Manu Shankar-Hari

Search results

• 2024

  From ICU Syndromes to ICU Subphenotypes: Consensus Report and Recommendations for Developing Precision Medicine in the ICU

  Gordon, A. C., Alipanah-Lechner, N., Bos, L. D., Dianti, J., Diaz, J. V., Finfer, S., Fujii, T., Giamarellos-Bourboulis, E. J., Goligher, E. C., Gong, M. N., Karakike, E., Liu, V. X., Lumlertgul, N., Marshall, J. C., Menon, D. K., Meyer, N. J., Munroe, E. S., Myatra, S. N., Ostermann, M., Prescott, H. C., & 13 othersRandolph, A. G., Schenck, E. J., Seymour, C. W., Shankar-Hari, M., Singer, M., Smit, M. R., Tanaka, A., Taccone, F. S., Thompson, B. T., Torres, L. K., van der Poll, T., Vincent, J-L. & Calfee, C. S., 15 Jul 2024, In: American Journal of Respiratory and Critical Care Medicine. 210, 2, p. 155-166 12 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Endotype 100%

• Reframing sepsis immunobiology for translation: towards informative subtyping and targeted immunomodulatory therapies

  Shankar-Hari, M., Calandra, T., Soares, M. P., Bauer, M., Wiersinga, W. J., Prescott, H. C., Knight, J. C., Baillie, K. J., Bos, L. D. J., Derde, L. P. G., Finfer, S., Hotchkiss, R. S., Marshall, J., Openshaw, P. J. M., Seymour, C. W., Venet, F., Vincent, J-L., Le Tourneau, C., Maitland-van der Zee, A. H., McInnes, I. B., & 1 othersvan der Poll, T., 2 Apr 2024, In: The Lancet Respiratory Medicine. 12, 4, p. 323-336 14 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Immunology 100%
  • Immunomodulation 66%
  • Host Immune Response 66%
  • Homeostasis 33%
  • Immunosuppressive Drug 33%

• Profiling the dysregulated immune response in sepsis: overcoming challenges to achieve the goal of precision medicine

  Cajander, S., Kox, M., Scicluna, B. P., Weigand, M. A., Mora, R. A., Flohé, S. B., Martin-Loeches, I., Lachmann, G., Girardis, M., Garcia-Salido, A., Brunkhorst, F. M., Bauer, M., Torres, A., Cossarizza, A., Monneret, G., Cavaillon, J-M., Shankar-Hari, M., Giamarellos-Bourboulis, E. J., Winkler, M. S., Skirecki, T., & 5 othersOsuchowski, M., Rubio, I., Bermejo-Martin, J. F., Schefold, J. C. & Venet, F., 1 Apr 2024, In: The Lancet Respiratory Medicine. 12, 4, p. 305-322 18 p.

  Research output: Contribution to journal › Review article › peer-review

  • Immune Response 100%
  • Sepsis 100%
  • Personalized Medicine 100%
  • Artificial Intelligence 100%
  • Immune Dysregulation 100%
• 2023

  Post-acute sequelae of COVID-19: understanding and addressing the burden of multisystem manifestations

  Parotto, M., Gyöngyösi, M., Howe, K., Myatra, S. N., Ranzani, O., Shankar-Hari, M. & Herridge, M. S., 31 Jul 2023, In: The Lancet Respiratory Medicine. 11, p. 739-754 16 p.

  Research output: Contribution to journal › Review article › peer-review

  • Sequela 100%
  • COVID-19 100%
  • Critical Illness 62%
  • Severe Acute Respiratory Syndrome Coronavirus 2 25%
  • Adult 12%
• 2021

  Precision medicine in acute respiratory distress syndrome: workshop report and recommendations for future research

  Bos, L. D. J., Artigas, A., Constantin, J-M., Hagens, L. A., Heijnen, N., Laffey, J. G., Meyer, N., Papazian, L., Pisani, L., Schultz, M. J., Shankar-Hari, M., Smit, M. R., Summers, C., Ware, L. B., Scala, R. & Calfee, C. S., 31 Mar 2021, In: European Respiratory Review. 30, 159

  Research output: Contribution to journal › Review article › peer-review

  • Acute Respiratory Distress Syndrome 100%
  • Personalized Medicine 100%
  • Adult Respiratory Distress Syndrome 100%
  • Inpatient 25%
  • Phenotype 25%
• 2020

  Paediatric Inflammatory Multisystem Syndrome Temporally-Associated with SARS-CoV-2 Infection: An Overview

  Carter, M. J., Shankar-Hari, M. & Tibby, S. M., 14 Oct 2020, In: Intensive Care Medicine. 47, 1, p. 90-93 4 p.

  Research output: Contribution to journal › Review article › peer-review

• Convalescent plasma to treat critically ill patients with COVID-19: Framing the need for randomised clinical trials

  Shankar-Hari, M., Estcourt, L., Harvala, H., Roberts, D., Menon, D. K., Shankar-Hari, M., Harvala, H., Roberts, D. & Menon, D. K., 20 Jul 2020, In: Critical Care. 24, 1, 449.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

• Rethinking animal models of sepsis - Working towards improved clinical translation whilst integrating the 3Rs

  Nandi, M., Jackson, S. K., Macrae, D., Shankar-Hari, M., Tremoleda, J. L. & Lilley, E., 10 Jul 2020, In: Clinical science. 134, 13, p. 1715-1734 20 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Animal Model 100%
  • Sepsis 100%
  • Animal Models 100%
  • Research 60%
  • Construct Validity 40%

• Auf Wiedersehen SIRS? Angeborene, trainierte und adaptive Immunität und Pathogenese von Organfunktionsstörungen

  Translated title of the contribution: Goodbye SIRS? Innate, trained and adaptive immunity and pathogenesis of organ dysfunctionGhnewa, Y. G., Fish, M., Jennings, A., Carter, M. J. & Shankar-Hari, M., 1 May 2020, In: Medizinische Klinik - Intensivmedizin und Notfallmedizin. 115, p. 10-14 5 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Serositis 100%
  • Organ 100%
  • Syndrome 100%
  • Sepsis 100%
  • Pathogenesis 100%

• Rate and risk factors for rehospitalisation in sepsis survivors: systematic review and meta-analysis

  Shankar-Hari, M., Saha, R., Wilson, J., Prescott, H. C., Harrison, D., Rowan, K., Rubenfeld, G. D. & Adhikari, N. K. J., 1 Apr 2020, In: Intensive Care Medicine. 46, 4, p. 619-636 18 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Sepsis 100%
  • Hospital Readmission 100%
  • Meta Analysis 100%
  • Systematic Review 100%
  • Meta-Analysis 100%

• Current Understanding of Leukocyte Phenotypic and Functional Modulation During Extracorporeal Membrane Oxygenation: A Narrative Review

  Ki, K. K., Millar, J. E., Langguth, D., Passmore, M. R., McDonald, C. I., Shekar, K., Shankar-Hari, M., Cho, H. J., Suen, J. Y. & Fraser, J. F., 2020, In: Frontiers in Immunology. 11, p. 600684

  Research output: Contribution to journal › Review article › peer-review

  • Leukocyte 100%
  • Complication 16%
  • Procoagulant 16%
  • Blood 16%
  • Illness 16%
• 2019

  Current gaps in sepsis immunology: new opportunities for translational research

  Rubio, I., Osuchowski, M. F., Shankar-Hari, M., Skirecki, T., Winkler, M. S., Lachmann, G., La Rosée, P., Monneret, G., Venet, F., Bauer, M., Brunkhorst, F. M., Kox, M., Cavaillon, J. M., Uhle, F., Weigand, M. A., Flohé, S. B., Wiersinga, W. J., Martin-Fernandez, M., Almansa, R., Martin-Loeches, I., & 10 othersTorres, A., Giamarellos-Bourboulis, E. J., Girardis, M., Cossarizza, A., Netea, M. G., van der Poll, T., Scherag, A., Meisel, C., Schefold, J. C. & Bermejo-Martín, J. F., Dec 2019, In: The Lancet Infectious Diseases. 19, 12, p. e422-e436

  Research output: Contribution to journal › Review article › peer-review

  • Immunology 100%
  • Immunity 66%
  • Immune System 33%
  • Immunocompetent Cell 33%
  • Lymphopenia 33%

• Population enrichment for critical care trials: Phenotypes and differential outcomes

  Shankar-Hari, M. & Rubenfeld, G. D., 1 Oct 2019, In: Current Opinion in Critical Care. 25, 5, p. 489-497 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Intensive Care 100%
  • Acute Respiratory Distress Syndrome 100%
  • Sepsis 100%
  • Phenotype 100%
  • Distress Syndrome 100%

• Systematic review and consensus definitions for the Standardised Endpoints in Perioperative Medicine (StEP) initiative: infection and sepsis

  the StEP-COMPAC group, 1 Apr 2019, In: British Journal of Anaesthesia. 122, 4, p. 500-508 9 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Systematic Review 100%
  • Sepsis 100%
  • Infection 100%
  • Consensus 100%
  • Clinical Trial 28%
• 2018

  Major surgery and the immune system: from pathophysiology to treatment

  Hari, M. S. & Summers, C., Dec 2018, In: Current Opinion in Critical Care. 24, 6, p. 588-593

  Research output: Contribution to journal › Review article › peer-review
• 2017

  Septic shock resuscitation in the first hour

  Simpson, N., Lamontagne, F. & Shankar-Hari, M., Dec 2017, In: Current Opinion in Critical Care. 23, 6, p. 561-566

  Research output: Contribution to journal › Review article › peer-review
• 2016

  Understanding Long-Term Outcomes Following Sepsis: Implications and Challenges

  Shankar-Hari, M. & Rubenfeld, G. D., Nov 2016, In: CURRENT INFECTIOUS DISEASE REPORTS. 18, 11

  Research output: Contribution to journal › Review article › peer-review
• 2015

  Endogenous IgG hypogammaglobulinaemia in critically ill adults with sepsis: systematic review and meta-analysis

  Shankar-Hari, M., Culshaw, N., Post, B., Tamayo, E., Andaluz-Ojeda, D., Bermejo-Martin, J. F., Dietz, S., Werdan, K., Beale, R., Spencer, J. & Singer, M., Aug 2015, In: Intensive Care Medicine. 41, 8, p. 1393-1401

  Research output: Contribution to journal › Review article › peer-review
• 2012

  Bench-to-bedside review: Immunoglobulin therapy for sepsis - biological plausibility from a critical care perspective

  Shankar-Hari, M., Spencer, J., Sewell, W. A., Rowan, K. M. & Singer, M., 2012, In: Critical Care. 16, 2

  Research output: Contribution to journal › Review article › peer-review