Manu Shankar-Hari

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Personal profile

Biography

Manu Shankar-Hari trained in Intensive Care Medicine in London, completed MSc in Epidemiology from the London School of Hygiene and Tropical Medicine, and did his PhD in Immunology at the Peter Gorer Department of Immunobiology at King's College London, UK.

Manu was appointed as a consultant physician in Intensive Care Medicine at Guy's and St Thomas' Hospital NHS Foundation Trust in 2009. He was awarded the NIHR Clinician Scientist Fellowship in 2016 to investigate the long-term health consequences of sepsis survivors and to undertake a clinical trial of vaccinating to reduce long-term health care burden in adult sepsis survivors.

Manu was appointed to the Chair of Translation Critical Care Medicine at the University of Edinburgh in 2022.

Research Interests

Critical illness is a major cause of morbidity and mortality globally. Even for the two most common critical illness syndromes - sepsis and acute respiratory distress syndrome (ARDS) - there are no effective treatments other than supportive care.

My lab pursues the hypothesis that critical illnesses reflect perturbations within intracellular and intercellular networks that link cells, and organ systems. Illness networks arise from functional interdependencies between the molecular components within human cells. Many of these illness networks are causal and determine clinical phenotypes.

Thus, my lab's two focussed research themes of immunobiology and epidemiology converge to a core aim of determining these observable and treatable immunological abnormalities in critical illness (treatable traits).

The immunobiology focus of my lab are the phenotypic and molecular changes in T and B lymphocytes during critical illness and resolution from critical illness, to determine modifiable changes that could improve patient outcomes. This information is used to design seamless early to late phase human randomised clinical trials to translate immune system changes into treatments for patients using systems immunology principles.

External positions

Trustee, Intensive Care National Audit and Research Centre (ICNARC)

28 Apr 2022 → …

Associate Editor, Editor in Chief, Intensive Care Medicine, Paris, France.

1 Jan 2019 → …

EME Funding Board, NIHR

2019 → …

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  • Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial

    Investigators, W. C. F. T. REMAP-CAP., Estcourt, L. J., Turgeon, A. F., McQuilten, Z. K., McVerry, B. J., Al-Beidh, F., Annane, D., Arabi, Y. M., Arnold, D. M., Beane, A., Bégin, P., van Bentum-Puijk, W., Berry, L. R., Bhimani, Z., Birchall, J. E., Bonten, M. J. M., Bradbury, C. A., Brunkhorst, F. M., Buxton, M., Callum, J. L. & 31 others, Chassé, M., Cheng, A. C., Cove, M. E., Daly, J., Derde, L., Detry, M. A., De Jong, M., Evans, A., Fergusson, D. A., Fish, M., Fitzgerald, M., Foley, C., Goossens, H., Gordon, A. C., Gosbell, I. B., Green, C., Haniffa, R., Harvala, H., Higgins, A. M., Hills, T. E., Hoad, V. C., Horvat, C., Huang, D. T., Hudson, C. L., Ichihara, N., Laing, E., Lamikanra, A. A., Lamontagne, F., Lawler, P. R., Rynne, J. & Shankar-Hari, M., 2 Nov 2021, In: Journal of the American Medical Association. 326, 17, p. 1690-1702 13 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    File
  • Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission

    Relph, K. A., Russell, C. D., Fairfield, C. J., Turtle, L., De Silva, T., Siggins, M. K., Drake, T. M., Thwaites, R. S., Abrams, S., Moore, S. C., Hardwick, H. E., Oosthuyzen, W., Harrison, E. M., Docherty, A. B., Openshaw, P. J. M., Baillie, J. K., Semple, M. G., Ho, A., Baillie, J. K., Semple, M. G. & 348 others, Openshaw, P. J. M., Carson, G., Alex, B., Bach, B., Barclay, W. S., Bogaert, D., Chand, M., Cooke, G. S., Docherty, A. B., Dunning, J., Filipe, A. D. S., Fletcher, T., Green, C. A., Harrison, E. M., Hiscox, J. A., Ho, A. Y. W., Horby, P. W., Ijaz, S., Khoo, S., Klenerman, P., Law, A., Lim, W. S., Mentzer, A. J., Merson, L., Meynert, A. M., Noursadeghi, M., Moore, S. C., Palmarini, M., Paxton, W. A., Pollakis, G., Price, N., Rambaut, A., Robertson, D. L., Russell, C. D., Sancho-shimizu, V., Scott, J. T., De Silva, T., Sigfrid, L., Solomon, T., Sriskandan, S., Stuart, D., Summers, C., Tedder, R. S., Thomson, E. C., Roger Thompson, A. A., Thwaites, R. S., Turtle, L. C. W., Gupta, R. K., Zambon, M., Hardwick, H., Donohue, C., Lyons, R., Griffiths, F., Oosthuyzen, W., Norman, L., Pius, R., Drake, T. M., Fairfield, C. J., Knight, S. R., Mclean, K. A., Murphy, D., Shaw, C. A., Dalton, J., Girvan, M., Saviciute, E., Roberts, S., Harrison, J., Marsh, L., Connor, M., Halpin, S., Jackson, C., Gamble, C., Leeming, G., Law, A., Wham, M., Clohisey, S., Hendry, R., Scott-brown, J., Greenhalf, W., Shaw, V., Mcdonald, S., Keating, S., Ahmed, K. A., Armstrong, J. A., Ashworth, M., Asiimwe, I. G., Bakshi, S., Barlow, S. L., Booth, L., Brennan, B., Bullock, K., Catterall, B. W. A., Clark, J. J., Clarke, E. A., Cole, S., Cooper, L., Cox, H., Davis, C., Dincarslan, O., Dunn, C., Dyer, P., Elliott, A., Evans, A., Finch, L., Fisher, L. W. S., Foster, T., Garcia-dorival, I., Greenhalf, W., Gunning, P., Hartley, C., Jensen, R. L., Jones, C. B., Jones, T. R., Khandaker, S., King, K., Kiy, R. T., Koukorava, C., Lake, A., Lant, S., Latawiec, D., Lavelle-langham, L., Lefteri, D., Lett, L., Livoti, L. A., Mancini, M., Mcdonald, S., Mcevoy, L., Mclauchlan, J., Metelmann, S., Miah, N. S., Middleton, J., Mitchell, J., Moore, S. C., Murphy, E. G., Penrice-randal, R., Pilgrim, J., Prince, T., Reynolds, W., Matthew Ridley, P., Sales, D., Shaw, V. E., Shears, R. K., Small, B., Subramaniam, K. S., Szemiel, A., Taggart, A., Tanianis-hughes, J., Thomas, J., Trochu, E., Van Tonder, L., Wilcock, E., Eunice Zhang, J., Flaherty, L., Maziere, N., Cass, E., Doce Carracedo, A., Carlucci, N., Holmes, A., Massey, H., Murphy, L., Wrobel, N., Mccafferty, S., Morrice, K., Maclean, A., Adeniji, K., Agranoff, D., Agwuh, K., Ail, D., Aldera, E. L., Alegria, A., Angus, B., Ashish, A., Atkinson, D., Bari, S., Barlow, G., Barnass, S., Barrett, N., Bassford, C., Basude, S., Baxter, D., Beadsworth, M., Bernatoniene, J., Berridge, J., Best, N., Bothma, P., Chadwick, D., Brittain-long, R., Bulteel, N., Burden, T., Burtenshaw, A., Caruth, V., Chadwick, D., Chambler, D., Chee, N., Child, J., Chukkambotla, S., Clark, T., Collini, P., Cosgrove, C., Cupitt, J., Cutino-moguel, M., Dark, P., Dawson, C., Dervisevic, S., Donnison, P., Douthwaite, S., Durand, I., Dushianthan, A., Dyer, T., Evans, C., Eziefula, C., Fegan, C., Finn, A., Fullerton, D., Garg, S., Garg, S., Garg, A., Gkrania-klotsas, E., Godden, J., Goldsmith, A., Graham, C., Hardy, E., Hartshorn, S., Harvey, D., Havalda, P., Hawcutt, D. B., Hobrok, M., Hodgson, L., Hormis, A., Jacobs, M., Jain, S., Jennings, P., Kaliappan, A., Kasipandian, V., Kegg, S., Kelsey, M., Kendall, J., Kerrison, C., Kerslake, I., Koch, O., Koduri, G., Koshy, G., Laha, S., Laird, S., Larkin, S., Leiner, T., Lillie, P., Limb, J., Linnett, V., Little, J., Lyttle, M., Macmahon, M., Macnaughton, E., Mankregod, R., Masson, H., Matovu, E., Mccullough, K., Mcewen, R., Meda, M., Mills, G., Minton, J., Mirfenderesky, M., Mohandas, K., Mok, Q., Moon, J., Moore, E., Morgan, P., Morris, C., Mortimore, K., Moses, S., Mpenge, M., Mulla, R., Murphy, M., Nagel, M., Nagarajan, T., Nelson, M., O’shea, M. K., Otahal, I., Ostermann, M., Pais, M., Panchatsharam, S., Papakonstantinou, D., Paraiso, H., Patel, B., Pattison, N., Pepperell, J., Peters, M., Phull, M., Pintus, S., Pooni, J. S., Post, F., Price, D., Prout, R., Rae, N., Reschreiter, H., Reynolds, T., Richardson, N., Roberts, M., Roberts, D., Rose, A., Rousseau, G., Ryan, B., Saluja, T., Shah, A., Shanmuga, P., Sharma, A., Shawcross, A., Sizer, J., Shankar-hari, M., Smith, R., Snelson, C., Spittle, N., Staines, N., Stambach, T., Stewart, R., Subudhi, P., Szakmany, T., Tatham, K., Thomas, J., Thompson, C., Thompson, R., Tridente, A., Tupper-carey, D., Twagira, M., Ustianowski, A., Vallotton, N., Vincent-smith, L., Visuvanathan, S., Vuylsteke, A., Waddy, S., Wake, R., Walden, A., Welters, I., Whitehouse, T., Whittaker, P., Whittington, A., Papineni, P., Wijesinghe, M., Williams, M., Wilson, L., Cole, S., Winchester, S., Wiselka, M., Wolverson, A., Wootton, D. G., Workman, A., Yates, B. & Young, P., 1 May 2022, In: Open forum infectious diseases. 9, 5

    Research output: Contribution to journalArticlepeer-review

    Open Access
    File
  • Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial

    REMAP-CAP Writing Committee for the REMAP-CAP Investigators, 22 Mar 2022, (E-pub ahead of print) In: Journal of the American Medical Association.

    Research output: Contribution to journalArticlepeer-review