue International and Musculoskeletal Research. p. 449-468 20 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Spatial lipidomic profiling of mouse joint tissue demonstrates the essential role of PHOSPHO1 in growth plate homeostasis: Spatially resolving the joint lipidome
Tzvetkov, J., Stephen, L. A., Dillon, S., Milan, J. L., Roelofs, A. J., De Bari, C., Farquharson, C., Larson, T. & Genever, P., May 2023, In: Journal of Bone and Mineral Research. 38, 5, p. 792-807Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Increased PHOSPHO1 and Alkaline Phosphatase expression during the anabolic bone response to intermittent parathyroid hormone delivery: Control of PHOSPHO1 and TNAP expression by iPTH
Houston, D., Stephen, L., Jayash, S. N., Myers, K., Little, K., Hopkinson, M., Pitsillides, A., MacRae, V., millan, J. L., Staines, K. A. & Farquharson, C., 20 Dec 2022, (E-pub ahead of print) In: Cell Biochemistry and Function. p. 1-13Research output: Contribution to journal › Article › peer-review
Open AccessFile
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Allyship in Academia: Creating a Community where we all belong.
Louise Stephen (Assessor)
24 Sept 2021Activity: Academic talk or presentation types › Invited talk
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Bone Research Society (External organisation)
Louise Stephen (Advisor)
1 Oct 2020 → …Activity: Membership types › Membership of committee
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Scottish Microscopy Group (External organisation)
Louise Stephen (Advisor)
1 Aug 2019 → …Activity: Membership types › Membership of committee
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Vitae (External organisation)
Louise Stephen (Advisor)
1 Jun 2017 → …Activity: Membership types › Membership of peer review panel or committee
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Scales: Understanding biomineralisation in the fish dermal skeleton in health and development
2/10/23 → 1/10/26
Project: Research
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Understanding biomineralisation in the fish dermal skeleton and its role in health and development
1/09/23 → 31/08/26
Project: Research