Research output per year
Research output per year
Personal profile
Biography
2005-2009 MBiochem University of Oxford, UK
2009-2013 PhD CRUK LRI Clare Hall laboratories, London, UK
2013-2016 Postdoc SLRI Mount Sinai Hospital, Toronto, Canada
2016-2018 Postdoc Francis Crick Institute, London, UK
2018-present Sir Henry Dale Fellow and Lecturer in Structural Cell Biology, University of Edinburgh
Websites
Research Interests
We are interested in understanding how epigenetic marks are placed, read and interpreted on chromatin. Chromatin becomes decorated with post-translational modifications to control the myriad of DNA-related processes in the cell. We create modified chromatin using chemical biology and biochemical methods. We then use our defined modified chromatin to study individual nucleosome-chromatin protein complexes using single-particle cryo-electron microscopy (cryo-EM), Biochemical, Biophysical and Cell Biology approaches to investigate histone marks and DNA methylation.
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How is DNA Methylation guided by chromatin?
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How do post-translational modifications foster DNA repair?
- What is the structure of chromatin in diverse eukaryotes?
Positions available
If you are interested in joining our group please contact Marcus with a CV to discuss potential opportunities.
A number of fully funded PhD studentships are available for both UK/EU and worldwide students. Please get in touch if you are interested.
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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BRCA1-BARD1 combines multiple chromatin recognition modules to bridge nascent nucleosomes
Burdett, H., Foglizzo, M., Musgrove, L. J., Kumar, D., Clifford, G., Campbell, L. J., Heath, G. R., Zeqiraj, E. & Wilson, M. D., 12 Oct 2023, (E-pub ahead of print) In: Nucleic Acids Research. gkad793.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Histone divergence in trypanosomes results in unique alterations to nucleosome structure
Deák, G., Wapenaar, H., Sandoval, G., Chen, R., Taylor, M. R. D., Burdett, H., Watson, J., Tuijtel, M. W., Webb, S. & Wilson, M. D., 10 Jul 2023, In: Nucleic Acids Research. 66 p., gkad577.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Pore dynamics and asymmetric cargo loading in an encapsulin nanocompartment
Ross, J., McIver, Z., Lambert, T., Piergentili, C., Bird, J. E., Gallagher, K. J., Cruickshank, F. L., James, P., Zarazúa-Arvizu, E., Horsfall, L. E., Waldron, K. J., Wilson, M. D., Logan Mackay, C., Baslé, A., Clarke, D. J. & Marles-Wright, J., 26 Jan 2022, (E-pub ahead of print) In: Science Advances. 8, 4, eabj4461.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
BARD1 reads H2A Lys-15 ubiquitination to direct homologous recombination
Becker, J. R., Clifford, G., Bonnet, C., Groth, A., Wilson, M. D. & Chapman, J. R., 28 Jul 2021, In: Nature. 33 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Estimation of the motor threshold for near-rectangular stimuli using the Hodgkin-Huxley model
Memarian Sorkhabi, M., Wendt, K., Wilson, M. T. & Denison, T., 31 May 2021, In: Computational intelligence and neuroscience. 2021, 10 p., 4716161.Research output: Contribution to journal › Article › peer-review
Open AccessFile
Projects
- 2 Finished
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Recruitment of BRCA1-A complex to nucleosomes and sites of DNA damage
1/09/20 → 31/08/23
Project: Research
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Mechanistic understanding of the reading and writing of DNA methylation¿¿¿
1/07/18 → 1/11/23
Project: Research