Research output per year
Research output per year
Personal profile
Biography
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2013-present: Head of Pre-Clinical Research at the Muir Maxwell Epilepsy Centre
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2010-present: Chair of Neuronal Cell Biology, Centre for Integrative Physiology, University of Edinburgh
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2008-2010: Reader, Centre for Integrative Physiology, University of Edinburgh
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2004-2008: Senior Lecturer, Centre for Integrative Physiology, University of Edinburgh
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2000-2004: Lecturer, Biomedical Sciences, University of Edinburgh
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1998-2000: Human Frontiers of Science Long-Term Fellow, Children’s Medical Research Institute, Sydney, Australia
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1997-1998: Royal Society Travelling Fellow, Children’s Medical Research Institute, Sydney, Australia
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1994-1997: Postdoctoral Research Fellow, Neurosciences Institute, University of Dundee
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1994: PhD Biochemistry, University of Dundee
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1991: BSc (Hons I) Biochemistry, University of Edinburgh
Current Research Interests
- Understanding the molecular mechanism of activity-dependent bulk endocytosis
- Determining the physiologycal role of activity-dependent bulk endocytosis
- Understanding how interactions between synaptic vesicle control their retireval during endocytosis
- Understanding how presynaptic dysfunction results in human disease
My research in a nutshell
The recycling of synaptic vesicles (SVs) is central to neurotransmitter release, synaptic function and brain communication. Our laboratory studies the molecular mechanisms that control bot the endocytosis and recycling of SVs. We also investigate how presynaptic dysfunction precipitates a series of neurodegenerative and neurodevelopmental conditions and disorders of neuronal excitability.
Teaching
Undergraduate
Year 2: Biomedical Sciences 2
Year 3: Physiology 3
Year 4: Honours Physiology, Developmental and Clinical Neuroscience, Synaptic Function and Plasticity in Health and Disease, Membrane Biology
Postgraduate
MSc by Research Biomedical Sciences (Life Sciences),
MSc by Research Integrative Neuroscience
Exam Boards
Year 4: Honours Physiology, Honours Medical Sciences
Postgraduate MSc by Research Integrative Neuroscience
Course organiser
Year 3: Physiology 3
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Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG-Syt1-SV2 plasma membrane nanocluster for synaptic vesicle entry
Joensuu, M., Syed, P., Saber, S. H., Lanoue, V., Wallis, T. P., Rae, J., Blum, A., Gormal, R. S., Small, C., Sanders, S., Jiang, A., Mahrhold, S., Krez, N., Cousin, M. A., Cooper-White, R., Cooper-White, J. J., Collins, B. M., Parton, R. G., Balistreri, G., Rummel, A., & 1 others, 25 May 2023, (E-pub ahead of print) In: EMBO Journal. e112095.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Epilepsy-related CDKL5 deficiency slows synaptic vesicle endocytosis in central nerve terminals
Kontaxi, C., Ivanova, D., Davenport, E., Kind, P. C. & Cousin, M. A., 9 Feb 2023, (E-pub ahead of print) In: Journal of Neuroscience.Research output: Contribution to journal › Article › peer-review
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Dynamin is primed at endocytic sites for ultrafast endocytosis
Imoto, Y., Raychaudhuri, S., Ma, Y., Fenske, P., Sandoval, E., Itoh, K., Blumrich, E-M., Matsubayashi, H. T., Mamer, L., Zarebidaki, F., Sohl-Kielczynski, B., Trimbuch, T., Nayak, S., Iwasa, J. H., Liu, J., Wu, B., Ha, T., Inoue, T., Jorgensen, E. M., Cousin, M. A., & 2 others, 8 Jul 2022, (E-pub ahead of print) In: Neuron.Research output: Contribution to journal › Article › peer-review
Open Access -
Synaptic vesicle recycling and the endolysosomal system: a reappraisal of form and function
Ivanova, D. & Cousin, M. A., 25 Feb 2022, (E-pub ahead of print) In: Frontiers in synaptic neuroscience.Research output: Contribution to journal › Article › peer-review
Open Access -
FMRP sustains presynaptic function via control of activity-dependent bulk endocytosis
Bonnycastle, K., Kind, P. C. & Cousin, M. A., 23 Feb 2022, In: Journal of Neuroscience. 42, 8, p. 1618-1628Research output: Contribution to journal › Article › peer-review
Open AccessFile
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Determining the role of activity-dependent bulk endocytosis via new molecules
30/01/17 → 15/10/23
Project: Research
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Proof of Principle for DNM1 epileptic encephalopathy treatment using CRISPR-based gene/RNA therapies
Cousin, M. & Gonzalez Sulser, A.
1/09/21 → 31/08/22
Project: Research
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Molecular basis of presynaptic dysfunction in Huntington's Disease
3/06/19 → 26/07/19
Project: Research
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Determining the molecular mechanism of loss of presynaptic huntingtin function in Huntington's Disease
1/02/19 → 30/06/22
Project: Research
Datasets
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Figure 4 Gordon et al (2016) A fine balance of synaptophysin levels underlies efficient retrieval of synaptobrevin II to synaptic vesicles (PLOS ONE)
Cousin, M. (Creator) & Gordon, S. (Creator), Edinburgh DataShare, 15 Jan 2016
DOI: 10.7488/ds/1312
Dataset
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Macropinocyosis filopodia
Cousin, M. (Creator), Edinburgh DataShare, 11 Jan 2022
DOI: 10.7488/ds/3273
Dataset
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Figure 1 Gordon et al (2016) A fine balance of synaptophysin levels underlies efficient retrieval of synaptobrevin II to synaptic vesicles (PLOS ONE)
Cousin, M. (Creator) & Smillie, K. (Creator), Edinburgh DataShare, 15 Jan 2016
DOI: 10.7488/ds/1310
Dataset
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Figures 2/3 Gordon et al (2016) A fine balance of synaptophysin levels underlies efficient retrieval of synaptobrevin II to synaptic vesicles (PLOS ONE)
Cousin, M. (Creator) & Harper, C. (Creator), Edinburgh DataShare, 15 Jan 2016
DOI: 10.7488/ds/1311
Dataset
Press/Media
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Mike Cousin leads study shedding light on causes of epilepsy seizures
19/11/15
1 item of Media coverage
Press/Media: Research
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Dr Michael Cousin comments on schizophrenia medication
7/06/12
1 item of Media coverage
Press/Media: Expert Comment
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Professor Mike Cousin comments on research that won Nobel prize for Medicine
8/10/13
8 items of Media coverage
Press/Media: Expert Comment
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Professor Mike Cousin explains the science involved in vesicles
8/10/13
1 item of Media coverage
Press/Media: Expert Comment
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Dr Mike Cousin pinpoints protein linked to epileptic seizures
4/09/13
7 items of Media coverage
Press/Media: Research