Accepting PhD Students
Title: Applying biotechnology to understanding, detection, and elimination of bacterial pathogens.
Our lab is focused around exploiting biotechnology for addressing issues of microbiology. We focus mainly on bacterial pathogens associated with food borne infection (e.g. Salmonella, Campylobacter, Clostridia) or medical implant infections (e.g. Staphylococcus, Streptococcus, Enterococcus, Enterobacter, Klebsiella). Our aim is, through understanding of bacterial physiology, to develop better ways of detection and elimination of these pathogens. Key approaches include vaccines development; molecular adaptation mechanisms (e.g. cold shock and peroxide stress), development of antibiotic tolerant persister cells in biofilms; biodetection systems for imaging infected implants; synthetic polymers for binding or repelling bacteria (e.g. for surface coatings).
Applicants who are interested in applying biotechnology to fundamental issues of bacteriology or bacterial physiology are encouraged to apply and to develop a specific project related to ongoing work in the laboratory.
1) Stress adaptation - Yamanaka, K et al (1998) Mol. Microbiol. 11, 811-818; Craig, JE et al (1998) Microbiol. 144, 697-704. Morgan, HP, Estibeiro, P, Wear, MA, Max, KEA, Heinemann, U, Cubeddu, L, Gallagher, MP , Sadler, PJ, and MD Walkinshaw (2007). Sequence specificity of single-stranded DNA-binding proteins: a novel DNA microarray approach. Nucleic Acids Res. 35: e75.
(2) Host/pathogen interaction - Francis, KP & MP Gallagher(1992) Infect Immun 61, 640-64; Francis, KP, et al (1997) J Bacteriol 179,4046-4048; Taylor et al (1998) Infect Immun 66, 3208-3217.
3) Pernagallo, S, Wu, M, Gallagher, MP and M Bradley (2011). Colonising new frontiers - microarrays reveal biofilm modulating polymers. J. Mater. Chem. Volume 21(1), 96-101.
Microbiology, Biotechnology, Cell Biology, Genetics, Molecular Biology, Food Science, Biochemistry, Immunology