Research output per year
Research output per year
Personal profile
Biography
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2013-present: Head of Pre-Clinical Research at the Muir Maxwell Epilepsy Centre
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2010-present: Chair of Neuronal Cell Biology, Centre for Integrative Physiology, University of Edinburgh
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2008-2010: Reader, Centre for Integrative Physiology, University of Edinburgh
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2004-2008: Senior Lecturer, Centre for Integrative Physiology, University of Edinburgh
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2000-2004: Lecturer, Biomedical Sciences, University of Edinburgh
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1998-2000: Human Frontiers of Science Long-Term Fellow, Children’s Medical Research Institute, Sydney, Australia
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1997-1998: Royal Society Travelling Fellow, Children’s Medical Research Institute, Sydney, Australia
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1994-1997: Postdoctoral Research Fellow, Neurosciences Institute, University of Dundee
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1994: PhD Biochemistry, University of Dundee
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1991: BSc (Hons I) Biochemistry, University of Edinburgh
Current Research Interests
- Understanding the molecular mechanism of activity-dependent bulk endocytosis
- Determining the physiologycal role of activity-dependent bulk endocytosis
- Understanding how interactions between synaptic vesicle control their retireval during endocytosis
- Understanding how presynaptic dysfunction results in human disease
My research in a nutshell
The recycling of synaptic vesicles (SVs) is central to neurotransmitter release, synaptic function and brain communication. Our laboratory studies the molecular mechanisms that control bot the endocytosis and recycling of SVs. We also investigate how presynaptic dysfunction precipitates a series of neurodegenerative and neurodevelopmental conditions and disorders of neuronal excitability.
Teaching
Undergraduate
Year 2: Biomedical Sciences 2
Year 3: Physiology 3
Year 4: Honours Physiology, Developmental and Clinical Neuroscience, Synaptic Function and Plasticity in Health and Disease, Membrane Biology
Postgraduate
MSc by Research Biomedical Sciences (Life Sciences),
MSc by Research Integrative Neuroscience
Exam Boards
Year 4: Honours Physiology, Honours Medical Sciences
Postgraduate MSc by Research Integrative Neuroscience
Course organiser
Year 3: Physiology 3
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Key roles of C2/GAP domains in SYNGAP1-related pathophysiology
Katsanevaki, D., Till, S. M., Buller-Peralta, I., Nawaz, M. S., Louros, S. R., Kapgal, V., Tiwari, S., Walsh, D., Anstey, N. J., Petrović, N. G., Cormack, A., Salazar-Sanchez, V., Harris, A., Farnworth-Rowson, W., Sutherland, A., Watson, T. C., Dimitrov, S., Jackson, A. D., Arkell, D. & Biswal, S. & 13 others, , 24 Sept 2024, In: Cell Reports. 43, 9, 114733.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
SV2A controls the surface nanoclustering and endocytic recruitment of Syt1 during synaptic vesicle recycling
Small, C., Harper, C., Jiang, A., Kontaxi, C., Pronot, M., Yak, N., Malapaka, A., Davenport, E. C., Wallis, T. P., Gormal, R. S., Joensuu, M., Martínez‐mármol, R., Cousin, M. A. & Meunier, F. A., 1 Aug 2024, (E-pub ahead of print) In: Journal of Neurochemistry. 168, 9Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Delayed recruitment of activity-dependent bulk endocytosis in Fmr1 knockout neurons
Kim, N., Bonnycastle, K., Kind, P. C. & Cousin, M. A., 8 Jul 2024, (E-pub ahead of print) In: Journal of Neurochemistry.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Phospholipid Scramblase-1 controls efficient neurotransmission and synaptic vesicle retrieval at cerebellar synapses
Caputo, M., Ivanova, D., Chasserot-Golaz, S., Doussau, F., Marie Haeberlé, A., Royer, C., Ozkan, S., Ecard, J., Vitale, N., Cousin, M. A., Tóth, P., Gasman, S. & Ory, S., 3 Jul 2024, In: The Journal of Neuroscience. 44, 27Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Synaptopathy: presynaptic convergence in frontotemporal dementia and amyotrophic lateral sclerosis
Clayton, E. L., Huggon, L., Cousin, M. A. & Mizielinska, S., 28 Jun 2024, In: Brain. 147, 7, p. 2289–2307Research output: Contribution to journal › Article › peer-review
Open AccessFile
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Investigating the role of PCDH10 in excitatory synapse assembling and physiology
Cousin, M. (Principal Investigator)
2/12/24 → 1/12/26
Project: Research
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Investigating the functional consequences of SUMOylation in Intellectual Disability
Cousin, M. (Principal Investigator)
1/01/24 → 31/12/25
Project: Research
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Mechanism and therapy in DNM1 epileptic encephalopathy
Cousin, M. (Principal Investigator)
1/01/24 → 31/08/27
Project: Research
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Assessing connections between activity-induced synapse sprouting and epileptogenesis
Smillie, K. (Principal Investigator), Cousin, M. (Co-investigator) & Ivanova, D. (Co-investigator)
Epilepsy Research Institute UK
1/01/23 → 30/06/25
Project: Research
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Molecular links to altered synaptotagmin-1 trafficking and pathogenic SV2A epilepsy mutations
Cousin, M. (Principal Investigator)
10/06/24 → 21/07/24
Project: Research
Datasets
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Macropinocyosis filopodia
Cousin, M. (Creator), Edinburgh DataShare, 11 Jan 2022
DOI: 10.7488/ds/3273
Dataset
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Figures 2/3 Gordon et al (2016) A fine balance of synaptophysin levels underlies efficient retrieval of synaptobrevin II to synaptic vesicles (PLOS ONE)
Cousin, M. (Creator) & Harper, C. (Creator), Edinburgh DataShare, 15 Jan 2016
DOI: 10.7488/ds/1311
Dataset
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Figure 1 Gordon et al (2016) A fine balance of synaptophysin levels underlies efficient retrieval of synaptobrevin II to synaptic vesicles (PLOS ONE)
Cousin, M. (Creator) & Smillie, K. (Creator), Edinburgh DataShare, 15 Jan 2016
DOI: 10.7488/ds/1310
Dataset
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Figure 4 Gordon et al (2016) A fine balance of synaptophysin levels underlies efficient retrieval of synaptobrevin II to synaptic vesicles (PLOS ONE)
Cousin, M. (Creator) & Gordon, S. (Creator), Edinburgh DataShare, 15 Jan 2016
DOI: 10.7488/ds/1312
Dataset
Press/Media
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Professor Mike Cousin comments on research that won Nobel prize for Medicine
8/10/13
8 items of Media coverage
Press/Media: Expert Comment
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Mike Cousin leads study shedding light on causes of epilepsy seizures
19/11/15
1 item of Media coverage
Press/Media: Research
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Dr Mike Cousin pinpoints protein linked to epileptic seizures
4/09/13
7 items of Media coverage
Press/Media: Research
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Dr Michael Cousin comments on schizophrenia medication
7/06/12
1 item of Media coverage
Press/Media: Expert Comment
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Professor Mike Cousin explains the science involved in vesicles
8/10/13
1 item of Media coverage
Press/Media: Expert Comment