Research output per year
Research output per year
Personal profile
Biography
2005-2009 MBiochem University of Oxford, UK
2009-2013 PhD CRUK LRI Clare Hall laboratories, London, UK
2013-2016 Postdoc SLRI Mount Sinai Hospital, Toronto, Canada
2016-2018 Postdoc Francis Crick Institute, London, UK
2018-present Sir Henry Dale Fellow and Lecturer in Structural Cell Biology, University of Edinburgh
Websites
Research Interests
We are interested in understanding how epigenetic marks are placed, read and interpreted on chromatin. Chromatin becomes decorated with post-translational modifications to control the myriad of DNA-related processes in the cell. We create modified chromatin using chemical biology and biochemical methods. We then use our defined modified chromatin to study individual nucleosome-chromatin protein complexes using single-particle cryo-electron microscopy (cryo-EM), Biochemical, Biophysical and Cell Biology approaches to investigate histone marks and DNA methylation.
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How is DNA Methylation guided by chromatin?
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How do post-translational modifications foster DNA repair?
- What is the structure of chromatin in diverse eukaryotes?
Positions available
If you are interested in joining our group please contact Marcus with a CV to discuss potential opportunities.
A number of fully funded PhD studentships are available for both UK/EU and worldwide students. Please get in touch if you are interested.
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Collaborations and top research areas from the last five years
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The kinetoplastid kinetochore protein KKT23 acetyltransferase is a structural homolog of GCN5 that acetylates the histone H2A C-terminal tail
Ludzia, P., Ishii, M., Deák, G., Spanos, C., Wilson, M. D., Redfield, C. & Akiyoshi, B., 2 Jan 2025, In: Structure. 33, 1, p. 123-135.e10 24 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
The N-terminal region of DNMT3A engages the nucleosome surface to aid chromatin recruitment.
Wapenaar, H., Clifford, G., Rolls, W., Pasquier, M., Burdett, H., Zhang, Y., Deák, G., Zou, J., Spanos, C., Taylor, M. R. D., Mills, J., Watson, J. A., Kumar, D., Clark, R., Das, A., Valsakumar, D., Bramham, J., Voigt, P., Sproul, D. & Wilson, M. D., 6 Dec 2024, In: EMBO Reports. 25, 12, p. 5743-5779 37 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Using human disease mutations to understand de novo DNA methyltransferase function.
Rolls, W., Wilson, M. D. & Sproul, D., 24 Oct 2024, In: Biochemical Society Transactions.Research output: Contribution to journal › Review article › peer-review
Open AccessFile -
DNMT3B PWWP mutations cause hypermethylation of heterochromatin
Taglini, F., Kafetzopoulos, I., Rolls, W., Musialik, K. I., Yang Lee, H., Zhang, Y., Marenda, M., Kerr, L., M. Finan, H., Rubio Ramon, C., Gautier, P., Wapenaar, H., Kumar, D., Davidson-Smith, H., Wills, J., Murphy, L., Wheeler, A. P., Wilson, M. D. & Sproul, D., 30 Jan 2024, In: EMBO Reports.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
BRCA1-BARD1 combines multiple chromatin recognition modules to bridge nascent nucleosomes
Burdett, H., Foglizzo, M., Musgrove, L. J., Kumar, D., Clifford, G., Campbell, L. J., Heath, G. R., Zeqiraj, E. & Wilson, M. D., 10 Nov 2023, In: Nucleic Acids Research. 51, 20, p. 11080-11103 gkad793.Research output: Contribution to journal › Article › peer-review
Open AccessFile
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Mechanistic understanding of the reading and writing of DNA methylation�
1/07/18 → 31/08/26
Project: Research
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Recruitment of BRCA1-A complex to nucleosomes and sites of DNA damage
1/09/20 → 31/08/24
Project: Research
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Recruitment of BRCA1-A complex to nucleosomes and sites of DNA damage
1/09/20 → 31/08/23
Project: Research
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Mechanistic understanding of the reading and writing of DNA methylation¿¿¿
1/07/18 → 1/11/23
Project: Research