Manu Shankar-Hari


Accepting PhD Students

Personal profile


Manu is the Chair of Translation Critical Care Medicine at the University of Edinburgh.

Manu Shankar-Hari trained in Intensive Care Medicine in London, completed MSc in Epidemiology from the London School of Hygiene and Tropical Medicine, and did his PhD in Immunology was on B cell biology in sepsis at the Spencer lab, Peter Gorer Department of Immunobiology at King's College London, UK.

Manu's NIHR Clinician Scientist Fellowship investigated the long-term health consequences of sepsis survivors and included the first clinical trial of vaccinating to reduce long-term health care burden in adult sepsis survivors.

Research Interests

For the last decade Manu has focussed his research on a concept for which he is a global pioneer: improving care for critically ill patients (especially those with sepsis) could be achieved by integrating the clues from multiple domains within the immune responses with clues from patient's clinical features to enable better targeting of treatments.

Manu's lab pursues the hypothesis that critical illnesses reflect perturbations within intracellular networks and intercellular networks that link cells, and organ systems. Illness networks arise from functional interdependencies between the molecular components within human cells. Many of these illness networks are causal and determine observable and treatable immunological abnormalities in critical illness (treatable traits).

The immunobiology focus of Manu's lab are the phenotypic, functional and molecular changes in T and B lymphocytes during critical illness, resolution from critical illness, and long-term reprgramming of immune cells following critical illness/ treatments during critical illness - i.e., translate immune system changes into treatments for patients using systems immunology principles.

External positions

Trustee, Intensive Care National Audit and Research Centre (ICNARC)

28 Apr 2022 → …

Deputy Editor, Thorax

1 Feb 2022 → …

Associate Editor, Editor in Chief, Intensive Care Medicine, Paris, France.

1 Jan 2019 → …

EME Funding Board, NIHR

2019 → …


Dive into the research topics where Manu Shankar-Hari is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
  • 1 Similar Profiles

Collaborations and top research areas from the last five years

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
  • Developing a New Definition and Assessing New Clinical Criteria for Septic Shock For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

    Shankar-Hari, M., Phillips, G. S., Levy, M. L., Seymour, C. W., Liu, V. X., Deutschman, C. S., Angus, D. C., Rubenfeld, G. D. & Singer, M., 23 Feb 2016, In: Journal of the American Medical Association. 315, 8, p. 775-787

    Research output: Contribution to journalArticlepeer-review

  • Peripheral immunophenotypes in children with multisystem inflammatory syndrome associated with SARS-CoV-2 infection

    Carter, M. J., Fish, M., Jennings, A., Doores, K. J., Wellman, P., Seow, J., Acors, S., Graham, C., Timms, E., Kenny, J., Neil, S., Malim, M. H., Tibby, S. M. & Shankar-Hari, M., Nov 2020, In: Nature Medicine. 26, 11, p. 1701-1707 7 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • A dynamic COVID-19 immune signature includes associations with poor prognosis

    Laing, A. G., Lorenc, A., Del Molino Del Barrio, I., Das, A., Fish, M., Monin, L., Muñoz-Ruiz, M., McKenzie, D. R., Hayday, T. S., Francos-Quijorna, I., Kamdar, S., Joseph, M., Davies, D., Davis, R., Jennings, A., Zlatareva, I., Vantourout, P., Wu, Y., Sofra, V., Cano, F., & 30 othersGreco, M., Theodoridis, E., Freedman, J. D., Gee, S., Chan, J. N. E., Ryan, S., Bugallo-Blanco, E., Peterson, P., Kisand, K., Haljasmägi, L., Chadli, L., Moingeon, P., Martinez, L., Merrick, B., Bisnauthsing, K., Brooks, K., Ibrahim, M. A. A., Mason, J., Lopez Gomez, F., Babalola, K., Abdul-Jawad, S., Cason, J., Mant, C., Seow, J., Graham, C., Doores, K. J., Di Rosa, F., Edgeworth, J., Shankar-Hari, M. & Hayday, A. C., 17 Aug 2020, In: Nature Medicine. 26, 10, p. 1623-1635 13 p.

    Research output: Contribution to journalArticlepeer-review

  • Redefining Critical Illness

    Maslove, D. M., Tang, B., Shankar-Hari, M., Lawler, P. R., Angus, D. C., Baillie, J. K., Baron, R. M., Bauer, M., Buchman, T. G., Calfee, C. S., dos Santos, C. C., Giamarellos-Bourboulis, E. J., Gordon, A., Kellum, J. A., Knight, J. C., Leligdowicz, A., McAuley, D. F., McLean, A. S., Menon, D. K., Meyer, N. J., & 19 othersMoldawer, L. L., Reddy, K., Reilly, J. P., Russell, J. K., Sevransky, J. E., Seymour, C. W., Shapiro, N. I., Singer, M., Summers, C., Sweeney, T. E., Thompson, T., Poll, T. V. D., Venkatesh, B., Walley, K. R., Walsh, T. S., War, L. B., Wong, H. R., Zsolt, Z. E. & Marshall, J. C., 17 Jun 2022, In: Nature Medicine. 28, p. 1141–1148 8 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial

    Investigators, W. C. F. T. REMAP-CAP., Estcourt, L. J., Turgeon, A. F., McQuilten, Z. K., McVerry, B. J., Al-Beidh, F., Annane, D., Arabi, Y. M., Arnold, D. M., Beane, A., Bégin, P., van Bentum-Puijk, W., Berry, L. R., Bhimani, Z., Birchall, J. E., Bonten, M. J. M., Bradbury, C. A., Brunkhorst, F. M., Buxton, M., Callum, J. L., & 31 othersChassé, M., Cheng, A. C., Cove, M. E., Daly, J., Derde, L., Detry, M. A., De Jong, M., Evans, A., Fergusson, D. A., Fish, M., Fitzgerald, M., Foley, C., Goossens, H., Gordon, A. C., Gosbell, I. B., Green, C., Haniffa, R., Harvala, H., Higgins, A. M., Hills, T. E., Hoad, V. C., Horvat, C., Huang, D. T., Hudson, C. L., Ichihara, N., Laing, E., Lamikanra, A. A., Lamontagne, F., Lawler, P. R., Rynne, J. & Shankar-Hari, M., 2 Nov 2021, In: Journal of the American Medical Association. 326, 17, p. 1690-1702 13 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access