Research output per year
Research output per year
Personal profile
Current Research Interests
My research is currently focused on the development of advanced MR imaging techniques and their application in neurological diseases.
Disease areas:
- Cerebral small vessel disease
- Multiple sclerosis
- Pre-term birth
Techniques:
- Quantitative magnetic resonance imaging of the brain
- Dynamic contrast-enhanced MRI (DCE-MRI) for probing the blood-brain barrier
- MR cerebrovascular reactivity imaging
- MR imaging of fluid flow
- MR spectroscopy and brain temperature measurement
- MR relaxometry
- Magnetisation transfer
- MR phantom development
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Research output
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A four-dimensional computational model of dynamic contrast-enhanced magnetic resonance imaging measurement of subtle blood-brain barrier leakage
Bernal, J., Valdés-hernández, M. D. C., Escudero, J., Heye, A. K., Sakka, E., Armitage, P. A., Makin, S., Touyz, R. M., Wardlaw, J. M. & Thrippleton, M. J., 23 Jan 2021, In: NeuroImage. 230, p. 117786Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Cerebrovascular Reactivity Measurement Using Magnetic Resonance Imaging: A Systematic Review
Sleight, E., Stringer, M. S., Marshall, I., Wardlaw, J. M. & Thrippleton, M. J., 25 Feb 2021, In: Frontiers in physiology. 12Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies
Best, J. G., Ambler, G., Wilson, D., Lee, K., Lim, J., Shiozawa, M., Koga, M., Li, L., Lovelock, C., Chabriat, H., Hennerici, M., Wong, Y. K., Mak, H. K. F., Prats-sanchez, L., Martínez-domeño, A., Inamura, S., Yoshifuji, K., Arsava, E. M., Horstmann, S., Purrucker, J. & 31 others, , 17 Mar 2021, In: The Lancet Neurology. 20, 4, p. 294-303Research output: Contribution to journal › Article › peer-review
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Lacunar Stroke Lesion Extent and Location and White Matter Hyperintensities Evolution 1 Year Post-lacunar Stroke
Valdés Hernández, M. D. C., Grimsley-moore, T., Sakka, E., Thrippleton, M. J., Chappell, F. M., Armitage, P. A., Makin, S. & Wardlaw, J. M., 5 Mar 2021, In: Frontiers in Neurology. 12Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Post-stroke Cognition at 1 and 3 Years Is Influenced by the Location of White Matter Hyperintensities in Patients With Lacunar Stroke
Valdés Hernández, M. D. C., Grimsley-moore, T., Chappell, F. M., Thrippleton, M. J., Armitage, P. A., Sakka, E., Makin, S. & Wardlaw, J. M., 1 Mar 2021, In: Frontiers in Neurology. 12Research output: Contribution to journal › Article › peer-review
Open AccessFile
Activities
- 1 Oral presentation
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Comparison of five quantitative analysis methods for the assessment of subtle blood-brain barrier permeability using DCE-MRI
Maria Valdes Hernandez (Contributor), Anna K. Heye (Speaker), Michael Thrippleton (Contributor), Paul Armitage (Contributor) & Joanna Wardlaw (Contributor)
3 Oct 2013Activity: Academic talk or presentation types › Oral presentation
Projects
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Wellcome Trust, INSTITUTIONAL STRATEGIC SUPPORT FUND: Investigating mechanisms of brain and cognitive development in children born preterm
Richardson, H., Bastin, M., Thrippleton, M., Fletcher-Watson, S. & Boardman, J.
1/03/21 → 28/02/22
Project: University Awarded Project Funding
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Magnetic resonance imaging (MRI) of brain vascular changes and white matter hyperintensities (WMH) in humans
Meijboom, R., Thrippleton, M., Waldman, A. & Wardlaw, J.
1/04/18 → 31/03/19
Project: Research
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Establishing a protocol for post-mortem MR-pathological correlation for studies of ageing, neurodegeneration and cerebrovascular disease
Valdes Hernandez, M., Wardlaw, J., Smith, C., Marshall, I., Thrippleton, M. & Jansen, M.
1/01/12 → 30/06/13
Project: University Awarded Project Funding
Datasets
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Long-echo-time MR spectroscopic imaging in human brain at 1.5T and 3T
Thrippleton, M. (Creator), Parikh, J. (Creator), Semple, S. (Creator), Harris, B. (Creator), Wardlaw, J. (Creator), Marshall, I. (Creator) & Andrews, P. J. D. (Creator), Edinburgh DataShare, 12 Dec 2017
DOI: 10.7488/ds/2267
Dataset
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A four-dimensional computational model of dynamic contrast-enhanced magnetic resonance imaging measurement of subtle blood-brain barrier leakage: source code
Bernal Moyano, J. (Creator), Valdes Hernandez, M. (Creator), Armitage, P. (Creator), Makin, S. (Creator), Touyz, R. M. (Creator), Wardlaw, J. (Creator), Thrippleton, M. (Creator), Sakka, E. (Creator), Escudero Rodriguez, J. (Creator) & Heye, A. (Creator), Edinburgh DataShare, 17 Dec 2020
DOI: 10.7488/ds/2966, https://www.preprints.org/manuscript/202010.0200/v1
Dataset
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Magnetisation transfer saturation (MTsat) processing
York, B. (Creator), Thrippleton, M. (Creator) & Waldman, A. (Creator), Edinburgh DataShare, 17 Dec 2020
DOI: 10.7488/ds/2965
Dataset
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Methods to quantify and visualize venules using structural magnetic resonance imaging scans
Jochems, A. (Creator), Blair, G. (Creator), Stringer, M. (Creator), Thrippleton, M. (Creator), Clancy, U. (Creator), Chappell, F. (Creator), Brown, R. (Creator), Jaime García, D. (Creator), Hamilton, O. (Creator), Morgan, A. (Creator), Marshall, I. (Creator), Hetherington, K. (Creator), Wiseman, S. (Creator), MacGillivray, T. (Creator), Valdes Hernandez, M. (Creator), Doubal, F. (Creator) & Wardlaw, J. (Creator), Edinburgh DataShare, 21 Jan 2020
DOI: 10.7488/ds/2755
Dataset
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MATLAB-based framework for simulating DCE-MRI of subtle blood-brain barrier breakdown
Manning, C. (Creator) & Thrippleton, M. (Creator), Edinburgh DataShare, 9 Mar 2021
DOI: 10.7488/ds/2997
Dataset