Malcolm MacLeod

2015

Risk of Bias in Reports of In Vivo Research: A Focus for Improvement

Macleod, M. R., Lawson Mclean, A., Kyriakopoulou, A., Serghiou, S., de Wilde, A., Sherratt, N., Hirst, T., Hemblade, R., Bahor, Z., Nunes-Fonseca, C., Potluru, A., Thomson, A., Baginskitae, J., Egan, K., Vesterinen, H., Currie, G. L., Churilov, L., Howells, D. W. & Sena, E. S., 13 Oct 2015, In: PLoS Biology. 13, 10, e1002273.

Research output: Contribution to journal › Article › peer-review

Open Access

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Prof Benchie and Dr Athena-A modern tragedy...

Macleod, M., 1 Aug 2015, In: Evidence-based Preclinical Medicine. 2, 1, p. 16-19

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

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The development of an online database for interventions tested in transgenic mouse models of Alzheimer's disease: Database on interventions for Alzheimer's disease

Egan, K. J., Vesterinen, H. M., Mccann, S. K., Sena, E. S. & Macleod, M. R., 1 Aug 2015, In: Evidence-based Preclinical Medicine. 2, 1, p. 20-26

Research output: Contribution to journal › Article › peer-review

Open Access

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Efficacy and safety of very early mobilisation within 24 h of stroke onset (AVERT): A randomised controlled trial

The AVERT Trial Collaboration group, 4 Jul 2015, In: The Lancet. 386, 9988, p. 46-55 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Interventions for post-stroke fatigue

Wu, S., Kutlubaev, M. A., Chun, H-Y. Y., Cowey, E., Pollock, A., Macleod, M. R., Dennis, M., Keane, E., Sharpe, M. & Mead, G. E., 2 Jul 2015, (E-pub ahead of print) In: Cochrane Database of Systematic Reviews. 7, p. CD007030

Research output: Contribution to journal › Article › peer-review

Effect of endothelin receptor antagonists on clinically relevant outcomes after experimental subarachnoid hemorrhage: a systematic review and meta-analysis

Laban, K. G., Vergouwen, M. D. I., Dijkhuizen, R. M., Sena, E. S., Macleod, M. R., Rinkel, G. J. E. & van der Worp, H. B., Jul 2015, In: Journal of Cerebral Blood Flow and Metabolism. 35, 7, p. 1085-1089 5 p.

Research output: Contribution to journal › Article › peer-review

Increasing value and reducing waste in animal models of rheumatological disease

Currie, G. L. & Macleod, M. R., Jun 2015, In: International journal of rheumatic diseases. 18, 5, p. 485-487 3 p.

Research output: Contribution to journal › Editorial › peer-review

Drug repurposing: a systematic approach to evaluate candidate oral neuroprotective interventions for secondary progressive multiple sclerosis

Vesterinen, H. M., Connick, P., Irvine, C. M. J., Sena, E. S., Egan, K. J., Carmichael, G. G., Tariq, A., Pavitt, S., Chataway, J., Macleod, M. R. & Chandran, S., 9 Apr 2015, In: PLoS ONE. 10, 4, e0117705.

Research output: Contribution to journal › Article › peer-review

Open Access

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Experimental design and reporting standards for improving the internal validity of pre-clinical studies in the field of pain: Consensus of the IMI-Europain consortium

Knopp, K. L., Stenfors, C., Baastrup, C., Bannon, A. W., Calvo, M., Caspani, O., Currie, G., Finnerup, N. B., Huang, W., Kennedy, J. D., Lefevre, I., Machin, I., Macleod, M., Rees, H., Rice, A. S. C., Rutten, K., Segerdahl, M., Serra, J., Wodarski, R., Berge, O. G., & 1 othersTreede, R. D., 1 Apr 2015, In: Scandinavian Journal of Pain. 7, p. 58-70 13 p.

Research output: Contribution to journal › Review article › peer-review

Magnetic resonance imaging in experimental stroke and comparison with histology: systematic review and meta-analysis

Milidonis, X., Marshall, I., Macleod, M. R. & Sena, E. S., Mar 2015, In: Stroke; a journal of cerebral circulation. 46, 3, p. 843-851 9 p.

Research output: Contribution to journal › Article › peer-review

Model of Understanding Fatigue After Stroke

Wu, S., Mead, G., Macleod, M. & Chalder, T., Mar 2015, In: Stroke; a journal of cerebral circulation. 46, 3, p. 893-898 6 p.

Research output: Contribution to journal › Literature review › peer-review

Similar effect of autologous and allogeneic cell therapy for ischemic heart disease: systematic review and meta-analysis of large animal studies

Jansen Of Lorkeers, S. J., Eding, J. E. C., Vesterinen, H. M., van der Spoel, T. I. G., Sena, E. S., Duckers, H. J., Doevendans, P. A., Macleod, M. R. & Chamuleau, S. A. J., 2 Jan 2015, In: Circulation Research. 116, 1, p. 80-86 7 p.

Research output: Contribution to journal › Article › peer-review

2014

A systematic review and meta-analysis of gene therapy in animal models of cerebral glioma: why did promise not translate to human therapy?

Hirst, T. C., Vesterinen, H. M., Conlin, S., Egan, K. J., Antonic, A., Lawson Mclean, A., Macleod, M. R., Grant, R., Brennan, P. M., Sena, E. S. & Whittle, I. R., 1 Dec 2014, In: Evidence-based Preclinical Medicine. 1, 1, p. 21-33

Research output: Contribution to journal › Article › peer-review

Open Access

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Incidence, Prevalence and Predictors of Chemotherapy Induced Peripheral Neuropathy: a Systematic Review and Meta-Analysis

Seretny, M., Currie, G. L., Sena, E. S., Ramnarine, S., Grant, R., MacLeod, M. R., Colvin, L. & Fallon, M., Dec 2014, In: Pain. 155, 12, p. 2461-2470

Research output: Contribution to journal › Article › peer-review

Open Access

File

Efficacy of antidepressants in animal models of ischemic stroke: a systematic review and meta-analysis

McCann, S. K., Irvine, C., Mead, G. E., Sena, E. S., Currie, G. L., Egan, K. E., Macleod, M. R. & Howells, D. W., Oct 2014, In: Stroke. 45, 10, p. 3055-3063 9 p.

Research output: Contribution to journal › Article › peer-review

Exercise Reduces Infarct Volume and Facilitates Neurobehavioral Recovery: Results From a Systematic Review and Meta-analysis of Exercise in Experimental Models of Focal Ischemia

Egan, K. J., Janssen, H., Sena, E. S., Longley, L., Speare, S., Howells, D. W., Spratt, N. J., Macleod, M. R., Mead, G. E. & Bernhardt, J., Oct 2014, In: Neurorehabilitation and Neural Repair. 28, 8, p. 800-812 13 p.

Research output: Contribution to journal › Article › peer-review

WHY ANIMAL MODELS OF GENE THERAPY HAVE LET GLIOMA PATIENTS DOWN

Hirst, T. C., Vesterinen, H. M., Conlin, S., Egan, K. J., Antonic, A., McLean, A. L., Macleod, M. R., Whittle, I. R., Grant, R., Brennan, P. M. & Sena, E. S., Oct 2014, In: Neuro-Oncology. 16, 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

EuroHYP-1: European multicenter, randomized, phase III clinical trial of therapeutic hypothermia plus best medical treatment vs. best medical treatment alone for acute ischemic stroke

EuroHYP-1 Investigators, van der Worp, H. B., Macleod, M. R., Bath, P. M. W., Demotes, J., Durand-Zaleski, I., Gebhardt, B., Gluud, C., Kollmar, R., Krieger, D. W., Lees, K. R., Molina, C., Montaner, J., Roine, R. O., Petersson, J., Staykov, D., Szabo, I., Wardlaw, J. M. & Schwab, S., Jul 2014, In: International Journal of Stroke. 9, 5, p. 642-645 4 p.

Research output: Contribution to journal › Article › peer-review

Preclinical research: Design animal studies better

Macleod, M. R., 5 Jun 2014, In: Nature. 510, 7503, p. 35

Research output: Contribution to journal › Article

Psychological associations of poststroke fatigue: a systematic review and meta-analysis

Wu, S., Barugh, A., Macleod, M. & Mead, G., Jun 2014, In: Stroke; a journal of cerebral circulation. 45, 6, p. 1778-83 6 p.

Research output: Contribution to journal › Article › peer-review

Using animal models to understand cancer pain in humans

Currie, G. L., Sena, E. S., Fallon, M. T., Macleod, M. R. & Colvin, L. A., Jun 2014, In: Current pain and headache reports. 18, 6, 8 p., 423.

Research output: Contribution to journal › Literature review › peer-review

Clopidogrel plus aspirin versus warfarin in patients with stroke and aortic arch plaques

Aortic Arch Related Cerebral Hazard Trial Investigators, Amarenco, P., Davis, S., Jones, E. F., Cohen, A. A., Heiss, W-D., Kaste, M., Laouénan, C., Young, D., Macleod, M. & Donnan, G. A., May 2014, In: Stroke; a journal of cerebral circulation. 45, 5, p. 1248-57 10 p.

Research output: Contribution to journal › Article › peer-review

End-of-life decisions in patients with severe acute brain injury

Geurts, M., Macleod, M. R., van Thiel, G. J. M. W., van Gijn, J., Kappelle, L. J. & van der Worp, H. B., May 2014, In: Lancet Neurology. 13, 5, p. 515-24 10 p.

Research output: Contribution to journal › Article › peer-review

Similar effect of autologous and allogeneic cell therapy for ischaemic heart disease: systematic review and meta-analysis of large animal studies

Lorkeers, S. J. J. O., Eding, J. E. C., van der Spoel, T. I. G., Vesterinen, H. M., Sena, E. S., Duckers, H. J., Doevendans, P. A., Macleod, M. R. & Chamuleau, S. A. J., May 2014, In: European journal of clinical investigation. 44, p. 5-6 2 p.

Research output: Contribution to journal › Meeting abstract › peer-review

Systematic reviews and meta-analysis of preclinical studies: why perform them and how to appraise them critically

Sena, E. S., Currie, G. L., McCann, S. K., Macleod, M. R. & Howells, D. W., May 2014, In: Journal of Cerebral Blood Flow and Metabolism. 34, 5, p. 737-42 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Research: increasing value, reducing waste – Authors' reply

Glasziou, P., Macleod, M., Chalmers, I., Ioannidis, J. P. A., Al-Shahi Salman, R. & Chan, A-W., 29 Mar 2014, In: The Lancet. 383, 9923, p. 1126-1127 2 p.

Research output: Contribution to journal › Letter

A (mini) pill for stroke?

Macleod, M., Feb 2014, In: Brain. 137, Pt 2, p. 311-2 2 p.

Research output: Contribution to journal › Article

Some salt with your statin, professor?

Macleod, M., 21 Jan 2014, In: PLoS Biology. 12, 1, p. e1001768

Research output: Contribution to journal › Article › peer-review

Open Access

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Meta-analysis of data from animal studies: A practical guide

Vesterinen, H. M., Sena, E. S., Egan, K. J., Hirst, T., Churolov, L., Currie, G., Antonic, A., Howells, D. W. & Macleod, M. R., 15 Jan 2014, In: Journal of Neuroscience Methods. 221, p. 92-102 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Biomedical research: increasing value, reducing waste

Macleod, M. R., Michie, S., Roberts, I., Dirnagl, U., Chalmers, I., Ioannidis, J. P. A., Al-Shahi Salman, R., Chan, A-W. & Glasziou, P., 11 Jan 2014, In: The Lancet. 383, 9912, p. 101-4 4 p.

Research output: Contribution to journal › Comment/debate › peer-review

Increasing value and reducing waste in biomedical research regulation and management

Al-Shahi Salman, R., Beller, E., Kagan, J., Hemminki, E., Phillips, R. S., Savulescu, J., Macleod, M., Wisely, J. & Chalmers, I., 11 Jan 2014, In: The Lancet. 383, 9912, p. 176-85 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Increasing value and reducing waste in research design, conduct, and analysis

Ioannidis, J. P. A., Greenland, S., Hlatky, M. A., Khoury, M. J., Macleod, M. R., Moher, D., Schulz, K. F. & Tibshirani, R., 11 Jan 2014, In: The Lancet. 383, 9912, p. 166-175 10 p.

Research output: Contribution to journal › Article › peer-review

Bringing rigour to translational medicine

Howells, D. W., Sena, E. S. & Macleod, M. R., Jan 2014, In: Nature Reviews Neurology. 10, 1, p. 37-43 7 p.

Research output: Contribution to journal › Literature review › peer-review

Edaravone improves functional and structural outcomes in animal models of focal cerebral ischemia: A systematic review

Wu, S., Sena, E., Egan, K., Macleod, M. & Mead, G., Jan 2014, In: International Journal of Stroke. 9, 1, p. 101-106 6 p.

Research output: Contribution to journal › Article › peer-review

Effect and reporting bias of RhoA/ROCK-blockade intervention on locomotor recovery after spinal cord injury: a systematic review and meta-analysis

Watzlawick, R., Sena, E. S., Dirnagl, U., Brommer, B., Kopp, M. A., Macleod, M. R., Howells, D. W. & Schwab, J. M., Jan 2014, In: JAMA Neurology. 71, 1, p. 91-9 9 p.

Research output: Contribution to journal › Article › peer-review

Efficacy and safety of mesenchymal stromal cells in preclinical models of acute lung injury: a systematic review protocol

Canadian Critical Care Translational Biology Group, Lalu, M. M., Moher, D., Marshall, J., Fergusson, D., Mei, S. H., Macleod, M., Griffin, G., Turgeon, A. F., Rudnicki, M., Fishman, J., Avey, M. T., Skidmore, B., Grimshaw, J. M., Stewart, D. J., Singh, K. & McIntyre, L., 2014, In: Systematic Reviews. 3, p. 48

Research output: Contribution to journal › Article › peer-review

Hypothermia protects human neurons

Antonic, A., Dottori, M., Leung, J., Sidon, K., Batchelor, P. E., Wilson, W., Macleod, M. R. & Howells, D. W., 2014, In: International Journal of Stroke.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Systematic review and meta-analysis of interventions tested in animal models of lacunar stroke

Pedder, H., Vesterinen, H. M., Macleod, M. R. & Wardlaw, J. M., 2014, In: Stroke; a journal of cerebral circulation. 45, 2, p. 563-570 8 p.

Research output: Contribution to journal › Article › peer-review

2013

Stem cell transplantation in traumatic spinal cord injury: a systematic review and meta-analysis of animal studies

Antonic, A., Sena, E. S., Lees, J. S., Wills, T. E., Skeers, P., Batchelor, P. E., Macleod, M. R. & Howells, D. W., Dec 2013, In: PLoS Biology. 11, 12, e1001738.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Edoxaban versus warfarin in patients with atrial fibrillation

Giugliano, R. P., Ruff, C. T., Braunwald, E., Murphy, S. A., Wiviott, S. D., Halperin, J. L., Waldo, A. L., Ezekowitz, M. D., Weitz, J. I., Špinar, J., Ruzyllo, W., Ruda, M., Koretsune, Y., Betcher, J., Shi, M., Grip, L. T., Patel, S. P., Patel, I., Hanyok, J. J., Mercuri, M., & 3 othersAntman, E. M., ENGAGE AF-TIMI 48 Investigators & MacLeod, M., 28 Nov 2013, In: New England Journal of Medicine. 369, 22, p. 2093-104 12 p.

Research output: Contribution to journal › Article › peer-review

Therapeutic Hypothermia and the Risk of Infection: A Systematic Review and Meta-Analysis

Geurts, M., Macleod, M. R., Kollmar, R., Kremer, P. H. C. & van der Worp, H. B., 7 Oct 2013, In: Critical Care Medicine.

Research output: Contribution to journal › Article › peer-review

Hypertension and experimental stroke therapies

O'Collins, V. E., Donnan, G. A., Macleod, M. R. & Howells, D. W., Aug 2013, In: Journal of Cerebral Blood Flow and Metabolism. 33, 8, p. 1141-1147 7 p.

Research output: Contribution to journal › Literature review › peer-review

Animal Models of Stroke Versus Clinical Stroke: Comparison of Infarct Size, Cause, Location, Study Design, and Efficacy of Experimental Therapies

O'Collins, V. E., Donnan, G. A., Macleod, M. R. & Howells, D. W., Jul 2013, Animal Models for the Study of Human Disease. Elsevier, p. 531-568 38 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Evaluation of Excess Significance Bias in Animal Studies of Neurological Diseases

Tsilidis, K. K., Panagiotou, O. A., Sena, E. S., Aretouli, E., Evangelou, E., Howells, D. W., Al-Shahi Salman, R., Macleod, M. R. & Ioannidis, J. P. A., Jul 2013, In: PLoS Biology. 11, 7, p. e1001609

Research output: Contribution to journal › Article › peer-review

Open Access

File

A concerted appeal for international cooperation in preclinical stroke research

Dirnagl, U., Hakim, A., Macleod, M., Fisher, M., Howells, D., Alan, S. M., Steinberg, G., Planas, A., Boltze, J., Savitz, S., Iadecola, C. & Meairs, S., Jun 2013, In: Stroke; a journal of cerebral circulation. 44, 6, p. 1754-60 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Systematic review and stratified meta-analysis of the efficacy of RhoA and Rho kinase inhibitors in animal models of ischaemic stroke

Vesterinen, H. M., Currie, G. L., Carter, S., Mee, S., Watzlawick, R., Egan, K. J., Macleod, M. R. & Sena, E. S., 20 May 2013, In: Systematic Reviews. 2, 1, p. 33

Research output: Contribution to journal › Article › peer-review

Open Access

File

Evidence-based translational medicine

Howells, D. W. & MacLeod, M. R., May 2013, In: Stroke. 44, 5, p. 1466-1471 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Prevalence and natural history of pain in adults with multiple sclerosis: Systematic review and meta-analysis

Foley, P. L., Vesterinen, H. M., Laird, B. J., Sena, E. S., Colvin, L. A., Chandran, S., Macleod, M. R. & Fallon, M. T., May 2013, In: Pain. 154, 5, p. 632-642 11 p.

Research output: Contribution to journal › Article › peer-review

Transparency in the reporting of in vivo pre-clinical pain research: The relevance and implications of the ARRIVE (Animal Research: Reporting In Vivo Experiments) guidelines

Rice, A. S. C., Morland, R., Huang, W., Currie, G. L., Sena, E. S. & Macleod, M. R., 1 Apr 2013, In: Scandinavian Journal of Pain. 4, 2, p. 58-62

Research output: Contribution to journal › Article › peer-review

The benefit of hypothermia in experimental ischemic stroke is not affected by pethidine

Sena, E. S., Jeffreys, A. L., Cox, S. F., Sastra, S. A., Churilov, L., Rewell, S., Batchelor, P. E., van der Worp, H. B., Macleod, M. R. & Howells, D. W., Apr 2013, In: International Journal of Stroke. 8, 3, p. 180-185 6 p.

Research output: Contribution to journal › Article › peer-review

Malcolm MacLeod

Research output

Search results