Margaret Frame

2025

Drug Combinations Targeting FAK and MEK Overcomes 2 Tumour Heterogeneity in Glioblastoma

Furqan, M., Elliott, R., Nagle, P., Dawson, J. C., Masalmeh, R., Alvarez Garcia, V., Munro, A., Drake, C., Morrison, G., Pollard, S. M., Ebner, D., Brunton, V. G., Frame, M. C. & Carragher, N. O., 23 Apr 2025, (E-pub ahead of print) In: Pharmaceutics.

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2024

An ILK/STAT3 pathway controls glioblastoma stem cell plasticity

Loftus, A. E. P., Romano, M. S., Phuong, A. N., J McKinnel, B., Muir, M. T., Furqan, M., Dawson, J. C., Avalle, L., Douglas, A. T., L. Mort, R., Byron, A., Carragher, N. O., Pollard, S. M., Brunton, V. G. & Frame, M. C., 25 Sept 2024, In: Developmental Cell.

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The intrinsic substrate specificity of the human tyrosine kinome

Yaron-Barir, T. M., Joughin, B. A., Huntsman, E. M., Kerelsky, A., Cizin, D. M., Cohen, B. M., Regev, A., Song, J., Vasan, N., Lin, T.-Y., Orozco, J. M., Schoenherr, C., Sagum, C., Bedford, M. T., Wynn, R. M., Tso, S.-C., Chuang, D. T., Li, L., Li, S.S.-C. & Creixell, P. & 16 others, Krismer, K., Takegami, M., Lee, H., Zhang, B., Lu, J., Cossentino, I., Landry, S. D., Uduman, M., Blenis, J., Elemento, O., Frame, M. C., Hornbeck, P. V., Cantley, L. C., Turk, B. E., Yaffe, M. B. & Johnson, J. L., 8 May 2024, In: Nature. 629, 8014, p. 1174-1181

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2023

Quantitative proteomics identifies tumour matrisome signatures in patients with non-small cell lung cancer

Titmarsh, H., von Kriegsheim, A., O'Connor, R. A., Dhaliwal, K., Frame, M. C., Pattle, S. B., Dorward, D., Byron, A. & Akram, A. R., 16 Jun 2023, In: Frontiers in Oncology.

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Mena regulates nesprin-2 to control actin– 1 nuclear lamina associations, trans-nuclear 2 membrane signalling and gene expression

Li Mow Chee, F., Beernaert Dominguez, B., Griffith, B., Loftus, A., Kumar, Y., Wills, J., Lee, M., Valli, J., Wheeler, A. P., Armstrong, J. D., Parsons, M., Leigh, I. M., Proby, C., von Kriegsheim, A., Bickmore, W. A., Frame, M. C. & Byron, A., 23 Mar 2023, (E-pub ahead of print) In: Nature Communications.

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Kindlin-1 regulates IL-6 secretion and modulates the immune environment in breast cancer models

Webb, E. R., Dodd, G., Nosková, M., Bullock, E., Muir, M. T., Frame, M. C., Serrels, A. & Brunton, V. G., 8 Mar 2023, In: eLIFE. 12, e85739.

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2022

Toll-like receptor 2 orchestrates a tumor suppressor response in non-small cell lung cancer

Millar, F., Pennycuick, A., Muir, M., Quintanilla, A., Hari, P., Freyer, E., Gautier, P., Meynert, A. M., Grimes, G., Salomo Coll, C., Zdral, S., Victorelli, S., Teixeira, V. H., Connelly, J., Passos, J. F., Ros, M. A., Wallace, W. A. H., Frame, M. C., Sims, A. H. & Boulter, L. & 3 others, Janes, S. M., Wilkinson, S. & Acosta, J. C., 8 Nov 2022, In: Cell Reports. 41, 6, 111596.

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Characterisation of a nucleo-adhesome

Byron, A., Griffith, B. G. C., Herrero, A., Loftus, A. E. P., Koeleman, E. S., Kogerman, L., Dawson, J. C., McGivern, N., Culley, J., Grimes, G. R., Serrels, B., von Kriegsheim, A., Brunton, V. G. & Frame, M. C., 1 Jun 2022, (E-pub ahead of print) In: Nature Communications. 13, 3053.

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A fluorogenic probe for granzyme B enables in-biopsy evaluation and screening of response to anticancer immunotherapies

Scott, J., Mendive Tapia, L., Gordon, D., Barth, N., Thompson, E., Cheng, Z., Taggart, D., Kitamura, T., Blas, A. B., Roberts, E. W., Juarez Jimenez, J., Michel, J., Piet, B., de Vries, I. J., Verdoes, M., Dawson, J. C., Carragher, N. O., O'Connor, R. A., Akram, A. R. & Serrels, A. & 2 others, Frame, M. C. & Vendrell, M., 2 May 2022, In: Nature Communications.

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2021

Pathway profiling of a novel SRC inhibitor, AZD0424, in combination with MEK inhibitors

Dawson, J. C., Munro, A., Macleod, K., Muir, M., Timpson, P., Williams, R. J., Frame, M. C., Brunton, V. G. & Carragher, N. O., 2 Dec 2021, (E-pub ahead of print) In: Molecular Oncology.

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A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability

Temps, C., Leitha, D., Webb, E., Li, X.-F., Dawson, J. C., Muir, M., Macleod, K., Valero, T., Munro, A., Contreras-montoya, R., Luque-Ortega, J. R., Fraser, C., Beetham, H., Schoenherr, C., Lopalco, M., Arends, M. J., Frame, M. C., Qian, B.-Z., Brunton, V. G. & Carragher, N. O. & 1 others, Unciti-Broceta, A., 20 Aug 2021, (E-pub ahead of print) In: Cancer Research.

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Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion

Gangoso, E., Southgate, B., Bradley, L., Rus, S., Galvez-Cancino, F., McGivern, N., Güç, E., Kapourani, C.-A., Byron, A., Ferguson, K. M., Alfazema, N., Morrison, G., Grant, V., Blin, C., Sou, I., Marques-Torrejon, M. A., Conde, L., Parrinello, S., Herrero, J. & Beck, S. & 9 others, Brandner, S., Brennan, P. M., Bertone, P., Pollard, J. W., Quezada, S. A., Sproul, D., Frame, M. C., Serrels, A. & Pollard, S. M., 14 Apr 2021, In: Cell.

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Targeting FAK in anti-cancer combination therapies

Dawson, J. C., Serrels, A., Stupack, D. G., Schlaepfer, D. D. & Frame, M. C., 17 Mar 2021, (E-pub ahead of print) In: Nature Reviews Cancer.

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FAK regulates IL-33 expression by controlling chromatin accessibility at c-Jun motifs

Griffith, B., Upstill-Goddard, R., Brunton, H., Grimes, G., Biankin, A. V., Serrels, B., Byron, A. & Frame, M. C., 8 Jan 2021, (E-pub ahead of print) In: Scientific Reports. 11, 229.

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2020

Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer

Dreyer, S. B., Upstill-goddard, R., Paulus-hock, V., Paris, C., Lampraki, E.-M., Dray, E., Serrels, B., Caligiuri, G., Rebus, S., Plenker, D., Galluzzo, Z., Brunton, H., Cunningham, R., Tesson, M., Nourse, C., Bailey, U.-M., Jones, M., Moran-jones, K., Wright, D. W. & Duthie, F. & 226 others, Oien, K., Evers, L., Mckay, C. J., Mcgregor, G. A., Gulati, A., Brough, R., Bajrami, I., Pettitt, S., Dziubinski, M. L., Candido, J., Balkwill, F., Barry, S. T., Grützmann, R., Rahib, L., Johns, A., Pajic, M., Froeling, F. E. M., Beer, P., Musgrove, E. A., Petersen, G. M., Ashworth, A., Frame, M. C., Crawford, H. C., Simeone, D. M., Lord, C., Mukhopadhyay, D., Pilarsky, C., Tuveson, D. A., Cooke, S. L., Jamieson, N. B., Morton, J. P., Sansom, O. J., Bailey, P. J., Biankin, A. V., Chang, D. K., Allison, S., Bailey, P. J., Bailey, U.-M., Biankin, A. V., Beraldi, D., Brunton, H., Caligiuri, G., Cameron, E., Chang, D. K., Cooke, S. L., Cunningham, R., Dreyer, S., Grimwood, P., Kelly, S., Lampraki, E.-M., Marshall, J., Martin, S., Mcdade, B., Mcelroy, D., Musgrove, E. A., Nourse, C., Paulus-hock, V., Ramsay, D., Upstill-goddard, R., Wright, D. W., Jones, M. D., Evers, L., Rebus, S., Rahib, L., Serrels, B., Hair, J., Jamieson, N. B., Mckay, C. J., Westwood, P., Williams, N., Duthie, F., Biankin, A. V., Johns, A. L., Mawson, A., Chang, D. K., Scarlett, C. J., Brancato, M.-A. L., Rowe, S. J., Simpson, S. H., Martyn-smith, M., Thomas, M. T., Chantrill, L. A., Chin, V. T., Chou, A., Cowley, M. J., Humphris, J. L., Jones, M. D., Mead, R. S., Nagrial, A. M., Pajic, M., Pettit, J., Pinese, M., Rooman, I., Wu, J., Tao, J., Dipietro, R., Watson, C., Steinmann, A., Lee, H. C., Wong, R., Pinho, A. V., Giry-laterriere, M., Daly, R. J., Musgrove, E. A., Sutherland, R. L., Grimmond, S. M., Waddell, N., Kassahn, K. S., Miller, D. K., Wilson, P. J., Patch, A.-M., Song, S., Harliwong, I., Idrisoglu, S., Nourse, C., Nourbakhsh, E., Manning, S., Wani, S., Gongora, M., Anderson, M., Holmes, O., Leonard, C., Taylor, D., Wood, S., Xu, C., Nones, K., Fink, J. L., Christ, A., Bruxner, T., Cloonan, N., Newell, F., Pearson, J. V., Bailey, P., Quinn, M., Nagaraj, S., Kazakoff, S., Waddell, N., Krisnan, K., Quek, K., Wood, D., Samra, J. S., Gill, A. J., Pavlakis, N., Guminski, A., Toon, C., Asghari, R., Merrett, N. D., Pavey, D., Das, A., Cosman, P. H., Ismail, K., O’connnor, C., Lam, V. W., Mcleod, D., Pleass, H. C., Richardson, A., James, V., Kench, J. G., Cooper, C. L., Joseph, D., Sandroussi, C., Crawford, M., Gallagher, J., Texler, M., Forest, C., Laycock, A., Epari, K. P., Ballal, M., Fletcher, D. R., Mukhedkar, S., Spry, N. A., Deboer, B., Chai, M., Zeps, N., Beilin, M., Feeney, K., Nguyen, N. Q., Ruszkiewicz, A. R., Worthley, C., Tan, C. P., Debrencini, T., Chen, J., Brooke-smith, M. E., Papangelis, V., Tang, H., Barbour, A. P., Clouston, A. D., Martin, P., O’rourke, T. J., Chiang, A., Fawcett, J. W., Slater, K., Yeung, S., Hatzifotis, M., Hodgkinson, P., Christophi, C., Nikfarjam, M., Mountain, A., Biobank, V. C., Eshleman, J. R., Hruban, R. H., Maitra, A., Iacobuzio-donahue, C. A., Schulick, R. D., Wolfgang, C. L., Morgan, R. A., Hodgin, M., Scarpa, A., Lawlor, R. T., Beghelli, S., Corbo, V., Scardoni, M., Bassi, C., Tempero, M. A., Biankin, A. V., Grimmond, S. M., Chang, D. K., Musgrove, E. A., Jones, M. D., Nourse, C., Jamieson, N. B., Graham, J. S., Biankin, A. V., Chang, D. K., Jamieson, N. B. & Graham, J. S., 8 Oct 2020, (E-pub ahead of print) In: Gastroenterology. 160, 1, p. 362-377.e13

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Structural basis of Focal Adhesion Kinase activation on lipid membranes.

Acebrón, I., D. Righetto, R., Schoenherr, C., de Buhr, S., Redondo, P., Culley, J., F Rodríguez, C., Daday, C., Biyani, N., Llorca, O., Byron, A., Chami, M., Gräter, F., Boskovic, J., Frame, M. C., Stahlberg, H. & Lietha, D., 1 Oct 2020, In: EMBO Journal. 39, 19, e104743.

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The autophagy protein Ambra1 regulates gene expression by supporting novel transcriptional complexes

Schoenherr, C., Byron, A., Griffith, B., Loftus, A., Wills, J. C., Munro, A. F., Von Kriegsheim, A. & Frame, M. C., 2 Jul 2020, (E-pub ahead of print) In: Journal of Biological Chemistry. p. jbc.RA120.012565

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Novel Roles of PRK1 and PRK2 in cilia and cancer biology

Patel, T., Li, J., Herrero Mier, A., Kroboth, J., Byron, A., Von Kriegsheim, A., Brunton, V., Carragher, N., Hurd, T. & Frame, M., 3 Mar 2020, (E-pub ahead of print) In: Scientific Reports.

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A synergistic anti-cancer FAK and HDAC inhibitor combination discovered by a novel chemical-genetic high-content phenotypic screen

Dawson, J. C., Serrels, B., Byron, A., Muir, M., Makda, A., Garcia-Muñoz, A., von Kriegsheim, A., Lietha, D., Carragher, N. O. & Frame, M., Feb 2020, In: Molecular Cancer Therapeutics. 19, 2, p. 637–649 13 p.

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2018

Structure-based design, synthesis and characterization of the first irreversible inhibitor of Focal Adhesion Kinase

Yen-Pon, E., Li, B., Acebron-Garcia de Eulate, M., Tomkieqicz-Raulet, C., Dawson, J., Lietha, D., Frame, M. C., Coumoul, X., Garbay, C., Etheve-Quelquejeu, M. & Chen, H., 13 Jun 2018, (E-pub ahead of print) In: Acs chemical biology.

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Rapid Polymer Conjugation Strategies for the Generation of pH-Responsive, Cancer Targeting, Polymeric Nanoparticles

Li, W., Geng, J., Titmarsh, H., Megia-fernandez, A., Dhaliwal, K., Frame, M. & Bradley, M., 24 Apr 2018, (E-pub ahead of print) In: Biomacromolecules.

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2017

IL-33 and ST2 mediate FAK-dependent antitumor immune evasion through transcriptional networks

Serrels, B., McGivern, N., Canel, M., Byron, A., Johnson, S. C., McSorley, H. J., Quinn, N., Taggart, D., Von Kriegsheim, A., Anderton, S. M., Serrels, A. & Frame, M. C., 5 Dec 2017, In: Science Signaling. 10, 508, eaan8355.

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Nuclear FAK and Runx1 cooperate to regulate IGFBP3, cell cycle progression and tumor growth

Canel, M., Byron, A., Sims, A. H., Cartier, J., Patel, H., Frame, M. C., Brunton, V. G., Serrels, B. & Serrels, A., 1 Oct 2017, In: Cancer Research. 77, 19, p. 5301-5312

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Ambra1 spatially regulates Src activity and Src/FAK-mediated cancer cell invasion via trafficking networks

Schoenherr, C., Byron, A., Sandilands, E., Paliashvili, K., Baillie, G. S., Garcia-Munoz, A., Valacca, C., Cecconi, F., Serrels, B. & Frame, M. C., 31 Mar 2017, In: eLIFE. 6, e23172.

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2016

Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells

Spender, L. C., Ferguson, G. J., Liu, S., Cui, C., Romina Girotti, M., Sibbet, G., Higgs, E. B., K. Shuttleworth, M., Hamilton, T., Lorigan, P., Weller, M., Vincent, D. F., Sansom, O. J., Frame, M., ten Dijke, P., Marais, R. & J. Inman, G., 9 Nov 2016, In: Oncotarget.

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Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines that Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase

Fraser, C., Dawson, J. C., Dowling, R., Houston, D. R., Weiss, J. T., Munro, A. F., Muir, M., Harrington, L., Webster, S. P., Frame, M. C., Brunton, V. G., Patton, E. E., Carragher, N. O. & Unciti-Broceta, A., 26 May 2016, In: Journal of Medicinal Chemistry.

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Kindlin1 regulates microtubule function to ensure normal mitosis

Patel, H., Stavrou, I., Shrestha, R. L., Draviam, V., Frame, M. C. & Brunton, V. G., 18 Mar 2016, In: Journal of Molecular Cell Biology.

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The ROCKs on which tumour cells thrive

Wilkinson, S. & Frame, M. C., 7 Mar 2016, In: eLIFE. 5

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Translation Microscopy (TRAM) for super-resolution imaging

Qiu, Z., Wilson, R. S., Liu, Y., R Dun, A., Saleeb, R. S., Liu, D., Rickman, C., Frame, M., Duncan, R. R. & Lu, W., 29 Jan 2016, In: Scientific Reports. 6, p. 19993

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FAK goes nuclear to control anti-tumor immunity – a new target in cancer immuno-therapy

Serrels, A. & Frame, M. C., 13 Jan 2016, (E-pub ahead of print) In: OncoImmunology. p. 00-00

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2015

ADF and Cofilin1 Control Actin Stress Fibers, Nuclear Integrity, and Cell Survival

Kanellos, G., Zhou, J., Patel, H., Ridgway, R. A., Huels, D., Gurniak, C. B., Sandilands, E., Carragher, N. O., Sansom, O. J., Witke, W., Brunton, V. G. & Frame, M. C., 1 Dec 2015, In: Cell Reports. 13, 9, p. 1949–1964

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A direct interaction between fascin and microtubules contributes to adhesion dynamics and cell migration

Villari, G., Jayo, A., Zanet, J., Fitch, B., Serrels, B., Frame, M., Stramer, B. M., Goult, B. T. & Parsons, M., 5 Nov 2015, In: Journal of Cell Science.

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Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity

Serrels, A., Lund, T., Serrels, B., Byron, A., McPherson, R. C., von Kriegsheim, A., Gomez-Cuadrado, L., Canel, M., Muir, M., Ring, J. E., Maniati, E., Sims, A. H., Pachter, J. A., Brunton, V. G., Gilbert, N., Anderton, S. M., Nibbs, R. J. B. & Frame, M. C., 24 Sept 2015, In: Cell. 163, 1, p. 160-173 14 p.

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p70S6K is regulated by Focal Adhesion Kinase and is required for Src-selective autophagy

Sandilands, E., Schoenherr, C. & Frame, M., Sept 2015, In: Cellular Signalling. 27, 9

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Paradox-Breaking RAF Inhibitors that Also Target SRC Are Effective in Drug-Resistant BRAF Mutant Melanoma

Girotti, M. R., Lopes, F., Preece, N., Niculescu-Duvaz, D., Zambon, A., Davies, L., Whittaker, S., Saturno, G., Viros, A., Pedersen, M., Suijkerbuijk, B. M. J. M., Menard, D., McLeary, R., Johnson, L., Fish, L., Ejiama, S., Sanchez-Laorden, B., Hohloch, J., Carragher, N. & Macleod, K. & 8 others, Ashton, G., Marusiak, A. A., Fusi, A., Brognard, J., Frame, M., Lorigan, P., Marais, R. & Springer, C., 12 Jan 2015, In: Cancer Cell. 27, 1, p. 85-96 12 p.

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In vivo imaging of the tumor and its associated microenvironment using combined CARS / 2-photon microscopy

Lee, M., Downes, A., Chau, Y.-Y., Serrels, B., Hastie, N., Elfick, A., Brunton, V., Frame, M. & Serrels, A., 2015, In: IntraVital. 4, 1, 8 p., e1055430.

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2014

Epidermal Growth Factor Receptor substrate 8 (Eps8) controls Src/FAK-dependent phenotypes in squamous carcinoma cells

Schoenherr, C., Serrels, B., Proby, C., Cunningham, D. L., Findlay, J. E., Baillie, G. S., Heath, J. K. & Frame, M. C., 15 Dec 2014, In: Journal of Cell Science. 127, 24, p. 5303-5316 14 p.

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The MacBlue Binary Transgene (csf1r-gal4VP16/UAS-ECFP) Provides a Novel Marker for Visualisation of Subsets of Monocytes, Macrophages and Dendritic Cells and Responsiveness to CSF1 Administration

Sauter, K. A., Pridans, C., Sehgal, A., Bain, C., Scott, C., Moffat, L., Rojo, R., Stutchfield, B. M., Davies, C., Donaldson, D. S., Renault, K., McColl, B. W., Mowat, A. M., Serrels, A., Frame, M. C., Mabbott, N. A. & Hume, D. A., 19 Aug 2014, In: PLoS ONE. 9, 8, p. e105429

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c-Src drives intestinal regeneration and transformation

Cordero, J. B., Ridgway, R. A., Valeri, N., Nixon, C., Frame, M. C., Muller, W. J., Vidal, M. & Sansom, O. J., 1 Jul 2014, In: EMBO Journal. 33, 13, p. 1474-1491 18 p.

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FAK Acts as a Suppressor of RTK-MAP Kinase Signalling in Drosophila melanogaster Epithelia and Human Cancer Cells

Macagno, J. P., Diaz Vera, J., Yu, Y., Macpherson, I., Sandilands, E., Palmer, R., Norman, J. C., Frame, M. & Vidal, M., 27 Mar 2014, In: PLoS Genetics. 10, 3, e1004262.

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2013

V-SRC informs integrin signalling

Frame, M. C., Sept 2013, In: Nature reviews Molecular cell biology. 14, 9, p. 548 1 p.

Research output: Contribution to journal › Article › peer-review

Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of src in pancreatic cancer

Nobis, M., McGhee, E. J., Morton, J. P., Schwarz, J. P., Karim, S. A., Quinn, J., Edward, M., Campbell, A. D., McGarry, L. C., Evans, T. R. J., Brunton, V. G., Frame, M. C., Carragher, N. O., Wang, Y., Sansom, O. J., Timpson, P. & Anderson, K. I., 1 Aug 2013, In: Cancer Research. 73, 15, p. 4674-86 13 p.

Research output: Contribution to journal › Article › peer-review

2012

Src-dependent autophagic degradation of Ret in FAK-signalling-defective cancer cells

Sandilands, E., Serrels, B., Wilkinson, S. & Frame, M. C., Aug 2012, In: EMBO Reports. 13, 8, p. 733-740 8 p.

Research output: Contribution to journal › Article › peer-review

Combining imaging and pathway profiling: an alternative approach to cancer drug discovery.

Carragher, N., Brunton, V. & Frame, M., Mar 2012, In: Drug Discovery Today. 17, 5-6, p. 203-214 12 p.

Research output: Contribution to journal › Article › peer-review

CD24 interacts with and promotes the activity of c-src within lipid rafts in breast cancer cells, thereby increasing integrin-dependent adhesion

Baumann, P., Thiele, W., Cremers, N., Muppala, S., Krachulec, J., Diefenbacher, M., Kassel, O., Mudduluru, G., Allgayer, H., Frame, M. & Sleeman, J. P., 1 Feb 2012, In: Cellular and Molecular Life Sciences. 69, 3, p. 435-448

Research output: Contribution to journal › Article › peer-review

Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling

Sandilands, E., Serrels, B., McEwan, D. G., Morton, J. P., Macagno, J. P., McLeod, K., Stevens, C., Brunton, V. G., Langdon, W. Y., Vidal, M., Sansom, O. J., Dikic, I., Wilkinson, S. & Frame, M. C., Jan 2012, In: Nature Cell Biology. 14, 1, p. 51-60 10 p.

Research output: Contribution to journal › Article › peer-review

Diversity of matriptase expression level and function in breast cancer

Welman, A., Sproul, D., Mullen, P., Muir, M., Kinnaird, A. R., Harrison, D. J., Faratian, D., Brunton, V. G. & Frame, M. C., 2012, In: PLoS ONE. 7, 4, p. e34182

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Margaret Frame

Research output

Search results