Manu Shankar-Hari

2025

Sepsis subtypes and differential treatment response to vitamin C: Biological sub study of the LOVIT Trial

Rynne, J., Mosavie, M., Masse, M-H., Menard, J., Battista, M-C., Maslove, D. M., del Sorbo, L., St-Arnaud, C., D’aragon, F., Fox-Robichaud, A., Charbonney, E., Adhikari, N. K. J., Lamontagne, F. & Shankar-Hari, M., 7 Jan 2025, In: Intensive Care Medicine.

Research output: Contribution to journal › Article › peer-review

Open Access

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2024

Blood Pressure Targets for Adults with Vasodilatory Shock: An Individual Patient Data Meta-Analysis

Angriman, F., Momenzade, N., Adhikari, N. K. J., Mouncey, P. R., Asfar, P., Yarnell, C. J., Ong, S. W. X., Pinto, R., Doidge, J. C., Shankar-Hari, M., Harhay, M. O., Masse, M-H., Harrison, D., Rowan, K. M., Carter, F., Camirand-Lemyre, F. & Lamontagne, F., 18 Nov 2024, (E-pub ahead of print) In: NEJM evidence.

Research output: Contribution to journal › Article › peer-review

Open Access

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Causal inference can lead us to modifiable mechanisms and informative archetypes in sepsis

Baillie, J. K., Angus, D., Burnham, K., Calandra, T., Calfee, C., Gutteridge, A., Hacohen, N., Khatri, P., Langley, R., Ma’ayan, A., Marshall, J., Maslove, D., Prescott, H. C., Rowan, K., Scicluna, B. P., Seymour, C., Shankar-Hari, M., Shapiro, N., Wiersinga, W. J., Singer, M., & 1 othersRandolph, A. G., 21 Oct 2024, (E-pub ahead of print) In: Intensive Care Medicine.

Research output: Contribution to journal › Article › peer-review

Open Access

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Sodium–glucose co-transporter-2 inhibitors for hospitalised patients with COVID-19: a prospective meta-analysis of randomised trials

WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group, Vale, C., Godolphin, P. J., Fisher, D., Horby, P., Kosiborod, M. N., Hochman, J. S., Webster, K., Higgins, J. P. T., Althouse, A. D., Berwanger, O., Furtado, R. H. M., Gasparyan, S. B., Haynes, R., Koch, G. G., Landray, M., Leifer, E., Marshall, J., Murthy, S., Neal, M. D., & 4 othersStaplin, N., Diaz, J., Sterne, J. A. C. & Shankar-Hari, M., Oct 2024, In: The Lancet Diabetes & Endocrinology. 12, 10, p. 735-747

Research output: Contribution to journal › Article › peer-review

Open Access

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Long-term ill health in sepsis survivors: An ignored healthcare challenge?

Beane, A. & Shankar-Hari, M., 28 Sept 2024, In: The Lancet. 404, 10459, p. 1178-1180

Research output: Contribution to journal › Article › peer-review

Open Access

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Shared neutrophil and T cell dysfunction is accompanied by a distinct interferon signature during severe febrile illnesses in children

the DIAMONDS Consortium, 19 Sept 2024, In: Nature Communications. 15, 1, p. 8224 8224.

Research output: Contribution to journal › Article › peer-review

Open Access

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Informative Subtyping of Patients with Sepsis

Cafferkey, J. & Shankar-Hari, M., Aug 2024, In: Seminars in respiratory and critical care medicine. 45, 4, p. 516-522

Research output: Contribution to journal › Article › peer-review

Long-term impact of COVID-19 hospitalisation among individuals with pre-existing airway diseases in the UK: a multicentre, longitudinal cohort study - PHOSP-COVID

PHOSP-COVID Study Collaborative Group, Elneima, O., Hurst, J. R., Echevarria, C., Quint, J. K., Walker, S., Siddiqui, S., Novotny, P., Pfeffer, P. E., Brown, J. S., Shankar-Hari, M., McAuley, H. J. C., Leavy, O. C., Shikotra, A., Singapuri, A., Sereno, M., Richardson, M., Saunders, R. M., Harris, V. C., Houchen-Wolloff, L., & 16 othersGreening, N. J., Harrison, E. M., Docherty, A. B., Lone, N. I., Chalmers, J. D., Ho, L-P., Horsley, A., Marks, M., Poinasamy, K., Raman, B., Evans, R. A., Wain, L. V., Sheikh, A., Brightling, C. E., De Soyza, A. & Heaney, L. G., 15 Jul 2024, In: ERJ Open Research. 10, 4, 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Albumin Versus Balanced Crystalloid for the Early Resuscitation of Sepsis: An Open Parallel-Group Randomized Feasibility Trial. The ABC-Sepsis Trial

Albumin, Balanced, and Crystalloid-Sepsis (ABC-Sepsis) Investigators, Gray, A. J., Oatey, K., Grahamslaw, J., Irvine, S., Cafferkey, J., Kennel, T., Norrie, J., Walsh, T., Lone, N. I., Horner, D., Appelboam, A., Hall, P., Skipworth, R. J. E., Bell, D., Rooney, K., Shankar-Hari, M. & Corfield, A., 24 Jun 2024, (E-pub ahead of print) In: Critical Care Medicine.

Research output: Contribution to journal › Article › peer-review

Patient stratification using plasma cytokines and their regulators in sepsis: relationship to outcomes, treatment effect and leucocyte transcriptomic subphenotypes

Antcliffe, D. B., Mi, Y., Santhakumaran, S., Burnham, K. L., Prevost, A. T., Ward, J. K., Marshall, T. J., Bradley, C., Al-Beidh, F., Hutton, P., McKechnie, S., Davenport, E. E., Hinds, C. J., O'Kane, C. M., McAuley, D. F., Shankar-Hari, M., Gordon, A. C. & Knight, J. C., 20 May 2024, In: Thorax. 79, 6, p. 515-523 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Antibiotics, Sedatives, and Catecholamines Further Compromise Sepsis-Induced Immune Suppression in Peripheral Blood Mononuclear Cells

Miller, M., Melis, M. J., Miller, J. R. C., Kleyman, A., Shankar-Hari, M. & Singer, M., 1 Apr 2024, In: Critical Care Medicine. 52, 4, p. 596-606 11 p.

Research output: Contribution to journal › Article › peer-review

Elevated ferritin, mediated by IL-18 is associated with systemic inflammation and mortality in acute respiratory distress syndrome (ARDS)

Mehta, P., Samanta, R. J., Wick, K., Coll, R. C., Mawhinney, T., McAleavey, P. G., Boyle, A. J., Conlon, J., Shankar-Hari, M., Rogers, A., Calfee, C. S., Matthay, M. A., Summers, C., Chambers, R. C., McAuley, D. F. & O'Kane, C. M., 28 Mar 2024, In: Thorax. 79, 3, p. 227-235 9 p.

Research output: Contribution to journal › Article › peer-review

Temporal Trends in Mortality of Critically Ill Patients with Sepsis in the United Kingdom, 1988-2019

Prescott, H. C., Harrison, D. A., Rowan, K. M., Shankar-Hari, M. & Wunsch, H., 1 Mar 2024, In: American Journal of Respiratory and Critical Care Medicine. 209, 5, p. 507-516 10 p.

Research output: Contribution to journal › Article › peer-review

Reframing Sepsis Immunobiology for Translation

Shankar-Hari, M., Calandra, T., Soares, M. P., Bauer, M., Wiersinga, W. J., Prescott, H. C., Knight, J. C., Baillie, J. K., Bos, L. D. J., Derde, L. P. G., Finfer, S., Hotchkiss, R. S., Marshall, J., Openshaw, P., Seymour, C. W., Venet, F., Vincent, J-L., Le Tourneau, C., Maitland-van der Zee, A-H., McInnes, I. B., & 1 othersPoll, T. V. D., 23 Feb 2024, In: The Lancet Respiratory Medicine.

Research output: Contribution to journal › Article › peer-review

Open Access

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Accelarated immune ageing is associated with COVID-19 disease severity

ISARIC4C Investigators, Adeloye, D., Baillie, JK., Bularga, A., Daines, L., Lone, NI., Mills, NL., Newby, DE., Pius, R., Shankar-Hari, M., Sheikh, A., Sudlow, CL., Walmsley, S. & Zheng, B., 11 Jan 2024, In: Immunity and Ageing. 21, 1, 18 p., 6.

Research output: Contribution to journal › Article › peer-review

Open Access

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2023

Simvastatin in Critically Ill Patients with Covid-19

REMAP-CAP Investigators, 21 Dec 2023, In: New England Journal of Medicine. 389, p. 2341-2354

Research output: Contribution to journal › Article › peer-review

Open Access

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Elevated Plasma Interleukin-18 Identifies High-Risk Acute Respiratory Distress Syndrome Patients not Distinguished by Prior Latent Class Analyses Using Traditional Inflammatory Cytokines: A Retrospective Analysis of Two Randomized Clinical Trials

Moore, A. R., Pienkos, S. M., Sinha, P., Guan, J., O'Kane, C. M., Levitt, J. E., Wilson, J. G., Shankar-Hari, M., Matthay, M. A., Calfee, C. S., Baron, R. M., McAuley, D. F. & Rogers, A. J., 1 Dec 2023, In: Critical Care Medicine. 51, 12, p. e269-e274

Research output: Contribution to journal › Article › peer-review

Intravenous Vitamin C for Patients Hospitalized With COVID-19: Two Harmonized Randomized Clinical Trials

LOVIT-COVID Investigators, on behalf of the Canadian Critical Care Trials Group, and the REMAP-CAP Investigators, 14 Nov 2023, In: Journal of the American Medical Association. 330, 18, p. 1745-1759

Research output: Contribution to journal › Article › peer-review

Open Access

Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study

The C-MORE/PHOSP-COVID Collaborative Group, Nov 2023, In: The Lancet Respiratory Medicine. 11, 11, p. 1003-1019 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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A randomised phase 2a study to investigate the effects of blocking interleukin-33 with tozorakimab in patients hospitalised with COVID-19: Accord-2

Wilkinson, T., De Soyza, A., Carroll, M., Chalmers, J. D., Crooks, M. G., Griffiths, G., Shankar-Hari, M., Ho, L-P., Horsley, A., Kell, C., Lara, B., Mishra, B., Moate, R., Page, C., Pandya, H., Raw, J., Reid, F., Saralaya, D., Scott, I. C., Siddiqui, S., & 4 othersUstianowski, A., van Zuydam, N., Woodcock, A. & Singh, D., 2 Oct 2023, In: ERJ Open Research. 9, 5, 00249-2023.

Research output: Contribution to journal › Article › peer-review

Open Access

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A second update on mapping the human genetic architecture of COVID-19

The COVID-19 Host Genetics Initiative, 6 Sept 2023, In: Nature. 621, 7977, p. E7-E26

Research output: Contribution to journal › Article › peer-review

Open Access

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Investigation into P2Y Receptor function in platelets from patients with sepsis

Arkless, K. L., Fish, M., Jennings, A., Page, C. P., Shankar-Hari, M. & Pitchford, S. C., 1 Aug 2023, In: Shock: Injury, Inflammation and Sepsis. 60, 2, p. 172-180

Research output: Contribution to journal › Article › peer-review

Open Access

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Estimating the attributable fraction of mortality from acute respiratory distress syndrome to inform enrichment in future randomised clinical trials

Saha, R., Pham, T., Sinha, P., Maddali, M. V., Bellani, G., Fan, E., Summers, C., Douiri, A., Rubenfeld, G. D., Calfee, C. S., Laffey, J. G., Mcauley, D. F. & Shankar-Hari, M., 26 Jul 2023, (E-pub ahead of print) In: Thorax. 78, 10, p. 990-1003

Research output: Contribution to journal › Article › peer-review

Open Access

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Cross-Linking Mass Spectrometry Uncovers Interactions Between High-Density Lipoproteins and the SARS-CoV-2 Spike Glycoprotein

Burnap, S. A., Ortega-Prieto, A. M., Jimenez-Guardeño, J. M., Ali, H., Takov, K., Fish, M., Shankar-Hari, M., Giacca, M., Malim, M. H. & Mayr, M., 20 Jul 2023, In: Molecular & Cellular Proteomics (MCP). 22, 8, p. 100600 100600.

Research output: Contribution to journal › Article › peer-review

Open Access

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Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls

PHOSP-COVID Study Collaborative Group, Zheng, B., Vivaldi, G., Daines, L., Leavy, O. C., Richardson, M., Elneima, O., McAuley, H. J. C., Shikotra, A., Singapuri, A., Sereno, M., Saunders, R. M., Harris, V. C., Houchen-Wolloff, L., Greening, N. J., Peffer, P. E., Hurst, J. R., Brown, J. S., Shankar-Hari, M., Echevarria, C., & 17 othersDe Soyza, A., Harrison, E. M., Docherty, A. B., Lone, N. I., Quint, J. K., Chalmers, J. D., Ho, L-P., Horsley, A., Marks, M. P., Poinasamy, K., Raman, B., Heaney, L. G., Wain, L. V., Evans, R. A., Brightling, C. E., Martineau, A. R. & Sheikh, A., Jun 2023, In: The Lancet Regional Health - Europe. 29, 100635.

Research output: Contribution to journal › Article › peer-review

Open Access

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Phase 2 randomised placebo-controlled trial of spironolactone and dexamethasone versus dexamethasone in COVID-19 hospitalised patients in Delhi

Wadhwa, B., Malhotra, V., Kerai, S., Husain, F., Pandey, N. B., Saxena, K. N., Singh, V., Quinn, T. M., Li, F., Gaughan, E., Shankar-Hari, M., Mills, B., Antonelli, J., Bruce, A., Finlayson, K., Moore, A., Dhaliwal, K. & Edwards, C., 15 May 2023, In: BMC Infectious Diseases. 23, 1

Research output: Contribution to journal › Article › peer-review

Open Access

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Major adverse cardiovascular events (MACE) in patients with severe COVID-19 registered in the ISARIC WHO clinical characterization protocol: A prospective, multinational, observational study

ISARIC Characterisation Group, Reyes, L. F., Garcia-Gallo, E., Murthy, S., Fuentes, Y. V., Serrano, C. C., Ibáñez-Prada, E. D., Lee, J., Rojek, A., Citarella, B. W., Gonçalves, B. P., Dunning, J., Rätsep, I., Viñan-Garces, A. E., Kartsonaki, C., Rello, J., Martin-Loeches, I., Shankar-Hari, M., Olliaro, P. L. & Merson, L., 9 May 2023, (E-pub ahead of print) In: Journal of Critical Care. 77, 154318.

Research output: Contribution to journal › Article › peer-review

Open Access

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Repair of Acute Respiratory Distress Syndrome in COVID-19 by Stromal Cells (REALIST-COVID Trial): A Multicentre, Randomised, Controlled Trial

Gorman, E. A., Rynne, J., Gardiner, H. J., Rostron, A. J., Bannard-Smith, J., Bentley, A. M., Brealey, D., Campbell, C., Curley, G., Clarke, M., Dushianthan, A., Hopkins, P., Jackson, C., Kefela, K., Krasnodembskaya, A., Laffey, J. G., McDowell, C., McFarland, M., McFerran, J., McGuigan, P., & 12 othersPerkins, G. D., Silversides, J., Smythe, J., Thompson, J., Tunnicliffe, W. S., Welters, I. D., Amado-Rodríguez, L., Albaiceta, G., Williams, B., Shankar-Hari, M., McAuley, D. F. & O'Kane, C. M., 8 May 2023, (E-pub ahead of print) In: American Journal of Respiratory and Critical Care Medicine.

Research output: Contribution to journal › Article › peer-review

Open Access

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GWAS and meta-analysis identifies 49 genetic variants underlying critical Covid-19

GenOMICC Investigators, SCOURGE Consortium, ISARIC4C Investigators, 23andMe Covid-19 Team, Pairo-Castineira, E., Rawlik, K., Bretherick, A. D., Qi, T., Wu, Y., Nassiri, I., McConkey, G. A., Zechner, M., Klaric, L., Griffiths, F., Oosthuyzen, W., Kousathanas, A., Richmond, A., Millar, J., Russell, C. D., Malinauskas, T., & 39 othersThwaites, R., Morrice, K., Keating, S., Maslove, D. M., Nichol, A. D., Semple, M. G., Knight, J., Shankar-Hari, M., Summers, C., Hinds, C., Horby, P., Ling, L., McAuley, D. F., Montgomery, H., Openshaw, P. J. M., Begg, C., Walsh, T. S., Tenesa, A., Flores, C., Riancho, J. A., Rojas-Martinez, A., Lapunzina, P., Yang, J., Ponting, C. P., Wilson, J. F., Vitart, V., Abedalthagafi, M. S., Luchessi, A., Parra, E. J., Cruz, R., Carracedo, A., Fawkes, A., Murphy, L., Rowan, K., Pereira, A. C., Law, A., Fairfax, B. P., Clohisey Hendry, S. & Baillie, J. K., May 2023, In: Nature. 617, 7962, p. 764-768 30 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Causal Bayesian machine learning to assess treatment effect heterogeneity by dexamethasone dose for patients with COVID-19 and severe hypoxemia

Blette, B. S., Granholm, A., Li, F., Shankar-Hari, M., Lange, T., Munch, M. W., Møller, M. H., Perner, A. & Harhay, M. O., 21 Apr 2023, In: Scientific Reports. 13, 1, 6570.

Research output: Contribution to journal › Article › peer-review

Open Access

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Risk factors for developing ventilator-associated lower respiratory tract infection in patients with severe COVID-19: a multinational, multicentre study, prospective, observational study

LIVEN-Covid-19, SEMICYUC Study Group, Reyes, L. F., Rodriguez, A., Fuentes, Y. V., Duque, S., García-Gallo, E., Bastidas, A., Serrano-Mayorga, C. C., Ibáñez-Prada, E. D., Moreno, G., Ramirez-Valbuena, P. C., Ospina-Tascon, G., Hernandez, G., Silva, E., Díaz, A. M., Jibaja, M., Vera-Alarcon, M., Díaz, E., Bodí, M., & 13 othersSolé-Violán, J., Ferrer, R., Albaya-Moreno, A., Socias, L., Figueroa, W., Lozano-Villanueva, J. L., Varón-Vega, F., Estella, Á., Loza-Vazquez, A., Jorge-García, R., Sancho, I., Shankar-Hari, M. & Martin-Loeches, I., 21 Apr 2023, In: Scientific Reports. 13, 1, 6553.

Research output: Contribution to journal › Article › peer-review

Open Access

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Effect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Initiation on Organ Support-Free Days in Patients Hospitalized With COVID-19: A Randomized Clinical Trial

Writing Committee for the REMAP-CAP Investigators, 11 Apr 2023, In: Journal of the American Medical Association. 329, 14, p. 1183-1196 14 p.

Research output: Contribution to journal › Article › peer-review

The association between time of in hospital cardiac arrest and mortality: a retrospective analysis of two UK databases

McGuigan, P. J., Edwards, J., Blackwood, B., Dark, P., Doidge, J. C., Harrison, D. A., Kitchen, G., Lawson, I., Nichol, A. D., Rowan, K. M., Shankar-Hari, M. & McAuley, D. F., 25 Feb 2023, (E-pub ahead of print) In: Resuscitation. 109750.

Research output: Contribution to journal › Article › peer-review

Open Access

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Comparison of systemic inflammatory profiles in COVID-19 and community-acquired pneumonia patients: a prospective cohort study

Ibáñez-Prada, E. D., Fish, M., Fuentes, Y. V., Bustos, I. G., Serrano-Mayorga, C. C., Lozada, J., Rynne, J., Jennings, A., Crispin, A. M., Santos, A. M., Londoño, J., Shankar-Hari, M. & Reyes, L. F., 22 Feb 2023, In: Respiratory research. 24, 1, 60.

Research output: Contribution to journal › Article › peer-review

Open Access

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Evolving Management Practices for Early Sepsis-induced Hypoperfusion: A Narrative Review

Munroe, E. S., Hyzy, R. C., Semler, M. W., Shankar-Hari, M., Young, P. J., Zampieri, F. G. & Prescott, H. C., 22 Feb 2023, (E-pub ahead of print) In: American Journal of Respiratory and Critical Care Medicine.

Research output: Contribution to journal › Article › peer-review

Open Access

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Stimulation of platelet P2Y1 receptors by different endogenous nucleotides leads to functional selectivity via biased signalling

Arkless, K. L., Pan, D., Shankar‐hari, M., Amison, R. T., Page, C. P., Rahman, K. M. & Pitchford, S. C., 24 Jan 2023, (E-pub ahead of print) In: British Journal of Pharmacology.

Research output: Contribution to journal › Article › peer-review

Open Access

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The effect of blood pressure on mortality following out of hospital cardiac arrest: a retrospective cohort study of the United Kingdom Intensive Care National Audit and Research Centre database

McGuigan, P. J., Giallongo, E., Blackwood, B., Doidge, J., Harrison, D. A., Nichol, A. D., Rowan, K. M., Shankar-Hari, M., Skrifvars, M. B., Thomas, K., McAuley, D. F. & McGuigan, P. J., 5 Jan 2023, In: Critical Care. 27, 4.

Research output: Contribution to journal › Article › peer-review

Open Access

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Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial

Writing Committee for the REMAP-CAP Investigators, 3 Jan 2023, In: Journal of the American Medical Association. 329, 1, p. 39-51 13 p.

Research output: Contribution to journal › Article › peer-review

Airway pressure release ventilation: a survey of UK practice

Rose, L., Camporota, L., Mills, G. H., Laffey, J. G., Perkins, G. D., Shankar-hari, M., Szakmany, T. & Mcauley, D., 1 Jan 2023, In: British Journal of Anaesthesia. 130, 1, p. e25-e27

Research output: Contribution to journal › Article › peer-review

Open Access

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2022

Improving risk prediction model quality in the critically ill: data linkage study

Ferrando-Vivas, P., Shankar-Hari, M., Thomas, K., Doidge, J., Caskey, F., Forni, L., Harris, S., Ostermann, M., Gornik, I., Holman, N., Lone, N. I., Young, B., Jenkins, D., Webb, S., Nolan, J., Soar, J., Rowan, K. & Harrison, D., 22 Dec 2022, In: Health and Social Care Delivery Research . 10, 39, 228 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Prevalence, risk factors, and treatments for post-COVID breathlessness: a systematic review and meta-analysis

Zheng, B., Daines, L., Han, Q., Hurst, J. R., Pfeffer, P. E., Shankar-Hari, M., Elneima, O., Walker, S., Brown, J. S., Siddiqui, S., Quint, J. K., Brightling, C. E., Evans, R. A., Wain, L. V., Heaney, L. G. & Sheikh, A., 21 Dec 2022, In: European Respiratory Review. 31, 166, 20 p., 220071.

Research output: Contribution to journal › Article › peer-review

Open Access

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Role of immunosuppression in an antibiotic stewardship intervention and its association with clinical outcomes and antibiotic use: protocol for an observational study (RISC-sepsis)

Scott, J., Trevi, L., McNeil, H., Ewen, T., Mawson, P., McDonald, D., Filby, A., Lall, R., Booth, K., Boschman, G., Melkebeek, V., Perkins, G., McMullan, R., McAuley, D. F., McCullagh, I. J., Walsh, T., Rostron, A., Shankar-Hari, M., Dark, P., Simpson, A. J., & 2 othersConway Morris, A. & Hellyer, T. P., 9 Dec 2022, In: BMJ Open. 12, 12, p. e068321

Research output: Contribution to journal › Article › peer-review

Open Access

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Butyrate Supplementation Exacerbates Myocardial and Immune Cell Mitochondrial Dysfunction in a Rat Model of Faecal Peritonitis

Peters, V. B. M., Arulkumaran, N., Melis, M. J., Gaupp, C., Roger, T., Shankar-hari, M. & Singer, M., 6 Dec 2022, In: Life. 12, 12, p. 2034

Research output: Contribution to journal › Article › peer-review

Open Access

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Protocol for a scoping review of sepsis epidemiology

Wilcox, M. E., Daou, M., Dionne, J. C., Dodek, P., Englesakis, M., Garland, A., Lauzon, C., Loubani, O., Rochwerg, B., Shankar-hari, M., Thavorn, K. & Tricco, A. C., 1 Dec 2022, In: Systematic Reviews. 11, 1, 25.

Research output: Contribution to journal › Article › peer-review

Open Access

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Repair of acute respiratory distress syndrome by stromal cell administration (REALIST): a structured study protocol for an open-label dose-escalation phase 1 trial followed by a randomised, triple-blind, allocation concealed, placebo-controlled phase 2 trial

Gorman, E., Shankar-Hari, M., Hopkins, P., Tunnicliffe, W. S., Perkins, G. D., Silversides, J., McGuigan, P., Jackson, C., Boyle, R., McFerran, J., McDowell, C., Campbell, C., McFarland, M., Smythe, J., Thompson, J., Williams, B., Curley, G., Laffey, J. G., Clarke, M., McAuley, D. F., & 1 othersO’Kane, C., Dec 2022, In: Trials. 23, 1, 401.

Research output: Contribution to journal › Article › peer-review

Open Access

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Coronavirus disease 2019 subphenotypes and differential treatment response to convalescent plasma in critically ill adults: secondary analyses of a randomized clinical trial

REMAP-CAP Immunoglobulin Domain UK Investigators, Fish, M., Rynne, J., Jennings, A., Lam, C., Lamikanra, A., Ratcliff, J., Cellone-Trevelin, S., Timms, E., Jeriha, J., Tosi, I., Pramanik, R., Simmonds, P., Seth, S., Williams, J., Gordon, A. C., Knight, J., Smith, D. J., Whalley, J., Harrison, D., & 7 othersRowan, K., Harvala, H., Klenerman, P., Estcourt, L., Menon, D. K., Roberts, D. & Shankar-Hari, M., 1 Nov 2022, In: Intensive Care Medicine. 48, 11, p. 1525-1538 38 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Compartmentalisation of immune responses in critical illness: does it matter?

Conway Morris, A., Rynne, J. & Shankar-Hari, M., Nov 2022, In: Intensive Care Medicine. 48, 11, p. 1617-1620 4 p.

Research output: Contribution to journal › Article › peer-review

Risk of myocarditis following sequential doses of COVID-19 vaccine and SARS-CoV-2 infection by age and sex

Patone, M., Mei, X. W., Handunnetthi, L., Dixon, S., Zaccardi, F., Shankar-Hari, M., Watkinson, P., Khunti, K., Harnden, A., Coupland, C. AC., Channon, K. M., Mills, N. L., Sheikh, A. & Hippisley-Cox, J., 22 Aug 2022, In: Circulation. 146, 10, p. 743-754

Research output: Contribution to journal › Article › peer-review

Open Access

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An Inhaled Galectin-3 Inhibitor in COVID-19 Pneumonitis (DEFINE): A Phase Ib/IIa Randomised Controlled Trial

Gaughan, E. E., Quinn, T. M., Mills, A., Bruce, A. M., Antonelli, J., Mackinnon, A., Aslanis, V., Li, F., O'connor, R., Boz, C., Mills, R., Emanuel, P., Burgess, M., Rinaldi, G., Valanciute, A., Mills, B., Scholefield, E., Hardisty, G., Gwyer Findlay, E., Parker, R. A., & 19 othersNorrie, J., Dear, J. W., Akram, A. R., Koch, O., Templeton, K., Dockrell, D. H., Walsh, T. S., Partridge, S., Humphries, D., Wang-jairaj, J., Slack, R. J., Schambye, H., Phung, D., Gravelle, L., Lindmark, B., Shankar-Hari, M., Hirani, N., Sethi, T. & Dhaliwal, K., 16 Aug 2022, (E-pub ahead of print) In: American Journal of Respiratory and Critical Care Medicine.

Research output: Contribution to journal › Article › peer-review

Open Access

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SARS-CoV-2-specific memory B cell responses are maintained after recovery from natural infection and post vaccination

Moore, T., Hossain, R., Doores, K. J., Shankar-Hari, M. & Flear, D. J., 2 Aug 2022, In: Viral Immunology. 35, 6, p. 425-436

Research output: Contribution to journal › Article › peer-review

Open Access

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Manu Shankar-Hari

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