Malcolm MacLeod

Search results

• 2008

  A systematic review and meta-analysis of the efficacy of piracetam and piracetam-like compounds in experimental stroke

  Wheble, P. C. R., Sena, E. S. & Macleod, M. R., 2008, In: Cerebrovascular diseases. 25, 1-2, p. 5-11 7 p.

  Research output: Contribution to journal › Literature review › peer-review

  • Piracetam 100%
  • Experimental Stroke 100%
  • Stroke 100%
  • Meta-Analysis 100%
  • Animal 37%
• 2007

  Hypothermia in animal models of acute ischaemic stroke: A systematic review and meta-analysis

  Van Der Worp, H. B., Sena, E. S., Donnan, G. A., Howells, D. W. & Macleod, M. R., Dec 2007, In: Brain. 130, 12, p. 3063-3074 12 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Hypothermia 100%
  • Meta-Analysis 100%
  • Ischemic Stroke 100%
  • Ischemia 50%
  • Stroke 10%

• How can we improve the pre-clinical development of drugs for stroke?

  Sena, E., van der Worp, H. B., Howells, D. & Macleod, M., Sept 2007, In: Trends in Neurosciences. 30, 9, p. 433-439 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Drug 100%
  • Clinical Trial 100%
  • Enalapril Maleate 100%
  • Preclinical Study 100%
  • Stroke 100%

• Vanishing diplopia: A problem case

  Connor, M., Williams, A., Macleod, M. & Smith, C., Aug 2007, In: Practical Neurology. 7, 4, p. 268-271 4 p.

  Research output: Contribution to journal › Article › peer-review

• Forebrain mineralocorticoid receptor overexpression enhances memory, reduces anxiety and attenuates neuronal loss in cerebral ischaemia

  Lai, M., Horsburgh, K., Bae, S-E., Carter, R. N., Stenvers, D. J., Fowler, J. H., Yau, J. L., Gomez-Sanchez, C. E., Holmes, M. C., Kenyon, C. J., Seckl, J. R. & Macleod, M. R., Mar 2007, In: European Journal of Neuroscience. 25, 6, p. 1832-1842 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Forebrain 100%
  • Mineralocorticoid Receptor 100%
  • Ischemia 100%
  • Memory 100%
  • Anxiety 100%

• Systematic review and meta-analysis of the efficacy of tirilazad in experimental stroke

  Sena, E., Wheble, P., Sandercock, P. & Macleod, M., Feb 2007, In: Stroke. 38, 2, p. 388-394 7 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Meta-Analysis 100%
  • Systematic Review 100%
  • Tirilazad 100%
  • Experimental Stroke 100%
  • Animal 100%

• Comparison of treatment effects between animal experiments and clinical trials: systematic review

  Perel, P., Roberts, I., Sena, E., Wheble, P., Briscoe, C., Sandercock, P., Macleod, M., Mignini, L. E., Jayaram, P. & Khan, K. S., 27 Jan 2007, In: British Medical Journal (BMJ). 334, 7586, p. 197-197

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Therapeutic Procedure 100%
  • Systematic Review 100%
  • Clinical Trial 100%
  • Animal 100%
  • Antenatal Corticosteroid 36%
• 2006

  Aortic arch atheroma

  Zavala, J. A., Amarrenco, P., Davis, S. M., Jones, E. F., Young, D., Macleod, M. R., Horky, L. L. & Donnan, G. A., May 2006, In: International Journal of Stroke. 1, 2, p. 74-80 7 p.

  Research output: Contribution to journal › Review article › peer-review

  • Atheroma 100%
  • Aortic Arch 100%
  • Inpatient 37%
  • Apoplexy 37%
  • Embolism 25%

• 1,026 Experimental treatments in acute stroke

  O'Collins, V. E., Macleod, M. R., Donnan, G. A., Horky, L. L., Van Der Worp, B. H. & Howells, D. W., Mar 2006, In: Annals of Neurology. 59, 3, p. 467-477 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Experimental Therapy 100%
  • Apoplexy 100%
  • Cerebrovascular Accident 100%
  • Drug 100%
  • Stroke 100%

• Greater incidence of both fatal and nonfatal strokes in disadvantaged areas: The Northeast Melbourne Stroke Incidence Study

  Thrift, A. G., Dewey, H. M., Sturm, J. W., Paul, S. L., Gilligan, A. K., Srikanth, V. K., Macdonell, R. A. L., McNeil, J. J., Macleod, M. R. & Donnan, G. A., Mar 2006, In: Stroke. 37, 3, p. 877-882 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Incidence 100%
  • Prevention 11%
  • Socioeconomic Status 11%
  • Mortality 11%
  • Standard 11%

• Hemicraniectomy after middle cerebral artery infarction with life-threatening Edema trial (HAMLET). Protocol for a randomised controlled trial of decompressive surgery in space-occupying hemispheric infarction

  Hofmeijer, J., Amelink, G. J., Algra, A., Van Gijn, J., Macleod, M. R., Kappelle, L. J. & Van Der Worp, H. B., 1 Jan 2006, In: Trials. 7, 1, p. 29

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Decompression Surgery 100%
  • Edema 100%
  • Randomized Controlled Trial 100%
  • Brain Infarction 100%
  • Conservative Treatment 75%
• 2005

  Surveying the literature from animal experiments: Systematic review and meta-analysis are important contributions

  Macleod, M. R., Ebrahim, S. & Roberts, I., 9 Jul 2005, In: British Medical Journal. 331, 7508, p. 110

  Research output: Contribution to journal › Letter › peer-review

• MicroRNA - Taking regulation of protein synthesis to another level

  Lai, M. & Macleod, M., 8 Jul 2005, In: Cerebrovascular diseases. 20, 1, p. 49-50 2 p.

  Research output: Contribution to journal › Article › peer-review

• Systematic review and metaanalysis of the efficacy of FK506 in experimental stroke

  Macleod, M. R., O'Collins, T., Horky, L. L., Howells, D. W. & Donnan, G. A., Jun 2005, In: Journal of Cerebral Blood Flow and Metabolism. 25, 6, p. 713-721 9 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Meta-Analysis 100%
  • Systematic Review 100%
  • Experimental Stroke 100%
  • Tacrolimus 100%
  • Stroke 100%

• Overexpression of the mineralocorticoid receptor protects against injury in PC12 cells

  Lai, M., Seckl, J. & Macleod, M., 27 Apr 2005, In: Molecular brain research. 135, 1-2, p. 276-279 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Mineralocorticoid Receptor 100%
  • Glucose 50%
  • Staurosporine 50%
  • Receptor Expression 50%
  • Stroke 50%

• Gender and deprivation and rates of referral and thereby admission to a national neurorehabilitation service

  Macleod, M. R. & Smith, S. J., Jan 2005, In: Clinical Rehabilitation. 19, 1, p. 109-115 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Gender 100%
  • Neurorehabilitation 100%
  • Patient Referral 100%
  • Subarachnoid Hemorrhage 71%
  • Hospital 71%

• Systematic review and meta-analysis of the efficacy of melatonin in experimental stroke

  Macleod, M. R., O'Collins, T., Horky, L. L., Howells, D. W. & Donnan, G. A., Jan 2005, In: Journal of pineal research. 38, 1, p. 35-41 7 p.

  Research output: Contribution to journal › Review article › peer-review

  • Melatonin 100%
  • Experimental Stroke 100%
  • Stroke 100%
  • Meta-Analysis 100%
  • Animal 55%

• Results of a multicentre, randomised controlled trial of intra-arterial urokinase in the treatment of acute posterior circulation lschaemic stroke

  Macleod, M. R., Davis, S. M., Mitchell, P. J., Gerraty, R. P., Fitt, G., Hankey, G. J., Stewart-Wynne, E. G., Rosen, D., McNeil, J. J., Bladin, C. F., Chambers, B. R., Herkes, G. K., Young, D. & Donnan, G. A., 2005, In: Cerebrovascular diseases. 20, 1, p. 12-17 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Therapeutic Procedure 100%
  • Randomized Controlled Trial 100%
  • Apoplexy 100%
  • Patient 100%
  • Urokinase 100%
• 2004

  Nicotinamide Attenuates Focal Ischemic Brain Injury: Meta-Analysis or Mechanism of Protection: Response

  Yao, H., Sadanaga-Akiyoshi, F., Ibayashi, S., Iida, M., Macleod, M., O'Collins, T., Howells, D. & Donnan, G., 1 Dec 2004, In: Stroke. 35, 12, p. 2757-2758 2 p.

  Research output: Contribution to journal › Letter › peer-review

• Inequalities in the incidence and management of, and outcome from, neurological diseases in older people

  Macleod, M., Aug 2004, In: Reviews in Clinical Gerontology. 13, 3, p. 261-268 8 p.

  Research output: Contribution to journal › Review article › peer-review

• Atheroma of the aortic arch: An important and poorly recognised factor in the aetiology of stroke

  Macleod, M. R., Amarenco, P., Davis, S. M. & Donnan, G. A., 1 Jul 2004, In: Lancet Neurology. 3, 7, p. 408-414 7 p.

  Research output: Contribution to journal › Review article › peer-review

  • Atheroma 100%
  • Etiology 100%
  • Apoplexy 100%
  • Aortic Arch 100%
  • Thrombus 40%

• Pooling of animal experimental data reveals influence of study design and publication bias

  Macleod, M. R., O'Collins, T., Howells, D. W. & Donnan, G. A., May 2004, In: Stroke. 35, 5, p. 1203-1208 6 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Chemotherapeutic Agent 100%
  • Drug 100%
  • Study Design 100%
  • Experimental Animal 100%
  • Ischemia 75%
• 2003

  Atheroma of the aortic arch: the missing link in the secondary prevention of stroke?

  Macleod, M. R. & Donnan, G. A., Nov 2003, In: Expert Review of Cardiovascular Therapy. 1, 4, p. 487-489 3 p.

  Research output: Contribution to journal › Editorial › peer-review

  • Secondary Prevention 100%
  • Alka-Seltzer 100%
  • Warfarin 50%
  • Patient 50%

• Mineralocorticoid receptor expression and increased survival following neuronal injury; A new therapeutic target in cerebral ischemia

  Macleod, M., Johansson, I. M., Soderstrom, I., Lai, M., Gido, G., Wieloch, T., Seckl, J. & Olsson, T., Aug 2003, In: Journal of Neurology, Neurosurgery & Psychiatry. 74, 8, p. 1178-1178 1 p.

  Research output: Contribution to journal › Book/Film/Article review › peer-review

• Effect of deprivation on time to hospital in acute stroke

  Macleod, M. R., Lewis, S. C. & Dennis, M. S., Apr 2003, In: Journal of Neurology, Neurosurgery & Psychiatry. 74, 4, p. 545-6 2 p.

  Research output: Contribution to journal › Article › peer-review

• Mineralocorticoid receptor expression and increased survival following neuronal injury

  Macleod, M. R., Johansson, I. M., Söderström, I., Lai, M., Gidö, G., Wieloch, T., Seckl, J. R. & Olsson, T., Apr 2003, In: European Journal of Neuroscience. 17, 8, p. 1549-1555 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Mineralocorticoid Receptor 100%
  • Receptor Expression 100%
  • Brain Injury 28%
  • Ischemia 28%
  • In Vivo 28%

• Reduced NMDA-induced apoptosis in neurons lacking ataxia telangiectasia mutated protein

  Macleod, M. R., Ramage, L., McGregor, A. & Seckl, J. R., 10 Feb 2003, In: Neuroreport. 14, 2, p. 215-217 3 p.

  Research output: Contribution to journal › Article › peer-review

  • N-Methyl-D-Aspartic Acid 100%
  • Apoptosis 100%
  • Neuron 100%
  • Gene 40%
  • Stroke 40%
• 2002

  PubMed: http://www.pubmed.org

  Macleod, M. R., 1 Dec 2002, In: Journal of neurology, neurosurgery, and psychiatry. 73, 6, p. 746 1 p.

  Research output: Contribution to journal › Article › peer-review

• What's a good doctor and how do you make one? How not to do it

  Macleod, M. R., 28 Sept 2002, In: BMJ (Clinical Research ed.). 325, 7366, p. 715

  Research output: Contribution to journal › Letter › peer-review

• Nitric-oxide-synthase-mediated cyclic guanosine monophosphate production in neonatal rat cerebellar prisms is resistant to calcineurin inhibition

  Macleod, M. R. & Butcher, S. P., 29 Mar 2002, In: Neuroscience Letters. 322, 1, p. 41-44 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Rat 100%
  • Cyclic GMP 100%
  • Tacrolimus 100%
  • Nitric Oxide Synthase 100%
  • Calcineurin 100%

• Effect of deprivation and gender on the incidence and management of acute brain disorders

  Macleod, M. R. & Andrews, P. J. D., 2002, In: Intensive Care Medicine. 28, 12, p. 1729-1734 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Brain Disease 100%
  • Gender 100%
  • Incidence 100%
  • Hospital 83%
  • Death 66%
• 2001

  FLAIR MRI in sporadic Creutzfeldt-Jakob disease

  Zeidler, M., Collie, D. A., Macleod, M. A., Sellar, R. J., Knight, R. & Sellar, R., 23 Jan 2001, In: Neurology. 56, 2, p. 282

  Research output: Contribution to journal › Article › peer-review

• Serum withdrawal causes apoptosis in SHSY 5Y cells

  Macleod, M. R., Allsopp, T. E., McLuckie, J. & Kelly, J. S., 19 Jan 2001, In: Brain Research. 889, 1-2, p. 308-315 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Apoptosis 100%
  • Caspase 3 100%
  • Nerve Growth Factor 50%
  • Sensory Neuron 25%
  • Poly ADP Ribose Polymerase 25%
• 2000

  The pulvinar sign on magnetic resonance imaging in variant Creutzfeldt-Jakob disease

  Zeidler, M., Sellar, R. J., Collie, D. A., Knight, R., Stewart, G., Macleod, M. A., Ironside, J. W., Cousens, S., Colchester, A. C., Hadley, D. M., Will, R. G., Colchester, A. F. & Sellar, R., 22 Apr 2000, In: The Lancet. 355, 9213, p. 1412-8 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Pulvinar 100%
  • Variant Creutzfeldt-Jakob Disease 100%
  • Magnetic Resonance Imaging 100%
  • Assessment 66%
  • Patient 55%

• Caspase 6 activity initiates caspase 3 activation in cerebellar granule cell apoptosis

  Allsopp, T. E., McLuckie, J., Kerr, L. E., Macleod, M., Sharkey, J. & Kelly, J. S., 2000, In: Cell Death & Differentiation (CDD). 7, 10, p. 984-93 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Caspase 3 100%
  • Apoptosis 100%
  • Caspase 6 100%
  • Procaspase 3 11%
  • Western Blot 11%
• 1995

  The effect of tumour associated epilepsy on performance/handicap scales used in cerebral glioma

  Macleod, M., Slattery, J. & Grant, R., 1995, In: British Journal of Neurosurgery . 9, 5, p. 653-658 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Epilepsy 100%
  • Ganglioglioma 100%
  • Neoplasm 100%
  • Brain Tumor 33%
  • Epileptic Seizure 33%
• 1994

  Ischaemic heart disease and cholesterol There's more to heart disease than cholesterol

  Bonneux, L., Barendregt, J. J., Ravnskov, U., Ramsay, L. E., Yeo, W. W., Jackson, P. R., Sheldon, T. A., Song, F., Millo, J., Sudlow, C. L. M., Macleod, M. R., Heady, J. A., Morris, J. N., Oliver, M. F., Vine, D. L., Hastings, G. E., Durrington, P. N., Dugdale, A., Law, M. R., wu, T., & 3 othersWald, N. J., Hackshaw, A. & Thompson Bailey, A. S. G., 16 Apr 1994, In: BMJ. 308, 6935, p. 1038 1 p.

  Research output: Contribution to journal › Letter › peer-review